Synthesis of 4-aminoquinoline - Pyrimidine hybrids as potent antimalarials and their mode of action studies

European Journal of Medicinal Chemistry

Volumn 66, Issue , 2013, Pages 314-323

  Singh, Kamaljit ^a   Kaur, Hardeep ^a   Chibale, Kelly ^b   Balzarini, Jan ^c  

^a GURU NANAK DEV UNIVERSITY   (India)

^b UNIVERSITY OF CAPE TOWN   (South Africa)

^c REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

4 Aminoquinolines; Antimalarials; Drug discovery; Heme binding; Hybrid molecules

Indexed keywords

4 AMINOQUINOLINE; ANTIMALARIAL AGENT; ARTEMISININ; DNA; HEME; PYRIMIDINE; 4 AMINOQUINOLINE DERIVATIVE; ETHYL 2 [3 [(7 CHLOROQUINOLIN 4 YL)AMINO]PROPOXY] 4 METHYL 6 PHENYLPYRIMIDINE 5 CARBOXYLATE; ETHYL 2 [3 [(7 CHLOROQUINOLIN 4 YL)AMINO]PROPYLAMINO] 4 METHYLPYRIMIDINE 5 CARBOXYLATE3; ETHYL 2 [4 [(7 CHLOROQUINOLIN 4 YL)AMINO]BUTYLAMINO] 4 METHYL 6 (2 NITROPHENYL)PYRIMIDINE 5 CARBOXYLATE; ETHYL 4 (4 CHLOROPHENYL) 2 [4 [(7 CHLOROQUINOLIN 4 YL)AMINO]BUTYLAMINO] 6 METHYLPYRIMIDINE 5 CARBOXYLATE; ETHYL 4 (4 FLUOROPHENYL) 2 [4 [(7 CHLOROQUINOLIN 4 YL)AMINO]BUTYLAMINO] 6 METHYLPYRIMIDINE 5 CARBOXYLATE; I PROPYL 2 [4 [(7 CHLOROQUINOLIN 4 YL)AMINO]BUTYLAMINO] 4 METHYL 6 PHENYLPYRIMIDINE 5 CARBOXYLATE; METHYL 2 [3 [(7 CHLOROQUINOLIN 4 YL)AMINO]PROPYLAMINO] 4 METHYL 6 PHENYLPYRIMIDINE 5 CARBOXYLATE; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIBIOTIC RESISTANCE; ANTIMALARIAL ACTIVITY; ARTICLE; DRUG BINDING; DRUG POTENCY; DRUG SYNTHESIS; HYBRIDIZATION; NONHUMAN; PLASMODIUM FALCIPARUM; ANIMAL CELL; ANTIVIRAL ACTIVITY; CYTOTOXICITY; DRUG ACTIVITY; DRUG DNA BINDING; DRUG STRUCTURE; STRUCTURE ACTIVITY RELATION;

EID: 84879494495     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2013.05.046     Document Type: Article

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