Inhibition of human coronavirus 229E infection in human epithelial lung cells (L132) by chloroquine: Involvement of p38 MAPK and ERK

Antiviral Research

Volumn 77, Issue 2, 2008, Pages 150-152

  Kono, Masakazu ^a   Tatsumi, Koichiro ^a   Imai, Alberto M ^a   Saito, Kengo ^a   Kuriyama, Takayuki ^a   Shirasawa, Hiroshi ^a  

^a CHIBA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

229E; Chloroquine; Coronavirus; ERK; MAPK; p38

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; CHLOROQUINE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; MITOGEN ACTIVATED PROTEIN KINASE P38 INHIBITOR; VIRUS RNA;

ANTIVIRAL ACTIVITY; ARTICLE; CELL LINE; CELL STRAIN L132; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORONAVIRUS; CYTOPATHOGENIC EFFECT; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SARS CORONAVIRUS; VIRUS ENTRY; VIRUS INHIBITION; VIRUS LOAD; VIRUS REPLICATION;

ANTIVIRAL AGENTS; CELL LINE; CHLOROQUINE; CORONAVIRUS 229E, HUMAN; CYTOPATHOGENIC EFFECT, VIRAL; EPITHELIAL CELLS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HUMANS; IMIDAZOLES; LUNG; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PYRIDINES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; VIRUS REPLICATION;

CORONAVIRUS; HUMAN CORONAVIRUS 229E;

EID: 38149111989     PISSN: 01663542     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.antiviral.2007.10.011     Document Type: Article

References (14)

1. Banerjee S., et al. Murine coronavirus replication-induced p38 mitogen-activated protein kinase activation promotes interleukin-6 production and virus replication in cultured cells. J. Virol. 76 (2002) 5937-5948
2. Barnard D.L., et al. Evaluation of immunomodulators, interferons and known in vitro SARS-CoV inhibitors for inhibition of SARS-CoV replication in BALB/c mice. Antivir. Chem. Chemother. 17 (2006) 275-284
3. Kopecky-Bromberg, et al. 7a Protein of severe acute respiratory syndrome coronavirus inhibits cellular protein synthesis and activates p38 mitogen-activated protein kinase. J. Virol. 80 (2006) 785-793
4. Nauwynck H.J., et al. Entry of porcine reproductive and respiratory syndrome virus into porcine alveolar macrophages via receptor-mediated endocytosis. J. Gen. Virol. 80 (1999) 297-305
5. Ng M.L., et al. Proliferative growth of SARS coronavirus in Vero E6 cells. J. Gen. Virol. 84 (2003) 3291-3303
6. Pleschka S., et al. Influenza virus propagation is impaired by inhibition of the Raf/MEK/ERK signalling cascade. Nat. Cell Biol. 3 (2001) 301-305
7. Savarino A., et al. Effects of chloroquine on viral infections: an old drug against today's diseases?. Lancet Infect. Dis. 3 (2003) 722-727
8. Sperber K., et al. Inhibition of human immunodeficiency virus type 1 replication by hydroxychloroquine in T cells and monocytes. AIDS Res. Hum. Retrov. 9 (1993) 9-13
9. Su H.-L., et al. Japanese encephalitis virus infection initiates endoplasmic reticulum stress and an unfolded protein response. J. Virol. 76 (2002) 4162-4171
10. van Elden L.J., et al. Frequent detection of human coronaviruses in clinical specimens from patients with respiratory tract infection by use of a novel real-time reverse-transcriptase polymerase chain reaction. J. Infect. Dis. 189 (2004) 652-657
11. Vincent M.J., et al. Chloroquine is a potent inhibitor of SARS coronavirus infection and spread. Virol. J. 2 (2005) 69
12. Weber S.M., et al. Inhibition of mitogen-activated protein kinase signaling by chloroquine. J. Immunol. 168 (2002) 5303-5309
13. Xia Z., et al. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science 24 (1995) 1326-1331
14. Yi A.K., and Krieg A.M. Rapid induction of mitogen-activated protein kinases by immune stimulatory CpG DNA. J. Immunol. 161 (1998) 4493-4497