Identification of monoclonal insulin autoantibodies in insulin autoimmune syndrome associated with HLA-DRB1*0401

Hormone Research

Volumn 54, Issue 1, 2000, Pages 49-52

  Murakami, Masami ^a   Mizuide, Masafumi ^a   Kashima, Koji ^a   Kojima, Akira ^a   Tomioka, Shin Ichi ^b   Kohama, Tomoko ^a   Araki, Osamu ^a   Ogiwara, Takayuki ^a   Mizuma, Haruo ^a   Mori, Masatomo ^a  

^a GUNMA UNIVERSITY   (Japan)

^b Tone Chuo Hospital   (Japan)

Author keywords

Hypoglycemia; Immunoglobulin; Scatchard plot

Indexed keywords

AUTOANTIBODY; HLA DR ANTIGEN; HLA DR4 ANTIGEN; IMMUNOGLOBULIN G; INSULIN ANTIBODY; MONOCLONAL ANTIBODY;

AGED; ARTICLE; AUTOIMMUNE DISEASE; BINDING AFFINITY; CASE REPORT; CLINICAL FEATURE; DISEASE ASSOCIATION; DISEASE COURSE; FEMALE; HLA TYPING; HUMAN; INSULIN AUTOIMMUNE SYNDROME; JAPAN; PRIORITY JOURNAL; SYNDROME;

EID: 0034485013     PISSN: 03010163     EISSN: None     Source Type: Journal    
DOI: 10.1159/000053230     Document Type: Article

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4. Strong association of insulin autoimmune syndrome with HLA-DR4
5. Haplotypic diversity of DQA1*03 and *05 subtypes differing at amino acid residue 160 encoded in the third exon in 2215 Japanese individuals
6. Method for rapid quantitation and characterization of insulin antibodies
7. Increase in insulin antibodies during continuous subcutaneous insulin infusion and multiple-injection therapy in contrast to conventional treatment
8. The attraction of protein for small molecules and ions
9. Differential immunogenic determinants of polyclonal insulin autoimmune syndrome (Hirata's disease) and monoclonal insulin autoimmune syndrome
10. The immunoglobulin class, the subclass and the ratio of κ:λ light chain of autoantibodies to human insulin in insulin autoimmune syndrome
11. HLA-DR4 genotype and insulin-processing in insulin autoimmune syndrome
12. Recognition of human insulin in the context of HLA-DRB1*0406 products by T cells of insulin autoimmune syndrome patients and healthy donors
13. Antigen-specific T cells with monogamous or promiscuous restriction patterns are sensitive to different HLA-DRB chain substitutions
14. Mutations in the third, but not the first or second, hypervariable regions of DR(B1*0101) eliminate DRB1-restricted recognition of a pertussis toxin peptide
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16. Insulin autoimmune syndrome: HLA genes may be a marker of disease heterogeneity
17. Critical contribution of β chain residue 57 in peptide binding ability of both HLA-DR and -DQ molecules