메뉴 건너뛰기




Volumn 7, Issue 4, 2013, Pages 365-377

Molecular biomarkers in cervical cancer diagnosis: A critical appraisal

Author keywords

Carcinogenesis; HPV; Integration; Methylation; P16; Screening

Indexed keywords

CELL ADHESION MOLECULE; CYCLIN DEPENDENT KINASE 4; CYCLIN DEPENDENT KINASE 6; CYCLIN DEPENDENT KINASE INHIBITOR 2A; INHIBITOR OF APOPTOSIS PROTEIN 2; MYELIN AND LYMPHOCYTE PROTEIN; PROTEIN E6; PROTEIN E7; PROTEIN P16; PROTEIN P53; RETINOBLASTOMA PROTEIN; SURVIVIN; TELOMERASE REVERSE TRANSCRIPTASE; TUMOR NECROSIS FACTOR ALPHA; TUMOR MARKER;

EID: 84879612071     PISSN: 17530059     EISSN: 17530067     Source Type: Journal    
DOI: 10.1517/17530059.2013.808621     Document Type: Review
Times cited : (30)

References (100)
  • 1
    • 34548053843 scopus 로고    scopus 로고
    • Cervical cancer quiz 4p
    • Cervical cancer. NIH Consens Statement 1996;14:1-38; quiz 4p
    • (1996) NIH Consens Statement , vol.14 , pp. 1-38
  • 3
    • 78049485263 scopus 로고    scopus 로고
    • Estimates of worldwide burden of cancer in 2008: Globocan 2008
    • Ferlay J, Shin HR, Bray F, et al. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer 2010;127:2893-917
    • (2010) Int J Cancer , vol.127 , pp. 2893-2917
    • Ferlay, J.1    Shin, H.R.2    Bray, F.3
  • 4
    • 37049191651 scopus 로고
    • A new procedure for staining vaginal smears
    • Papanicolaou GN. A new procedure for staining vaginal smears. Science 1942;95:438-9
    • (1942) Science , vol.95 , pp. 438-439
    • Papanicolaou, G.N.1
  • 5
    • 84879639109 scopus 로고    scopus 로고
    • Hpv infection and cervical carcinogenesis: Epidemiology and prevention
    • Ayhan A, Reed N, Gultekin M, Dursun P, editors Günes Publishing Ankara, Turkey
    • De Pokomandy A, Franco E. HPV infection and cervical carcinogenesis: Epidemiology and prevention. In: Ayhan A, Reed N, Gultekin M, Dursun P, editors. Textbook of gynaecological oncology. Günes Publishing; Ankara, Turkey: 2011. p. 75
    • (2011) Textbook of gynaecological oncology , pp. 75
    • De Pokomandy, A.1    Franco, E.2
  • 6
    • 70350716239 scopus 로고    scopus 로고
    • Comparison of liquid-based cytology with conventional cytology for detection of cervical cancer precursors: A randomized controlled trial
    • Siebers AG, Klinkhamer PJ, Grefte JM, et al. Comparison of liquid-based cytology with conventional cytology for detection of cervical cancer precursors: A randomized controlled trial. JAMA 2009;302:1757-64
    • (2009) JAMA , vol.302 , pp. 1757-1764
    • Siebers, A.G.1    Klinkhamer, P.J.2    Grefte, J.M.3
  • 11
    • 41749114532 scopus 로고    scopus 로고
    • Results at recruitment from a randomized controlled trial comparing human papillomavirus testing alone with conventional cytology as the primary cervical cancer screening test
    • Ronco G, Giorgi-Rossi P, Carozzi F, et al. Results at recruitment from a randomized controlled trial comparing human papillomavirus testing alone with conventional cytology as the primary cervical cancer screening test. J Natl Cancer Inst 2008;100:492-501
    • (2008) J Natl Cancer Inst , vol.100 , pp. 492-501
    • Ronco, G.1    Giorgi-Rossi, P.2    Carozzi, F.3
  • 12
    • 84873411140 scopus 로고    scopus 로고
    • 2012 cervical cancer screening guidelines and the future role of HPV testing
    • Priebe AM. 2012 cervical cancer screening guidelines and the future role of HPV testing. Clin Obstet Gynecol 2013;56:44-50
    • (2013) Clin Obstet Gynecol , vol.56 , pp. 44-50
    • Priebe, Am.1
  • 13
    • 77956638411 scopus 로고    scopus 로고
    • The health and economic effects of HPV DNA screening in The Netherlands
    • Berkhof J, Coupe VM, Bogaards JA, et al. The health and economic effects of HPV DNA screening in The Netherlands. Int J Cancer 2010;127:2147-58
    • (2010) Int J Cancer , vol.127 , pp. 2147-2158
    • Berkhof, J.1    Coupe, V.M.2    Bogaards, J.A.3
  • 14
    • 84872845690 scopus 로고    scopus 로고
    • Primary human papillomavirus testing in organized cervical screening
    • Dillner J. Primary human papillomavirus testing in organized cervical screening. Curr Opin Obstet Gynecol 2013;25:11-16
    • (2013) Curr Opin Obstet Gynecol , vol.25 , pp. 11-16
    • Dillner, J.1
  • 15
    • 54049129625 scopus 로고    scopus 로고
    • Pivotal evaluation of the accuracy of a biomarker used for classification or prediction: Standards for study design
