Fish Oil and the Pan-PPAR Agonist Tetradecylthioacetic Acid Affect the Amino Acid and Carnitine Metabolism in Rats

PLoS ONE

Volumn 8, Issue 6, 2013, Pages

  Bjørndal, Bodil ^a   Brattelid, Trond ^b   Strand, Elin ^a   Vigerust, Natalya Filipchuk ^a   Svingen, Gard Frodahl Tveitevåg ^a   Svardal, Asbjørn ^a   Nygård, Ottar ^a,c   Berge, Rolf Kristian ^a,c  

^a UNIVERSITY OF BERGEN   (Norway)

^b INSTITUTE OF MARINE RESEARCH   (Norway)

^c HAUKELAND UNIVERSITY HOSPITAL   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCARNITINE; ARGININE; CARNITINE; FATTY ACID ESTER; FISH OIL; GAMMA BUTYROBETAINE; ISOVALERYLCARNITINE; LYSINE; OCTANOYLCARNITINE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR AGONIST; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PROPIONYLCARNITINE; TETRADECYLTHIOACETIC ACID; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; VALERYLCARNITINE;

AMINO ACID BLOOD LEVEL; AMINO ACID COMPOSITION; AMINO ACID METABOLISM; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; LIPID METABOLISM; MALE; MOUSE; NONHUMAN; WEIGHT REDUCTION;

AMINO ACIDS; AMMONIUM COMPOUNDS; ANIMALS; BODY WEIGHT; CARNITINE; DIET; FEEDING BEHAVIOR; FISH OILS; GENE EXPRESSION REGULATION; LIVER; MALE; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS; RATS; RATS, WISTAR; SULFIDES; UREA;

ANIMALIA; RATTUS; RATTUS NORVEGICUS;

EID: 84879494451     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0066926     Document Type: Article

References (47)

