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Volumn 54, Issue 4, 2013, Pages 778-789

Flow cytometric immunophenotyping of regulatory T cells in chronic lymphocytic leukemia: Comparative assessment of various markers and use of novel antibody panel with CD127 as alternative to transcription factor FoxP3

Author keywords

CD127low ; CD25high; CD4; Chronic lymphocytic leukemia; FoxP3; Limited antibody panel; Novel; Regulatory T cell

Indexed keywords

ANTINEOPLASTIC AGENT; INTERLEUKIN 7 RECEPTOR; TRANSCRIPTION FACTOR FOXP3;

EID: 84879522118     PISSN: 10428194     EISSN: 10292403     Source Type: Journal    
DOI: 10.3109/10428194.2012.730614     Document Type: Article
Times cited : (12)

References (38)
  • 1
    • 24744432528 scopus 로고    scopus 로고
    • Reduced frequencies and suppressive function of CD4 + CD25hi regulatory T cells in patients with chronic lymphocytic leukemia after therapy with fludarabine
    • Beyer M, Kochanek M, Darabi K, et al. Reduced frequencies and suppressive function of CD4 + CD25hi regulatory T cells in patients with chronic lymphocytic leukemia after therapy with fludarabine. Blood 2005; 106: 2018-2025.
    • (2005) Blood , vol.106 , pp. 2018-2025
    • Beyer, M.1    Kochanek, M.2    Darabi, K.3
  • 2
    • 54549110000 scopus 로고    scopus 로고
    • Characterization of regulatory T cells in patients with B-cell chronic lymphocytic leukemia
    • Giannopoulos K, Schmitt M, Kowal M, et al. Characterization of regulatory T cells in patients with B-cell chronic lymphocytic leukemia. Oncol Rep 2008; 20: 677-682.
    • (2008) Oncol Rep , vol.20 , pp. 677-682
    • Giannopoulos, K.1    Schmitt, M.2    Kowal, M.3
  • 3
    • 68449083231 scopus 로고    scopus 로고
    • Xpansion of regulatory t cells in b chronic lymphocytic leukemia: Enhanced brakes on host immunity
    • Deutsch V, Perry C, Polliack A. E xpansion of regulatory T cells in B chronic lymphocytic leukemia: Enhanced " brakes " on host immunity. Leuk Lymphoma 2009; 50: 687-688.
    • (2009) Leuk Lymphoma , vol.50 , pp. 687-688
    • Deutsch, V.1    Perry, C.2    Polliack, A.E.3
  • 4
    • 68449093742 scopus 로고    scopus 로고
    • Enhanced formation and survival of CD4 + CD25hi Foxp3 + T-cells in chronic lymphocytic leukemia
    • Jak M, Mous R, Remmerswaal E BM, et al. Enhanced formation and survival of CD4 + CD25hi Foxp3 + T-cells in chronic lymphocytic leukemia. Leuk Lymphoma 2009; 50: 788-801.
    • (2009) Leuk Lymphoma , vol.50 , pp. 788-801
    • Jak, M.1    Mous, R.2    Remmerswaal, E.B.M.3
  • 5
    • 79952100710 scopus 로고    scopus 로고
    • Regulatory T-cell number is increased in chronic lymphocytic leukemia patients and correlates with progressive disease
    • D' Arena G, Laurenti L, Minervini MM, et al. Regulatory T-cell number is increased in chronic lymphocytic leukemia patients and correlates with progressive disease. Leuk Res 2011; 35: 363-368.
    • (2011) Leuk Res , vol.35 , pp. 363-368
    • D'Arena, G.1    Laurenti, L.2    Minervini, M.M.3
  • 6
    • 0033572883 scopus 로고    scopus 로고
    • The national cancer data base report on age, gender, treatment, and outcomes of patients with chronic lymphocytic leukemia
    • The American College Of Surgeons Commission On Cancer And The American Cancer Society.
    • Diehl LF, Karnell LH, Menck HR. The American College of Surgeons Commission on Cancer and the American Cancer Society. The National Cancer Data Base report on age, gender, treatment, and outcomes of patients with chronic lymphocytic leukemia. Cancer 1999; 86: 2684-2692.