    • Pepe MS, Feng Z, Janes H, et al. Pivotal evaluation of the accuracy of a biomarker used for classification or prediction: Standards for study design. J Natl Cancer Inst 2008;100:1432-8
    • (2008) J Natl Cancer Inst , vol.100 , pp. 1432-1438
    • Pepe, M.S.1    Feng, Z.2    Janes, H.3
  • 17
    • 0033728049 scopus 로고    scopus 로고
    • Human papillomavirus and cancer: The epidemiological evidence
    • Munoz N. Human papillomavirus and cancer: The epidemiological evidence. J Clin Virol 2000;19:1-5
    • (2000) J Clin Virol , vol.19 , pp. 1-5
    • Munoz, N.1
  • 18
    • 0036559896 scopus 로고    scopus 로고
    • Papillomaviruses and cancer: From basic studies to clinical application
    • zur Hausen H. Papillomaviruses and cancer: From basic studies to clinical application. Nat Rev Cancer 2002;2:342-50
    • (2002) Nat Rev Cancer , vol.2 , pp. 342-350
    • Zur Hausen, H.1
  • 19
    • 0034600355 scopus 로고    scopus 로고
    • Papillomaviruses causing cancer: Evasion from host-cell control in early events in carcinogenesis
    • zur Hausen H. Papillomaviruses causing cancer: Evasion from host-cell control in early events in carcinogenesis. J Natl Cancer Inst 2000;92:690-8 (Pubitemid 30365529)
    • (2000) Journal of the National Cancer Institute , vol.92 , Issue.9 , pp. 690-698
    • Zur Hausen, H.1
  • 22
    • 77950938389 scopus 로고    scopus 로고
    • Classification of papillomaviruses (PVs) based on 189 PV types and proposal of taxonomic amendments
    • Bernard HU, Burk RD, Chen Z, et al. Classification of papillomaviruses (PVs) based on 189 PV types and proposal of taxonomic amendments. Virology 2010;401:70-9
    • (2010) Virology , vol.401 , pp. 70-79
    • Bernard, H.U.1    Burk, R.D.2    Chen, Z.3
  • 23
    • 0026605955 scopus 로고
    • Relationship of human papillomavirus type to grade of cervical intraepithelial neoplasia
    • Lungu O, Sun XW, Felix J, et al. Relationship of human papillomavirus type to grade of cervical intraepithelial neoplasia. JAMA 1992;267:2493-6
    • (1992) JAMA , vol.267 , pp. 2493-2496
    • Lungu, O.1    Sun, X.W.2    Felix, J.3
  • 25
    • 77954955259 scopus 로고    scopus 로고
    • Human papillomavirus oncoproteins: Pathways to transformation
    • Moody CA, Laimins LA. Human papillomavirus oncoproteins: Pathways to transformation. Nat Rev Cancer 2010;10:550-60
    • (2010) Nat Rev Cancer , vol.10 , pp. 550-560
    • Moody, C.A.1    Laimins, L.A.2
  • 26
    • 84875771195 scopus 로고    scopus 로고
    • The biology and life-cycle of human papillomaviruses
    • Doorbar J, Quint W, Banks L, et al. The biology and life-cycle of human papillomaviruses. Vaccine 2012;30(Suppl 5):F55-70
    • (2012) Vaccine , vol.30 , Issue.SUPPL. 5
    • Doorbar, J.1    Quint, W.2    Banks, L.3
  • 27
    • 34347324180 scopus 로고    scopus 로고
    • Biomarkers in cervical cancer screening
    • HUMAN PAPILLOMAVIRUSES AND CERVICAL CANCER
    • Wentzensen N, von Knebel Doeberitz M. Biomarkers in cervical cancer screening. Dis Markers 2007;23:315-30 (Pubitemid 47015791)
    • (2007) Disease Markers , vol.23 , Issue.4 , pp. 315-330
    • Wentzensen, N.1    Von Knebel Doeberitz, M.2
  • 28
    • 84859550524 scopus 로고    scopus 로고
    • Epithelial cell responses to infection with human papillomavirus
    • Stanley MA. Epithelial cell responses to infection with human papillomavirus. Clin Microbiol Rev 2012;25:215-22
    • (2012) Clin Microbiol Rev , vol.25 , pp. 215-222
    • Stanley, M.A.1
  • 29
    • 0034044451 scopus 로고    scopus 로고
    • Analysis of relative binding affinity of E7-pRB of human papillomavirus 16 clinical variants using the yeast two-hybrid system
    • Choo KB, Wang TS, Huang CJ. Analysis of relative binding affinity of E7-pRB of human papillomavirus 16 clinical variants using the yeast two-hybrid system. J Med Virol 2000;61:298-302
    • (2000) J Med Virol , vol.61 , pp. 298-302
    • Choo, K.B.1    Wang, T.S.2    Huang, C.J.3
  • 30
    • 0023144684 scopus 로고
    • Structural and transcriptional analysis of human papillomavirus type 16 sequences in cervical carcinoma cell lines
    • Baker CC, Phelps WC, Lindgren V, et al. Structural and transcriptional analysis of human papillomavirus type 16 sequences in cervical carcinoma cell lines. J Virol 1987;61:962-71 (Pubitemid 17044004)
    • (1987) Journal of Virology , vol.61 , Issue.4 , pp. 962-971
    • Baker, C.C.1    Phelps, W.C.2    Lindgren, V.3
  • 31
    • 0021986880 scopus 로고
    • Structure and transcription of human papillomavirus sequences in cervical carcinoma cells
    • DOI 10.1038/314111a0
