HLA-DRB1 Alleles Are Associated with the Susceptibility to Sporadic Parkinson's Disease in Chinese Han Population

PLoS ONE

Volumn 7, Issue 11, 2013, Pages

  Sun, Congcong ^a   Wei, Lei ^a,b   Luo, Feifei ^a,c   Li, Yi ^d   Li, Jiaobiao ^e   Zhu, Feiqi ^f   Kang, Ping ^g   Xu, Rensi ^h   Xiao, LuLu ⁱ   Liu, Zhuolin ^a   Xu, Pingyi ^a  

^a THE FIRST AFFILIATED HOSPITAL OF SUN YAT SEN UNIVERSITY   (China)

^b THE THIRD AFFILIATED HOSPITAL OF SUN YAT SEN UNIVERSITY   (China)

^c Third People's Hospital of Chengdu   (China)

^d GUANGZHOU RED CROSS HOSPITAL   (China)

^e Department of Neurology   (China)

^f SHANTOU UNIVERSITY MEDICAL COLLEGE   (China)

^g First People's Hospital of Shaoguan   (China)

^h NANCHANG UNIVERSITY   (China)

ⁱ SOUTHERN MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

HLA DRB1 ANTIGEN; HLA DRB1*03:01 ANTIGEN; HLA DRB1*04:06 ANTIGEN; HLA-DRB1*03:01 ANTIGEN; HLA-DRB1*04:06 ANTIGEN;

ADOLESCENT; ADULT; AGED; ARTICLE; ASIAN; CAUCASIAN; CHINESE; CONTROLLED STUDY; ETHNIC DIFFERENCE; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC RISK; GENETIC SUSCEPTIBILITY; HLA DRB1 GENE; HUMAN; MAJOR CLINICAL STUDY; MALE; ONSET AGE; PARKINSON DISEASE; RISK ASSESSMENT; SPORADIC PARKINSON DISEASE; ALLELE; CASE CONTROL STUDY; CHINA; ETHNIC GROUP; GENETIC PREDISPOSITION; GENETICS; MIDDLE AGED; PHENOTYPE; RISK FACTOR;

AGED; ALLELES; ASIAN CONTINENTAL ANCESTRY GROUP; CASE-CONTROL STUDIES; CHINA; ETHNIC GROUPS; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; HLA-DRB1 CHAINS; HUMANS; MALE; MIDDLE AGED; PARKINSON DISEASE; PHENOTYPE; RISK FACTORS;

EID: 84879733357     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0048594     Document Type: Article

References (80)