    • (1999) Cancer , vol.86 , pp. 2684-2692
    • Diehl, L.F.1    Karnell, L.H.2    Menck, H.R.3
  • 7
    • 34250625632 scopus 로고    scopus 로고
    • Chronic lymphocytic leukemia in India-a clinico-hematological profile
    • Agrawal N, Naithani R, Mahapatra M, et al. Chronic lymphocytic leukemia in India-a clinico-hematological profi le. Hematology 2007; 12: 229-233.
    • (2007) Hematology , vol.12 , pp. 229-233
    • Agrawal, N.1    Naithani, R.2    Mahapatra, M.3
  • 8
    • 3042818252 scopus 로고    scopus 로고
    • Use of the world health organization (WHO) classifi cation of non-Hodgkin's lymphoma in Mumbai, India: A review of 200 consecutive cases by a panel of fi ve expert hematopathologists
    • Naresh KN, Agarwal B, Nathwani BN, et al. Use of the World Health Organization (WHO) classifi cation of non-Hodgkin's lymphoma in Mumbai, India: A review of 200 consecutive cases by a panel of fi ve expert hematopathologists. Leuk Lymphoma 2004; 45: 1569-1577.
    • (2004) Leuk Lymphoma , vol.45 , pp. 1569-1577
    • Naresh, K.N.1    Agarwal, B.2    Nathwani, B.N.3
  • 9
    • 0036433396 scopus 로고    scopus 로고
    • Lympho-hemopoietic malignancies in India
    • Bhutani M, Vora A, Kumar L, et al. Lympho-hemopoietic malignancies in India. Med Oncol 2002; 19: 141-150.
    • (2002) Med Oncol , vol.19 , pp. 141-150
    • Bhutani, M.1    Vora, A.2    Kumar, L.3
  • 10
    • 0032052774 scopus 로고    scopus 로고
    • Trisomy 12 in chronic lymphocytic leukemia-geographical variation
    • Nair CN, Chougule A, Dhond S, et al. Trisomy 12 in chronic lymphocytic leukemia-geographical variation. Leuk Res 1998; 22: 313-317.
    • (1998) Leuk Res , vol.22 , pp. 313-317
    • Nair, C.N.1    Chougule, A.2    Dhond, S.3
  • 11
    • 0028959982 scopus 로고
    • Chronic lymphocytic leukemia: Present status
    • Montserrat E, Rozman C. C hronic lymphocytic leukemia: Present status. Ann Oncol 1995; 6: 219-235.
    • (1995) Ann Oncol , vol.6 , pp. 219-235
    • Montserrat, E.1    Rozman, C.2
  • 12
    • 0015172562 scopus 로고
    • Infectious immunological tolerance
    • Gershon R K, Kondo K. I nfectious immunological tolerance. Immunology 1971; 21: 903-914.
    • (1971) Immunology , vol.21 , pp. 903-914
    • Gershon, R.K.1    Kondo, K.2
  • 13
    • 0029150110 scopus 로고
    • Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases
    • Sakaguchi S, Sakaguchi N, Asano M, et al. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Immunol 1995; 155: 1151-1164.
    • (1995) J Immunol , vol.155 , pp. 1151-1164
    • Sakaguchi, S.1    Sakaguchi, N.2    Asano, M.3
  • 14
    • 0347785480 scopus 로고    scopus 로고
    • Control of regulatory T cell development by the transcription factor Foxp3
    • Hori S, Nomura T, Sakaguchi S. Control of regulatory T cell development by the transcription factor Foxp3. Science 2003; 299: 1057-1061.
    • (2003) Science , vol.299 , pp. 1057-1061
    • Hori, S.1    Nomura, T.2    Sakaguchi, S.3
  • 15
    • 0037385330 scopus 로고    scopus 로고
    • Foxp3 programs the development and function of CD4 + CD25 + regulatory T cells
    • Fontenot JD, Gavin MA, Rudensky AY. Foxp3 programs the development and function of CD4 + CD25 + regulatory T cells. Nat Immunol 2003; 4: 330-336.
