Prediction of drug-drug interactions between various antidepressants and efavirenz or boosted protease inhibitors using a physiologically based pharmacokinetic modelling approach

Clinical Pharmacokinetics

Volumn 52, Issue 7, 2013, Pages 583-592

  Siccardi, Marco ^a   Marzolini, Catia ^b   Seden, Kay ^a   Almond, Lisa ^c   Kirov, Anna ^a   Khoo, Saye ^a   Owen, Andrew ^a   Back, David ^a  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

^b UNIVERSITY HOSPITAL BASEL   (Switzerland)

^c CERTARA UK LIMITED   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMFEBUTAMONE; ANTIDEPRESSANT AGENT; ATAZANAVIR; CITALOPRAM; DARUNAVIR; DESIPRAMINE; EFAVIRENZ; FLUOXETINE; MARAVIROC; MIDAZOLAM; MIRTAZAPINE; RITONAVIR; SERTRALINE; SILDENAFIL; TOLBUTAMIDE; VENLAFAXINE;

AREA UNDER THE CURVE; ARTICLE; DEMETHYLATION; DRUG ABSORPTION; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG METABOLISM; HUMAN; IN VITRO STUDY; IN VIVO STUDY; LIVER METABOLISM; OXIDATION; PHARMACOKINETICS; PLASMA CONCENTRATION-TIME CURVE; PRIORITY JOURNAL; SIMULATION; SINGLE DRUG DOSE; VIRTUAL REALITY;

ANTI-RETROVIRAL AGENTS; ANTIDEPRESSIVE AGENTS; BENZOXAZINES; DRUG INTERACTIONS; HUMANS; MODELS, BIOLOGICAL; OLIGOPEPTIDES; PYRIDINES; RITONAVIR; SULFONAMIDES;

EID: 84879640684     PISSN: 03125963     EISSN: 11791926     Source Type: Journal    
DOI: 10.1007/s40262-013-0056-7     Document Type: Article

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