    • Schwarz E, Freese UK, Gissmann L, et al. Structure and transcription of human papillomavirus sequences in cervical carcinoma cells. Nature 1985;314:111-14 (Pubitemid 15142033)
    • (1985) Nature , vol.314 , Issue.6006 , pp. 111-114
    • Schwarz, E.1    Freese, U.F.2    Gissmann, L.3
  • 33
    • 2442602302 scopus 로고    scopus 로고
    • DNA Aneuploidy and Integration of Human Papillomavirus Type 16 E6/E7 Oncogenes in Intraepithelial Neoplasia and Invasive Squamous Cell Carcinoma of the Cervix Uteri
    • DOI 10.1158/1078-0432.CCR-03-0565
    • Melsheimer P, Vinokurova S, Wentzensen N, et al. DNA aneuploidy and integration of human papillomavirus type 16 e6/e7 oncogenes in intraepithelial neoplasia and invasive squamous cell carcinoma of the cervix uteri. Clin Cancer Res 2004;10:3059-63 (Pubitemid 38619683)
    • (2004) Clinical Cancer Research , vol.10 , Issue.9 , pp. 3059-3063
    • Melsheimer, P.1    Vinokurova, S.2    Wentzensen, N.3    Bastert, G.4    Von Knebel Doeberitz, M.5
  • 35
    • 66349112294 scopus 로고    scopus 로고
    • Mechanism of genomic instability in cells infected with the high-risk human papillomaviruses
    • Kadaja M, Isok-Paas H, Laos T, et al. Mechanism of genomic instability in cells infected with the high-risk human papillomaviruses. PLoS Pathog 2009;5:e1000397
    • (2009) PLoS Pathog , vol.5
    • Kadaja, M.1    Isok-Paas, H.2    Laos, T.3
  • 37
    • 1242316161 scopus 로고    scopus 로고
    • Acquisition of high-level chromosomal instability is associated with integration of human papillomavirus type 16 in cervical keratinocytes
    • DOI 10.1158/0008-5472.CAN-03-3214
    • Pett MR, Alazawi WO, Roberts I, et al. Acquisition of high-Level chromosomal instability is associated with integration of human papillomavirus type 16 in cervical keratinocytes. Cancer Res 2004;64:1359-68 (Pubitemid 38235604)
    • (2004) Cancer Research , vol.64 , Issue.4 , pp. 1359-1368
    • Pett, M.R.1    Alazawi, W.O.F.2    Roberts, I.3    Dowen, S.4    Smith, D.I.5    Stanley, M.A.6    Coleman, N.7
  • 38
    • 77951027069 scopus 로고    scopus 로고
    • A population-based prospective study of carcinogenic human papillomavirus variant lineages, viral persistence, and cervical neoplasia
    • Schiffman M, Rodriguez AC, Chen Z, et al. A population-based prospective study of carcinogenic human papillomavirus variant lineages, viral persistence, and cervical neoplasia. Cancer Res 2010;70:3159-69
    • (2010) Cancer Res , vol.70 , pp. 3159-3169
    • Schiffman, M.1    Rodriguez, A.C.2    Chen, Z.3
  • 40
    • 0142125393 scopus 로고    scopus 로고
    • Chapter 2: Natural history of anogenital human papillomavirus infection and neoplasia
    • Schiffman M, Kjaer SK. Chapter 2: Natural history of anogenital human papillomavirus infection and neoplasia. J Natl Cancer Inst Monogr 2003(31):14-19
    • (2003) J Natl Cancer Inst Monogr , vol.31 , pp. 14-19
    • Schiffman, M.1    Kjaer, S.K.2
  • 41
    • 77956297607 scopus 로고    scopus 로고
    • Local immune response in the microenvironment of CIN2-3 with and without spontaneous regression
    • Ovestad IT, Gudlaugsson E, Skaland I, et al. Local immune response in the microenvironment of CIN2-3 with and without spontaneous regression. Mod Pathol 2010;23:1231-40
    • (2010) Mod Pathol , vol.23 , pp. 1231-1240
    • Ovestad, I.T.1    Gudlaugsson, E.2    Skaland, I.3
  • 43
    • 50149109644 scopus 로고    scopus 로고
    • Evolving immunosuppressive microenvironment during human cervical carcinogenesis
    • Kobayashi A, Weinberg V, Darragh T, Smith-McCune K. Evolving immunosuppressive microenvironment during human cervical carcinogenesis. Mucosal Immunol 2008;1:412-20
    • (2008) Mucosal Immunol , vol.1 , pp. 412-420
    • Kobayashi, A.1    Weinberg, V.2    Darragh, T.3    Smith-McCune, K.4
  • 44
    • 84857033535 scopus 로고    scopus 로고
    • Cellular transformation by human papillomaviruses: Lessons learned by comparing high-And low-risk viruses
    • Klingelhutz AJ, Roman A. Cellular transformation by human papillomaviruses: Lessons learned by comparing high-And low-risk viruses. Virology 2012;424:77-98
    • (2012) Virology , vol.424 , pp. 77-98
    • Klingelhutz, A.J.1    Roman, A.2
  • 45
    • 40649105478 scopus 로고    scopus 로고
    • Low p53 and retinoblastoma protein expression in cervical intraepithelial neoplasia grade 3 lesions is associated with coexistent adenocarcinoma in situ
