NPY and brain monoamines in the pathogenesis of cancer anorexia

Nutrition

Volumn 24, Issue 9, 2008, Pages 802-805

  Laviano, Alessandro ^a   Inui, Akio ^b   Meguid, Michael M ^c   Molfino, Alessio ^a   Conte, Caterina ^a   Rossi Fanelli, Filippo ^a  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b KAGOSHIMA UNIVERSITY   (Japan)

^c State University of New York Upstate Medical University: College of Medicine   (United States)

Author keywords

Anorexia; Cytokines; Food intake; Melanocortin; Serotonin

Indexed keywords

BRAIN MONOAMINE; CYTOKINE; MELANOCORTIN; NEUROPEPTIDE Y; SEROTONIN;

ADIPOSE TISSUE; ANOREXIA; CALORIC INTAKE; CANCER ANOREXIA; CATABOLISM; ENERGY EXPENDITURE; HUMAN; HYPOTHALAMUS; NAUSEA; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DEGRADATION; REVIEW; SATIETY; TASTE;

ANOREXIA; BIOGENIC MONOAMINES; BRAIN; HUMANS; HYPOTHALAMUS; MELANOCORTINS; NEOPLASMS; NEUROPEPTIDE Y;

EID: 49749138909     PISSN: 08999007     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nut.2008.06.005     Document Type: Review

References (29)

