Correlation of hedgehog signal activation with chemoradiotherapy sensitivity and survival in esophageal squamous cell carcinomas

Japanese Journal of Clinical Oncology

Volumn 41, Issue 3, 2011, Pages 386-393

  Zhu, Weiguo ^a   You, Zhenbin ^a   Li, Tao ^a   Yu, Changhua ^a   Tao, Guangzhou ^a   Hu, Mingli ^a   Chen, Xiaofei ^a  

^a NANJING MEDICAL UNIVERSITY   (China)

Author keywords

Esophageal squamous cell carcinoma; GLI 1; Hedgehog signal pathway; Prognosis; PTCH1

Indexed keywords

CISPLATIN; FLUOROURACIL; PROTEIN PATCHED 1; TRANSCRIPTION FACTOR GLI1;

ADULT; ARTICLE; CANCER COMBINATION CHEMOTHERAPY; CANCER GROWTH; CANCER LOCALIZATION; CANCER RADIOTHERAPY; CANCER SIZE; CANCER SURVIVAL; CHEMOSENSITIVITY; CONTINUOUS INFUSION; DISEASE SEVERITY; DRUG RESPONSE; ESOPHAGEAL SQUAMOUS CELL CARCINOMA; ESOPHAGUS BIOPSY; FEMALE; GENE EXPRESSION PROFILING; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; MULTIPLE CYCLE TREATMENT; OVERALL SURVIVAL; PROGNOSIS; PROGRESSION FREE SURVIVAL; RADIATION RESPONSE; RADIOSENSITIVITY; SURVIVAL TIME;

ANTINEOPLASTIC AGENTS; CARCINOMA, SQUAMOUS CELL; COMBINED MODALITY THERAPY; ESOPHAGEAL NEOPLASMS; FEMALE; FOLLOW-UP STUDIES; HUMANS; IMMUNOENZYME TECHNIQUES; MALE; MIDDLE AGED; RADIOTHERAPY; RECEPTORS, CELL SURFACE; SURVIVAL RATE; TRANSCRIPTION FACTORS; TREATMENT OUTCOME; TUMOR MARKERS, BIOLOGICAL;

EID: 79952387584     PISSN: 03682811     EISSN: 14653621     Source Type: Journal    
DOI: 10.1093/jjco/hyq217     Document Type: Article

References (23)

1. Yi Y, Li B, Wang Z, Sun H, Gong H, Zhang Z. CYFRA21-1 and CEA are useful markers for predicting the sensitivity to chemoradiotherapy of esophageal squamous cell carcinoma. Biomarkers 2009;14:480-5.
2. Ishida M, Morita M, Saeki H, Ohga T, Sadanaga N, Watanabe M, et al. Expression of p53 and p21 and the clinical response for hyperthermochemoradiotherapy in patients with squamous cell carcinoma of the esophagus. Anticancer Res 2007;27:3501-6.
3. Tahara M, Ohtsu A, Hironaka S, Boku N, Ishikura S, Miyata Y, et al. Clinical impact of criteria for complete response (CR) of primary site to treatment of esophageal cancer. Jpn J Clin Oncol 2005;35:316-23.
4. Samejima R, Kitajima Y, Yunotani S, Miyazaki K. Cyclin D1 is a possible predictor of sensitivity to chemoradiotherapy for esophageal squamous cell carcinoma. Anticancer Res 1999;19:5515-21.
5. He LR, Liu MZ, Li BK, Rao HL, Liao YJ, Guan XY, et al. Prognostic impact of H3K27me3 expression on locoregional progression after chemoradiotherapy in esophageal squamous cell carcinoma. BMC Cancer 2009;9:461.
6. He LR, Liu MZ, Li BK, Rao HL, Liao YJ, Zhang LJ, et al. Clusterin as a predictor for chemoradiotherapy sensitivity and patient survival in esophageal squamous cell carcinoma. Cancer Sci 2009;100:2354-60.
7. Gotoh M, Takiuchi H, Kawabe S, Ohta S, Kii T, Kuwakado S, et al. Epidermal growth factor receptor is a possible predictor of sensitivity to chemoradiotherapy in the primary lesion of esophageal squamous cell carcinoma. Jpn J Clin Oncol 2007;37:652-7.
8. Kim R, Inoue H, Toge T. Bax is an important determinant for radiation sensitivity in esophageal carcinoma cells. Int J Mol Med 2004;14: 697-706.
9. Okumura H, Natsugoe S, Matsumoto M. The predictive value of p53, p53R2, and p21 for the effect of chemoradiation therapy on oesophageal squamous cell carcinoma. Br J Cancer 2005;92:284-9.
10. Sur M, Sur RK, Cooper K, Bizos D. Preliminary report on the effect of brachytherapy on expression of p53, bc1-2 and apoptosis in squamous cell carcinoma of the oesophagus. S Afr J Surg 2003;41:14-20.
11. Dreilich M, Wanders A, Brattstrom D. HER-2 overexpression (3+) in patients with squamous cell esophageal carcinoma correlates with poorer survival. Dis Esophagus 2006;19:224-31.
12. Ingham PW. Transducing hedgehog: the story so far. EMBO J 1998;17:3505-11.
13. Berman DM, Desai N, Wang X, Karhadkar SS, Reynon M, Abate-Shen C. Roles for hedgehog signaling in androgen production and prostate ductal morphogenesis. Dev Biol 2004;267:387-98.
14. Wang BE, Shou J, Ross S, Koeppen H, De Sauvage FJ, Gao WQ. Inhibition of epithelial ductal branching in the prostate by sonic hedgehog is indirectly mediated by stromal cells. J Biol Chem 2003;278:18506-13.
15. Clement V, Sanchez P, de Tribolet N, Radovanovic I, Ruiz i Altaba A. Hedgehog-Gli1 signaling regulates human glioma growth, cancer stem cell self-renewal, and tumorigenicity. Curr Biol 2007;17:165-72.
16. Ruiz i Altaba A. The Gli code: an information nexus regulating cell fate, stemness and cancer. Trends Cell Biol 2007;17:438-47.
17. Sanchez P. Inhibition of prostate cancer proliferation by interference with SONIC HEDGEHOG-GLI1 signaling. Proc Natl Acad Sci USA 2004;101:12561-6.
18. Feldmann G. Blockade of hedgehog signaling inhibits pancreatic cancer invasion and metastases: a new paradigm for combination therapy in solid cancers. Cancer Res 2007;67:2187-96.
19. Huang S. Activation of the hedgehog pathway in human hepatocellular carcinomas. Carcinogenesis 2006;27:1334-40.
20. Isohata N, Aoyagi K, Mabuchi T, Daiko H, Fukaya M, Ohta H, et al. Hedgehog and epithelial-mesenchymal transition signaling in normal and malignant epithelial cells of the esophagus. Int J Cancer 2009;125:1212-21.
21. Yoshikawa R, Nakano Y, Tao L, Koishi K, Matsumoto T, Sasako M, et al. Hedgehog signal activation in oesophageal cancer patients undergoing neoadjuvant chemoradiotherapy. Br J Cancer 2008;98:1670-4.
22. Mori Y, Okumura T, Tsunoda S, Sakai Y, Shimada Y. Gli-1 expression is associated with lymph node metastasis and tumor progression in esophageal squamous cell carcinoma. Oncology 2006;70:378-89.
23. Sims-Mourtada J, Izzo JG, Apisarnthanarax S, Wu TT, Malhotra U, Luthra R, et al. Hedgehog: an attribute to tumor regrowth after chemoradiotherapy and a target to improve radiation response. Clin Cancer Res 2006;12:6565-72.