Integrin α2β1 is a receptor for the cartilage matrix protein chondroadherin

Journal of Cell Biology

Volumn 138, Issue 5, 1997, Pages 1159-1167

  Camper, Lisbet ^a   Heinegård, Dick ^a   Lundgren Åkerlund, Evy ^a  

^a LUND UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; CELL SURFACE RECEPTOR; COLLAGEN TYPE 2; INTEGRIN; CALCIUM; CHONDROADHERIN; COLLAGEN RECEPTOR; MAGNESIUM; MANGANESE; PHORBOL 13 ACETATE 12 MYRISTATE; SCLEROPROTEIN;

ANIMAL CELL; ARTICLE; CARTILAGE CELL; CATTLE; CELL ADHESION; CELL SPREADING; EXTRACELLULAR MATRIX; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; MOLECULAR WEIGHT; NONHUMAN; PRIORITY JOURNAL; AFFINITY CHROMATOGRAPHY; ANIMAL; ARTICULAR CARTILAGE; CELL CULTURE; CELL MOTION; CYTOLOGY; DRUG EFFECT; FIBROBLAST; ISOLATION AND PURIFICATION; KINETICS; METABOLISM; PHYSIOLOGY;

ANIMALS; CALCIUM; CARTILAGE, ARTICULAR; CATTLE; CELL ADHESION; CELL MOVEMENT; CELLS, CULTURED; CHROMATOGRAPHY, AFFINITY; EXTRACELLULAR MATRIX PROTEINS; FIBROBLASTS; HUMANS; INTEGRINS; KINETICS; MAGNESIUM; MANGANESE; RECEPTORS, COLLAGEN; TETRADECANOYLPHORBOL ACETATE;

EID: 0030610917     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.138.5.1159     Document Type: Article

References (50)

