Pyrrolidine-5,5-trans-lactams. 4. Incorporation of a P3/P4 Urea Leads to Potent Intracellular Inhibitors of Hepatitis C Virus NS3/4A Protease

Organic Letters

Volumn 5, Issue 24, 2003, Pages 4627-4630

  Slater, Martin J ^a   Amphlett, Elizabeth M ^a   Andrews, David M ^a   Bamborough, Paul ^a   Carey, Seb J ^a   Johnson, Martin R ^a   Jones, Paul S ^a   Mills, Gail ^a   Parry, Nigel R ^a   Somers, Donald O'N ^a   Stewart, Alan J ^a   Skarzynski, Tadeusz ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIVIRUS AGENT; LACTAM DERIVATIVE; PROTEINASE INHIBITOR; UREA;

ARTICLE; BIOCHEMISTRY; CONCENTRATION RESPONSE; DRUG POTENCY; DRUG STRUCTURE; HEPATITIS C VIRUS; IC 50; INTRACELLULAR SPACE; VIRUS STRAIN;

ANTIVIRAL AGENTS; CRYSTALLOGRAPHY, X-RAY; HEPACIVIRUS; INHIBITORY CONCENTRATION 50; LACTAMS; MOLECULAR CONFORMATION; MOLECULAR STRUCTURE; PROTEASE INHIBITORS; PYRROLIDINES; UREA; VIRAL NONSTRUCTURAL PROTEINS; VIRUS REPLICATION;

EID: 10744225987     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol035826v     Document Type: Article

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28. Deposition of the atomic coordinates into the Protein Data Bank is in progress.