Prognostic significance of p21, p27 and survivin protein expression in patients with oral squamous cell carcinoma

Oncology Letters

Volumn 6, Issue 2, 2013, Pages 381-386

  Zhang, Mingbin ^a,b   Li, Jiang ^c   Wang, Lizhen ^c   Tian, Zhen ^c   Zhang, Ping ^c   Xu, Qin ^c   Zhang, Chenping ^c   Wei, Fengcai ^a   Chen, Wantao ^c  

^a SHANDONG UNIVERSITY   (China)

^b Tai'an Central Hospital   (China)

^c SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Biomarker; Oral squamous cell carcinoma; p21; p27; Prognosis; Survivin

Indexed keywords

PROTEIN P21; PROTEIN P27; SURVIVIN;

ADULT; AGED; ARTICLE; CANCER PROGNOSIS; CELL PROLIFERATION; CONTROLLED STUDY; CORRELATION ANALYSIS; FEMALE; FOLLOW UP; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; MOUTH SQUAMOUS CELL CARCINOMA; PATHOLOGY; PROTEIN EXPRESSION; TUMOR VOLUME;

EID: 84879495771     PISSN: 17921074     EISSN: 17921082     Source Type: Journal    
DOI: 10.3892/ol.2013.1381     Document Type: Article

References (50)