    • Kruse AJ, Skaland I, Munk AC, et al. Low p53 and retinoblastoma protein expression in cervical intraepithelial neoplasia grade 3 lesions is associated with coexistent adenocarcinoma in situ. Hum Pathol 2008;39:573-8
    • (2008) Hum Pathol , vol.39 , pp. 573-578
    • Kruse, A.J.1    Skaland, I.2    Munk, A.C.3
  • 46
    • 77949433498 scopus 로고    scopus 로고
    • Pathology and epidemiology of HPV infection in females
    • Stanley M. Pathology and epidemiology of HPV infection in females. Gynecol Oncol 2010;117:S5-10
    • (2010) Gynecol Oncol , vol.117
    • Stanley, M.1
  • 48
    • 84859393428 scopus 로고    scopus 로고
    • Biomarkers for cervical cancer screening: The role of p16(INK4a) to highlight transforming HPV infections
    • von Knebel Doeberitz M, Reuschenbach M, Schmidt D, Bergeron C. Biomarkers for cervical cancer screening: The role of p16(INK4a) to highlight transforming HPV infections. Expert Rev Proteomics 2012;9:149-63
    • (2012) Expert Rev Proteomics , vol.9 , pp. 149-163
    • Von Knebel Doeberitz, M.1    Reuschenbach, M.2    Schmidt, D.3    Bergeron, C.4
  • 50
    • 0031740497 scopus 로고    scopus 로고
    • Expression status of p16 protein is associated with human papillomavirus oncogenic potential in cervical and genital lesions
    • Sano T, Oyama T, Kashiwabara K, et al. Expression status of p16 protein is associated with human papillomavirus oncogenic potential in cervical and genital lesions. Am J Pathol 1998;153:1741-8 (Pubitemid 28550662)
    • (1998) American Journal of Pathology , vol.153 , Issue.6 , pp. 1741-1748
    • Sano, T.1    Oyama, T.2    Kashiwabara, K.3    Fukuda, T.4    Nakajima, T.5
  • 51
    • 83655167360 scopus 로고    scopus 로고
    • Evaluation of cervical cone biopsies for coexpression of p16INK4a and Ki-67 in epithelial cells
    • Reuschenbach M, Seiz M, von Knebel Doeberitz C, et al. Evaluation of cervical cone biopsies for coexpression of p16INK4a and Ki-67 in epithelial cells. Int J Cancer 2012;130:388-94
    • (2012) Int J Cancer , vol.130 , pp. 388-394
    • Reuschenbach, M.1    Seiz, M.2    Von Knebel Doeberitz, C.3
  • 52
    • 79957472045 scopus 로고    scopus 로고
    • Triaging Pap cytology negative, HPV positive cervical cancer screening results with p16/Ki-67 Dual-stained cytology
    • Petry KU, Schmidt D, Scherbring S, et al. Triaging Pap cytology negative, HPV positive cervical cancer screening results with p16/Ki-67 Dual-stained cytology. Gynecol Oncol 2011;121:505-9
    • (2011) Gynecol Oncol , vol.121 , pp. 505-509
    • Petry, K.U.1    Schmidt, D.2    Scherbring, S.3
  • 53
    • 80051606647 scopus 로고    scopus 로고
    • P16/ki-67 dual-stain cytology in the triage of ASCUS and LSIL papanicolaou cytology: Results from the European equivocal or mildly abnormal Papanicolaou cytology study
    • Schmidt D, Bergeron C, Denton KJ, Ridder R. p16/ki-67 dual-stain cytology in the triage of ASCUS and LSIL papanicolaou cytology: Results from the European equivocal or mildly abnormal Papanicolaou cytology study. Cancer Cytopathol 2011;119:158-66
    • (2011) Cancer Cytopathol , vol.119 , pp. 158-166
    • Schmidt, D.1    Bergeron, C.2    Denton, K.J.3    Ridder, R.4
  • 54
    • 84859410919 scopus 로고    scopus 로고
    • High sensitivity and high specificity of p16/Ki-67 dual-stained cytology from screening and triage trials in over 28,000 women
    • Bergeron C, Schmidt D, Ikenberg H, Ridder R. High sensitivity and high specificity of p16/Ki-67 dual-stained cytology from screening and triage trials in over 28,000 women. Cancer Cytopathol 2010;118:305-6
    • (2010) Cancer Cytopathol , vol.118 , pp. 305-306
    • Bergeron, C.1    Schmidt, D.2    Ikenberg, H.3    Ridder, R.4
  • 56
    • 84868533854 scopus 로고    scopus 로고
    • Interaction of epithelial biomarkers, local immune response and condom use in cervical intraepithelial neoplasia 2-3 regression
    • Munk AC, Gudlaugsson E, Ovestad IT, et al. Interaction of epithelial biomarkers, local immune response and condom use in cervical intraepithelial neoplasia 2-3 regression. Gynecol Oncol 2012;127:489-94
    • (2012) Gynecol Oncol , vol.127 , pp. 489-494
    • Munk, A.C.1    Gudlaugsson, E.2    Ovestad, I.T.3
  • 57
    • 0028243099 scopus 로고
    • Elevated wild-Type p53 protein levels in human epithelial cell lines immortalized by the human papillomavirus type 16 E7 gene
    • Demers GW, Halbert CL, Galloway DA. Elevated wild-Type p53 protein levels in human epithelial cell lines immortalized by the human papillomavirus type 16 E7 gene. Virology 1994;198:169-74
