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Volumn 30, Issue 2, 2013, Pages 651-658

The microRNA-218 and ROBO-1 signaling axis correlates with the lymphatic metastasis of pancreatic cancer

Author keywords

Lymphatic metastasis; microRNA; Pancreatic cancer

Indexed keywords

LET 7; MICRORNA; MICRORNA 145; MICRORNA 218; MICRORNA 663; ROBO 1 PROTEIN; UNCLASSIFIED DRUG;

EID: 84879649031     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2013.2516     Document Type: Article
Times cited : (39)

References (40)
  • 2
    • 77957762440 scopus 로고    scopus 로고
    • The miR-217 microRNA functions as a potential tumor suppressor in pancreatic ductal adenocarcinoma by targeting KRAS
    • Zhao WG, Yu SN, Lu ZH, Ma YH, Gu YM and Chen J: The miR-217 microRNA functions as a potential tumor suppressor in pancreatic ductal adenocarcinoma by targeting KRAS. Carcinogenesis 31: 1726-1733, 2010.
    • (2010) Carcinogenesis , vol.31 , pp. 1726-1733
    • Zhao, W.G.1    Yu, S.N.2    Lu, Z.H.3    Ma, Y.H.4    Gu, Y.M.5    Chen, J.6
  • 3
    • 77955033963 scopus 로고    scopus 로고
    • miRNA-96 suppresses KRAS and functions as a tumor suppressor gene in pancreatic cancer
    • Yu SN, Lu ZH, Liu CZ, et al: miRNA-96 suppresses KRAS and functions as a tumor suppressor gene in pancreatic cancer. Cancer Res 70: 6015-6025, 2010.
    • (2010) Cancer Res , vol.70 , pp. 6015-6025
    • Yu, S.N.1    Lu, Z.H.2    Liu, C.Z.3
  • 4
    • 68949213672 scopus 로고    scopus 로고
    • Let-7 microRNA transfer in pancreatic cancer-derived cells inhibits in vitro cell proliferation but fails to alter tumor progression
    • Torrisani J, Bournet B, du Rieu MC, et al: Let-7 microRNA transfer in pancreatic cancer-derived cells inhibits in vitro cell proliferation but fails to alter tumor progression. Hum Gene Ther 20: 831-844, 2009.
    • (2009) Hum Gene Ther , vol.20 , pp. 831-844
    • Torrisani, J.1    Bournet, B.2    Du Rieu, M.C.3
  • 5
    • 69949087531 scopus 로고    scopus 로고
    • MicroRNA miR-34 inhibits human pancreatic cancer tumor-initiating cells
    • Ji Q, Hao X, Zhang M, et al: MicroRNA miR-34 inhibits human pancreatic cancer tumor-initiating cells. PLoS One 4: e6816, 2009.
    • (2009) PLoS One , vol.4
    • Ji, Q.1    Hao, X.2    Zhang, M.3
  • 6
    • 84894886596 scopus 로고    scopus 로고
    • MicroRNA-200c modulates the expression of MUC4 and MUC16 in human pancreatic cancer. The 42nd Annual Meeting of the American Pancreatic Association
    • Radhakrishnan P, Mohr AM, Grandgenet PM and Hollingsworth MA: MicroRNA-200c modulates the expression of MUC4 and MUC16 in human pancreatic cancer. The 42nd Annual Meeting of the American Pancreatic Association. Pancreas 40: 1350, 2011.
    • (2011) Pancreas , vol.40 , pp. 1350
    • Radhakrishnan, P.1    Mohr, A.M.2    Grandgenet, P.M.3    Hollingsworth, M.A.4
  • 7
    • 78751582064 scopus 로고    scopus 로고
    • Knockdown of microRNA-21 inhibits proliferation and increases cell death by targeting programmed cell death 4 (PDCD4) in pancreatic ductal adenocarcinoma
    • Bhatti I, Lee A, James V, et al: Knockdown of microRNA-21 inhibits proliferation and increases cell death by targeting programmed cell death 4 (PDCD4) in pancreatic ductal adenocarcinoma. J Gastrointest Surg 15: 199-208, 2011.
