The hunger hormone ghrelin in cachexia

Expert Opinion on Biological Therapy

Volumn 13, Issue 4, 2013, Pages 465-468

  Molfino, Alessio ^a   Gioia, Gianfranco ^a   Muscaritoli, Maurizio ^a  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

Anorexia; Cachexia; Cancer; Ghrelin; Uremia

Indexed keywords

GHRELIN; BIOLOGICAL MARKER;

ABDOMINAL PAIN; ASTHENIA; CACHEXIA; CANCER PATIENT; CHRONIC OBSTRUCTIVE LUNG DISEASE; DIAPHORESIS; DIARRHEA; DISEASE ASSOCIATION; DRUG EFFICACY; DRUG SAFETY; DYSPNEA; ENERGY METABOLISM; ESOPHAGUS RESECTION; HOMEOSTASIS; HUMAN; HUNGER; INTESTINE FUNCTION; KIDNEY FAILURE; NAUSEA; NONHUMAN; REVIEW; SIDE EFFECT; SWEATING; TOTAL STOMACH RESECTION; UREMIA; VOMITING; XEROSTOMIA; ANIMAL; BLOOD; COMPLICATION; NEOPLASM; PHYSIOLOGY;

ANIMALS; BIOLOGICAL MARKERS; CACHEXIA; GHRELIN; HUMANS; HUNGER; NEOPLASMS; UREMIA;

EID: 84879585891     PISSN: 14712598     EISSN: None     Source Type: Journal    
DOI: 10.1517/14712598.2013.748031     Document Type: Review

References (23)

1. Molfino A, Laviano A, Rossi Fanelli F. Contribution of anorexia to tissue wasting in cachexia. Curr Opin Support Palliat Care 2010;4:249-53
2. Fearon K, Strasser F, Anker SD, et al. Definition and classification of cancer cachexia: an international consensus. Lancet Oncol 2011;12:489-95
3. Muscaritoli M, Molfino A, Gioia G, et al. The "parallel pathway": a novel nutritional and metabolic approach to cancer patients. Intern Emerg Med 2011;6:105-12
4. Stengel A, Goebel M, Wang L, Tache Y. Ghrelin, des-acyl ghrelin and nesfatin-1 in gastric X/A-like cells: role as regulators of food intake and body weight. Peptides 2010;31:357-69
5. Laviano A, Inui A, Meguid MM, et al. NPY and brain monoamines in the pathogenesis of cancer anorexia. Nutrition 2008;24:802-5
6. Kojima M, Hosoda H, Date Y, et al. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 1999;402:656-60
7. Parker JA, Bloom SR. Hypothalamic neuropeptides and the regulation of appetite. Neuropharmacology 2012;63:18-30
8. Krasnow SM, Marks DL. Neuropeptides in the pathophysiology and treatment of cachexia. Curr Opin Support Palliat Care 2010;4:266-71
9. Gallas S, Fetissov SO. Ghrelin, appetite and gastric electrical stimulation. Peptides 2011;32:2283-9
10. Argiles JM, Stemmler B. The potential of ghrelin in the treatment of cancer cachexia. Expert Opin Biol Ther 2013;13(1):67-76
11. DeBoer MD, Zhu XX, Levasseur P, et al. Ghrelin treatment causes increased food intake and retention of lean body mass in a rat model of cancer cachexia. Endocrinology 2007;148:3004-12
12. Neary NM, Small CJ, Wren AM, et al. Ghrelin increases energy intake in cancer patients with impaired appetite: acute, randomized, placebo-controlled trial. J Clin Endocrinol Metab 2004;89:2832-6
13. Strasser F, Lutz TA, Maeder MT, et al. Safety, tolerability and pharmacokinetics of intravenous ghrelin for cancer-related anorexia/cachexia: a randomised, placebo-controlled, double-blind, double-crossover study. Br J Cancer 2008;98:300-8
14. Laviano A, Krznaric Z, Sanchez-Lara K, et al. Chronic renal failure, cachexia, and ghrelin. Int J Pept 2010; doi:10.1155/2010/648045
15. Wynne K, Giannitsopoulou K, Small CJ, et al. Subcutaneous ghrelin enhances acute food intake in malnourished patients who receive maintenance peritoneal dialysis: a randomized, placebo-controlled trial. J Am Soc Nephrol 2005;16:2111-18
16. Ashby DR, Ford HE, Wynne KJ, et al. Sustained appetite improvement in malnourished dialysis patients by daily ghrelin treatment. Kidney Int 2009;76:199-206
17. Deboer MD, Zhu X, Levasseur PR, et al. Ghrelin treatment of chronic kidney disease: improvements in lean body mass and cytokine profile. Endocrinology 2008;149:827-35
18. Barazzoni R, Zhu X, Deboer M, et al. Combined effects of ghrelin and higher food intake enhance skeletal muscle mitochondrial oxidative capacity and AKT phosphorylation in rats with chronic kidney disease. Kidney Int 2010;77:23-8
19. Nagaya N, Moriya J, Yasumura Y, et al. Effects of ghrelin administration on left ventricular function, exercise capacity, and muscle wasting in patients with chronic heart failure. Circulation 2004;110:3674-9
20. Nagaya N, Itoh T, Murakami S, et al. Treatment of cachexia with ghrelin in patients with COPD. Chest 2005;128:1187-93
21. Imazu Y, Yanagi S, Miyoshi K, et al. Ghrelin ameliorates bleomycin-induced acute lung injury by protecting alveolar epithelial cells and suppressing lung inflammation. Eur J Pharmacol 2011;672:153-8
22. Adachi S, Takiguchi S, Okada K, et al. Effects of ghrelin administration after total gastrectomy: a prospective, randomized, placebo-controlled phase II study. Gastroenterology 2010;138:1312-20
23. Yamamoto K, Takiguchi S, Miyata H, et al. Randomized phase II study of clinical effects of ghrelin after esophagectomy with gastric tube reconstruction. Surgery 2010;148:31-8