PET/SPECT imaging of hindlimb ischemia: Focusing on angiogenesis and blood flow

Angiogenesis

Volumn 16, Issue 2, 2013, Pages 279-287

  Orbay, Hakan ^a   Hong, Hao ^a   Zhang, Yin ^a   Cai, Weibo ^a,b  

^a UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^b UNIVERSITY OF WISCONSIN   (United States)

Author keywords

Angiogenesis; Hindlimb ischemia; Molecular imaging; Peripheral artery disease (PAD); Positron emission tomography (PET); Single photon emission computed tomography (SPECT)

Indexed keywords

FLUORODEOXYGLUCOSE F 18; MARACICLATIDE TC 99M; METHOXY ISOBUTYL ISONITRILE TECHNETIUM TC 99M; NATRIURETIC FACTOR; PYROPHOSPHATE TECHNETIUM TC 99M; VASCULOTROPIN RECEPTOR;

ANGIOGENESIS; ARTERY BLOOD FLOW; DIAGNOSTIC IMAGING; DRUG UPTAKE; HUMAN; INTERMETHOD COMPARISON; ISOTOPE LABELING; LIMB ISCHEMIA; MOLECULAR IMAGING; NONHUMAN; PERIPHERAL OCCLUSIVE ARTERY DISEASE; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; REVIEW; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY;

ANIMALS; HINDLIMB; HUMANS; ISCHEMIA; LASER-DOPPLER FLOWMETRY; MICE; NEOVASCULARIZATION, PHYSIOLOGIC; POSITRON-EMISSION TOMOGRAPHY; REGIONAL BLOOD FLOW; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON;

ANIMALIA; MURINAE;

EID: 84879506134     PISSN: 09696970     EISSN: 15737209     Source Type: Journal    
DOI: 10.1007/s10456-012-9319-4     Document Type: Review

References (76)