    • (2011) J Gastrointest Surg , vol.15 , pp. 199-208
    • Bhatti, I.1    Lee, A.2    James, V.3
  • 8
    • 78049236980 scopus 로고    scopus 로고
    • miR-218 inhibits the invasive ability of glioma cells by direct downregulation of IKK-β
    • Song L, Huang Q, Chen K, et al: miR-218 inhibits the invasive ability of glioma cells by direct downregulation of IKK-β. Biochem Biophys Res Commun 402: 135-140, 2010.
    • (2010) Biochem Biophys Res Commun , vol.402 , pp. 135-140
    • Song, L.1    Huang, Q.2    Chen, K.3
  • 9
    • 77949564293 scopus 로고    scopus 로고
    • Aberrant MicroRNA-155 expression is an early event in the multistep progression of pancreatic adenocarcinoma
    • Ryu JK, Hong SM, Karikari CA, Hruban RH, Goggins MG and Maitra A: Aberrant MicroRNA-155 expression is an early event in the multistep progression of pancreatic adenocarcinoma. Pancreatology 10: 66-73, 2010.
    • (2010) Pancreatology , vol.10 , pp. 66-73
    • Ryu, J.K.1    Hong, S.M.2    Karikari, C.A.3    Hruban, R.H.4    Goggins, M.G.5    Maitra, A.6
  • 10
    • 34248200155 scopus 로고    scopus 로고
    • MicroRNA expression alterations are linked to tumorigenesis and non-neoplastic processes in pancreatic ductal adenocarcinoma
    • DOI 10.1038/sj.onc.1210228, PII 1210228
    • Szafranska AE, Davison TS, John J, et al: MicroRNA expression alterations are linked to tumorigenesis and non-neoplastic processes in pancreatic ductal adenocarcinoma. Oncogene 26: 4442-4452, 2007. (Pubitemid 47014466)
    • (2007) Oncogene , vol.26 , Issue.30 , pp. 4442-4452
    • Szafranska, A.E.1    Davison, T.S.2    John, J.3    Cannon, T.4    Sipos, B.5    Maghnouj, A.6    Labourier, E.7    Hahn, S.A.8
  • 13
    • 81855183857 scopus 로고    scopus 로고
    • MicroRNA-150 directly targets MUC4 and suppresses growth and malignant behavior of pancreatic cancer cells
    • Srivastava SK, Bhardwaj A, Singh S, et al: MicroRNA-150 directly targets MUC4 and suppresses growth and malignant behavior of pancreatic cancer cells. Carcinogenesis 32: 1832-1839, 2011.
    • (2011) Carcinogenesis , vol.32 , pp. 1832-1839
    • Srivastava, S.K.1    Bhardwaj, A.2    Singh, S.3
  • 14
    • 80051552504 scopus 로고    scopus 로고
    • MicroRNA expression as a predictive marker for gemcitabine response after surgical resection of pancreatic cancer
    • Ohuchida K, Mizumoto K, Kayashima T, et al: MicroRNA expression as a predictive marker for gemcitabine response after surgical resection of pancreatic cancer. Ann Surg Oncol 18: 2381-2387, 2011.
    • (2011) Ann Surg Oncol , vol.18 , pp. 2381-2387
    • Ohuchida, K.1    Mizumoto, K.2    Kayashima, T.3
  • 15
    • 80054930119 scopus 로고    scopus 로고
    • MicroRNA-10b is overexpressed in pancreatic cancer, promotes its invasiveness, and correlates with a poor prognosis
    • Nakata K, Ohuchida K, Mizumoto K, et al: MicroRNA-10b is overexpressed in pancreatic cancer, promotes its invasiveness, and correlates with a poor prognosis. Surgery 150: 916-922, 2011.
    • (2011) Surgery , vol.150 , pp. 916-922
    • Nakata, K.1    Ohuchida, K.2    Mizumoto, K.3
  • 16
    • 80053360154 scopus 로고    scopus 로고
    • MicroRNA-148a is down-regulated in human pancreatic ductal adenocarcinomas and regulates cell survival by targeting CDC25B
    • Liffers ST, Munding JB, Vogt M, et al: MicroRNA-148a is down-regulated in human pancreatic ductal adenocarcinomas and regulates cell survival by targeting CDC25B. Lab Invest 91: 1472-1479, 2011.
