A New Functional MRI Approach for Investigating Modulations of Brain Oxygen Metabolism

PLoS ONE

Volumn 8, Issue 6, 2013, Pages

  Griffeth, Valerie E M ^a   Blockley, Nicholas P ^a   Simon, Aaron B ^a   Buxton, Richard B ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CAFFEINE; CENTRAL STIMULANT AGENT; OXYGEN;

ARTICLE; BOLD SIGNAL; BRAIN BLOOD FLOW; BRAIN BLOOD VOLUME; BRAIN FUNCTION; BRAIN OXYGEN CONSUMPTION; CONTROLLED STUDY; FUNCTIONAL MAGNETIC RESONANCE IMAGING; HEMODYNAMICS; HUMAN; IMAGING; MAGNETIC FIELD; MATHEMATICAL MODEL; MEASUREMENT; NONLINEAR SYSTEM; SPIN LABELING; STIMULUS RESPONSE; SYSTEMATIC ERROR; BIOLOGICAL MODEL; BLOOD FLOW; BRAIN; BRAIN CIRCULATION; COMPUTER SIMULATION; DIAGNOSTIC IMAGING; DRUG EFFECTS; METABOLISM; NUCLEAR MAGNETIC RESONANCE IMAGING; OXYGEN CONSUMPTION; PHYSIOLOGY; PROCEDURES;

BRAIN; CAFFEINE; CENTRAL NERVOUS SYSTEM STIMULANTS; CEREBROVASCULAR CIRCULATION; COMPUTER SIMULATION; HUMANS; MAGNETIC FIELDS; MAGNETIC RESONANCE IMAGING; MODELS, NEUROLOGICAL; NONLINEAR DYNAMICS; OXYGEN; OXYGEN CONSUMPTION; REGIONAL BLOOD FLOW;

EID: 84879522926     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0068122     Document Type: Article

References (48)