1. Bengtsson, E., P.J. Neames, D. Heinegard, and Y. Sommarin. 1995. The primary structure of a basic leucine-rich repeat protein, PRELP, found in connective tissue. J. Biol. Chem. 270:25639-25644.
2. Blochberger, T.C., J.-P. Vergnes, J. Hempel, and J.R. Hassell. 1992. cDNA to chick lumican (corneal keratan sulfate proteoglycan) reveals homology to the small interstitial proteoglycan gene family and expression in muscle and intestine. J. Biol. Chem. 267:347-352.
3. Carter, W., E. Wayner, T. Bouchard, and P. Kaur. 1990. The role of integrins α2β1 in cell-cell and cell-substrate adhesion of human epidermal cells. J. Cell Biol. 110:1387-1404.
4. Chan, B.M.C., and M.E. Hemler. 1993. Multiple functional forms of integrin VLA-2 can be derived from a single α2 cDNA clone: interconversion of forms induced by an anti-β1 antibody. J. Cell Biol. 120:537-543.
5. Chen, J.D., J.P. Kim, K. Zhang, Y. Sarret, K.C. Wynn, R.H. Kramer, and D.T. Woodley. 1993. Epidermal growth factor (EGF) promotes human keratinocyte locomotion on collagen by increasing the α2 integrin subunit. Exp. Cell Res. 209:216-223.
6. Corpuz, L.M., J.L. Funderburgh, M.L. Funderburgh, G.S. Bottomley, S. Prakash, and G.W. Conrad. 1996. Molecular cloning and tissue distribution of keratocan. J. Biol. Chem. 271:9759-9763.
7. Danilov, Y.N., and R.L. Juliano. 1989. Phorbol ester modulation of integrin-mediated cell adhesion: a postreceptor event. J. Cell Biol. 108:1925-1933.
8. Dürr, J., S. Goodman, A. Potocnik, H. von der Mark, and K. von der Mark. 1993. Localization of β1-integrins in human cartilage and their role in chondrocyte adhesion to collagen and fibronectin. Exp. Cell Res. 207: 235-244.
9. Elices, M.J., and M.E. Hemler. 1989. The human integrin VLA-2 is a collagen receptor on some cells and a collagen/laminin receptor on others. Proc. Natl. Acad. Sci. USA. 86:9906-9910.
10. Elices, M.J., L.A. Urry, and M.E. Hemler. 1991. Receptor functions for the integrin VLA-3: fibronectin, collagen, and laminin binding are differentially influenced by ARG-GLY-ASP peptide and by divalent cations. J. Cell Biol. 112:169-181.
11. Eyre, D.R., J.-J. Wu, and P. Woods. 1992. Cartilage-specific collagens. Structural studies. In Articular Cartilage and Osteoarthritis. K.E. Kuettner, R. Schleyerbach, J.G. Peyron, and V.C. Hascall, editors. Raven Press, Ltd., New York. 119-131.
12. Fisher, L.W., J.D. Termine, and M.F. Young. 1989. Deduced protein sequence of bone small proteoglycan I (biglycan) shows homolgy with proteoglycan II (decorin) and several nonconnective tissue proteins in a variety of species. J. Biol. Chem. 264:4571-4576.
13. Gailit, J., and E. Ruoslahti. 1988. Regulation of the fibronectin receptor affinity by divalent cations. J. Biol. Chem. 263:12927-12932.
14. Garratt, A.N., and M.J. Humphries. 1995. Recent insights into ligand binding, activation and signalling by integrin adhesion receptors. Acta Anat. 154:34-45.
15. Gullberg, D., L. Terracio, T.K. Borg, and K. Rubin. 1989. Identification of integrin-like matrix receptors with affinity for interstitial collagens. J. Biol. Chem. 264:12686-12694.
16. Hardingham, T.E., A.J. Fosang, and J. Dudhia. 1992. Aggrecan, the chondroitin sulfate/keratan sulfate proteoglycan from cartilage. In Articular Cartilage and Osteoarthritis. K.E. Kuettner, R. Schleyerbach, J.G. Peyron, and V.C. Hascall, editors. Raven Press, Ltd., New York. 5-20.
17. Häuselmann, H.J., M.B. Aydelotte, B.L. Schumacher, K.E. Kuettner, S.H. Gitelis, and E.J.-M.A. Thonar. 1992. Synthesis and turnover of proteoglycans by human and bovine adult articular chondrocytes cultured in alginate beads. Matrix. 12:116-129.
18. Hedbom, E., and D. Heinegård. 1993. Binding of fibromodulin and decorin to separate sites on fibrillar collagens. J. Biol. Chem. 268:27307-27312.
19. Heinegård, D., and M. Paulsson. 1987. Cartilage. In Methods in Enzymology. Structural and Contractile Proteins. Part E. Extracellular Matrix. L.W. Cunningham, editor. Academic Press Inc., Orlando, FL. 336-363.
20. Heinegård, D., and Å. Oldberg. 1989. Structure and biology of cartilage and bone matrix noncollagenous macromolecules. FASEB (Fed. Am. Soc. Exp. Biol.) J. 3:2042-2051.
21. Heino, J., and J. Massagué. 1989. Transforming growth factor-β switches the pattern of integrins expressed in MG-63 human osteosarcoma cells and causes a selective loss of cell adhesion to laminin. J. Biol. Chem. 264: 21806-21811.
22. Hemler, M.E. 1990. VLA-proteins in the integrin family: structure, functions, and their role on leukocytes. Annu. Rev. Immnnol. 8:365-400.
23. Hemler, M.E., F. Sanchez-Madrid, T.J. Flotte, A.M. Krensky, S.J. Burakoff, A.K. Bhan, T.A. Springer, and J.L. Strominger. 1984. Glycoproteins of 210,000 and 130,000 m.w. on activated T cells: cell distribution and antigenic relation to components on resting cells and T cell lines. J. Immunol. 132:3011-3018.
