A SMAD3 gene polymorphism is related with osteoarthritis in a Northeast Chinese population

Rheumatology International

Volumn 33, Issue 7, 2013, Pages 1763-1768

  Liying, Jiang ^a   Yuchun, Tao ^b   Youcheng, Wang ^c   Yingchen, Wang ^b   Chunyu, Jin ^d   Yanling, Yin ^e   Hongmei, Jin ^f   Yujie, Li ^b  

^a NANTONG UNIVERSITY   (China)

^b HARBIN MEDICAL UNIVERSITY   (China)

^c HEILONGJIANG PROVINCIAL HOSPITAL   (China)

^d THE SECOND AFFILIATED HOSPITAL OF HARBIN MEDICAL UNIVERSITY   (China)

^e Department of Chemistry   (China)

^f Heilongjiang Center for Disease Control and Prevention   (China)

Author keywords

Genetic variation; Osteoarthritis; SMAD3

Indexed keywords

SMAD3 PROTEIN;

ADULT; ARTICLE; CHINESE; CONTROLLED STUDY; FEMALE; GENE; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GENOTYPE; HAND OSTEOARTHRITIS; HUMAN; JOINT RADIOGRAPHY; KNEE OSTEOARTHRITIS; MAJOR CLINICAL STUDY; MALE; PATHOGENESIS; POLYMERASE CHAIN REACTION; POPULATION BASED CASE CONTROL STUDY; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; SMAD3 GENE;

AGED; CASE-CONTROL STUDIES; CHI-SQUARE DISTRIBUTION; CHINA; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; HAND JOINTS; HUMANS; MALE; MIDDLE AGED; ODDS RATIO; OSTEOARTHRITIS; OSTEOARTHRITIS, KNEE; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK FACTORS; SMAD3 PROTEIN;

EID: 84879689967     PISSN: 01728172     EISSN: 1437160X     Source Type: Journal    
DOI: 10.1007/s00296-012-2593-z     Document Type: Article

References (17)

1. Reginster JY (2002) The prevalence and burden of arthritis. Rheumatology (Oxford) 41(Supp 1):3-6
2. Sun BH, Wu CW, Kalunian KC (2007) New developments in osteoarthritis. Rheum Dis Clin North Am 33:135-148
3. Jensen CH, Rofail S (1999) Knee injury and obesity in patients undergoing total knee replacement: a retrospective study in 115 patients. J Orthop Sci 4:5-7
4. Schouten JS, de Bie RA, Swaen G (2002) An update on the relationship between occupational factors and osteoarthritis of the hip and knee. Curr Opin Rheumatol 14:89-92
5. Blagojevic M, Jinks C, Jeffery A, Jordan KP (2010) Risk factors for onset of osteoarthritis of the knee in older adults: a systematic review and meta-analysis. Osteoarthritis Cartilage 18(1):24-33
6. Grotle M, Hagen KB, Natvig B, Dahl FA, Kvien TK (2008) Obesity and osteoarthritis in knee, hip and/or hand: an epidemiological study in the general population with 10 years follow-up. BMC Musculoskelet Disord 9:132
7. Loughlin J (2005) The genetic epidemiology of human primary osteoarthritis: current status. Expert Rev Mol Med 7:1-12
8. Valdes AM, Loughlin J, Oene MV, Chapman K, Surdulescu GL, Doherty M et al (2007) Sex and ethnic differences in the association of ASPN, CALM1, COL2A1, COMP, and FRZB with genetic susceptibility to osteoarthritis of the knee. Arthritis Rheum 56(1):137-146
9. Neame RL, Muir K, Doherty S, Doherty M (2004) Genetic risk of knee osteoarthritis: a sibling study. Ann Rheum Dis 63(9):1022-1027
10. van der Kraan PM, Blaney Davidson EN, Blom A, van den Berg WB (2009) TGF-beta signaling in chondrocyte terminal differentiation and osteoarthritis: modulation and integration of signaling pathways through receptor-Smads. Osteoarthritis Cartilage 17(12):1539-1545
11. Yang X, Chen L, Xu X, Li C, Huang C, Deng CX (2001) TGF-beta/SMAD3 signals repress chondrocyte hypertrophic differentiation and are required for maintaining articular cartilage. Cell Biol 153(1):35-46
12. Li TF, Darowish M, Zuscik MJ, Chen D, Schwarz EM, Rosier RN et al (2006) SMAD3-deficient chondrocytes have enhanced BMP signaling and accelerated differentiation. J Bone Miner Res 21(1):14-16
13. Wu Q, Kim KO, Sampson ER, Chen D, Awad H, O'Brien T et al (2008) Induction of an osteoarthritis-like phenotype and degradation of phosphorylated SMAD3 by Smurf2 in transgenic mice. Arthritis Rheum 58(10):3132-3144
14. Yao JY, Wang Y, An J, Mao CM, Hou N, Lv YX et al (2003) Mutation analysis of the SMAD3 gene in human osteoarthritis. Eur J Hum Genet 11(9):714-717
15. Valdes AM, Spector TD, Tamm A, Kisand K, Doherty SA, Dennison EM et al (2010) Genetic variation in the SMAD3 gene is associated with hip and knee osteoarthritis. Arthritis Rheum 62(8):2347-2352
16. Van de Laar IM, van der Linde D, Oei EH, Bos PK, Bessems JH, Bierma-Zeinstra SM et al (2012) Phenotypic spectrum of the SMAD3-related aneurysms-osteoarthritis syndrome. J Med Genet 49(1):47-57
17. Loughlin J (2011) Genetics of osteoarthritis. Curr Opin Rheumatol 23(5):479-483