Critical contribution of oxidative stress to TNFα-induced necroptosis downstream of RIPK1 activation

Biochemical and Biophysical Research Communications

Volumn 436, Issue 2, 2013, Pages 212-216

  Shindo, Ryodai ^a   Kakehashi, Hidenao ^b   Okumura, Ko ^a   Kumagai, Yoshito ^b   Nakano, Hiroyasu ^a  

^a JUNTENDO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b UNIVERSITY OF TSUKUBA   (Japan)

Author keywords

Butylated hydroxylanisole; Necroptosis; Necrostatin 1; Oxidative stress; RIP kinase 1; TNF

Indexed keywords

ANTIOXIDANT; BUTYLATED HYDROXYANISOLE; HYDROXYL GROUP; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NECROSTATIN 1; PHOSPHOTRANSFERASE; REACTIVE OXYGEN METABOLITE; RECEPTOR INTERACTING SERINE THREONINE KINASE 1; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; NECROPTOSIS; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; STRUCTURE ANALYSIS;

ANIMALS; ANTIOXIDANTS; APOPTOSIS; BLOTTING, WESTERN; BUTYLATED HYDROXYANISOLE; CELL SURVIVAL; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; EMBRYO, MAMMALIAN; ENZYME ACTIVATION; FIBROBLASTS; IMIDAZOLES; INDOLES; INHIBITOR OF APOPTOSIS PROTEINS; MICE; MICE, KNOCKOUT; MODELS, BIOLOGICAL; NECROSIS; OXIDATIVE STRESS; PHOSPHORYLATION; REACTIVE OXYGEN SPECIES; RECEPTOR-INTERACTING PROTEIN SERINE-THREONINE KINASES; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84879607629     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2013.05.075     Document Type: Article

References (19)

1. Ghosh S., Karin M. Missing pieces in the NF-kB puzzle. Cell 2002, 109(Supp):S81-S96.
2. Vallabhapurapu S., Karin M. Regulation and function of NF-kappaB transcription factors in the immune system. Annu. Rev. Immunol. 2009, 27:693-733.
3. Pasparakis M. Regulation of tissue homeostasis by NF-kB signalling: implications for inflammatory diseases. Nat. Rev. Immunol. 2009, 9:778-788.
4. L, directly binds to MKK7 and inhibits the JNK pathway. EMBO J. 2006, 25:5549-5559.
5. Chang L., Kamata H., Solinas G., Luo J.L., Maeda S., Venuprasad K., Liu Y.C., Karin M. The E3 ubiquitin ligase itch couples JNK activation to TNFalpha-induced cell death by inducing c-FLIP(L) turnover. Cell 2006, 124:601-613.
6. Weinlich R., Dillon C.P., Green D.R. Ripped to death. Trends Cell Biol. 2011, 21:630-637.
7. Vandenabeele P., Galluzzi L., Vanden Berghe T., Kroemer G. Molecular mechanisms of necroptosis: an ordered cellular explosion. Nat. Rev. Mol. Cell Biol. 2010, 11:700-714.
8. Degterev A., Hitomi J., Germscheid M., Ch'en I.L., Korkina O., Teng X., Abbott D., Cuny G.D., Yuan C., Wagner G., Hedrick S.M., Gerber S.A., Lugovskoy A., Yuan J. Identification of RIP1 kinase as a specific cellular target of necrostatins. Nat. Chem. Biol. 2008, 4:313-321.
9. He S., Wang L., Miao L., Wang T., Du F., Zhao L., Wang X. Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alpha. Cell 2009, 137:1100-1111.
10. Feoktistova M., Geserick P., Kellert B., Dimitrova D.P., Langlais C., Hupe M., Cain K., MacFarlane M., Hacker G., Leverkus M. CIAPs block Ripoptosome formation, a RIP1/caspase-8 containing intracellular cell death complex differentially regulated by cFLIP isoforms. Mol. Cell 2011, 43:449-463.
11. Tenev T., Bianchi K., Darding M., Broemer M., Langlais C., Wallberg F., Zachariou A., Lopez J., MacFarlane M., Cain K., Meier P. The Ripoptosome, a signaling platform that assembles in response to genotoxic stress and loss of IAPs. Mol. Cell 2011, 43:432-448.
12. Sun L., Wang H., Wang Z., He S., Chen S., Liao D., Wang L., Yan J., Liu W., Lei X., Wang X. Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase. Cell 2012, 148:213-227.
13. Geserick P., Hupe M., Moulin M., Wong W.W., Feoktistova M., Kellert B., Gollnick H., Silke J., Leverkus M. Cellular IAPs inhibit a cryptic CD95-induced cell death by limiting RIP1 kinase recruitment. J. Cell Biol. 2009, 187:1037-1054.
14. Vercammen D., Beyaert R., Denecker G., Goossens V., Van Loo G., Declercq W., Grooten J., Fiers W., Vandenabeele P. Inhibition of caspases increases the sensitivity of L929 cells to necrosis mediated by tumor necrosis factor. J. Exp. Med. 1998, 187:1477-1485.
15. Sakon S., Xue X., Takekawa M., Sasazuki T., Okazaki T., Kojima Y., Piao J.H., Yagita H., Okumura K., Doi T., Nakano H. NF-kB inhibits TNF-induced accumulation of ROS that mediate prolonged MAPK activation and necrotic cell death. EMBO J. 2003, 22:3898-3909.
16. Piao X., Komazawa-Sakon S., Nishina T., Koike M., Piao J.H., Ehlken H., Kurihara H., Hara M., Van Rooijen N., Schutz G., Ohmuraya M., Uchiyama Y., Yagita H., Okumura K., He Y.W., Nakano H. c-FLIP maintains tissue homeostasis by preventing apoptosis and programmed necrosis. Sci. Signal. 2012, 5:93.
17. Kinoshita E., Kinoshita-Kikuta E., Takiyama K., Koike T. Phosphate-binding tag, a new tool to visualize phosphorylated proteins. Mol. Cell. Proteomics 2006, 5:749-757.
18. Wang Z., Jiang H., Chen S., Du F., Wang X. The mitochondrial phosphatase PGAM5 functions at the convergence point of multiple necrotic death pathways. Cell 2012, 148:228-243.
19. Zhang D.W., Shao J., Lin J., Zhang N., Lu B.J., Lin S.C., Dong M.Q., Han J. RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis. Science 2009, 325:332-336.