    • (1994) Virology , vol.198 , pp. 169-174
    • Demers, G.W.1    Halbert, C.L.2    Galloway, D.A.3
  • 58
    • 0025932933 scopus 로고
    • A cellular protein mediates association of p53 with the E6 oncoprotein of human papillomavirus types 16 or 18
    • Huibregtse JM, Scheffner M, Howley PM. A cellular protein mediates association of p53 with the E6 oncoprotein of human papillomavirus types 16 or 18. EMBO J 1991;10:4129-35 (Pubitemid 21905444)
    • (1991) EMBO Journal , vol.10 , Issue.13 , pp. 4129-4135
    • Huibregtse, J.M.1    Scheffner, M.2    Howley, P.M.3
  • 59
    • 0035933897 scopus 로고    scopus 로고
    • The cytokines tumor necrosis factor-Alpha (TNF-Alpha) and TNF-related apoptosisinducing ligand differentially modulate proliferation and apoptotic pathways in human keratinocytes expressing the human papillomavirus-16 E7 oncoprotein
    • Basile JR, Zacny V, Munger K. The cytokines tumor necrosis factor-Alpha (TNF-Alpha) and TNF-related apoptosisinducing ligand differentially modulate proliferation and apoptotic pathways in human keratinocytes expressing the human papillomavirus-16 E7 oncoprotein. J Biol Chem 2001 ;276:22522-8
    • (2001) J Biol Chem , vol.276 , pp. 22522-22528
    • Basile, J.R.1    Zacny, V.2    Munger, K.3
  • 60
    • 0037077205 scopus 로고    scopus 로고
    • The human papillomavirus 16 E6 protein binds to tumor necrosis factor (TNF) R1 and protects cells from TNF-induced apoptosis
    • DOI 10.1074/jbc.M200113200
    • Filippova M, Song H, Connolly JL, et al. The human papillomavirus 16 E6 protein binds to tumor necrosis factor (TNF) R1 and protects cells from TNF-induced apoptosis. J Biol Chem 2002 ;277:21730-9 (Pubitemid 34952324)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.24 , pp. 21730-21739
    • Filippova, M.1    Song, H.2    Connolly, J.L.3    Dermody, T.S.4    Duerksen-Hughes, P.J.5
  • 61
    • 33751398479 scopus 로고    scopus 로고
    • Modulation of apoptosis by human papillomavirus (HPV) oncoproteins
    • DOI 10.1007/s00705-006-0821-0
    • Garnett TO, Duerksen-Hughes PJ. Modulation of apoptosis by human papillomavirus (HPV) oncoproteins. Arch Virol 2006 ;151:2321-35 (Pubitemid 44819331)
    • (2006) Archives of Virology , vol.151 , Issue.12 , pp. 2321-2335
    • Garnett, T.O.1    Duerksen-Hughes, P.J.2
  • 62
    • 0029559190 scopus 로고
    • P53, retinoblastoma gene product, and cyclin protein expression in human papillomavirus virus DNA-positive cervical intraepithelial neoplasia and invasive cancer
    • Amortegui AJ, Meyer MP, Elborne VL, Amin RM. p53, retinoblastoma gene product, and cyclin protein expression in human papillomavirus virus DNA-positive cervical intraepithelial neoplasia and invasive cancer. Mod Pathol 1995 ;8:907-12 (Pubitemid 26025967)
    • (1995) Modern Pathology , vol.8 , Issue.9 , pp. 907-912
    • Amortegui, A.J.1    Meyer, M.P.2    Elborne, V.L.3    Amin, R.M.4
  • 63
    • 0034817061 scopus 로고    scopus 로고
    • Telomerase activity, MIB-1, PCNA, HPV 16 and p53 as diagnostic markers for cervical intraepithelial neoplasia
    • Herbsleb M, Knudsen UB, Orntoft TF, et al. Telomerase activity, MIB-1, PCNA, HPV 16 and p53 as diagnostic markers for cervical intraepithelial neoplasia. APMIS 2001 ;109:607-17 (Pubitemid 32929736)
    • (2001) APMIS , vol.109 , Issue.9 , pp. 607-617
    • Herbsleb, M.1    Knudsen, U.B.2    Orntoft, T.F.3    Bichel, P.4    Norrild, B.5    Knudsen, A.6    Mogensen, O.L.E.7
  • 64
    • 0032188831 scopus 로고    scopus 로고
    • Expression of ras, c-myc, and p53 proteins in cervical intraepithelial neoplasia
    • DOI 10.1002/(SICI)1097-0142(19981001)83:7<1401::AID-CNCR18>3.0. CO;2-8
    • Slagle BL, Kaufman RH, Reeves WC, Icenogle JP. Expression of ras, c-myc, and p53 proteins in cervical intraepithelial neoplasia. Cancer 1998 ;83:1401-8 (Pubitemid 28460092)
    • (1998) Cancer , vol.83 , Issue.7 , pp. 1401-1408
    • Slagle, B.L.1    Kaufman, R.H.2    Reeves, W.C.3    Icenogle, J.P.4
  • 67
    • 0030008177 scopus 로고    scopus 로고
    • Telomerase activation by the E6 gene product of human papillomavirus type 16
    • DOI 10.1038/380079a0
    • Klingelhutz AJ, Foster SA, McDougall JK. Telomerase activation by the E6 gene product of human papillomavirus type 16. Nature 1996 ;380:79-82 (Pubitemid 26076241)
    • (1996) Nature , vol.380 , Issue.6569 , pp. 79-82
    • Klingelhutz, A.J.1    Foster, S.A.2    McDougall, J.K.3
  • 69
    • 74049102961 scopus 로고    scopus 로고
