Promoter methylation of p16INK4A, hMLH1, and MGMT in liquid-based cervical cytology samples compared with clinicopathological findings and HPV presence

Infectious Diseases in Obstetrics and Gynecology

Volumn 2011, Issue , 2011, Pages

  Spathis, Aris ^a   Aga, Evaggelia ^a   Alepaki, Maria ^a   Chranioti, Aikaterini ^a   Meristoudis, Christos ^a   Panayiotides, Ioannis ^a   Kassanos, Dimitrios ^a   Karakitsos, Petros ^a  

^a NATIONAL AND KAPODISTRIAN UNIVERSITY OF ATHENS   (Greece)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 2A; MESSENGER RNA; METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE; PROTEIN MLH1; VIRUS DNA; DNA METHYLTRANSFERASE; MGMT PROTEIN, HUMAN; MLH1 PROTEIN, HUMAN; NUCLEAR PROTEIN; POLYDEOXYRIBONUCLEOTIDE SYNTHASE; SIGNAL TRANSDUCING ADAPTOR PROTEIN; TUMOR SUPPRESSOR PROTEIN;

AGED; ARTICLE; CARCINOGENESIS; COLPOSCOPY; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DIAGNOSTIC TEST ACCURACY STUDY; DIAGNOSTIC VALUE; DNA METHYLATION; FEMALE; HISTOLOGY; HUMAN; HUMAN PAPILLOMAVIRUS TYPE 16; HUMAN PAPILLOMAVIRUS TYPE 18; HUMAN PAPILLOMAVIRUS TYPE 31; HUMAN PAPILLOMAVIRUS TYPE 33; HUMAN PAPILLOMAVIRUS TYPE 45; HUMAN TISSUE; MAJOR CLINICAL STUDY; NONHUMAN; PRIORITY JOURNAL; PROMOTER METHYLATION; PROTEIN EXPRESSION; UTERINE CERVIX CANCER; UTERINE CERVIX CYTOLOGY; WART VIRUS; ADOLESCENT; ADULT; ALPHAPAPILLOMAVIRUS; ANALYSIS OF VARIANCE; CASE CONTROL STUDY; CHI SQUARE DISTRIBUTION; CYTOLOGY; GENETICS; ISOLATION AND PURIFICATION; METABOLISM; MIDDLE AGED; PAPILLOMAVIRUS INFECTION; PATHOLOGY; PROMOTER REGION; RECEIVER OPERATING CHARACTERISTIC; UTERINE CERVIX; UTERINE CERVIX TUMOR; VIROLOGY;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ALPHAPAPILLOMAVIRUS; ANALYSIS OF VARIANCE; CASE-CONTROL STUDIES; CERVIX UTERI; CHI-SQUARE DISTRIBUTION; COLPOSCOPY; CYCLIN-DEPENDENT KINASE INHIBITOR P16; DNA METHYLATION; DNA MODIFICATION METHYLASES; DNA REPAIR ENZYMES; FEMALE; HUMANS; MIDDLE AGED; NUCLEAR PROTEINS; PAPILLOMAVIRUS INFECTIONS; PROMOTER REGIONS, GENETIC; ROC CURVE; TUMOR SUPPRESSOR PROTEINS; UTERINE CERVICAL NEOPLASMS;

EID: 80052655064     PISSN: 10647449     EISSN: 10980997     Source Type: Journal    
DOI: 10.1155/2011/927861     Document Type: Article

References (25)

