Piromelatine decreases triglyceride accumulation in insulin resistant 3T3-L1 adipocytes: Role of ATGL and HSL

Biochimie

Volumn 95, Issue 8, 2013, Pages 1650-1654

  Wang, Ping Ping ^a   She, Mei Hua ^a   He, Ping Ping ^a   Chen, Wu Jun ^a   Laudon, Moshe ^b   Xu, Xuan Xuan ^a   Yin, Wei Dong ^a  

^a UNIVERSITY OF SOUTH CHINA   (China)

^b NEURIM PHARMACEUTICALS LTD   (Israel)

Author keywords

3T3 L1 adipocyte; ATGL HSL; Ca2+; Insulin resistance; Piromelatine; Triglyceride

Indexed keywords

ADIPOSE TRIGLYCERIDE LIPASE; HORMONE SENSITIVE LIPASE; INSULIN; LUZINDOLE; MELATONIN; PIROMELATINE; TRIACYLGLYCEROL; TRIACYLGLYCEROL LIPASE; UNCLASSIFIED DRUG; CHOLESTEROL ESTERASE; DESNUTRIN PROTEIN, MOUSE; INDOLE DERIVATIVE; N-(2-(5-METHOXY-INDOL-3-YL)-ETHYL)-4-OXO-4H-PYRAN-2-CARBOXAMIDE; PYRAN DERIVATIVE;

ADIPOCYTE; ARTICLE; CONTROLLED STUDY; GLUCOSE TRANSPORT; GLUCOSE UTILIZATION; INSULIN RESISTANCE; LIPID METABOLISM; LIPOLYSIS; PROTEIN EXPRESSION; WESTERN BLOTTING; 3T3 CELL LINE; ANIMAL; CELL CULTURE; DOWN REGULATION; DRUG EFFECTS; HUMAN; METABOLISM; MOUSE; RAT; SIGNAL TRANSDUCTION;

RATTUS;

3T3-L1 CELLS; ADIPOCYTES; ANIMALS; BLOTTING, WESTERN; CELLS, CULTURED; DOWN-REGULATION; HUMANS; INDOLES; INSULIN RESISTANCE; LIPASE; MICE; PYRANS; RATS; SIGNAL TRANSDUCTION; STEROL ESTERASE; TRIGLYCERIDES;

EID: 84879692831     PISSN: 03009084     EISSN: 61831638     Source Type: Journal    
DOI: 10.1016/j.biochi.2013.05.005     Document Type: Article

References (32)

