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Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 15, 2013, Pages 4447-4452

Peptide backbone replacement of hepatitis C virus NS3 serine protease C-terminal cleavage product analogs: Discovery of potent succinamide inhibitors

(8) Bailey, Murray D a Bordeleau, Josée a Garneau, Michel a Leblanc, Mélissa a Lemke, Christopher T a O'Meara, Jeff a White, Peter W a Llinàs Brunet, Montse a

a BOEHRINGER INGELHEIM CANADA LTD (Canada)

Author keywords

Hepatitis C NS3 protease; Peptide backbone replacement; Peptidomimetic; Succinamide

Indexed keywords

FALDAPREVIR; NONSTRUCTURAL PROTEIN 3; SERINE PROTEINASE; SERINE PROTEINASE INHIBITOR; SUCCINAMIDE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG DESIGN; DRUG HALF LIFE; DRUG METABOLISM; DRUG PENETRATION; HEPATITIS C VIRUS; HUMAN; HUMAN CELL; IC 50; LIVER MICROSOME; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; RAT;

AMIDES; ANIMALS; DOGS; HALF-LIFE; HAPLORHINI; HEPACIVIRUS; HUMANS; MICROSOMES, LIVER; MODELS, MOLECULAR; PROTEASE INHIBITORS; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; SUCCINATES; VIRAL NONSTRUCTURAL PROTEINS;

HEPATITIS C VIRUS;

EID: 84879688029 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2013.05.045 Document Type: Article

Times cited : (3)

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