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Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 15, 2013, Pages 4436-4440

Discovery of novel P2 substituted 4-biaryl proline inhibitors of hepatitis C virus NS3 serine protease

(3) Bailey, Murray D a Halmos, Teddy a Lemke, Christopher T a

a BOEHRINGER INGELHEIM CANADA LTD (Canada)

Author keywords

HCV NS3 protease; HCV protease inhibition; Hepatitis C virus; P2 4 biaryl praline

Indexed keywords

2 PHENYL 4 THIAZOLYLPROLINE DERIVATIVE; ANTIVIRUS AGENT; FUNCTIONAL GROUP; HYDROXYPROLINE; NONSTRUCTURAL PROTEIN 3; PROLINE DERIVATIVE; SERINE PROTEINASE INHIBITOR; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ARTICLE; CELL MEMBRANE PERMEABILITY; CELL STRAIN CACO 2; CRYSTAL STRUCTURE; DRUG POTENCY; DRUG STABILITY; DRUG TARGETING; HEPATITIS C VIRUS; MOLECULAR MODEL; PROTEIN MODIFICATION; PROTEIN MOTIF; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

ANTIVIRAL AGENTS; BINDING SITES; DRUG EVALUATION, PRECLINICAL; HEPACIVIRUS; MOLECULAR DOCKING SIMULATION; PROLINE; PROTEASE INHIBITORS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; STRUCTURE-ACTIVITY RELATIONSHIP; VIRAL NONSTRUCTURAL PROTEINS;

HEPATITIS C VIRUS;

EID: 84879689214 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2013.05.046 Document Type: Article

Times cited : (5)

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