Potent HIV protease inhibitors containing a novel (hydroxyethyl)amide isostere

Journal of Medicinal Chemistry

Volumn 40, Issue 14, 1997, Pages 2164-2176

  Beaulieu, P L ^a   Wernic, D ^a   Abraham, A ^a   Anderson, P C ^a   Bogri, T ^a   Bousquet, Y ^a   Croteau, G ^a   Guse, I ^a   Lamarre, D ^a   Liard, F ^a   Paris, W ^a   Thibeault, D ^a   Pav, S ^a   Tong, L ^a  

^a BOEHRINGER INGELHEIM CANADA LTD   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

2 (TERT BUTYLCARBAMOYL)CYCLOHEXANECARBOXYLIC ACID; ANTIVIRUS AGENT; PALINAVIR; PROTEINASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTIVIRAL ACTIVITY; ARTICLE; DRUG BIOAVAILABILITY; DRUG CONFORMATION; DRUG POTENCY; HUMAN IMMUNODEFICIENCY VIRUS; NONHUMAN; ORAL DRUG ADMINISTRATION; PROTEINASE INHIBITION; RAT; STRUCTURE ACTIVITY RELATION; VIRUS INHIBITION; VIRUS REPLICATION;

ADMINISTRATION, ORAL; ANIMALS; ASPARTIC ENDOPEPTIDASES; BIOLOGICAL AVAILABILITY; CARBAMATES; CRYSTALLOGRAPHY, X-RAY; HIV CORE PROTEIN P24; HIV PROTEASE; HIV PROTEASE INHIBITORS; HIV-1; HIV-2; KINETICS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MOLECULAR STRUCTURE; PROTEIN CONFORMATION; RATS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; VALINE; VIRUS REPLICATION;

EID: 0030874398     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9606608     Document Type: Article

References (34)