1. Lang AE, Lozano AM, (1998) Parkinson's disease. Second of two parts. N Engl J Med 339: 1130-1143.
2. Monahan AJ, Warren M, Carvey PM, (2008) Neuroinflammation and peripheral immune infiltration in Parkinson's disease: an autoimmune hypothesis. Cell Transplant 17: 363-372.
3. Ros-Bernal F, Hunot S, Herrero MT, Parnadeau S, Corvol JC, et al. (2011) Microglial glucocorticoid receptors play a pivotal role in regulating dopaminergic neurodegeneration in parkinsonism. Proc Natl Acad Sci U S A 108: 6632-6637.
4. Yong J, Lacan G, Dang H, Hsieh T, Middleton B, et al. (2011) BCG vaccine-induced neuroprotection in a mouse model of Parkinson's disease. PLoS One 6: e16610.
5. Mcgeer PL, Itagaki S, Boyes BE, Mcgeer EG, (1988) Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinson's and Alzheimer's disease brains. Neurology 38: 1285-1291.
6. Klein J, Sato A, (2000) The HLA system. First of two parts. N Engl J Med 343: 702-709.
7. Handunnetthi L, Ramagopalan SV, Ebers GC, Knight JC, (2010) Regulation of major histocompatibility complex class II gene expression, genetic variation and disease. Genes Immun 11: 99-112.
8. Zota V, Nemirovsky A, Baron R, Fisher Y, Selkoe DJ, et al. (2009) HLA-DR alleles in amyloid beta-peptide autoimmunity: a highly immunogenic role for the DRB1*1501 allele. J Immunol 183: 3522-3530.
9. Ma SL, Tang NL, Tam CW, Lui VW, Suen EW, et al. (2008) Association between HLA-A alleles and Alzheimer's disease in a southern Chinese community. Dement Geriatr Cogn Disord 26: 391-397.
10. Guerini FR, Tinelli C, Calabrese E, Agliardi C, Zanzottera M, et al. (2009) HLA-A*01 is associated with late onset of Alzheimer's disease in Italian patients. Int J Immunopathol Pharmacol 22: 991-999.
11. Neill D, Curran MD, Middleton D, Mawhinney H, Edwardson JA, et al. (1999) Risk for Alzheimer's disease in older late-onset cases is associated with HLA-DRB1*03. Neurosci Lett 275: 137-140.
12. Marttila RJ, Rinne UK, Tiilikainen A, (1981) Histocompatibility types in Parkinson's disease. J Neurol Sci 51: 217-221.
13. Leheny WA, Davidson DL, Devane P, House AO, Lenman JA, (1983) HLA antigens in Parkinson's disease. Tissue Antigens 21: 260-261.
14. Reed E, Lewison A, Mayeaux R, Suciu-Foca N, (1983) HLA antigens in Parkinson's disease. Tissue Antigens 21: 161-163.
15. Lampe JB, Gossrau G, Herting B, Kempe A, Sommer U, et al. (2003) HLA typing and Parkinson's disease. Eur Neurol 50: 64-68.
16. Saiki M, Baker A, Williams-Gray CH, Foltynie T, Goodman RS, et al. (2010) Association of the human leucocyte antigen region with susceptibility to Parkinson's disease. J Neurol Neurosurg Psychiatry 81: 890-891.
17. Hamza TH, Zabetian CP, Tenesa A, Laederach A, Montimurro J, et al. (2010) Common genetic variation in the HLA region is associated with late-onset sporadic Parkinson's disease. Nat Genet 42: 781-785.
18. Nalls MA, Plagnol V, Hernandez DG, Sharma M, Sheerin UM, et al. (2011) Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies. Lancet 377: 641-649.
19. Simón-Sánchez J, van Hilten JJ, van de Warrenburg B, Post B, Berendse HW, et al. (2011) Genome-wide association study confirms extant PD risk loci among the Dutch. Eur J Hum Genet (19) (): 655-661.
20. Satake W, Nakabayashi Y, Mizuta I, Hirota Y, Ito C, et al. (2009) Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease. Nat Genet 41: 1303-1307.
21. Marsh SG, (2012) WHO Nomenclature Committee for Factors of the HLA System (2012) Nomenclature for factors of the HLA system, update December 2011. Tissue Antigens 79: 230-234.
22. Hughes AJ, Daniel SE, Kilford L, Lees AJ, (1992) Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases. J Neurol Neurosurg Psychiatry 55: 181-184.
23. Creary LE, Girdlestone J, Zamora J, Brown J, Navarrete CV, (2009) Molecular typing of HLA genes using whole genome amplified DNA. Transfusion 49: 57-63.