    • A new multiparameter assay to assess HPV 16/18, viral load and physical status together with gain of telomerase genes in HPV-related cancers
    • Theelen W, Reijans M, Simons G, et al. A new multiparameter assay to assess HPV 16/18, viral load and physical status together with gain of telomerase genes in HPV-related cancers. Int J Cancer 2010 ;126:959-75
    • (2010) Int J Cancer , vol.126 , pp. 959-975
    • Theelen, W.1    Reijans, M.2    Simons, G.3
  • 70
    • 77957342894 scopus 로고    scopus 로고
    • Increase in viral load, viral integration, and gain of telomerase genes during uterine cervical carcinogenesis can be simultaneously assessed by the hpv 16/18 mlpa-Assay
    • Theelen W, Speel EJ, Herfs M, et al. Increase in viral load, viral integration, and gain of telomerase genes during uterine cervical carcinogenesis can be simultaneously assessed by the HPV 16/18 MLPA-Assay. Am J Pathol 2010 ;177:2022-33
    • (2010) Am J Pathol , vol.177 , pp. 2022-2033
    • Theelen, W.1    Speel, E.J.2    Herfs, M.3
  • 72
    • 33746429487 scopus 로고    scopus 로고
    • Using a quality control approach to define an 'adequately cellular' liquid-based cervical cytology specimen
    • McQueen F, Duvall E. Using a quality control approach to define an 'adequately cellular' liquid-based cervical cytology specimen. Cytopathology 2006 ;17:168-7
    • (2006) Cytopathology , vol.17 , pp. 168-177
    • McQueen, F.1    Duvall, E.2
  • 73
    • 79951673521 scopus 로고    scopus 로고
    • Hpv mrna tests for the detection of cervical intraepithelial neoplasia: A systematic review
    • Burger EA, Kornor H, Klemp M, et al. HPV mRNA tests for the detection of cervical intraepithelial neoplasia: A systematic review. Gynecol Oncol 2011 ;120:430-8
    • (2011) Gynecol Oncol , vol.120 , pp. 430-438
    • Burger, E.A.1    Kornor, H.2    Klemp, M.3
  • 75
    • 0030972661 scopus 로고    scopus 로고
    • Proliferation and DNA aneuploidy in mild dysplasia imply early steps of cervical carcinogenesis
    • Steinbeck RG. Proliferation and DNA aneuploidy in mild dysplasia imply early steps of cervical carcinogenesis. Acta Oncol 1997 ;36:3-12 (Pubitemid 27135153)
    • (1997) Acta Oncologica , vol.36 , Issue.1 , pp. 3-12
    • Steinbeck, R.G.1
  • 76
    • 0035866774 scopus 로고    scopus 로고
    • Human papillomavirus type 16 E7 oncoprotein-induced abnormal centrosome synthesis is an early event in the evolving malignant phenotype
    • Duensing S, Duensing A, Crum CP, Munger K. Human papillomavirus type 16 E7 oncoprotein-induced abnormal centrosome synthesis is an early event in the evolving malignant phenotype. Cancer Res 2001 ;61:2356-60 (Pubitemid 32685804)
    • (2001) Cancer Research , vol.61 , Issue.6 , pp. 2356-2360
    • Duensing, S.1    Duensing, A.2    Crum, C.P.3    Munger, K.4
  • 77
    • 0034730196 scopus 로고    scopus 로고
    • The human papillomavirus type 16 E6 and E7 oncoproteins cooperate to induce mitotic defects and genomic instability by uncoupling centrosome duplication from the cell division cycle
    • Duensing S, Lee LY, Duensing A, et al. The human papillomavirus type 16 E6 and E7 oncoproteins cooperate to induce mitotic defects and genomic instability by uncoupling centrosome duplication from the cell division cycle. Proc Natl Acad Sci USA 2000 ;97:10002-7
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 10002-10007
    • Duensing, S.1    Lee, L.Y.2    Duensing, A.3
  • 78
    • 0036897282 scopus 로고    scopus 로고
    • The human papillomavirus type 16 E6 and E7 oncoproteins independently induce numerical and structural chromosome instability
    • Duensing S, Munger K. The human papillomavirus type 16 E6 and E7 oncoproteins independently induce numerical and structural chromosome instability. Cancer Res 2002 ;62:7075-82 (Pubitemid 35424103)
    • (2002) Cancer Research , vol.62 , Issue.23 , pp. 7075-7082
    • Duensing, S.1    Munger, K.2
  • 79
    • 0029809740 scopus 로고    scopus 로고
    • Expression of HPV16 E6 or E7 increases integration of foreign DNA
    • Kessis TD, Connolly DC, Hedrick L, Cho KR. Expression of HPV16 E6 or E7 increases integration of foreign DNA. Oncogene 1996 ;13:427-31 (Pubitemid 26334876)
    • (1996) Oncogene , vol.13 , Issue.2 , pp. 427-431
    • Kessis, T.D.1    Connolly, D.C.2    Hedrick, L.3    Cho, K.R.4
  • 82
    • 34547099574 scopus 로고    scopus 로고
    • Integration of high-risk human papillomavirus: A key event in cervical carcinogenesis?