1. Ogawa S, Menon RS, Tank DW, Kim S-G, Merkle H, et al. (1993) Functional brain mapping by blood oxygenation level- dependent contrast magnetic resonance imaging: a comparison of signal characteristics with a biophysical model. Biophysical J 64: 803-812.
2. Fox PT, Raichle ME, (1986) Focal physiological uncoupling of cerebral blood flow and oxidative metabolism during somatosensory stimulation in human subjects. Proc Natl Acad Sci USA 83: 1140-1144.
3. Ances BM, Leontiev O, Perthen JE, Liang C, Lansing AE, et al. (2008) Regional differences in the coupling of cerebral blood flow and oxygen metabolism changes in response to activation: Implications for BOLD-fMRI. Neuroimage 39: 1510-1521.
4. Donahue MJ, Blicher JU, Ostergaard L, Feinberg DA, MacIntosh BJ, et al. (2009) Cerebral blood flow, blood volume, and oxygen metabolism dynamics in human visual and motor cortex as measured by whole-brain multi-modal magnetic resonance imaging. J Cereb Blood Flow Metab 29: 1856-1866.
5. Ances BM, Liang CL, Leontiev O, Perthen JE, Fleisher AS, et al. (2009) Effects of aging on cerebral blood flow, oxygen metabolism, and blood oxygenation level dependent responses to visual stimulation. Hum Brain Mapp 30: 1120-1132.
6. Chen Y, Parrish TB, (2009) Caffeine's effects on cerebrovascular reactivity and coupling between cerebral blood flow and oxygen metabolism. Neuroimage 44: 647-652.
7. Griffeth VE, Perthen JE, Buxton RB, (2011) Prospects for quantitative fMRI: Investigating the effects of caffeine on baseline oxygen metabolism and the response to a visual stimulus in humans. Neuroimage 57: 809-816.
8. Moradi F, Buracas GT, Buxton RB, (2012) Attention strongly increases oxygen metabolic response to stimulus in primary visual cortex. Neuroimage 59: 601-607.
9. Davis TL, Kwong KK, Weisskoff RM, Rosen BR, (1998) Calibrated functional MRI: mapping the dynamics of oxidative metabolism. Proc Natl Acad Sci USA 95: 1834-1839.
10. Griffeth VE, Buxton RB, (2011) A theoretical framework for estimating cerebral oxygen metabolism changes using the calibrated-BOLD method: modeling the effects of blood volume distribution, hematocrit, oxygen extraction fraction, and tissue signal properties on the BOLD signal. Neuroimage 58: 198-212.
11. Hoge RD, Atkinson J, Gill B, Crelier GR, Marrett S, et al. (1999) Investigation of BOLD signal dependence on cerebral blood flow and oxygen consumption: the deoxyhemoglobin dilution model. Magn Reson Med 42: 849-863.
12. Hoge RD, Atkinson J, Gill B, Crelier GR, Marrett S, et al. (1999) Linear coupling between cerebral blood flow and oxygen consumption in activated human cortex. Proc Natl Acad Sci, USA 96: 9403-9408.
13. Kim SG, Rostrup E, Larsson HBW, Ogawa S, Paulson OB, (1999) Determination of relative CMRO2 from CBF and BOLD changes: significant increase of oxygen consumption rate during visual stimulation. Magn Reson Med 41: 1152-1161.
14. Kastrup A, Kruger G, Neumann-Haefelin T, Glover GH, Moseley ME, (2002) Changes of cerebral blood flow, oxygenation, and oxidative metabolism during graded motor activation. Neuroimage 15: 74-82.
15. Stefanovic B, Warnking JM, Kobayashi E, Bagshaw AP, Hawco C, et al. (2005) Hemodynamic and metabolic responses to activation, deactivation and epileptic discharges. Neuroimage 28: 205-215.
16. Uludag K, Dubowitz DJ, Yoder EJ, Restom K, Liu TT, et al. (2004) Coupling of cerebral blood flow and oxygen consumption during physiological activation and deactivation measured with fMRI. Neuroimage 23: 148-155.
17. St Lawrence KS, Ye FQ, Lewis BK, Frank JA, McLaughlin AC, (2003) Measuring the effects of indomethacin on changes in cerebral oxidative metabolism and cerebral blood flow during sensorimotor activation. Magn Reson Med 50: 99-106.
18. Chiarelli PA, Bulte DP, Gallichan D, Piechnik SK, Wise R, et al. (2007) Flow-metabolism coupling in human visual, motor, and supplementary motor areas assessed by magnetic resonance imaging. Magn Reson Med 57: 538-547.
19. Leontiev O, Buxton RB, (2007) Reproducibility of BOLD, perfusion, and CMRO(2) measurements with calibrated-BOLD fMRI. Neuroimage 35: 175-184.
20. Pike GB, (2012) Quantitative functional MRI: Concepts, issues and future challenges. Neuroimage 62: 1234-1240.
21. Blockley NP, Griffeth VEM, Simon AB, Buxton RB (in press) A review of calibrated BOLD methods for measuring task-induced changes in brain oxygen metabolism. NMR in Biomedicine.
22. Perthen JE, Lansing AE, Liau J, Liu TT, Buxton RB, (2008) Caffeine-induced uncoupling of cerebral blood flow and oxygen metabolism: a calibrated BOLD fMRI study. Neuroimage 40: 237-247.