1. Jemal A., Bray F., Center M. M., Ferlay J., Ward E., Forman D., Global cancer statistics CA: A Cancer Journal for Clinicians 2011 61 2 69 90
2. Walboomers J. M. M., Jacobs M. V., Manos M. M., Bosch F. X., Kummer J. A., Shah K. V., Snijders P. J. F., Peto J., Meijer C. J. L. M., Muoz N., Human papillomavirus is a necessary cause of invasive cervical cancer worldwide Journal of Pathology 1999 189 1 12 19 (Pubitemid 29406813)
3. Durst M., Bosch F. X., Glitz D., Schneider A., Zur Hausen H., Inverse relationship between human papillomavirus (HPV) type 16 early gene expression and cell differentiation in nude mouse epithelial cysts and tumors induced by HPV-positive human cell lines Journal of Virology 1991 65 2 796 804
4. Mnger K., Basile J. R., Duensing S., Eichten A., Gonzalez S. L., Grace M., Zacny V. L., Biological activities and molecular targets of the human papillomavirus E7 oncoprotein Oncogene 2001 20 54 7888 7898 (Pubitemid 33135315)
5. Mantovani F., Banks L., The Human Papillomavirus E6 protein and its contribution to malignant progression Oncogene 2001 20 54 7874 7887 (Pubitemid 33135314)
6. Dunne E. F., Unger E. R., Sternberg M., McQuillan G., Swan D. C., Patel S. S., Markowitz L. E., Prevalence of HPV infection among females in the United States Journal of the American Medical Association 2007 297 8 813 819 (Pubitemid 46333946)
7. Muoz N., Bosch F. X., De Sanjosé S., Herrero R., Castellsagué X., Shah K. V., Snijders P. J. F., Meijer C. J. L. M., Epidemiologic classification of human papillomavirus types associated with cervical cancer New England Journal of Medicine 2003 348 6 518 527 (Pubitemid 36159887)
8. Baseman J. G., Koutsky L. A., The epidemiology of human papillomavirus infections Journal of Clinical Virology 2005 32 supplement 1 S16 S24
9. Croce C. M., Oncogenes and cancer New England Journal of Medicine 2008 358 5 502 511 (Pubitemid 351185806)
10. Esteller M., Epigenetics provides a new generation of oncogenes and tumour-suppressor genes British Journal of Cancer 2006 94 2 179 183 (Pubitemid 43151531)
11. Virmani A. K., Muller C., Rathi A., Zoechbauer-Mueller S., Mathis M., Gazdar A. F., Aberrant methylation during cervical carcinogenesis Clinical Cancer Research 2001 7 3 584 589 (Pubitemid 32707982)
12. Gustafson K. S., Furth E. E., Heitjan D. F., Fansler Z. B., Clark D. P., DNA methylation profiling of cervical squamous intraepithelial lesions using liquid-based cytology specimens: an approach that utilizes receiver-operating characteristic analysis Cancer 2004 102 4 259 268 (Pubitemid 39097157)
13. Dong S. M., Kim H. S., Rha S. H., Sidransky D., Promoter hypermethylation of multiple genes in carcinoma of the uterine cervix Clinical Cancer Research 2001 7 7 1982 1986 (Pubitemid 32994835)
14. Henken F. E., Wilting S. M., Overmeer R. M., Van Rietschoten J. G. I., Nygren A. O. H., Errami A., Schouten J. P., Meijer C. J. L. M., Snijders P. J. F., Steenbergen R. D. M., Sequential gene promoter methylation during HPV-induced cervical carcinogenesis British Journal of Cancer 2007 97 10 1457 1464 (Pubitemid 350114795)
15. Herman J. G., Graff J. R., Myhnen S., Nelkin B. D., Baylin S. B., Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands Proceedings of the National Academy of Sciences of the United States of America 1996 93 18 9821 9826 (Pubitemid 26296693)
16. Esteller M., Risques R. A., Toyota M., Capella G., Moreno V., Peinado M. A., Baylin S. B., Herman J. G., Promoter hypermethylation of the DNA repair gene O(6)-methylguanine-DNA methyltransferase is associated with the presence of G:C to A:T transition mutations in p53 in human colorectal tumorigenesis Cancer Research 2001 61 12 4689 4692 (Pubitemid 32691877)
17. Fox E. J., Leahy D. T., Geraghty R., Mulcahy H. E., Fennelly D., Hyland J. M., O'Donoghue D. P., Sheahan K., Mutually exclusive promoter hypermethylation patterns of hMLH1 and O6-methylguanine DNA methyltransferase in colorectal cancer Journal of Molecular Diagnostics 2006 8 1 68 75 (Pubitemid 43257436)
18. Solomon D., Davey D., Kurman R., Moriarty A., O'Connor D., Prey M., Raab S., Sherman M., Wilbur D., Wright T., Young N., The 2001 Bethesda System: terminology for reporting results of cervical cytology Journal of the American Medical Association 2002 287 16 2114 2119 (Pubitemid 34437346)
19. Feng Q., Balasubramanian A., Hawes S. E., Toure P., Sow P. S., Dem A., Dembele B., Critchlow C. W., Xi L., Lu H., McIntosh M. W., Young A. M., Kiviat N. B., Detection of hypermethylated genes in women with and without cervical neoplasia Journal of the National Cancer Institute 2005 97 4 273 282 (Pubitemid 40310275)
20. Molden T., Kraus I., Karlsen F., Skomedal H., Hagmar B., Human papillomavirus E6/E7 mRNA expression in women younger than 30 years of age Gynecologic Oncology 2006 100 1 95 100 (Pubitemid 41815056)
21. Lin Z., Gao M., Zhang X., Kim Y. S., Lee E. S., Kim H. K., Kim I., The hypermethylation and protein expression of p16 and DNA repair gene O6-methylguanine-DNA methyltransferase in various uterine cervical lesions Journal of Cancer Research and Clinical Oncology 2005 131 6 364 370 (Pubitemid 40674621)
22. Tsiodras S., Georgoulakis J., Chranioti A., Voulgaris Z., Psyrri A., Tsivilika A., Panayiotides J., Karakitsos P., Hybrid capture vs. PCR screening of cervical human papilloma virus infections. Cytological and histological associations in 1270 women BMC Cancer 2010 10
23. Molden T., Nygrd J. F., Kraus I., Predicting CIN2+ when detecting HPV mRNA and DNA by PreTect HPV-proofer and consensus PCR: a 2-year follow-up of women with ASCUS or LSIL Pap smear International Journal of Cancer 2005 114 6 973 976
24. Ivanova T. A., Golovina D. A., Zavalishina L. E., Volgareva G. M., Katargin A. N., Andreeva Y. Y., Frank G. A., Kisseljov F. L., Kisseljova N. P., Up-regulation of expression and lack of 5′ CpG island hypermethylation of p16 INK4a in HPV-positive cervical carcinomas BMC Cancer 2007 7
25. Tsoumpou I., Valasoulis G., Founta C., Kyrgiou M., Nasioutziki M., Daponte A., Koliopoulos G., Malamou-Mitsi V., Karakitsos P., Paraskevaidis E., High-risk human papillomavirus DNA test and p16INK4a in the triage of LSIL: a prospective diagnostic study Gynecologic Oncology 2011 121 1 49 53