24. Shi YY, He L, (2005) SHEsis, a powerful software platform for analyses of linkage disequilibrium, haplotype construction, and genetic association at polymorphism loci. Cell Res 15: 97-98.
25. Hei AL, Li W, Deng ZH, He J, Jin WM, et al. (2009) Analysis of high-resolution HLA-A,-B,-Cw,-DRB1, and-DQB1 alleles and haplotypes in 718 Chinese marrow donors based on donor-recipient confirmatory typings. Int J Immunogenet 36: 275-282.
26. Deng YJ, Yang G, Wu DY, Hu SN, Li SB, et al. (2006) HLA-A, B, DRB1 gene polymorphism of Beijing population was studied by high-resolution polymerase chain reaction sequence-based typing. Zhonghua Yi Xue Yi Chuan Xue Za Zhi 23: 103-106.
27. Zhang BW, Xing PQ, Guo RH, Bie LL, Zhao L, et al. (2006) Study on the polymorphism of HLA genes in the stem cell donors of Henan province. Chinese journal of blood transfusion 19: 115-117.
28. Qin Qin P, Su F, Xiao Yan W, Xing Z, Meng P, et al. (2011) Distribution of human leucocyte antigen-A,-B and-DR alleles and haplotypes at high resolution in the population from Jiangsu province of China. Int J Immunogenet 38: 475-481.
29. Li WX, Shen G, Wu JM, Zhu YY, Liu GJ, et al. (2010) The HLA-DRB1 gene polymorphism at high resolution of Han population from Hubei Branch of CMDP. Chinese journal of blood transfusion 23: 443-445.
30. Huang CX, Cheng LH, Liu YZ, Li Z, (2011) Study on the association between HLA-DRB1 allele polymorphism and the genetic susceptibility with Breast Cancer. International Journal of laboratory medicine 32: 728-733.
31. Chen PL, Fann CS, Chu CC, Chang CC, Chang SW, et al. (2011) Comprehensive genotyping in two homogeneous Graves' disease samples reveals major and novel HLA association alleles. PLoS One 6: e16635.
32. Wen SH, Lai MJ, Yang KL, (2008) Human leukocyte antigen-A,-B, and-DRB1 haplotypes of cord blood units in the Tzu Chi Taiwan Cord Blood Bank. Hum Immunol. 69: 430-436.
33. Pan CF, Wu CJ, Chen HH, Dang CW, Chang FM, et al. (2009) Molecular analysis of HLA-DRB1 allelic associations with systemic lupus erythematous and lupus nephritis in Taiwan. Lupus 18: 698-704.
34. Lai MJ, Wen SH, Lin YH, Shyr MH, Lin PY, et al. (2010) Distributions of human leukocyte antigen-A,-B, and-DRB1 alleles and haplotypes based on 46,915 Taiwanese donors. Hum Immunol 71: 777-782.
35. Tanaka T, Ohmori M, Yasunaga S, Ohshima K, Kikuchi M, et al. (1999) DNA typing of HLA class II genes (HLA-DR,-DQ and-DP) in Japanese patients with histiocytic necrotizing lymphadenitis (Kikuchi's disease). Tissue Antigens 54: 246-253.
36. Hashimoto M, Kinoshita T, Yamasaki M, Tanaka H, Imanishi T, et al. (1994) Gene frequencies and haplotypic associations within the HLA region in 916 unrelated Japanese individuals. Tissue Antigens 44: 166-173.
37. Itoh Y, Mizuki N, Shimada T, Azuma F, Itakura M, et al. (2005) High-throughput DNA typing of HLA-A,-B,-C, and-DRB1 loci by a PCR-SSOP-Luminex method in the Japanese population. Immunogenetics 57: 717-729.
38. Mitsunaga S, Homma Y, Narita A, Kashiwase K, Okudaira Y, et al. (2011) Particular human leukocyte antigen alleles are associated with biochemical traits in the Japanese population. Hum Immunol 72: 566-570.
39. Park MH, Kim HS, Kang SJ, (1999) HLA-A,-B,-DRB1 allele and haplotype frequencies in 510 Koreans. Tissue Antigens 53: 386-390.
40. Song EY, Park H, Roh EY, Park MH, (2004) HLA-DRB1 and-DRB3 allele frequencies and haplotypic associations in Koreans. Hum Immunol 65: 270-276.
41. Song EY, Park S, Lee DS, Cho HI, Park MH, (2008) Association of human leukocyte antigen-DRB1 alleles with disease susceptibility and severity of aplastic anemia in Korean patients. Hum Immunol 69: 354-359.