    • (2003) Nat Immunol , vol.4 , pp. 330-336
    • Fontenot, J.D.1    Gavin, M.A.2    Rudensky, A.Y.3
  • 16
    • 34347258918 scopus 로고    scopus 로고
    • Regulatory T cells in health and disease
    • Rouse BT. Regulatory T cells in health and disease. J Intern Med 2007; 262: 78-95.
    • (2007) J Intern Med , vol.262 , pp. 78-95
    • Rouse, B.T.1
  • 17
    • 33746599842 scopus 로고    scopus 로고
    • Regulatory T cells in cancer
    • Beyer M, Schultze JL. Regulatory T cells in cancer. Blood 2006; 108: 804-811.
    • (2006) Blood , vol.108 , pp. 804-811
    • Beyer, M.1    Schultze, J.L.2
  • 18
    • 33748598236 scopus 로고    scopus 로고
    • Regulatory T-cells in the control of immunological diseases
    • Franzke A, Hunger JK, Dittmar KEJ, et al. Regulatory T-cells in the control of immunological diseases. Ann Hematol 2006; 85: 747-758.
    • (2006) Ann Hematol , vol.85 , pp. 747-758
    • Franzke, A.1    Hunger, J.K.2    Dittmar, K.E.J.3
  • 19
    • 0035413350 scopus 로고    scopus 로고
    • CD4+ CD25high regulatory cells in human peripheral blood
    • Baecher-Allan C, Brown JA, Freeman GJ, et al. CD4+ CD25high regulatory cells in human peripheral blood. J Immunol 2001; 167: 1245-1253.
    • (2001) J Immunol , vol.167 , pp. 1245-1253
    • Baecher-Allan, C.1    Brown, J.A.2    Freeman, G.J.3
  • 20
    • 33745817085 scopus 로고    scopus 로고
    • CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4 + T reg cells
    • Liu W, Putnam AL, Xu-Yu Z, et al. CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4 + T reg cells. J Exp Med 2006; 203: 1701-1711.
    • (2006) J Exp Med , vol.203 , pp. 1701-1711
    • Liu, W.1    Putnam, A.L.2    Xu-Yu, Z.3
  • 21
    • 33745813929 scopus 로고    scopus 로고
    • Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells
    • Seddiki N, Santner-Nanan B, Martinson J, et al. Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells. J Exp Med 2006; 203: 1693-1700.
    • (2006) J Exp Med , vol.203 , pp. 1693-1700
    • Seddiki, N.1    Santner-Nanan, B.2    Martinson, J.3
  • 22
    • 0035180065 scopus 로고    scopus 로고
    • Immunologic tolerance maintained by CD25 + CD4 + regulatory T cells: Their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance
    • Sakaguchi S, Sakaguchi N, Shimizu J, et al. Immunologic tolerance maintained by CD25 + CD4 + regulatory T cells: Their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance. Immunol Rev 2001; 182: 18-32.
    • (2001) Immunol Rev , vol.182 , pp. 18-32
    • Sakaguchi, S.1    Sakaguchi, N.2    Shimizu, J.3
  • 23
    • 33748561462 scopus 로고    scopus 로고
    • CCR6 regulates the function of alloreactive and regulatory CD4 + T cells during acute graft-versushost disease
    • Varona R, Cadenas V, Lozano M, et al. CCR6 regulates the function of alloreactive and regulatory CD4 + T cells during acute graft-versushost disease. Leuk Lymphoma 2006; 47: 1469-1476.
    • (2006) Leuk Lymphoma , vol.47 , pp. 1469-1476
    • Varona, R.1    Cadenas, V.2    Lozano, M.3
  • 24
    • 55049124957 scopus 로고    scopus 로고
    • The biology and therapeutic potential of natural regulatory T-cells in the bone marrow transplant setting
    • Coghill J M, Carlson M J, Moran T P, et al. The biology and therapeutic potential of natural regulatory T-cells in the bone marrow transplant setting. Leuk Lymphoma 2008; 49: 1860-1869.
