Investigation of BOLD signal dependence on cerebral blood flow and oxygen consumption: The deoxyhemoglobin dilution model

Magnetic Resonance in Medicine

Volumn 42, Issue 5, 1999, Pages 849-863

  Hoge, Richard D ^a   Atkinson, Jeff ^a   Gill, Brad ^a   Crelier, Gérard R ^a   Marrett, Sean ^b   Pike, G Bruce ^a  

^a MCGILL UNIVERSITY   (Canada)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Aerobic metabolism; BOLD contrast; Hypercapnia; Perfusion

Indexed keywords

HEMODYNAMICS; OXYGEN; SIGNAL SYSTEMS;

BLOOD OXYGENATION LEVEL DEPENDENT; BOLD CONTRAST; CEREBRAL BLOOD FLOW; CONSTANT PARAMETERS; HYPERCAPNIA; PERFUSION; PRIMARY VISUAL CORTEX; QUANTITATIVE MODELING;

BLOOD;

ARTICLE; BRAIN BLOOD FLOW; BRAIN OXYGEN CONSUMPTION; CLINICAL ARTICLE; DIAGNOSTIC ACCURACY; DIAGNOSTIC IMAGING; HUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; VISUAL CORTEX;

EID: 0032738184     PISSN: 07403194     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1522-2594(199911)42:5<849::AID-MRM4>3.0.CO;2-Z     Document Type: Article

References (40)