42. Maiers M, Gragert L, Klitz W, (2007) High-resolution HLA alleles and haplotypes in the United States population. Hum Immunol 68: 779-788.
43. Klitz W, Gragert L, Maiers M, Tu B, Lazaro A, et al. (2009) Four-locus high-resolution HLA typing in a sample of Mexican Americans. Tissue Antigens 74: 508-513.
44. Wang SS, Abdou AM, Morton LM, Thomas R, Cerhan JR, et al. (2010) Human leukocyte antigen class I and II alleles in non-Hodgkin lymphoma etiology. Blood 115: 4820-4823.
45. Mack SJ, Tu B, Yang R, Masaberg C, Ng J, et al. (2011) Human leukocyte antigen-A,-B,-C,-DRB1 allele and haplotype frequencies in Americans originating from southern Europe: contrasting patterns of population differentiation between Italian and Spanish Americans. Hum Immunol 72: 144-149.
46. Mack SJ, Tu B, Lazaro A, Yang R, Lancaster AK, et al. (2009) HLA-A,-B,-C, and-DRB1 allele and haplotype frequencies distinguish Eastern European Americans from the general European American population. Tissue Antigens 73: 17-32.
47. Schmidt AH, Solloch UV, Pingel J, Baier D, Böhme I, et al. (2011) High-resolution human leukocyte antigen allele and haplotype frequencies of the Polish population based on 20,653 stem cell donors. Hum Immunol 72: 558-565.
48. Schmidt AH, Baier D, Solloch UV, Stahr A, Cereb N, et al. (2009) Estimation of high-resolution HLA-A,-B,-C,-DRB1 allele and haplotype frequencies based on 8862 German stem cell donors and implications for strategic donor registry planning. Hum Immunol 70: 895-902.
49. Middleton D, Williams F, Hamill MA, Meenagh A, (2000) Frequency of HLA-B alleles in a Caucasoid population determined by a two-stage PCR-SSOP typing strategy. Hum Immunol 61: 1285-1297.
50. Vidal S, Morante MP, Moga E, Mosquera AM, Querol S, et al. (2002) Molecular analysis of HLA-DRB1 polymorphism in north-east Spain. Eur J Immunogenet 29: 75-77.
51. Meyer-Monard S, Passweg J, Troeger C, Eberhard HP, Roosnek E, et al. (2009) Cord blood banks collect units with different HLA alleles and haplotypes to volunteer donor banks: a comparative report from Swiss Blood stem cells. Bone Marrow Transplant 43: 771-778.
52. Gonzalez-Galarza FF, Christmas S, Middleton D, Jones AR, (2011) Allele frequency net: a database and online repository for immune gene frequencies in worldwide populations. Nucleic Acids Res 39: D913-919.
53. Manan H, Angham AM, Sitelbanat A, (2010) Genetic and diabetic auto-antibody markers in Saudi children with type 1 diabetes. Hum Immunol 71: 1238-1242.
54. de la Concha EG, Cavanillas ML, Cénit MC, Urcelay E, Arroyo R, et al. (2012) DRB1*03: 01 haplotypes: differential contribution to multiple sclerosis risk and specific association with the presence of intrathecal IgM bands. PLoS One 7: e31018.
55. Kaufman JF, Auffray C, Korman AJ, Shackelford DA, Strominger J, (1984) The class II molecules of the human and murine major histocompatibility complex. Cell 36: 1-13.
56. Idali F, Wikén M, Wahlström J, Mellstedt H, Eklund A, et al. (2006) Reduced Th1 response in the lungs of HLA-DRB1*0301 patients with pulmonary sarcoidosis. Eur Respir J 27: 451-459.
57. Wikén M, Grunewald J, Eklund A, Wahlström J, (2012) Multiparameter phenotyping of T-cell subsets in distinct subgroups of patients with pulmonary sarcoidosis. J Intern Med 271: 90-103.
58. Reynolds AD, Banerjee R, Liu J, Gendelman HE, Mosley RL, (2007) Neuroprotective activities of CD4+CD25+ regulatory T cells in an animal model of Parkinson's disease. J Leukoc Biol 82: 1083-1094.
59. Benner EJ, Banerjee R, Reynolds AD, Sherman S, Pisarev VM, et al. (2008) Nitrated alpha-synuclein immunity accelerates degeneration of nigral dopaminergic neurons. PLoS One 3: e1376.
60. Brochard V, Combadière B, Prigent A, Laouar Y, Perrin A, et al. (2009) Infiltration of CD4+ lymphocytes into the brain contributes to neurodegeneration in a mouse model of Parkinson disease. J Clin Invest 119: 182-192.