1. Sumner AD, Khalil YK, Reed JF 3rd (2012) The relationship of peripheral arterial disease and metabolic syndrome prevalence in asymptomatic US adults 40 years and older: results from the National Health and Nutrition Examination Survey (1999-2004). J Clin Hypertens (Greenwich) 14:144-148
2. van Weel V, van Tongeren RB, van Hinsbergh VW, van Bockel JH, Quax PH (2008) Vascular growth in ischemic limbs: a review of mechanisms and possible therapeutic stimulation. Ann Vasc Surg 22:582-597
3. Clair D, Shah S, Weber J (2012) Current state of diagnosis and management of critical limb ischemia. Curr Cardiol Rep 14:160-170
4. Hinchliffe RJ, Andros G, Apelqvist J, Bakker K, Friederichs S, Lammer J et al (2012) A systematic review of the effectiveness of revascularization of the ulcerated foot in patients with diabetes and peripheral arterial disease. Diabetes Metab Res Rev 28(Suppl 1):179-217
5. Ouriel K (2001) Peripheral arterial disease. Lancet 358:1257-1264 (Pubitemid 33010855)
6. Andersen CA (2010) Noninvasive assessment of lower extremity hemodynamics in individuals with diabetes mellitus. J Vasc Surg 52:76S-80S
7. Mathieu D, Mani R (2007) A review of the clinical significance of tissue hypoxia measurements in lower extremity wound management. Int J Low Extrem Wounds 6:273-283 (Pubitemid 350131918)
8. Tang GL, Chin J, Kibbe MR (2010) Advances in diagnostic imaging for peripheral arterial disease. Expert Rev Cardiovasc Ther 8:1447-1455
9. Galbraith JE, Murphy ML, de Soyza N (1978) Coronary angiogram interpretation. Interobserver variability. JAMA 240:2053-2056 (Pubitemid 9080917)
10. Leape LL, Park RE, Bashore TM, Harrison JK, Davidson CJ, Brook RH (2000) Effect of variability in the interpretation of coronary angiograms on the appropriateness of use of coronary revascularization procedures. Am Heart J 139:106-113 (Pubitemid 30043632)
11. Cavalcanti Filho JL, de Souza Leao Lima R, de Souza Machado Neto L, Kayat Bittencourt L, Domingues RC, da Fonseca LM (2011) PET/CT and vascular disease: current concepts. Eur J Radiol 80:60-67
12. Dobrucki LW, Sinusas AJ (2007) Imaging angiogenesis. Curr Opin Biotechnol 18:90-96 (Pubitemid 46227970)
13. Suh JW, Scheinost D, Dione DP, Dobrucki LW, Sinusas AJ, Papademetris X (2011) A non-rigid registration method for serial lower extremity hybrid SPECT/CT imaging. Med Image Anal 15:96-111
14. Cai W, Chen X (2007) Multimodality imaging of vascular endothelial growth factor and vascular endothelial growth factor receptor expression. Front Biosci 12:4267-4279
15. Cai W, Chen X (2008) Multimodality molecular imaging of tumor angiogenesis. J Nucl Med 49(Suppl 2):113S-128S (Pubitemid 351948040)
16. Waters RE, Terjung RL, Peters KG, Annex BH (2004) Preclinical models of human peripheral arterial occlusive disease: implications for investigation of therapeutic agents. J Appl Physiol 97:773-780 (Pubitemid 38967223)
17. Couffinhal T, Silver M, Zheng LP, Kearney M, Witzenbichler B, Isner JM (1998) Mouse model of angiogenesis. Am J Pathol 152:1667-1679 (Pubitemid 28275025)
18. Niiyama H, Huang NF, Rollins MD, Cooke JP (2009) Murine model of hindlimb ischemia. J Vis Exp 23:1035. doi: 10.3791/1035
19. James ML, Gambhir SS (2012) A molecular imaging primer: modalities, imaging agents, and applications. Physiol Rev 92:897-965
20. Ubbink DT, Tulevski II, den Hartog D, Koelemay MJ, Legemate DA, Jacobs MJ (1997) The value of non-invasive techniques for the assessment of critical limb ischaemia. Eur J Vasc Endovasc Surg 13:296-300 (Pubitemid 27170886)
21. 18F-based radiotracers. Am J Nucl Med Mol Imaging 2:55-76
22. Vach W, Høilund-Carlsen PF, Fischer BM, Gerke O, Weber W (2011) How to study optimal timing of PET/CT for monitoring of cancer treatment. Am J Nucl Med Mol Imaging 1:54-62
23. Zeman MN, Scott PJH (2012) Current imaging strategies in rheumatoid arthritis. Am J Nucl Med Mol Imaging 2:174-220