    • (2008) Leuk Lymphoma , vol.49 , pp. 1860-1869
    • Coghill, J.M.1    Carlson, M.J.2    Moran, T.P.3
  • 25
    • 0033168037 scopus 로고    scopus 로고
    • Tumor rejection by in vivo administration of anti-CD25 (interleukin-2 receptor alpha) monoclonal antibody
    • Onizuka S, Tawara I, Shimizu J, et al. Tumor rejection by in vivo administration of anti-CD25 (interleukin-2 receptor alpha) monoclonal antibody. Cancer Res 1999; 59: 3128-3133.
    • (1999) Cancer Res , vol.59 , pp. 3128-3133
    • Onizuka, S.1    Tawara, I.2    Shimizu, J.3
  • 26
    • 38849133434 scopus 로고    scopus 로고
    • Prognostic impact of tumor infi ltrating FOXP3 positive regulatory T cells in Diffuse large B-cell lymphoma at diagnosis
    • Lee N-R, Song E-K, Jang KY, et al. Prognostic impact of tumor infi ltrating FOXP3 positive regulatory T cells in Diffuse large B-cell lymphoma at diagnosis. Leuk Lymphoma 2008; 49: 247-256.
    • (2008) Leuk Lymphoma , vol.49 , pp. 247-256
    • Lee, N.-R.1    Song, E.-K.2    Jang, K.Y.3
  • 27
    • 66149179122 scopus 로고    scopus 로고
    • Increased frequency and suppression by regulatory T cells in patients with acute myelogenous leukemia
    • Szczepanski MJ, Szajnik M, Czystowska M, et al. Increased frequency and suppression by regulatory T cells in patients with acute myelogenous leukemia. Clin Cancer Res 2009; 15: 3325-3332.
    • (2009) Clin Cancer Res , vol.15 , pp. 3325-3332
    • Szczepanski, M.J.1    Szajnik, M.2    Czystowska, M.3
  • 28
    • 28044434385 scopus 로고    scopus 로고
    • Increased population of CD4 (+) CD25(high), regulatory T cells with their higher apoptotic and proliferating status in peripheral blood of acute myeloid leukemia patients
    • Wang X, Zheng J, Liu J, et al. Increased population of CD4 (+) CD25(high), regulatory T cells with their higher apoptotic and proliferating status in peripheral blood of acute myeloid leukemia patients. Eur J Haematol 2005; 75: 468-476.
    • (2005) Eur J Haematol , vol.75 , pp. 468-476
    • Wang, X.1    Zheng, J.2    Liu, J.3
  • 29
    • 33646575622 scopus 로고    scopus 로고
    • In vivo peripheral expansion of naive CD4 + CD25high FoxP3 + regulatory T cells in patients with multiple myeloma
    • Beyer M, Kochanek M, Giese T, et al. In vivo peripheral expansion of naive CD4 + CD25high FoxP3 + regulatory T cells in patients with multiple myeloma. Blood 2006; 107: 3940-3949.
    • (2006) Blood , vol.107 , pp. 3940-3949
    • Beyer, M.1    Kochanek, M.2    Giese, T.3
  • 30
    • 44749086828 scopus 로고    scopus 로고
    • Local and systemic induction of CD4 + CD25 + regulatory T-cell population by non-Hodgkin lymphoma
    • Mittal S, Marshall NA, Duncan L, et al. Local and systemic induction of CD4 + CD25 + regulatory T-cell population by non-Hodgkin lymphoma. Blood 2008; 111: 5359-5370.
    • (2008) Blood , vol.111 , pp. 5359-5370
    • Mittal, S.1    Marshall, N.A.2    Duncan, L.3
  • 31
    • 78549290311 scopus 로고    scopus 로고
    • Naturally occurring CD4+CD25 + FOXP3 + T-regulatory cells are increased in chronic myeloid leukemia patients not in complete cytogenetic remission and can be immunosuppressive
    • Rojas J M, Wang L, Owen S, et al. Naturally occurring CD4+CD25 + FOXP3 + T-regulatory cells are increased in chronic myeloid leukemia patients not in complete cytogenetic remission and can be immunosuppressive. Exp Hematol 2010; 38: 1209-1218.