61. Kebir H, Kreymborg K, Ifergan I, Dodelet-Devillers A, Cayrol R, et al. (2007) Human TH17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation. Nat Med 13: 1173-1175.
62. Murakami M, Mizuide M, Kashima K, Kojima A, Tomioka SI, et al. (2000) Identification of monoclonal insulin autoantibodies in insulin autoimmune syndrome associated with HLA-DRB1*0401. Horm Res 54: 49-52.
63. Ueki A, Isozaki Y, Kusaka M, (2005) Anti-caspase-8 autoantibody response in silicosis patients is associated with HLA-DRB1, DQB1 and DPB1 alleles. J Occup Health 47: 61-67.
64. Azuma H, Sada M, Tsuji T, Ueda H, Katsuoka Y, (1999) Relationship between HLA-DR antigen and HLA-DRB1 alleles and prostate cancer in Japanese men. Int Urol Nephrol 31: 343-349.
65. Miyagawa S, Amagai M, Niizeki H, Yamashina Y, Kaneshige T, et al. (1999) HLA-DRB1 polymorphisms and autoimmune responses to desmogleins in Japanese patients with pemphigus. Tissue Antigens 54: 333-340.
66. Zhang ZX, Roman GC, Hong Z, Wu CB, Qu QM, et al. (2005) Parkinson's disease in China: prevalence in Beijing, Xian, and Shanghai. Lancet 365: 595-597.
67. von Campenhausen S, Bornschein B, Wick R, Bötzel K, Sampaio C, et al. (2005) Prevalence and incidence of Parkinson's disease in Europe. Eur Neuropsychopharmacol 15: 473-490.
68. Driver JA, Logroscino G, Gaziano JM, Kurth T, (2009) Incidence and remaining lifetime risk of Parkinson disease in advanced age. Neurology 72: 432-438.
69. Wirdefeldt K, Adami HO, Cole P, Trichopoulos D, Mandel J, (2011) Epidemiology and etiology of Parkinson's disease: a review of the evidence. Eur J Epidemiol 26 (Suppl 1): S1-58.
70. Chun-Lai T, Padyukov L, Dhaliwal JS, Lundström E, Yahya A, et al. (2011) Shared epitope alleles remain a risk factor for anti-citrullinated proteins antibody (ACPA)-positive rheumatoid arthritis in three Asian ethnic groups. PLoS One 6: e21069.
71. Kojima Y, Takahara S, Nonomura N, Sada M, Tsuji T, et al. (2000) HLA-DRB genotypes in Japanese patients with renal cell carcinoma. Oncology 59: 57-62.
72. Monos DS, Papaioakim M, Ho TW, Li CY, Mckhann GM, (1997) Differential distribution of HLA alleles in two forms of Guillain- Barré syndrome. J Infect Dis 176 (Suppl 2): S180-182.
73. Luo H, Chen M, Yang R, Xu PC, Zhao MH, (2011) The association of HLA-DRB1 alleles with antineutrophil cytoplasmic antibody-associated systemic vasculitis in Chinese patients. Hum Immunol 72: 422-425.
74. Saha M, Harman K, Mortimer NJ, Binda V, Black MM, et al. (2010) Pemphigus vulgaris in White Europeans is linked with HLA Class II allele HLA DRB1*1454 but not DRB1*1401. J Invest Dermatol 130: 311-314.
75. Miretti MM, Walsh EC, Ke X, Delgado M, Griffiths M, et al. (2005) A high-resolution linkage-disequilibrium map of the human major histocompatibility complex and first generation of tag single-nucleotide polymorphisms. Am J Hum Genet 76: 634-646.
76. de Bakker PI, McVean G, Sabeti PC, Miretti MM, Green T, et al. (2006) A high-resolution HLA and SNP haplotype map for disease association studies in the extended human MHC. Nat Genet 38: 1166-1172.
77. Leslie S, Donnelly P, McVean G, (2008) A statistical method for predicting classical HLA alleles from SNP data. Am J Hum Genet 82: 48-56.
78. Tekola Ayele F, Hailu E, Finan C, Aseffa A, Davey G, et al. (2012) Prediction of HLA class II alleles using SNPs in an African population. PLoS One 7: e40206.
79. McElroy JP, Isobe N, Gourraud PA, Caillier SJ, Matsushita T, et al. (2011) SNP-based analysis of the HLA locus in Japanese multiple sclerosis patients. Genes Immun 12: 523-530.
80. Kitajima H, Sonoda M, Yamamoto K (2012) HLA and SNP haplotype mapping in the Japanese population. Genes Immun 35. In press.