    • DOI 10.1002/path.2192
    • Pett M, Coleman N. Integration of high-risk human papillomavirus: A key event in cervical carcinogenesis? J Pathol 2007 ;212:356-67 (Pubitemid 47099012)
    • (2007) Journal of Pathology , vol.212 , Issue.4 , pp. 356-367
    • Pett, M.1    Coleman, N.2
  • 83
    • 84879182552 scopus 로고    scopus 로고
    • Use of the HPV MLPA assay in cervical cytology for the prediction of high grade lesions
    • In press
    • Litjens RJ, Theelen W, Van de Pas Y, et al. Use of the HPV MLPA assay in cervical cytology for the prediction of high grade lesions. J Med Virol 2013 ; In press
    • (2013) J Med Virol
    • Litjens, R.J.1    Theelen, W.2    Van De Pas, Y.3
  • 84
    • 83655203604 scopus 로고    scopus 로고
    • Significance of HPV 16 and 18 viral load quantitation in women referred for colposcopy
    • Carcopino X, Henry M, Mancini J, et al. Significance of HPV 16 and 18 viral load quantitation in women referred for colposcopy. J Med Virol 2012 ;84:306-13
    • (2012) J Med Virol , vol.84 , pp. 306-313
    • Carcopino, X.1    Henry, M.2    Mancini, J.3
  • 86
    • 58249086718 scopus 로고    scopus 로고
    • High-risk human papillomavirus DNA load in a population-based cervical screening cohort in relation to the detection of high-grade cervical intraepithelial neoplasia and cervical cancer
    • Hesselink AT, Berkhof J, Heideman DA, et al. High-risk human papillomavirus DNA load in a population-based cervical screening cohort in relation to the detection of high-grade cervical intraepithelial neoplasia and cervical cancer. Int J Cancer 2009 ;124:381-6
    • (2009) Int J Cancer , vol.124 , pp. 381-386
    • Hesselink, A.T.1    Berkhof, J.2    Heideman, D.A.3
  • 87
    • 7244227748 scopus 로고    scopus 로고
    • Type-specific associations of human papillomavirus load with risk of developing cervical carcinoma in situ
    • DOI 10.1002/ijc.20480
    • Moberg M, Gustavsson I, Gyllensten U. Type-specific associations of human papillomavirus load with risk of developing cervical carcinoma in situ. Int J Cancer 2004 ;112:854-9 (Pubitemid 39435271)
    • (2004) International Journal of Cancer , vol.112 , Issue.5 , pp. 854-859
    • Moberg, M.1    Gustavsson, I.2    Gyllensten, U.3
  • 88
    • 33747893245 scopus 로고    scopus 로고
    • Chapter 10: New dimensions in cervical cancer screening
    • S3/90-7
    • Cuzick J, Mayrand MH, Ronco G, et al. Chapter 10: New dimensions in cervical cancer screening. Vaccine 2006;24(Suppl 3):S3/90-7
    • (2006) Vaccine , vol.24 , Issue.SUPPL. 3
    • Cuzick, J.1    Mayrand, M.H.2    Ronco, G.3
  • 89
    • 58249144847 scopus 로고    scopus 로고
    • Utility of methylation markers in cervical cancer early detection: Appraisal of the state-ofthe-science
    • Wentzensen N, Sherman ME, Schiffman M, Wang SS. Utility of methylation markers in cervical cancer early detection: Appraisal of the state-ofthe-science. Gynecol Oncol 2009 ;112:293-9
    • (2009) Gynecol Oncol , vol.112 , pp. 293-299
    • Wentzensen, N.1    Sherman, M.E.2    Schiffman, M.3    Wang, S.S.4
  • 90
    • 80052655064 scopus 로고    scopus 로고
    • Promoter methylation of p16(ink4a) hmlh1 and mgmt in liquid-based cervical cytology samples compared with clinicopathological findings and hpv presence
    • Spathis A, Aga E, Alepaki M, et al. Promoter methylation of p16(INK4A), hMLH1, and MGMT in liquid-based cervical cytology samples compared with clinicopathological findings and HPV presence. Infect Dis Obstet Gynecol 2011 ;2011:927861
    • (2011) Infect Dis Obstet Gynecol , vol.2011 , pp. 927861
    • Spathis, A.1    Aga, E.2    Alepaki, M.3
  • 91
    • 80052269041 scopus 로고    scopus 로고
    • Combined CADM1 and MAL promoter methylation analysis to detect (pre-)malignant cervical lesions in high-risk HPV-positive women