    • (2011) Lab Invest , vol.91 , pp. 1472-1479
    • Liffers, S.T.1    Munding, J.B.2    Vogt, M.3
  • 18
    • 77953169001 scopus 로고    scopus 로고
    • MicroRNA-21 in pancreatic cancer: Correlation with clinical outcome and pharmacologic aspects underlying its role in the modulation of gemcitabine activity
    • Giovannetti E, Funel N, Peters GJ, et al: MicroRNA-21 in pancreatic cancer: correlation with clinical outcome and pharmacologic aspects underlying its role in the modulation of gemcitabine activity. Cancer Res 70: 4528-4538, 2010.
    • (2010) Cancer Res , vol.70 , pp. 4528-4538
    • Giovannetti, E.1    Funel, N.2    Peters, G.J.3
  • 19
    • 72149086003 scopus 로고    scopus 로고
    • LyP-1-conjugated nanoparticles for targeting drug delivery to lymphatic metastatic tumors
    • Luo GP, Yu XJ, Jin C, et al: LyP-1-conjugated nanoparticles for targeting drug delivery to lymphatic metastatic tumors. Int J Pharm 385: 150-156, 2010.
    • (2010) Int J Pharm , vol.385 , pp. 150-156
    • Luo, G.P.1    Yu, X.J.2    Jin, C.3
  • 20
    • 80051549469 scopus 로고    scopus 로고
    • Magnetic functionalised carbon nanotubes as drug vehicles for cancer lymph node metastasis treatment
    • Yang F, Jin C, Yang D, et al: Magnetic functionalised carbon nanotubes as drug vehicles for cancer lymph node metastasis treatment. Eur J Cancer 47: 1873-1882, 2011.
    • (2011) Eur J Cancer , vol.47 , pp. 1873-1882
    • Yang, F.1    Jin, C.2    Yang, D.3
  • 21
    • 0027751663 scopus 로고
    • The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
    • DOI 10.1016/0092-8674(93)90529-Y
    • Lee RC, Feinbaum RL and Ambros V: The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell 75: 843-854, 1993. (Pubitemid 24014542)
    • (1993) Cell , vol.75 , Issue.5 , pp. 843-854
    • Lee, R.C.1    Feinbaum, R.L.2    Ambros, V.3
  • 22
    • 77956296766 scopus 로고    scopus 로고
    • Identification of microRNA-21 as a biomarker for chemoresistance and clinical outcome following adjuvant therapy in resectable pancreatic cancer
    • Hwang JH, Voortman J, Giovannetti E, et al: Identification of microRNA-21 as a biomarker for chemoresistance and clinical outcome following adjuvant therapy in resectable pancreatic cancer. PLoS One 5: e10630, 2010.
    • (2010) PLoS One , vol.5
    • Hwang, J.H.1    Voortman, J.2    Giovannetti, E.3
  • 23
    • 84879614534 scopus 로고    scopus 로고
    • Chemosensitivity of indole-3-carbinol via downregulation of microRNA-21 in gemcitabine-resistant pancreatic cancer cells. Asian Pacific Digestive Week, Oct, 2011
    • Kim HR, Jang SE, Beik WH, Lee SH and Hwang JH: Chemosensitivity of indole-3-carbinol via downregulation of microRNA-21 in gemcitabine-resistant pancreatic cancer cells. Asian Pacific Digestive Week, Oct, 2011. J Gastroen Hepatol 26: 232, 2011.
    • (2011) J Gastroen Hepatol , vol.26 , pp. 232
    • Kim, H.R.1    Jang, S.E.2    Beik, W.H.3    Lee, S.H.4    Hwang, J.H.5
  • 24
    • 71549129536 scopus 로고    scopus 로고
    • Prognostic significance of lymph node metastases in pancreatic head cancer treated with extended lymphadenectomy: Not just a matter of numbers
    • Massucco P, Ribero D, Sgotto E, Mellano A, Muratore A and Capussotti L: Prognostic significance of lymph node metastases in pancreatic head cancer treated with extended lymphadenectomy: not just a matter of numbers. Ann Surg Oncol 16: 3323-3332, 2009.
    • (2009) Ann Surg Oncol , vol.16 , pp. 3323-3332
    • Massucco, P.1    Ribero, D.2    Sgotto, E.3    Mellano, A.4    Muratore, A.5    Capussotti, L.6
  • 25
    • 67349211755 scopus 로고    scopus 로고
    • The lymph node ratio is the strongest prognostic factor after resection of pancreatic cancer
    • Riediger H, Keck T, Wellner U, et al: The lymph node ratio is the strongest prognostic factor after resection of pancreatic cancer. J Gastrointest Surg 13: 1337-1344, 2009.