1. B. Draznin Cytosolic calcium and insulin resistance Am. J. Kidney Dis. 21 1993 32 38
2. J.T. Padra, I. Seres, G. Foris, G. Paragh Jr., G. Konya, and G. Paragh Leptin triggers Ca(2+) imbalance in monocytes of overweight subjects Neuropeptides 46 2012 203 209
3. C. Ekmekcioglu Melatonin receptors in humans: biological role and clinical relevance Biomed. Pharmacother. 60 2006 97 108
4. R. Oertel, L. Goltz, and W. Kirch Elucidation of Neu-P11 metabolism in urine of volunteers by liquid chromatography-tandem mass spectrometry J. Chromatogr. A 1278 2013 69 75
5. E. Peschke, and E. Muhlbauer New evidence for a role of melatonin in glucose regulation Best Pract. Res. Clin. Endocrinol. Metab. 24 2010 829 841
6. S. Nishida Metabolic effects of melatonin on oxidative stress and diabetes mellitus Endocrine 27 2005 131 136
7. M.J. Rios-Lugo, P. Cano, V. Jimenez-Ortega, M.P. Fernandez-Mateos, P.A. Scacchi, D.P. Cardinali, and A.I. Esquifino Melatonin effect on plasma adiponectin, leptin, insulin, glucose, triglycerides and cholesterol in normal and high fat-fed rats J. Pineal Res. 49 2010 342 348
8. F. Nduhirabandi, E.F. du Toit, and A. Lochner Melatonin and the metabolic syndrome: a tool for effective therapy in obesity-associated abnormalities? Acta Physiol. (Oxf) 205 2012 209 223
9. C.N. Borges-Silva, M.H. Fonseca-Alaniz, M.I. Alonso-Vale, J. Takada, S. Andreotti, S.B. Peres, J. Cipolla-Neto, T.C. Pithon-Curi, and F.B. Lima Reduced lipolysis and increased lipogenesis in adipose tissue from pinealectomized rats adapted to training J. Pineal Res. 39 2005 178 184
10. L. Paulis, F. Simko, and M. Laudon Cardiovascular effects of melatonin receptor agonists Expert Opin. Investig. Drugs 21 2012 1661 1678
11. M. She, X. Deng, Z. Guo, M. Laudon, Z. Hu, D. Liao, X. Hu, Y. Luo, Q. Shen, Z. Su, and W. Yin NEU-P11, a novel melatonin agonist, inhibits weight gain and improves insulin sensitivity in high-fat/high-sucrose-fed rats Pharmacol. Res. 59 2009 248 253
12. J.W. Jocken, D. Langin, E. Smit, W.H. Saris, C. Valle, G.B. Hul, C. Holm, P. Arner, and E.E. Blaak Adipose triglyceride lipase and hormone-sensitive lipase protein expression is decreased in the obese insulin-resistant state J. Clin. Endocrinol. Metab. 92 2007 2292 2299
13. M.A. Ravier, M. Nenquin, T. Miki, S. Seino, and J.C. Henquin Glucose controls cytosolic Ca2+ and insulin secretion in mouse islets lacking adenosine triphosphate-sensitive K+ channels owing to a knockout of the pore-forming subunit Kir6.2 Endocrinology 150 2009 33 45
14. N. Nishino, Y. Tamori, and M. Kasuga Insulin efficiently stores triglycerides in adipocytes by inhibiting lipolysis and repressing PGC-1alpha induction Kobe J. Med. Sci. 53 2007 99 106
15. H.Y. Ling, H.S. Ou, S.D. Feng, X.Y. Zhang, Q.H. Tuo, L.X. Chen, B.Y. Zhu, Z.P. Gao, C.K. Tang, W.D. Yin, L. Zhang, and D.F. Liao CHANGES IN microRNA (miR) profile and effects of miR-320 in insulin-resistant 3T3-L1 adipocytes Clin. Exp. Pharmacol. Physiol. 36 2009 e32 e39
16. M.L. Dubocovich, K. Yun, W.M. Al-Ghoul, S. Benloucif, and M.I. Masana Selective MT2 melatonin receptor antagonists block melatonin-mediated phase advances of circadian rhythms FASEB J. 12 1998 1211 1220
17. S. Kersten Mechanisms of nutritional and hormonal regulation of lipogenesis EMBO Rep. 2 2001 282 286
18. M.J. Watt, B.J. van Denderen, L.A. Castelli, C.R. Bruce, A.J. Hoy, E.W. Kraegen, L. Macaulay, and B.E. Kemp Adipose triglyceride lipase regulation of skeletal muscle lipid metabolism and insulin responsiveness Mol. Endocrinol. 22 2008 1200 1212