1. Morley J.E., Thomas D.R., and Wilson W.W. Cachexia: pathophysiology and clinical relevance. Am J Clin Nutr 83 (2006) 735-743
2. Laviano A., Meguid M.M., Inui A., Muscaritoli M., and Rossi Fanelli F. Therapy insight: cancer anorexia-cachexia syndrome-when all you can eat is yourself. Nat Clin Pract Oncol 2 (2005) 158-165
3. Kalantar-Zadeh K., Block G., McAllister C.J., Humphreys M.H., and Kopple J.D. Appetite and inflammation, nutrition, anemia, and clinical outcome in hemodialysis patients. Am J Clin Nutr 80 (2004) 299-307
4. Cone R.D. Anatomy and regulation of the central melanocortin system. Nat Neurosci 8 (2005) 571-578
5. Mountjoy K.G., Robbins L.S., Mortrud M.T., and Cone R.D. The cloning of a family of genes that encode the melanocortin receptors. Science 257 (1992) 1248-1251
6. Joppa M.A., Gogas K.R., Foster A.C., and Markinson S. Central infusion of the melanocortin receptor antagonist agouti-related peptide [AgRP(83-132)] prevents cachexia-related symptoms induced by radiation and colon-26 tumors in mice. Peptides 28 (2007) 636-642
7. Makarenko I.G., Meguid M.M., Gatto L., Chen C., and Ugrumov M.V. Decreased NPY innervation of the hypothalamic nuclei in rats with cancer anorexia. Brain Res 961 (2003) 100-108
8. 1B) receptor and NPY in cancer after tumor resection: an immunocytochemical study. Neurosci Lett 383 (2005) 322-327
9. Meguid M.M., Ramos E.J., Laviano A., Varma M., Sato T., Chen C., et al. Tumor anorexia: effects on neuropeptide Y and monoamines in paraventricular nucleus. Peptides 25 (2004) 261-266
10. Chance W.T., Xiao C., Dayal R., and Sheriff S. Alteration of NPY and Y1 receptor in dorsomedial and ventromedial areas of hypothalamus in anorectic tumor-bearing rats. Peptides 28 (2007) 295-301
11. Ramos E.J., Suzuki S., Meguid M.M., Laviano A., Sato T., Chen C., and Das U. Changes in hypothalamic neuropeptide Y and monoaminergic system in tumor-bearing rats: pre- and post-tumor resection and at death. Surgery 136 (2004) 270-276
12. Jatoi A., Loprinzi C.L., Sloan J.A., Klee G.G., and Windschitl A.E. Neuropeptide Y, leptin, and cholecystokinin 8 in patients with advanced cancer and anorexia: a North Central Cancer Treatment Group exploratory investigation. Cancer 92 (2001) 629-633
13. McCarthy H.D., Crowder R.E., Dryden S., and Williams G. Megestrol acetate stimulates food and water intake in the rat: effects on regional hypothalamic neuropeptide Y concentrations. Eur J Pharmacol 265 (1994) 99-102
14. Inui A. Cancer anorexia-cachexia syndrome: are neuropeptides the key?. Cancer Res 59 (1999) 4493-4501
15. Plata-Salaman C.R., Ilyin S.E., and Gayle D. Brain cytokine mRNAs in anorectic rats bearing prostate adenocarcinoma tumor cells. Am J Physiol Regul Integr Comp Physiol 275 (1998) R566-R573
16. Opara E.I., Laviano A., Meguid M.M., and Yang Z.J. Correlation between food intake and CSF IL-1 alpha in anorectic tumor bearing rats. Neuroreport 6 (1995) 750-752
17. Laviano A., Gleason J.R., Meguid M.M., Yang Z.J., Cangiano C., and Rossi Fanelli F. Effects of intra-VMN mianserin and IL-1ra on meal number in anorectic tumor-bearing rats. J Investig Med 48 (2000) 40-48
18. Mantovani G., Macciò A., Lai P., Massa E., Ghiani M., and Santona M.C. Cytokine involvement in cancer anorexia/cachexia: role of megestrol acetate and medroxyprogesterone acetate on cytokine downregulation and improvement of clinical symptoms. Crit Rev Oncol 9 (1998) 99-106
19. Tecott L.H. Serotonin and the orchestration of energy balance. Cell Metab 6 (2007) 352-361
20. Meguid M.M., Fetissov S.O., Varma M., Sato T., Zhang L., Laviano A., and Rossi Fanelli F. Hypothalamic dopamine and serotonin in the regulation of food intake. Nutrition 16 (2000) 843-857
21. Blaha V., Yang Z.J., Meguid M.M., Chai J.K., Oler A., and Zadak Z. Ventromedial nucleus of hypothalamus is related to the development of cancer-induced anorexia: in vivo microdialysis study. Acta Med (Hradec Kralove) 41 (1998) 3-11
22. Cangiano C., Cascino A., Ceci F., Laviano A., Mulieri M., Muscaritoli M., and Rossi Fanelli F. Plasma and CSF tryptophan in cancer anorexia. J Neural Transm Gen Sect 81 (1990) 225-233
23. Laviano A., Muscaritoli M., Cascino A., Preziosa I., Inui A., Mantovani G., and Rossi Fanelli F. Branched-chain amino acids: the best compromise to achieve anabolism?. Curr Opin Clin Nutr Metab Care 8 (2005) 408-414
24. Heisler L.K., Cowley A., Tecott L.H., Fan W., Low M.J., Smart J.L., et al. Activation of central melanocortin pathways by fenfluramine. Science 297 (2002) 609-611
25. Heisler L.K., Jobst E.E., Sutton G.M., Zhou L., Borok E., Thorton-Jones Z., et al. Serotonin reciprocally regulates melanocortin neurons to modulate food intake. Neuron 51 (2006) 239-249
26. Sato T., Laviano A., Meguid M.M., Chen C., Rossi Fanelli F., and Hatakeyama K. Involvement of plasma leptin, insulin and free tryptophan in cytokine-induced anorexia. Clin Nutr 22 (2003) 139-146
27. Yang Z.J., Blaha V., Meguid M.M., Laviano A., Oler A., and Zadak Z. Interleukin-1alpha injection into ventromedial hypothalamic nucleus of normal rats depresses food intake and release of dopamine and serotonin. Pharmacol Biochem Behav 62 (1999) 61-65
28. Fetissov S.O., Hamze Sinno M., Coeffier M., Bole-Feysot C., Ducrotte P., Hokfelt T., and Dechelotte P. Autoantibodies against appetite-regulating peptide hormones and neuropeptides: putative modulation by gut microflora. Nutrition 24 (2008) 348-359
29. Broekhuizen R., Grimble R.F., Howell W.M., Shale D.J., Creutzberg E.C., Wouters E.F., and Schols A.M. Pulmonary cachexia, systemic inflammation profile, and the interleukin 1beta-511 single nucleotide polymorphism. Am J Clin Nutr 82 (2005) 1059-1064