    • Overmeer RM, Louwers JA, Meijer CJ, et al. Combined CADM1 and MAL promoter methylation analysis to detect (pre-)malignant cervical lesions in high-risk HPV-positive women. Int J Cancer 2011 ;129:2218-25
    • (2011) Int J Cancer , vol.129 , pp. 2218-2225
    • Overmeer, R.M.1    Louwers, J.A.2    Meijer, C.J.3
  • 92
    • 79954621220 scopus 로고    scopus 로고
    • Combined promoter methylation analysis of cadm1 and mal: An objective triage tool for high-risk human papillomavirus dna-positive women
    • Hesselink AT, Heideman DA, Steenbergen RD, et al. Combined promoter methylation analysis of CADM1 and MAL: An objective triage tool for high-risk human papillomavirus DNA-positive women. Clin Cancer Res 2011 ;17:2459-65
    • (2011) Clin Cancer Res , vol.17 , pp. 2459-2465
    • Hesselink, A.T.1    Heideman, D.A.2    Steenbergen, R.D.3
  • 93
    • 0027468148 scopus 로고
    • Natural history of cervical intraepithelial neoplasia: A critical review
    • Ostor AG. Natural history of cervical intraepithelial neoplasia: A critical review. Int J Gynecol Pathol 1993 ;12:186-92 (Pubitemid 23095196)
    • (1993) International Journal of Gynecological Pathology , vol.12 , Issue.2 , pp. 186-192
    • Ostor, A.G.1
  • 94
    • 84872863429 scopus 로고    scopus 로고
    • The role of co-factors in the progression from human papillomavirus infection to cervical cancer
    • Luhn P, Walker J, Schiffman M, et al. The role of co-factors in the progression from human papillomavirus infection to cervical cancer. Gynecol Oncol 2013 ;128:265-70
    • (2013) Gynecol Oncol , vol.128 , pp. 265-270
    • Luhn, P.1    Walker, J.2    Schiffman, M.3
  • 95
    • 42949143781 scopus 로고    scopus 로고
    • Natural history of cervical neoplasia and risk of invasive cancer in women with cervical intraepithelial neoplasia 3: A retrospective cohort study
    • McCredie MR, Sharples KJ, Paul C, et al. Natural history of cervical neoplasia and risk of invasive cancer in women with cervical intraepithelial neoplasia 3: A retrospective cohort study. Lancet Oncol 2008 ;9:425-34
    • (2008) Lancet Oncol , vol.9 , pp. 425-434
    • McCredie, M.R.1    Sharples, K.J.2    Paul, C.3
  • 96
    • 37549059578 scopus 로고    scopus 로고
    • Cervical intraepithelial neoplasia grade 3 lesions can regress
    • Munk AC, Kruse AJ, Van Diermen B, et al. Cervical intraepithelial neoplasia grade 3 lesions can regress. APMIS 2007 ;115:1409-14
    • (2007) APMIS , vol.115 , pp. 1409-1414
    • Munk, A.C.1    Kruse, A.J.2    Van Diermen, B.3
  • 98
    • 84863604262 scopus 로고    scopus 로고
    • The lower anogenital squamous terminology standardization project for hpv-Associated lesions: Background and consensus recommendations from the college of american pathologists and the american society for colposcopy and cervical pathology
    • Darragh TM, Colgan TJ, Cox JT, et al. The lower anogenital squamous terminology standardization project for HPV-Associated lesions: Background and consensus recommendations from the College of American Pathologists and the American Society for Colposcopy and Cervical Pathology. J Low Genit Tract Dis 2012 ;16:205-42
    • (2012) J Low Genit Tract Dis , vol.16 , pp. 205-242
    • Darragh, T.M.1    Colgan, T.J.2    Cox, J.T.3
  • 100
    • 84874940992 scopus 로고    scopus 로고
    • High-risk HPV testing on self-sampled versus clinician-collected specimens: A review on the clinical accuracy and impact on population attendance in cervical cancer screening
    • Snijders PJ, Verhoef VM, Arbyn M, et al. High-risk HPV testing on self-sampled versus clinician-collected specimens: A review on the clinical accuracy and impact on population attendance in cervical cancer screening. Int J Cancer 2013 ;132:2223-36
    • (2013) Int J Cancer , vol.132 , pp. 2223-2236
    • Snijders, P.J.1    Verhoef, V.M.2    Arbyn, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.