1. Landis SH, Murray T, Bolden S and Wingo PA: Cancer statistics, 1999. CA Cancer J Clin49: 8-31, 1999.
2. Coqueret O: New roles for p21 and p27 cell-cycle inhibitors: a function for each cell compartment? Trends Cell Biol13: 65-70, 2003.
3. Bandoh N, Hayashi T, Takahara M, et al: Loss of p21 expression is associated with p53 mutations and increased cell proliferation and p27 expression is associated with apoptosis in maxillary sinus squamous cell carcinoma. Acta Otolaryngol125: 779-785, 2005.
4. Lu Y and Cao W: The role of p21 (wafl/cip1) in human colorectal carcinoma cell apoptosis. Zhonghua Yi Xue Za Zhi81: 1330-1332, 2001 (In Chinese).
5. Bissonnette N and Hunting DJ: p21-induced cycle arrest in G1 protects cells from apoptosis induced by UV-irradiation or RNA polymerase II blockage. Oncogene16: 3461-3469, 1998.
6. Ravitz MJ and Wenner CE: Cyclin-dependent kinase regulation during G1 phase and cell cycle regulation by TGF-beta. Adv Cancer Res71: 165-207, 1997.
7. Suzuki A, Ito T, Kawano H, et al: Survivin initiates procaspase 3/p21 complex formation as a result of interaction with Cdk4 to resist Fas-mediated cell death. Oncogene19: 1346-1353, 2000.
8. Temme A, Diestelkoetter-Bachert P, Schmitz M, et al: Increased p21(ras) activity in human fibroblasts transduced with survivin enhances cell proliferation. Biochem Biophys Res Commun327: 765-773, 2005.
9. Xie X, Clausen OP and Boysen M: Prognostic significance of p21WAF1/CIP1 expression in tongue squamous cell carcinomas. Arch Otolaryngol Head Neck Surg128: 897-902, 2002.
10. Fischer CA, Jung M, Zlobec I, et al: Co-overexpression of p21 and Ki-67 in head and neck squamous cell carcinoma relative to a significantly poor prognosis. Head Neck33: 267-273, 2011.
11. Nemes JA, Nemes Z and Márton IJ: p21WAF1/CIP1 expression is a marker of poor prognosis in oral squamous cell carcinoma. J Oral Pathol Med34: 274-279, 2005.
12. Zhuang Y, Yin HT, Yin XL, Wang J and Zhang DP: High p27 expression is associated with a better prognosis in East Asian non-small cell lung cancer patients. Clin Chim Acta412: 2228-2231, 2011.
13. Kapranos N, Stathopoulos GP, Manolopoulos L, et al: p53, p21 and p27 protein expression in head and neck cancer and their prognostic value. Anticancer Res21: 521-528, 2001.
14. O'Sullivan, B and Shah J: New TNM staging criteria for head and neck tumors. Seminars Surg Oncol 21: 30-42, 2003.
15. Zhang M, Zhang P, Zhang C, et al: Prognostic significance of Bcl-2 and Bax protein expression in the patients with oral squamous cell carcinoma. J Oral Pathol Med38: 307-313, 2009.
16. Harper JW, Adami GR, Wei N, Keyomarsi K and Elledge SJ: The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell75: 805-816, 1993.
17. Gu Y, Turck CW and Morgan DO: Inhibition of CDK2 activity in vivo by an associated 20K regulatory subunit. Nature366: 707-710, 1993.
18. Cheng M, Olivier P, Diehl JA, et al: The p21(Cip1) and p27(Kip1) CDK 'inhibitors' are essential activators of cyclin D-dependent kinases in murine fibroblasts. EMBO J18: 1571-1583, 1999.
19. Zhang H, Hannon GJ and Beach D: p21-containing cyclin kinases exist in both active and inactive states. Genes Dev8: 1750-1758, 1994.
20. Soos TJ, Kiyokawa H, Yan JS, et al: Formation of p27-CDK complexes during the human mitotic cell cycle. Cell Growth Differ7: 135-146, 1996.
21. Blain SW, Montalvo E and Massagué J: Differential interaction of the cyclin-dependent kinase (Cdk) inhibitor p27Kip1 with cyclinA-Cdk2 and cyclin D2-Cdk4. J Biol Chem272: 25863-25872, 1997.
22. LaBaer J, Garrett MD, Stevenson LF, et al: New functional activities for the p21 family of CDK inhibitors. Genes Dev11: 847-862, 1997.
23. Zhang Y, Fujita N and Tsuruo T: Caspase-mediated cleavage of p21Waf1/Cip1 converts cancer cells from growth arrest to undergoing apoptosis. Oncogene18: 1131-1138, 1999.
24. Wang Z, Su ZZ, Fisher PB, Wang S, VanTuyle G and Grant S: Evidence of a functional role for the cyclin-dependent kinase inhibitor p21(WAF1/CIP1/MDA6) in the reciprocal regulation of PKC activator-induced apoptosis and differentiation in human myelomonocytic leukemia cells. Exp Cell Res244: 105-116, 1998.
25. Gartel AL and Tyner AL: The role of the cyclin-dependent kinase inhibitor p21 in apoptosis. Mol Cancer Ther1: 639-649, 2002.
26. Narayanan BA, Geoffroy O, Willingham MC, Re GG and NixonDW: p53/p21(WAF1/CIP1) expression and its possible role in G1 arrest and apoptosis in ellagic acid treated cancer cells. Cancer Lett136: 215-221, 1999.
