Facile transformation of Biginelli pyrimidin-2(1H)-ones to pyrimidines. In vitro evaluation as inhibitors of Mycobacterium tuberculosis and modulators of cytostatic activity

European Journal of Medicinal Chemistry

Volumn 46, Issue 6, 2011, Pages 2290-2294

  Singh, Kamaljit ^a   Singh, Kawaljit ^a   Wan, Baojie ^b   Franzblau, Scott ^b   Chibale, Kelly ^c   Balzarini, Jan ^d  

^a GURU NANAK DEV UNIVERSITY   (India)

^b UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^c UNIVERSITY OF CAPE TOWN   (South Africa)

^d REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

Biginelli compounds; Cytostatic activity; Inhibitors; MABA; Pyrimidines; Tuberculosis

Indexed keywords

2 (2 HYDROXYPHENYLAMINO) 4 METHYL 6 PHENYLPYRIMIDINE 5 CARBOXYLIC ACID ETHYL ESTER; 2 (3 AMINOPHENYLAMINO) 4 METHYL 6 PHENYLPYRIMIDINE 5 CARBOXYLIC ACID ETHYL ESTER; 2 (3 HYDROXYPROPYLAMINO) 4 METHYL 6 PHENYLPYRIMIDINE 5 CARBOXYLIC ACID ETHYL ESTER; 2 (4 HYDROXYPHENYLAMINO) 4 METHYL 6 PHENYLPYRIMIDINE 5 CARBOXYLIC ACID ETHYL ESTER; 2 (PIPERIDIN 1 YL) 4 METHYL 6 PHENYLPYRIMIDINE 5 CARBOXYLIC ACID ETHYL ESTER; 2 [2 (1H INDOL 3 YL) ETHYLAMINO] 4 METHYL 6 PHENYLPYRIMIDINE 5 CARBOXYLIC ACID ETHYL ESTER; 2 AMINO 4 METHYL 6 PHENYLPYRIMIDINE 5 CARBOXYLIC ACID ETHYL ESTER; 2 AMINO 4 METHYLPYRIMIDINE 5 CARBOXYLIC ACID ETHYL ESTER; 2 BENZYLAMINO 4 METHYL 6 PHENYLPYRIMIDINE 5 CARBOXYLIC ACID ETHYL ESTER; 2 BENZYLAMINO 4 METHYLPYRIMIDINE 5 CARBOXYLIC ACID ETHYL ESTER; 2 BUTYLAMINO 4 METHYL 6 PHENYLPYRIMIDINE 5 CARBOXYLIC ACID ETHYL ESTER; 2 ETHOXY 4 METHYL 6 PHENYLPYRIMIDINE 5 CARBOXYLIC ACID ETHYL ESTER; 2 ISOPROPYLAMINO 4 METHYL 6 PHENYLPYRIMIDINE 5 CARBOXYLIC ACID ETHYL ESTER; 2 MORPHOLINO 4 METHYL 6 PHENYLPYRIMIDINE 5 CARBOXYLIC ACID ETHYL ESTER; PYRIMIDINE DERIVATIVE; PYRIMIDINONE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIVIRAL ACTIVITY; ARTICLE; BACTERIAL STRAIN; BIGINELLI REACTION; CELL CULTURE; CELL PROLIFERATION; CONTROLLED STUDY; CYTOSTASIS; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IN VITRO STUDY; MINIMUM INHIBITORY CONCENTRATION; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; TUBERCULOSIS;

ANIMALS; ANTITUBERCULAR AGENTS; CELL PROLIFERATION; DRUG SCREENING ASSAYS, ANTITUMOR; HELA CELLS; HUMANS; MICE; MOLECULAR STRUCTURE; MYCOBACTERIUM TUBERCULOSIS; PYRIMIDINES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 79955599161     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.03.010     Document Type: Article

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