24. Holmvall, K., L. Camper, S. Johansson, K. Rubin, J.H. Kimura, and E. Lundgren-Åkerlund. 1995. Chondrocyte and chondrosarcoma cell integrins with affinity for collagen type II and their response to mechanical stress. Exp. Cell Res. 221:496-503.
25. Hynes, R.O. 1992. Integrins: versatility, modulation, and signaling in cell adhesion. Cell. 69:11-25.
26. Klein, C.E., D. Dressel, T. Steinmayer, C. Mauch, B. Eckes, T. Krieg, R.B. Bankert, and L. Weber. 1991. Integrin α2β1 is upregulated in fibroblasts and highly aggressive melanoma cells in three-dimensional collagen lattices and mediates the reorganization of collagen I fibrils. J. Cell Biol. 115:1427-1436.
27. Kramer, R.H., and N. Marks. 1989. Identification of integrin collagen receptors on human melanoma cells. J. Biol. Chem. 264:4684-4688.
28. Krusius, T., and E. Ruoslahti. 1986. Primary structure of an extracellular matrix proteoglycan core protein deduced from cloned cDNA. Proc. Natl. Acad. Sci. USA. 83:7683-7687.
29. Landegren, U. 1984. Measurement of cell numbers by means of the endogenous enzyme hexosaminidase. Application to detection of lymphokines and cell surface antigens. J. Immunol. Methods. 67:379-388.
30. Languino, L.R., K.R. Gehlsen, E. Wayner, W.G. Carter, and E. Engvall. 1989. Endothelial cells use α2β1 integrin as a laminin receptor. J. Cell Biol. 109:2455-2462.
31. Larsson, T., Y. Sommarin, M. Paulsson, P. Antonsson, E. Hedbom, M. Wendel, and D. Heinegård. 1991. Cartilage matrix proteins. A basic 36-kDa protein with a restricted distribution to cartilage and bone. J. Biol. Chem. 266:20428-20433.
32. Lundgren, E., E. Berger, and K.-E. Arfors. 1992. Effect of divalent cations on adhesion of polymorphonuclear leukocytes to matrix molecules in vitro. J. Leukocyte Biol. 51:603-608.
33. Maroudas, A. 1979. Physicochemical properties of articular cartilage. In Adult Articular Cartilage. M.A.R. Freeman, editor. Pittman, London. 215-290.
34. Miller, E.J. 1972. Structural studies on cartilage collagen employing limited cleavage and solubilizalion with pepsin. Biochemistry. 11:4903-4909.
35. Neame, P.J., Y. Sommarin, R.E. Boynton, and D. Heinegård. 1994. The structure of a 38-kDa leucine-rich protein (chondroadherin) isolated from bovine cartilage. J. Biol. Chem. 269:21547-21554.
36. Oldberg, Å., P. Antonsson, K. Lindblom, and D. Heinegård. 1989. A collagen-binding 59-kd protein (fibromodulin) is structurally related to the small interstitial proteoglycans PG-S1 and PG-S2 (decorin). EMBO (Eur. Mol. Biol. Organ.) J. 8:2601-2604.
37. Ruoslahti, E., and M.D. Pierschbacher. 1987. New perspectives in cell adhesion: RGD and integrins. Science (Wash. DC). 238:491-497.
38. Salter, D.M., D.E. Hughes, R. Simpson, and D.L. Gardner. 1992. Integrin expression by human articular chondrocytes. Br. J. Rheumatol. 31:231-234.
39. b are associated with a single amino acid polymorphism on glycoprotein Ia (integrin subunit α2). J. Clin. Invest. 92:2427-2432.
40. Schiro, J.A., B.M.C. Chan, W.T. Roswit, P.D. Kassner, A.P. Pentland, M.E. Hemler, A.Z. Eisen, and T.S. Kupper. 1991. Integrin α2β1 (VLA-2) mediates reorganization and contraction of collagen matrices by human cells. Cell 67:403-410.
41. Schonherr, E., P. Witsch-Prehm, B. Harrach, H. Robenek, J. Rauterberg, and H. Kresse. 1995. Interaction of biglycan with type I collagen. J. Biol. Chem. 270:2776-2783.
42. Shimitzu, Y., G.A. Van Seventer, K.J. Horgan, and S. Shaw. 1990. Regulated expression and binding of three VLA (β1) integrin receptors on T cells. Nature (Lond.). 345:250-253.
43. Sommarin, Y., and D. Heinegård. 1983. Specific interaction between cartilage proteoglycans and hyaluronic acid at the chondrocyte cell surface. Biochem. J. 214:777-784.
44. Sommarin, Y., T. Larsson, and D. Heinegård. 1989. Chondrocyte-matrix interactions. Attachment to proteins isolated from cartilage. Exp. Cell Res. 184:181-192.
45. Sonnenberg, A., C.J.T. Linders, P.W. Modderman, C.H. Damsky, M. Aumailley, and R. Timpl. 1990. Integrin recognition of different cell-binding fragments of Laminin (P1, E3, E8) and evidence that α6β1 but not α6β4 functions as a major receptor for fragment E8. J. Cell Biol. 110:2145-2155.
46. 2+-dependent adhesion of platelets to collagen. J. Cell Biol. 108: 1917-1924.
47. Vogel, K., M. Paulsson, and D. Heinegard. 1984. Specific inhibition of type I and type II collagen fibrillogenesis by the small proteoglycan of tendon. Biochem. J. 223:587-597.
48. Wessel, D., and U. I. Flügge. 1984. A method for the quantitative recovery of protein in dilute solution in the presence of detergents and lipids. Anal. Biochem. 138:141-143.
49. Wilkins, J.A., D. Stupack, S. Stewart, and S. Caixia. 1991. β1 integrin-mediated lymphocyte adherence to extracellular matrix is enhanced by phorbol ester treatment. Eur. J. Immunol. 21:517-522.
50. Woods, V.L., Jr, P.J. Schreck, D.S. Gesink, H.O. Pacheco, D. Amiel, W.H. Akeson, and M. Lotz. 1994. Integrin expression by human articular chondrocytes. Arthritis Rheum. 37:537-544.