24. Bhargava P, He G, Samarghandi A, Delpassand ES (2012) Pictorial review of SPECT/CT imaging applications in clinical nuclear medicine. Am J Nucl Med Mol Imaging 2:221-231
25. 123I-iomazenil SPECT imaging predicts cerebral hyperperfusion following endarterectomy for unilateral cervical internal carotid artery stenosis. Am J Nucl Med Mol Imaging 2:77-87
26. Stacy MR, Maxfield MW, Sinusas AJ (2012) Targeted molecular imaging of angiogenesis in PET and SPECT: a review. Yale J Biol Med 85:75-86
27. Gambhir SS, Czernin J, Schwimmer J, Silverman DH, Coleman RE, Phelps ME (2001) A tabulated summary of the FDG PET literature. J Nucl Med 42:1S-93S (Pubitemid 32423895)
28. Aparici CM, Carlson D, Nguyen N, Hawkins RA, Seo Y (2012) Combined SPECT and multidetector CT for prostate cancer evaluations. Am J Nucl Med Mol Imaging 2:48-54
29. 18F-FDG PET in sarcoma treatment response imaging. Am J Nucl Med Mol Imaging 1:47-53
30. Gambhir SS (2002) Molecular imaging of cancer with positron emission tomography. Nat Rev Cancer 2:683-693 (Pubitemid 37328919)
31. 11C-acetate. Am J Nucl Med Mol Imaging 2:33-47
32. 99mTc-EDDA/HYNIC-TOC SPECT/CT scintigraphy in Graves' ophthalmopathy. Am J Nucl Med Mol Imaging 2:242-247
33. Cai W, Rao J, Gambhir SS, Chen X (2006) How molecular imaging is speeding up anti-angiogenic drug development. Mol Cancer Ther 5:2624-2633 (Pubitemid 44848989)
34. Hao G, Hajibeigi A, De León-Rodríguez LM, Öz OK, Sun X (2011) Peptoid-based PET imaging of vascular endothelial growth factor receptor (VEGFR) expression. Am J Nucl Med Mol Imaging 1:65-75
35. Wang RE, Niu Y, Wu H, Amin MN, Cai J (2011) Development of NGR peptide-based agents for tumor imaging. Am J Nucl Med Mol Imaging 1:36-46
36. Zhang Y, Hong H, Engle JW, Yang Y, Barnhart TE, Cai W (2012) Positron emission tomography and near-infrared fluorescence imaging of vascular endothelial growth factor with dual-labeled bevacizumab. Am J Nucl Med Mol Imaging 2:1-13
37. Ferrara N (2004) Vascular endothelial growth factor: basic science and clinical progress. Endocr Rev 25:581-611 (Pubitemid 39099316)
38. Ferrara N (2002) VEGF and the quest for tumour angiogenesis factors. Nat Rev Cancer 2:795-803 (Pubitemid 37328914)
39. Cai W, Niu G, Chen X (2008) Imaging of integrins as biomarkers for tumor angiogenesis. Curr Pharm Des 14:2943-2973
40. Almutairi A, Rossin R, Shokeen M, Hagooly A, Ananth A, Capoccia B et al (2009) Biodegradable dendritic positron-emitting nanoprobes for the noninvasive imaging of angiogenesis. Proc Natl Acad Sci USA 106:685-690
41. 68Ga- labeled c(RGDyK)-isothiocyanatobenzyl-1,4,7-triazacyclononane-1,4,7-triacetic acid and feasibility studies in mice. J Nucl Med 49:830-836 (Pubitemid 351717550)
42. Potter LR, Hunter T (2001) Guanylyl cyclase-linked natriuretic peptide receptors: structure and regulation. J Biol Chem 276:6057-6060
43. van den Akker F (2001) Structural insights into the ligand binding domains of membrane bound guanylyl cyclases and natriuretic peptide receptors. J Mol Biol 311:923-937 (Pubitemid 32803710)
44. Liu Y, Pressly ED, Abendschein DR, Hawker CJ, Woodard GE, Woodard PK et al (2011) Targeting angiogenesis using a C-type atrial natriuretic factor-conjugated nanoprobe and PET. J Nucl Med 52:1956-1963
45. Cai W, Hong H (2011) Peptoid and positron emission tomography: an appealing combination. Am J Nucl Med Mol Imaging 1:76-79
46. 64Cu-labeled vascular endothelial growth factor-121 positron emission tomography. Circulation 117:915-922 (Pubitemid 351272589)
47. 13N-ammonia PET as a measurement of hindlimb perfusion in a mouse model of peripheral artery occlusive disease. J Nucl Med 48:1216-1223 (Pubitemid 47052663)
48. 99mTc-labeled peptide targeted at alphavbeta3 integrin after murine hindlimb ischemia. Circulation 111:3255-3260 (Pubitemid 40874998)
49. Dobrucki LW, Dione DP, Kalinowski L, Dione D, Mendizabal M, Yu J et al (2009) Serial noninvasive targeted imaging of peripheral angiogenesis: validation and application of a semiautomated quantitative approach. J Nucl Med 50:1356-1363