    • (2009) J Gastrointest Surg , vol.13 , pp. 1337-1344
    • Riediger, H.1    Keck, T.2    Wellner, U.3
  • 26
    • 78049398107 scopus 로고    scopus 로고
    • Distant metastasis occurs late during the genetic evolution of pancreatic cancer
    • Yachida S, Jones S, Bozic I, et al: Distant metastasis occurs late during the genetic evolution of pancreatic cancer. Nature 467: 1114-1117, 2010.
    • (2010) Nature , vol.467 , pp. 1114-1117
    • Yachida, S.1    Jones, S.2    Bozic, I.3
  • 27
    • 80052218238 scopus 로고    scopus 로고
    • The tumor suppressive microRNA miR-218 targets the mTOR component Rictor and inhibits AKT phosphorylation in oral cancer
    • Uesugi A, Kozaki K, Tsuruta T, et al: The tumor suppressive microRNA miR-218 targets the mTOR component Rictor and inhibits AKT phosphorylation in oral cancer. Cancer Res 71: 5765-5778, 2011.
    • (2011) Cancer Res , vol.71 , pp. 5765-5778
    • Uesugi, A.1    Kozaki, K.2    Tsuruta, T.3
  • 28
    • 79956046622 scopus 로고    scopus 로고
    • miR-218 on the genomic loss region of chromosome 4p15.31 functions as a tumor suppressor in bladder cancer
    • Tatarano S, Chiyomaru T, Kawakami K, et al: miR-218 on the genomic loss region of chromosome 4p15.31 functions as a tumor suppressor in bladder cancer. Int J Oncol 39: 13-21, 2011.
    • (2011) Int J Oncol , vol.39 , pp. 13-21
    • Tatarano, S.1    Chiyomaru, T.2    Kawakami, K.3
  • 29
    • 79955721096 scopus 로고    scopus 로고
    • Change in expression of miR-let7c, miR-100, and miR-218 from high grade localized prostate cancer to metastasis
    • Leite KRM, Sousa-Canavez JM, Reis ST, et al: Change in expression of miR-let7c, miR-100, and miR-218 from high grade localized prostate cancer to metastasis. Urol Oncol 29: 265-269, 2011.
    • (2011) Urol Oncol , vol.29 , pp. 265-269
    • Leite, K.R.M.1    Sousa-Canavez, J.M.2    Reis, S.T.3
  • 30
    • 79952751773 scopus 로고    scopus 로고
    • MiR-218 suppresses nasopharyngeal cancer progression through downregulation of survivin and the SLIT2-ROBO1 pathway
    • Alajez NM, Lenarduzzi M, Ito E, et al: MiR-218 suppresses nasopharyngeal cancer progression through downregulation of survivin and the SLIT2-ROBO1 pathway. Cancer Res 71: 2381-2391, 2011.
    • (2011) Cancer Res , vol.71 , pp. 2381-2391
    • Alajez, N.M.1    Lenarduzzi, M.2    Ito, E.3
  • 31
    • 74549147303 scopus 로고    scopus 로고
    • Reduced microRNA-218 expression is associated with high nuclear factor kappa B activation in gastric cancer
    • Gao CP, Zhang ZY, Liu WZ, Xiao SD, Gu WQ and Lu H: Reduced microRNA-218 expression is associated with high nuclear factor kappa B activation in gastric cancer. Cancer 116: 41-49, 2010.
    • (2010) Cancer , vol.116 , pp. 41-49
    • Gao, C.P.1    Zhang, Z.Y.2    Liu, W.Z.3    Xiao, S.D.4    Gu, W.Q.5    Lu, H.6
  • 32
    • 77958516991 scopus 로고    scopus 로고
    • MicroRNA-218 is deleted and downregulated in lung squamous cell carcinoma
    • Davidson MR, Larsen JE, Yang IA, et al: MicroRNA-218 is deleted and downregulated in lung squamous cell carcinoma. PLoS One 5: e12560, 2010.