1. o2 during functional challenge. In: Proceedings of the 5th Annual Meeting of ISMRM, Vancouver, Canada, 1997. p 155.
2. Davis TL, Kwong KK, Weisskoff RM, Rosen BR. Calibrated functional MRI: mapping the dynamics of oxidative metabolism. Proc Natl Acad Sci USA, 1998;95:1834-1839.
3. Ogawa S, Tank DW, Menon R, Ellermann JM, Kim SG, Merkle H, Uǧurbil K. Intrinsic signal changes accompanying sensory stimulation: functional brain mapping with magnetic resonance imaging. Proc Natl Acad Sci USA 1992;89:5951-5955.
4. 2 on cerebral blood volume, blood flow and vascular mean transit time. Stroke 1974;5:630-639.
5. Bruhn H, Kleinschmidt A, Boecker H, Merboldt KD, Hanicke W, Frahm J. The effect of acetazolamide on regional cerebral blood oxygenation at rest and under stimulation as assessed by MRI. J Cereb Blood Flow Metab 1994;14:742-748.
6. Zaharchuk G, Sasamata S, Mandevill JB, Moskowitz MA, Rosen BR. Increased perfusion after acetazolamide challenge demonstrated in the ischemic rat brain using echo-planar arterial spin label perfusion imaging. In: Proceedings of the 5th Annual Meeting of the ISMRM, Vancouver, Canada, 1997. p 604.
7. Schmidt RF, Thews G. Human physiology. Berlin: Springer-Verlag; 1983.
8. Mandeville JB, Marota JJA, Zaharchuk G, Ayata C, Davis TL, Moskowitz M, Weisskoff RM, Rosen BR. Evidence for a cerebral post-arteriole windkessel. In: Proceedings of the 6th Annual Meeting of ISMRM, Sydney, 1998. p 1144.
9. Ogawa S, Menon RS, Tank DW, Kim SG, Merkle H, Ellermann JM, Uǧurbil K. Functional brain mapping by blood oxygenation level-dependent contrast magnetic resonance imaging. A comparison of signal characteristics with a biophysical model. Biophys J 1993;64(3): 803-812.
10. Boxerman JL, Bandettini PA, Kwong KK, Baker JR, Davis TL, Rosen BR, Weisskoff RM. The intravascular contribution to fMRI signal change: Monte Carlo modeling and diffusion-weighted studies in vivo. Magn Reson Med 1995;34:4-10.
11. Kim S-G, Uǧurbil K. Comparison of blood oxygenation and cerebral blood flow effects in fMRI: estimation of relative oxygen consumption change. Magn Reson Med 1997;38:59-65.
12. Menon RS, Ogawa S, Hu X, Strupp JP, Anderson P, Uǧurbil K. BOLD based functional MRI at 4 Tesla includes a capillary bed contribution: echo-planar imaging correlates with previous optical imaging using intrinsic signals. Magn Reson Med 1995;33:453-459.
13. Jones RA, Schirmer T, Lipinski B, Elbel GK. Signal undershoots following visual stimulation: a comparison of gradient echo and spin-echo BOLD sequences. Magn Reson Med 1998;40:112-118.
14. Marrett S, Gjedde A. Changes of blood flow and oxygen consumption in visual cortex of living humans. Adv Exp Med Biol 1997;413:205-208.
15. Hoge RD, Gill B, Crelier GR, Pike GB. Comparison of perfusion and BOLD responses in human visual cortex to blob-selective stimuli, inter-blob-selective stimuli, and hypercapnia. In: Proceedings of the 6th Annual Meeting of ISMRM, Sydney, 1998. p 1537.
16. o2/CBF coupling in human V1 using FMRI. In: Proceedings of the 4th International Conference on Functional Mapping of the Human Brain, volume 1, Montreal, 1998. p 262.
17. Hoge RD, Atkinson J, Gill B, Crelier GR, Marrett S, Pike GB. Linear coupling between cerebral blood flow and oxygen consumption in activated human cortex. Proc Natl Acad Sci USA 1999;96:9403-9408.
18. Hoge RD, Atkinson J, Gill B, Crelier GR, Marrett S, Pike GB. Stimulus-dependent bold and perfusion dynamics in human V1. Neuroimage 1999;9:573-585.
19. Press WH, Teukolsky SA, Verrerling WT, Flannery BP. Numberical recipes in C. New York: Cambridge; 1992.
20. Ives HE. A chart of the flicker photometer. J Opt Soc Am Rev Sci Instr 1923;7:363.
21. Sereno MI, Dale AM, Reppas JB, Kwong KK, Belliveau JW, Brady TJ, Rosen BR, Tootell RBH. Borders of multiple visual areas in humans revealed by functional magnetic resonance imaging. Science 1995;268: 889-893.
22. Collins DL, Neelin P, Peters TM, Evans AC. Automatic 3D registration of MR volumetric data in standardized Talairach space. J Comput Assist Tomogr 1994;18:192-205.
23. Kim SG. Quantification of relative cerebral blood flow change by flow-sensitive alternating inversion recovery (FAIR) technique: application to functional mapping. Magn Reson Med 1995;34:293-301.
24. Crelier GR, Hoge RD, Munger P, Pike GB. Perfusion-based functional magnetic resonance imaging with single-shot rare and grase acquisitions. Magn Reson Med 1999;41:132-136.
25. Buxton RB, Miller KL, Wong EC, Frank LR. Application of the balloon model to the BOLD response to stimuli of different duration. In: Proceedings of the 7th Annual Meeting of ISMRM, Philadelphia, 1999. p 1735.
26. Buxton RB, Wong EC, Frank LR. Dynamics of blood flow and oxygenation changes during brain activation: the balloon model. Magn Reson Med 1998;39:855-864.
27. Hsu EW, Hedlund LW, MacFall JR. Functional MRI of the rat somatosensory cortex: effects of hyper-ventilation. Magn Reson Med 1998;40:421-426.
28. Ramsay SC, Murphy K, Shea SA, Friston KJ, Lammertsma AA, Clark JC, Adams L, Guz A, Frackowiak RSJ. Effect on regional cerebral blood flow during a neural activation task. J Physiol 1993;471:521-534.
29. Bandettini PA, Wong EC. A hypercapnia-based normalization method for improved spatial localization of human brain activation with fMRI. NMR Biomed 1997;10:197-203.
30. Tootell RBH, Silverman MS, Hamilton SL, De Valois RL, Switkes E. Functional anatomy of macacque striate cortex. III. Color. J Neurosci 1988;8:1569-1593.
31. Tootell RBH, Silverman MS, Hamilton SL, De Valois RL, Switkes E. Functional anatomy of macacque striate cortex. V. Spatial frequency. J Neurosci 1988;8:1610-1624.
32. Caramia F, Tootell RB, Jenkins BG, Rosen BR, Kwong KK. Comparison of fMRI signal changes produced by stimuli selective for blob vs. inter-blob cells in V1. In: Proceedings of the 1st International Conference on Functional Mapping of the Human Brain, volume 1, Paris, 1995. p 26.
33. Kruger G, Kleinschmidt A, Frahm J. Stimulus dependence of oxygenation-sensitive MRI responses to sustained visual activation. NMR Biomed 1998;11:75-79.
34. Bandettini PA, Kwong KK, Davis TL, Tootell RBH, Wong EC, Fox PT, Belliveau JW, Weisskoff RM, Rosen BA. Characterization of cerebral blood oxygenation and flow changes during prolonged brain activation. Hum Brain Mapp 1997;5:93-109.
35. o2) respond differently to the rate of visual stimulation. In: Proceedings of the 27th Annual Meeting of the Society for Neuroscience, New Orleans, 1997.
36. o2 changes correlated to varied neuronal activity in primary visual cortex of humans. In: Proceedings of the 6th Annual Meeting of the ISMRM, Sydney, 1998. p 10.
37. Wong EC, Buxton RB, Frank LR. Quantitative imaging of perfusion using a single subtraction (QUIPPS and QUIPPS II). Magn Reson Med 1998;39:702-708.
38. Buxton RB, Frank LR, Wong EC, Siewert B, Warach S, Edelman RR. A general kinetic model for quantitative perfusion imaging with arterial spin labelling. Magn Reson Med 1998;40:383-396.
39. Buxton RB, Frank LR. A model for the coupling between cerebral blood flow and oxygen metabolism during neural stimulation. J Cereb Blood Flow Metab 1997;17:64-72.
40. Hyder F, Shulman RG, Rothman DL. A model for the regulation of cerebral oxygen delivery. J Appl Physiol 1998;85:554-564.