19. J.W. Jocken, C. Roepstorff, G.H. Goossens, P. van der Baan, M. van Baak, W.H. Saris, B. Kiens, and E.E. Blaak Hormone-sensitive lipase serine phosphorylation and glycerol exchange across skeletal muscle in lean and obese subjects: effect of beta-adrenergic stimulation Diabetes 57 2008 1834 1841
20. M. Schweiger, R. Schreiber, G. Haemmerle, A. Lass, C. Fledelius, P. Jacobsen, H. Tornqvist, R. Zechner, and R. Zimmermann Adipose triglyceride lipase and hormone-sensitive lipase are the major enzymes in adipose tissue triacylglycerol catabolism J. Biol. Chem. 281 2006 40236 40241
21. R. Zechner, P.C. Kienesberger, G. Haemmerle, R. Zimmermann, and A. Lass Adipose triglyceride lipase and the lipolytic catabolism of cellular fat stores J. Lipid Res. 50 2009 3 21
22. K.T. Ong, M.T. Mashek, S.Y. Bu, A.S. Greenberg, and D.G. Mashek Adipose triglyceride lipase is a major hepatic lipase that regulates triacylglycerol turnover and fatty acid signaling and partitioning Hepatology 53 2011 116 126
23. H. Miyoshi, J.W. Perfield 2nd, M.S. Obin, and A.S. Greenberg Adipose triglyceride lipase regulates basal lipolysis and lipid droplet size in adipocytes J. Cell. Biochem. 105 2008 1430 1436
24. G. Haemmerle, A. Lass, R. Zimmermann, G. Gorkiewicz, C. Meyer, J. Rozman, G. Heldmaier, R. Maier, C. Theussl, S. Eder, D. Kratky, E.F. Wagner, M. Klingenspor, G. Hoefler, and R. Zechner Defective lipolysis and altered energy metabolism in mice lacking adipose triglyceride lipase Science 312 2006 734 737
25. R. Zimmermann, J.G. Strauss, G. Haemmerle, G. Schoiswohl, R. Birner-Gruenberger, M. Riederer, A. Lass, G. Neuberger, F. Eisenhaber, A. Hermetter, and R. Zechner Fat mobilization in adipose tissue is promoted by adipose triglyceride lipase Science 306 2004 1383 1386
26. M. Sanchez-Hidalgo, Z. Lu, D.X. Tan, M.D. Maldonado, R.J. Reiter, and R.I. Gregerman Melatonin inhibits fatty acid-induced triglyceride accumulation in ROS17/2.8 cells: implications for osteoblast differentiation and osteoporosis Am. J. Physiol. Regul. Integr. Comp. Physiol. 292 2007 R2208 R2215
27. J. Vanecek Melatonin inhibits increase of intracellular calcium and cyclic AMP in neonatal rat pituitary via independent pathways Mol. Cell. Endocrinol. 107 1995 149 153
28. A.C. de Oliveira, S. Andreotti, S. Farias Tda, F.L. Torres-Leal, A.R. de Proenca, A.B. Campana, A.H. de Souza, R.A. Sertie, A.R. Carpinelli, J. Cipolla-Neto, and F.B. Lima Metabolic disorders and adipose tissue insulin responsiveness in neonatally STZ-induced diabetic rats are improved by long-term melatonin treatment Endocrinology 153 2012 2178 2188
29. M.L. Dubocovich, and J.S. Takahashi Use of 2-[125I]iodomelatonin to characterize melatonin binding sites in chicken retina Proc. Natl. Acad. Sci. U.S.A. 84 1987 3916 3920
30. L. Zhang, P. Su, C. Xu, C. Chen, A. Liang, K. Du, Y. Peng, and D. Huang Melatonin inhibits adipogenesis and enhances osteogenesis of human mesenchymal stem cells by suppressing PPARgamma expression and enhancing Runx2 expression J. Pineal Res. 49 2010 364 372
31. M.I. Alonso-Vale, S.B. Peres, C. Vernochet, S.R. Farmer, and F.B. Lima Adipocyte differentiation is inhibited by melatonin through the regulation of C/EBPbeta transcriptional activity J. Pineal Res. 47 2009 221 227
32. K. Zwirska-Korczala, J. Jochem, M. Adamczyk-Sowa, P. Sowa, R. Polaniak, E. Birkner, M. Latocha, K. Pilc, and R. Suchanek Influence of melatonin on cell proliferation, antioxidative enzyme activities and lipid peroxidation in 3T3-L1 preadipocytes-an in vitro study J. Physiol. Pharmacol. 56 Suppl. 6 2005 91 99