    • (2010) PLoS One , vol.5
    • Davidson, M.R.1    Larsen, J.E.2    Yang, I.A.3
  • 33
    • 42249105032 scopus 로고    scopus 로고
    • Human papillomavirus type 16 reduces the expression of microRNA-218 in cervical carcinoma cells
    • DOI 10.1038/sj.onc.1210919, PII 1210919
    • Martinez I, Gardiner AS, Board KF, Monzon FA, Edwards RP and Khan SA: Human papillomavirus type 16 reduces the expression of microRNA-218 in cervical carcinoma cells. Oncogene 27: 2575-2582, 2008. (Pubitemid 351550884)
    • (2008) Oncogene , vol.27 , Issue.18 , pp. 2575-2582
    • Martinez, I.1    Gardiner, A.S.2    Board, K.F.3    Monzon, F.A.4    Edwards, R.P.5    Khan, S.A.6
  • 34
    • 77950428314 scopus 로고    scopus 로고
    • MiR-218 inhibits invasion and metastasis of gastric cancer by targeting the Robo1 receptor
    • Tie J, Pan YL, Zhao LN, et al: MiR-218 inhibits invasion and metastasis of gastric cancer by targeting the Robo1 receptor. PLoS Genet 6: e1000879, 2010.
    • (2010) PLoS Genet , vol.6
    • Tie, J.1    Pan, Y.L.2    Zhao, L.N.3
  • 35
    • 78650409847 scopus 로고    scopus 로고
    • Paxillin predicts survival and relapse in non-small cell lung cancer by microRNA-218 targeting
    • Wu DW, Cheng YW, Wang J, Chen CY and Lee H: Paxillin predicts survival and relapse in non-small cell lung cancer by microRNA-218 targeting. Cancer Res 70: 10392-10401, 2010.
    • (2010) Cancer Res , vol.70 , pp. 10392-10401
    • Wu, D.W.1    Cheng, Y.W.2    Wang, J.3    Chen, C.Y.4    Lee, H.5
  • 36
    • 77950189124 scopus 로고    scopus 로고
    • Polymorphisms involved in the miR-218-LAMB3 pathway and susceptibility of cervical cancer, a case-control study in Chinese women
    • Zhou XY, Chen XJ, Hu LM, et al: Polymorphisms involved in the miR-218-LAMB3 pathway and susceptibility of cervical cancer, a case-control study in Chinese women. Gynecol Oncol 117: 287-290, 2010.
    • (2010) Gynecol Oncol , vol.117 , pp. 287-290
    • Zhou, X.Y.1    Chen, X.J.2    Hu, L.M.3
  • 38
    • 0028064814 scopus 로고
    • Structure-function relationships in the receptor for urokinase-type plasminogen activator. Comparison to other members of the Ly-6 family and snake venom α-neurotoxins
    • Ploug M and Ellis V: Structure-function relationships in the receptor for urokinase-type plasminogen activator. Comparison to other members of the Ly-6 family and snake venom α-neurotoxins. FEBS Lett 349: 163-168, 1994.
    • (1994) FEBS Lett , vol.349 , pp. 163-168
    • Ploug, M.1    Ellis, V.2
  • 39
    • 84867334466 scopus 로고    scopus 로고
    • Silencing of miRNA-218 promotes migration and invasion of breast cancer via Slit2-Robo1 pathway
    • Yang L, Li Q, Wang Q, Jiang Z and Zhang L: Silencing of miRNA-218 promotes migration and invasion of breast cancer via Slit2-Robo1 pathway. Biomed Pharmacother 66: 535-540, 2012.
    • (2012) Biomed Pharmacother , vol.66 , pp. 535-540
    • Yang, L.1    Li, Q.2    Wang, Q.3    Jiang, Z.4    Zhang, L.5
  • 40
    • 84981210172 scopus 로고    scopus 로고
    • A novel Slit-Robo-miR-218 signaling axis regulates VEGF-mediated heart tube formation in zebrafish
    • The 69th Annual Meeting of the Society for Developmental Biology/ Japanese Society of Developmental Biologists
    • Woo S, Fish JE, Wythe JD, Bruneau BB, Stainier DY and Srivastava D: A novel Slit-Robo-miR-218 signaling axis regulates VEGF-mediated heart tube formation in zebrafish. The 69th Annual Meeting of the Society for Developmental Biology/ Japanese Society of Developmental Biologists. Dev Biol 344: 433, 2010.
    • (2010) Dev Biol , vol.344 , pp. 433
    • Woo, S.1    Fish, J.E.2    Wythe, J.D.3    Bruneau, B.B.4    Stainier, D.Y.5    Srivastava, D.6


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