27. Okaichi K, Wang LH, Sasaki J, Saya H, Tada M and OkumuraY: A point mutation of human p53, which was not detected as a mutation by a yeast functional assay, led to apoptosis but not p21Waf1/Cip1/Sdi1 expression in response to ionizing radiation in a human osteosarcoma cell line, Saos-2. Int J Radiat Oncol Biol Phys45: 975-980, 1999.
28. Yan Q and Sage EH: Transforming growth factor-beta1 induces apoptotic cell death in cultured retinal endothelial cells but not pericytes: association with decreased expression of p21waf1/cip1. J Cell Biochem70: 70-83, 1998.
29. Gunia S, Kakies C, Erbersdobler A, Hakenberg OW, Koch S and May M: Expression of p53, p21 and cyclin D1 in penile cancer: p53 predicts poor prognosis. J Clin Pathol65: 232-236, 2012.
30. Taghavi N, Biramijamal F, Sotoudeh M, et al: Association of p53/p21 expression with cigarette smoking and prognosis in esophageal squamous cell carcinoma patients. World J Gastroenterol16: 4958-4967, 2010.
31. Siu MK, Chan HY, Kong DS, et al: p21-activated kinase 4 regulates ovarian cancer cell proliferation, migration, and invasion and contributes to poor prognosis in patients. Proc Natl Acad Sci USA107: 18622-18627, 2010.
32. Mineo TC, Ambrogi V, Cufari ME and Pompeo E: May cyclooxygenase-2 (COX-2), p21 and p27 expression affect prognosis and therapeutic strategy of patients with malignant pleural mesothelioma? Eur J Cardiothorac Surg38: 245-252, 2010.
33. Ogino S, Nosho K, Shima K, et al: p21 expression in colon cancer and modifying effects of patient age and body mass index on prognosis. Cancer Epidemiol Biomarkers Prev18: 2513-2521, 2009.
34. Hu TH, Tai MH, Chuah SK, et al: Elevated p21 expression is associated with poor prognosis of rectal stromal tumors after resection. J Surg Oncol 98: 117-123, 2008.
35. Hafkamp HC, Mooren JJ, Claessen SM, et al: P21 Cip1/WAF1 expression is strongly associated with HPV-positive tonsillar carcinoma and a favorable prognosis. Mod Pathol22: 686-698, 2009.
36. Pasz-Walczak G, Kordek R and Faflik M: P21 (WAF1) expression in colorectal cancer: correlation with P53 and cyclinD1 expression, clinicopathological parameters and prognosis. Pathol Res Pract197: 683-689, 2001.
37. Fillies T, Woltering M, Brandt B, et al: Cell cycle regulating proteins p21 and p27 in prognosis of oral squamous cell carcinomas. Oncol Rep17: 355-359, 2007.
38. Adida C, Crotty PL, McGrath J, Berrebi D, Diebold J and AltieriDC: Developmentally regulated expression of the novel cancer anti-apoptosis gene survivin in human and mouse differentiation. Am J Pathol152: 43-49, 1998.
39. Ambrosini G, Adida C, Sirugo G and Altieri DC: Induction of apoptosis and inhibition of cell proliferation by survivin gene targeting. J Biol Chem273: 11177-11182, 1998.
40. Ambrosini G, Adida C and Altieri DC: A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma. Nat Med3: 917-921, 1997.
41. Li F, Ackermann EJ, Bennett CF, et al: Pleiotropic cell-division defects and apoptosis induced by interference with survivin function. Nat Cell Biol1: 461-466, 1999.
42. Kobayashi K, Hatano M, Otaki M, Ogasawara T and Tokuhisa T: Expression of a murine homologue of the inhibitor of apoptosis protein is related to cell proliferation. Proc Natl Acad Sci USA96: 1457-1462, 1999.
43. Li F, Ambrosini G, Chu EY, et al: Control of apoptosis and mitotic spindle checkpoint by survivin. Nature396: 580-584, 1998.
44. Suzuki A and Shiraki K: Tumor cell 'dead or alive': caspase and survivin regulate cell death, cell cycle and cell survival. Histol Histopathol16: 583-593, 2001.
45. Fukuda S, Mantel CR and Pelus LM: Survivin regulates hematopoietic progenitor cell proliferation through p21WAF1/Cip1-dependent and-independent pathways. Blood103: 120-127, 2004.
46. Tanaka C, Uzawa K, Shibahara T, Yokoe H, Noma H and Tanzawa H: Expression of an inhibitor of apoptosis, survivin, in oral carcinogenesis. J Dent Res82: 607-611, 2003.
47. Li C, Li Z, Zhu M, et al: Clinicopathological and prognostic significance of survivin over-expression in patients with esophageal squamous cell carcinoma: a meta-analysis. PloS One7: e44764, 2012.
48. Ekeblad S, Lejonklou MH, Stálberg P and Skogseid B: Prognostic relevance of survivin in pancreatic endocrine tumors. World J Surg36: 1411-1418, 2012.
49. Chang BD, Watanabe K, Broude EV, et al: Effects of p21Waf1/Cip1/Sdi1 on cellular gene expression: implications for carcinogenesis, senescence, and age-related diseases. Proc Natl Acad Sci USA97: 4291-4296, 2000.
50. Schmidt M and Fan Z: Protection against chemotherapy-induced cytotoxicity by cyclin-dependent kinase inhibitors (CKI) in CKI-responsive cells compared with CKI-unresponsive cells. Oncogene20: 6164-6171, 2001.