23. Jain V, Langham MC, Floyd TF, Jain G, Magland JF, et al. (2011) Rapid magnetic resonance measurement of global cerebral metabolic rate of oxygen consumption in humans during rest and hypercapnia. J Cereb Blood Flow Metab 31: 1504-1512.
24. Sicard KM, Duong TQ, (2005) Effects of hypoxia, hyperoxia, and hypercapnia on baseline and stimulus-evoked BOLD, CBF, and CMRO2 in spontaneously breathing animals. Neuroimage 25: 850-858.
25. Kim T, Hendrich KS, Masamoto K, Kim SG, (2007) Arterial versus total blood volume changes during neural activity-induced cerebral blood flow change: implication for BOLD fMRI. J Cereb Blood Flow Metab 27: 1235-1247.
26. Hillman EM, Devor A, Bouchard MB, Dunn AK, Krauss GW, et al. (2007) Depth-resolved optical imaging and microscopy of vascular compartment dynamics during somatosensory stimulation. Neuroimage 35: 89-104.
27. Liang CL, Ances BM, Perthen JE, Moradi F, Liau J, et al. (2013) Luminance contrast of a visual stimulus modulates the BOLD response more than the cerebral blood flow response in the human brain. Neuroimage 64: 104-111.
28. Severinghaus JW, (1979) Simple, accurate equations for human blood O2 dissociation computations. J Appl Physiol 46: 599-602.
29. Chiarelli PA, Bulte DP, Wise R, Gallichan D, Jezzard P, (2007) A calibration method for quantitative BOLD fMRI based on hyperoxia. Neuroimage 37: 808-820.
30. van der Zwaag W, Francis S, Head K, Peters A, Gowland P, et al. (2009) fMRI at 1.5, 3 and 7 T: characterising BOLD signal changes. Neuroimage 47: 1425-1434.
31. Silvennoinen MJ, Clingman CS, Golay X, Kauppinen RA, van Zijl PC, (2003) Comparison of the dependence of blood R2 and R2* on oxygen saturation at 1.5 and 4.7 Tesla. Magn Reson Med 49: 47-60.
32. Blockley NP, Jiang L, Gardener AG, Ludman CN, Francis ST, et al. (2008) Field strength dependence of R1 and R2* relaxivities of human whole blood to ProHance, Vasovist, and deoxyhemoglobin. Magn Reson Med 60: 1313-1320.
33. Chen JJ, Pike GB, (2009) BOLD-specific cerebral blood volume and blood flow changes during neuronal activation in humans. NMR Biomed 22: 1054-1062.
34. Chen JJ, Pike GB, (2010) Global cerebral oxidative metabolism during hypercapnia and hypocapnia in humans: implications for BOLD fMRI. J Cereb Blood Flow Metab 30: 1094-1099.
35. Jones M, Berwick J, Hewson-Stoate N, Gias C, Mayhew J, (2005) The effect of hypercapnia on the neural and hemodynamic responses to somatosensory stimulation. Neuroimage 27: 609-623.
36. Mark CI, Fisher JA, Pike GB, (2011) Improved fMRI calibration: precisely controlled hyperoxic versus hypercapnic stimuli. Neuroimage 54: 1102-1111.
37. Boxerman JL, Hamberg LM, Rosen BR, Weisskoff RM, (1995) MR contrast due to intravascular magnetic susceptibility perturbations. Magn Reson Med 34: 555-566.
38. Lin AL, Fox PT, Yang Y, Lu H, Tan LH, et al. (2008) Evaluation of MRI models in the measurement of CMRO2 and its relationship with CBF. Magn Reson Med 60: 380-389.
39. Moradi F, Buracas GT, Buxton RB (2012) Attention strongly increases oxygen metabolic response to stimulus in primary visual cortex. Neuroimage.
40. Stefanovic B, Warnking JM, Pike GB, (2004) Hemodynamic and metabolic responses to neuronal inhibition. Neuroimage 22: 771-778.
41. Wong EC, Buxton RB, Frank LR, (1998) Quantitative imaging of perfusion using a single subtraction (QUIPSS and QUIPSS II). Magn Reson Med 39: 702-708.
42. Gauthier CJ, Madjar C, Tancredi FB, Stefanovic B, Hoge RD, (2011) Elimination of visually evoked BOLD responses during carbogen inhalation: implications for calibrated MRI. Neuroimage 54: 1001-1011.
43. Grubb RL, Raichle ME, Eichling JO, Ter-Pogossian MM, (1974) The effects of changes in PaCO2 on cerebral blood volume, blood flow, and vascular mean transit time. Stroke 5: 630-639.
44. Spees WM, Yablonskiy DA, Oswood MC, Ackerman JJ, (2001) Water proton MR properties of human blood at 1.5 Tesla: magnetic susceptibility, T(1), T(2), T*(2), and non-Lorentzian signal behavior. Magn Reson Med 45: 533-542.
45. Uludag K, Muller-Bierl B, Ugurbil K, (2009) An integrative model for neuronal activity-induced signal changes for gradient and spin echo functional imaging. Neuroimage 48: 150-165.
46. Stephan KE, Weiskopf N, Drysdale PM, Robinson PA, Friston KJ, (2007) Comparing hemodynamic models with DCM. Neuroimage 38: 387-401.
47. Buxton RB, Wong EC, Frank LR, (1998) Dynamics of blood flow and oxygenation changes during brain activation: the balloon model. Magn Reson Med 39: 855-864.
48. Simon AB, Griffeth VE, Wong EC, Buxton RB, (2013) A novel method of combining blood oxygenation and blood flow sensitive magnetic resonance imaging techniques to measure the cerebral blood flow and oxygen metabolism responses to an unknown neural stimulus. PLoS One 8: e54816.