    • (2010) Exp Hematol , vol.38 , pp. 1209-1218
    • Rojas, J.M.1    Wang, L.2    Owen, S.3
  • 32
    • 79955500329 scopus 로고    scopus 로고
    • Regulatory T cells predict the time to initial treatment in early stage chronic lymphocytic leukemia
    • Weiss L, Melchardt T, Egle A, et al. Regulatory T cells predict the time to initial treatment in early stage chronic lymphocytic leukemia. Cancer 2011; 117: 2163-2169.
    • (2011) Cancer , vol.117 , pp. 2163-2169
    • Weiss, L.1    Melchardt, T.2    Egle, A.3
  • 33
    • 1442283424 scopus 로고    scopus 로고
    • Immunosuppressive regulatory T cells are abundant in the reactive lymphocytes of Hodgkin lymphoma
    • Marshall NA, Christie LE, Munro LR, et al. Immunosuppressive regulatory T cells are abundant in the reactive lymphocytes of Hodgkin lymphoma. Blood 2004; 103: 1755-1762.
    • (2004) Blood , vol.103 , pp. 1755-1762
    • Marshall, N.A.1    Christie, L.E.2    Munro, L.R.3
  • 34
    • 33646422454 scopus 로고    scopus 로고
    • Intratumoral CD4+ CD25+regulatory T-cell-mediated suppression of infi ltrating CD4 + T cells in B-cell non-Hodgkin lymphoma
    • Yang Z -Z, Novak A J, Stenson M J, et al. Intratumoral CD4+ CD25+regulatory T-cell-mediated suppression of infi ltrating CD4 + T cells in B-cell non-Hodgkin lymphoma. Blood 2006; 107: 3639-3646.
    • (2006) Blood , vol.107 , pp. 3639-3646
    • Yang, Z.-Z.1    Novak, A.J.2    Stenson, M.J.3
  • 35
    • 84865004942 scopus 로고    scopus 로고
    • Reciprocal changes in regulatory T cells and Th 17 helper cells induced by exercise in patients with chronic lymphocytic leukemia
    • Perry C, Herishanu Y, Hazan-Halevy I, et al. Reciprocal changes in regulatory T cells and Th 17 helper cells induced by exercise in patients with chronic lymphocytic leukemia. Leuk Lymphoma 2012; 53: 1807-1810.
    • (2012) Leuk Lymphoma , vol.53 , pp. 1807-1810
    • Perry, C.1    Herishanu, Y.2    Hazan-Halevy, I.3
  • 36
    • 15944410592 scopus 로고    scopus 로고
    • Inhibition of CD4 (+) 25 + T regulatory cell function implicated in enhanced immune response by low-dose cyclophosphamide
    • Lutsiak M EC, Semnani R T, D e Pascalis R, et al. Inhibition of CD4 (+) 25 + T regulatory cell function implicated in enhanced immune response by low-dose cyclophosphamide. Blood 2005; 105: 2862-2868.
    • (2005) Blood , vol.105 , pp. 2862-2868
    • Lutsiak, M.E.C.1    Semnani, R.T.2    De Pascalis, R.3
  • 37
    • 70350123882 scopus 로고    scopus 로고
    • Thalidomide exerts distinct molecular antileukemic Effects and combined thalidomide/fludarabine therapy is clinically effective in high-risk chronic lymphocytic leukemia
    • Giannopoulos K, Dmoszynska A, Kowal M, et al. Th alidomide exerts distinct molecular antileukemic Effects and combined thalidomide/fl udarabine therapy is clinically effective in high-risk chronic lymphocytic leukemia. Leukemia 2009; 23: 1771-1778.
    • (2009) Leukemia , vol.23 , pp. 1771-1778
    • Giannopoulos, K.1    Dmoszynska, A.2    Kowal, M.3
  • 38
    • 4644237613 scopus 로고    scopus 로고
    • Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival
    • Curiel T J, Coukos G, Zou L, et al. Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival. Nat Med 2004; 10: 942-949. Science and Technology), Government of India
    • (2004) Nat Med , vol.10 , pp. 942-949
    • Curiel, T.J.1    Coukos, G.2    Zou, L.3


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