50. 2 in normals and in patients with peripheral ischemia: a study using positron tomography. Int Angiol 7:254-257 (Pubitemid 18260541)
51. 2 using positron emission tomography. J Mal Vasc 13:107-115
52. Keenan GF, Ashcroft GP, Roditi GH, Hutchison JD, Evans NT, Mikecz P et al (1995) Measurement of lower limb blood flow in patients with neurogenic claudication using positron emission tomography. Spine (Phila Pa 1976) 20:408-411
53. 15 O positron emission tomography. Am J Phys Med Rehabil 89:473-486
54. Nawaz A, Saboury B, Basu S, Zhuang H, Moghadam-Kia S, Werner T et al (2012) Relation between popliteal-tibial artery atherosclerosis and global glycolytic metabolism in the affected diabetic foot: a pilot study using quantitative FDG-PET. J Am Podiatr Med Assoc 102:240-246
55. Nolting DD, Nickels ML, Guo N, Pham W (2012) Molecular imaging probe development: a chemistry perspective. Am J Nucl Med Mol Imaging 2:273-306
56. Beller GA, Sinusas AJ (1990) Experimental studies of the physiologic properties of technetium-99m isonitriles. Am J Cardiol 66:5E-8E (Pubitemid 20369697)
57. 99mTc-sestamibi uptake in the leg muscles and in the myocardium in patients with intermittent claudication. Angiology 44:971-976 (Pubitemid 23356612)
58. 201Tl. Eur J Nucl Med 9:12-16 (Pubitemid 14195989)
59. 99mTc-MIBI in early stages of atherosclerosis. Nucl Med Rev Cent East Eur 9:18-23 (Pubitemid 44043666)
60. 99mTc-MIBI in the assessment of peripheral vascular (arterial) disease. Nucl Med Commun 13:593-603
61. Forrest I, Hayes G, Smith A, Yip TC, Walker PM (1989) Identification of clinically significant skeletal muscle necrosis by single photon emission computed tomography. Can J Surg 32:109-112 (Pubitemid 19088616)
62. 99mTc pyrophosphate with single photon emission computed tomography. Nucl Med Commun 13:47-52
63. Bajnok L, Kozlovszky B, Varga J, Antalffy J, Olvaszto S, Fulop T Jr (1994) Technetium-99m sestamibi scintigraphy for the assessment of lower extremity ischaemia in peripheral arterial disease. Eur J Nucl Med 21:1326-1332 (Pubitemid 24371006)
64. Dobrucki LW, Sinusas AJ (2010) PET and SPECT in cardiovascular molecular imaging. Nat Rev Cardiol 7:38-47
65. Wu AM (2009) Antibodies and antimatter: the resurgence of immuno-PET. J Nucl Med 50:2-5
66. Wu AM, Senter PD (2005) Arming antibodies: prospects and challenges for immunoconjugates. Nat Biotechnol 23:1137-1146 (Pubitemid 41486395)
67. Zhang Y, Hong H, Engle JW, Yang Y, Theuer CP, Barnhart TE et al (2012) Positron emission tomography and optical imaging of tumor CD105 expression with a dual-labeled monoclonal antibody. Mol Pharm 9:645-653
68. 89Zr-Df-TRC105. Eur J Nucl Med Mol Imaging 39:138-148
69. 64Cu-labeled monoclonal antibody: NOTA is superior to DOTA. PLoS One 6:e28005
70. 66Ga-labeled monoclonal antibody. Mol Pharm 9:1441-1448
71. Dallas NA, Samuel S, Xia L, Fan F, Gray MJ, Lim SJ et al (2008) Endoglin (CD105): a marker of tumor vasculature and potential target for therapy. Clin Cancer Res 14:1931-1937 (Pubitemid 351551101)
72. Zhang Y, Yang Y, Hong H, Cai W (2011) Multimodality molecular imaging of CD105 (Endoglin) expression. Int J Clin Exp Med 4:32-42
73. Helisch A, Wagner S, Khan N, Drinane M, Wolfram S, Heil M et al (2006) Impact of mouse strain differences in innate hindlimb collateral vasculature. Arterioscler Thromb Vasc Biol 26:520-526
74. Tirziu D, Moodie KL, Zhuang ZW, Singer K, Helisch A, Dunn JF et al (2005) Delayed arteriogenesis in hypercholesterolemic mice. Circulation 112:2501-2509 (Pubitemid 41504501)
75. Saucy F, Dischl B, Delachaux A, Feihl F, Liaudet L, Waeber B et al (2006) Foot skin blood flow following infrainguinal revascularization for critical lower limb ischemia. Eur J Vasc Endovasc Surg 31:401-406
76. Murohara T, Asahara T, Silver M, Bauters C, Masuda H, Kalka C et al (1998) Nitric oxide synthase modulates angiogenesis in response to tissue ischemia. J Clin Invest 101:2567-2578 (Pubitemid 28270451)