1. Tontonoz P, Spiegelman BM, (2008) Fat and beyond: the diverse biology of PPARgamma. Annu Rev Biochem 77: 289-312.
2. Benetti E, Patel NS, Collino M, (2011) The role of PPARbeta/delta in the management of metabolic syndrome and its associated cardiovascular complications. Endocr Metab Immune Disord Drug Targets 11: 273-284.
3. Pyper SR, Viswakarma N, Yu S, Reddy JK, (2010) PPARalpha: energy combustion, hypolipidemia, inflammation and cancer. Nucl Recept Signal 8: e002.
4. Kersten S, Mandard S, Escher P, Gonzalez FJ, Tafuri S, et al. (2001) The peroxisome proliferator-activated receptor alpha regulates amino acid metabolism. FASEB J 15: 1971-1978.
5. Sheikh K, Camejo G, Lanne B, Halvarsson T, Landergren MR, et al. (2007) Beyond lipids, pharmacological PPARalpha activation has important effects on amino acid metabolism as studied in the rat. Am J Physiol Endocrinol Metab 292: E1157-1165.
6. Yu K, Bayona W, Kallen CB, Harding HP, Ravera CP, et al. (1995) Differential activation of peroxisome proliferator-activated receptors by eicosanoids. J Biol Chem 270: 23975-23983.
7. Forman BM, Chen J, Evans RM, (1997) Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors alpha and delta. Proc Natl Acad Sci U S A 94: 4312-4317.
8. Vigerust NF, Cacabelos D, Burri L, Berge K, Wergedahl H, et al. (2012) Fish oil and 3-thia fatty acid have additive effects on lipid metabolism but antagonistic effects on oxidative damage when fed to rats for 50 weeks. J Nutr Biochem 23: 1384-1393.
9. Burri L, Berge K, Wibrand K, Berge RK, Barger JL, (2011) Differential effects of krill oil and fish oil on the hepatic transcriptome in mice. Frontiers in Nutrigenomics 2: 1-8.
10. Chaput E, Saladin R, Silvestre M, Edgar AD, (2000) Fenofibrate and rosiglitazone lower serum triglycerides with opposing effects on body weight. Biochem Biophys Res Commun 271: 445-450.
11. Madsen L, Guerre-Millo M, Flindt EN, Berge K, Tronstad KJ, et al. (2002) Tetradecylthioacetic acid prevents high fat diet induced adiposity and insulin resistance. J Lipid Res 43: 742-750.
12. Berge RK, Tronstad KJ, Berge K, Rost TH, Wergedahl H, et al. (2005) The metabolic syndrome and the hepatic fatty acid drainage hypothesis. Biochimie 87: 15-20.
13. Westergaard M, Henningsen J, Svendsen ML, Johansen C, Jensen UB, et al. (2001) Modulation of keratinocyte gene expression and differentiation by PPAR-selective ligands and tetradecylthioacetic acid. J Invest Dermatol 116: 702-712.
14. Lovas K, Rost TH, Skorve J, Ulvik RJ, Gudbrandsen OA, et al. (2009) Tetradecylthioacetic acid attenuates dyslipidaemia in male patients with type 2 diabetes mellitus, possibly by dual PPAR-alpha/delta activation and increased mitochondrial fatty acid oxidation. Diabetes Obes Metab 11: 304-314.
15. Schoonjans K, Staels B, Auwerx J, (1996) Role of the peroxisome proliferator-activated receptor (PPAR) in mediating the effects of fibrates and fatty acids on gene expression. J Lipid Res 37: 907-925.
16. Lopez-Huertas E, (2012) The effect of EPA and DHA on metabolic syndrome patients: a systematic review of randomised controlled trials. Br J Nutr 107Suppl 2: S185-194.
17. Group AS, Ginsberg HN, Elam MB, Lovato LC, Crouse JR 3rd, et al (2010) Effects of combination lipid therapy in type 2 diabetes mellitus. N Engl J Med 362: 1563-1574.
18. Kwak SM, Myung SK, Lee YJ, Seo HG, Korean Meta-analysis Study G, (2012) Efficacy of omega-3 fatty acid supplements (eicosapentaenoic acid and docosahexaenoic acid) in the secondary prevention of cardiovascular disease: a meta-analysis of randomized, double-blind, placebo-controlled trials. Arch Intern Med 172: 686-694.
19. Rizos EC, Ntzani EE, Bika E, Kostapanos MS, Elisaf MS, (2012) Association between omega-3 fatty acid supplementation and risk of major cardiovascular disease events: a systematic review and meta-analysis. JAMA 308: 1024-1033.
20. Koch A, Konig B, Stangl GI, Eder K, (2008) PPAR alpha mediates transcriptional upregulation of novel organic cation transporters-2 and-3 and enzymes involved in hepatic carnitine synthesis. Exp Biol Med (Maywood) 233: 356-365.
21. Reuter SE, Evans AM, (2012) Carnitine and acylcarnitines: pharmacokinetic, pharmacological and clinical aspects. Clin Pharmacokinet 51: 553-572.
22. Blaak EE, (2005) Metabolic fluxes in skeletal muscle in relation to obesity and insulin resistance. Best Pract Res Clin Endocrinol Metab 19: 391-403.
23. Koves TR, Ussher JR, Noland RC, Slentz D, Mosedale M, et al. (2008) Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance. Cell Metab 7: 45-56.
24. Ueland T, Svardal A, Oie E, Askevold ET, Nymoen SH, et al. (2012) Disturbed carnitine regulation in chronic heart failure- Increased plasma levels of palmitoyl-carnitine are associated with poor prognosis. Int J Cardiol DOI: S0167-5273(12)00587-6 [pii] 10.1016/j.ijcard.2012.04.150.
25. Spydevold O, Bremer J, (1989) Induction of peroxisomal beta-oxidation in 7800 C1 Morris hepatoma cells in steady state by fatty acids and fatty acid analogues. Biochim Biophys Acta 1003: 72-79.
26. Liaset B, Hao Q, Jorgensen H, Hallenborg P, Du ZY, et al. (2011) Nutritional regulation of bile acid metabolism is associated with improved pathological characteristics of the metabolic syndrome. J Biol Chem 286: 28382-28395.
27. Liaset B, Julshamn K, Espe M, (2003) Chemical composition and theoretical nutritional evaluation of the produced fractions from enzymic hydrolysis of salmon frames with ProtamexTM. Proc Biochem 38: 1747-1759.
28. Vernez L, Wenk M, Krahenbuhl S, (2004) Determination of carnitine and acylcarnitines in plasma by high-performance liquid chromatography/electrospray ionization ion trap tandem mass spectrometry. Rapid Commun Mass Spectrom 18: 1233-1238.
29. Vigerust NF, Bohov P, Bjorndal B, Seifert R, Nygard O, et al. (2012) Free carnitine and acylcarnitines in obese patients with polycystic ovary syndrome and effects of pioglitazone treatment. Fertil Steril 98: 1620-6.e1.
30. Andersen CL, Jensen JL, Orntoft TF, (2004) Normalization of real-time quantitative reverse transcription-PCR data: a model-based variance estimation approach to identify genes suited for normalization, applied to bladder and colon cancer data sets. Cancer Res 64: 5245-5250.
31. Slinker BK, (1998) The statistics of synergism. J Mol Cell Cardiol 30: 723-731.
32. Lu Y, Boekschoten MV, Wopereis S, Muller M, Kersten S, (2011) Comparative transcriptomic and metabolomic analysis of fenofibrate and fish oil treatments in mice. Physiol Genomics 43: 1307-1318.
33. Lee SS, Pineau T, Drago J, Lee EJ, Owens JW, et al. (1995) Targeted disruption of the alpha isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators. Mol Cell Biol 15: 3012-3022.
34. Ammerschlaeger M, Beigel J, Klein KU, Mueller SO, (2004) Characterization of the species-specificity of peroxisome proliferators in rat and human hepatocytes. Toxicol Sci 78: 229-240.
35. Hagland HR, Nilsson LI, Burri L, Nikolaisen J, Berge RK, et al. (2013) Induction of mitochondrial biogenesis and respiration is associated with mTOR regulation in hepatocytes of rats treated with the pan-PPAR activator tetradecylthioacetic acid (TTA). Biochem Biophys Res Commun 430: 573-578.
36. Makowski L, Noland RC, Koves TR, Xing W, Ilkayeva OR, et al. (2009) Metabolic profiling of PPARalpha-/- mice reveals defects in carnitine and amino acid homeostasis that are partially reversed by oral carnitine supplementation. FASEB J 23: 586-604.
37. Wrzesinski K, Leon IR, Kulej K, Sprenger RR, Bjorndal B, et al. (2013) Proteomics identifies molecular networks affected by tetradecylthioacetic acid and fish oil supplemented diets. J Proteomics 84C: 61-77.
38. Burri L, Bjorndal B, Wergedahl H, Berge K, Bohov P, et al. (2011) Tetradecylthioacetic acid increases hepatic mitochondrial beta-oxidation and alters fatty acid composition in a mouse model of chronic inflammation. Lipids 46: 679-689.
39. Bjorndal B, Burri L, Wergedahl H, Svardal A, Bohov P, et al. (2011) Dietary supplementation of herring roe and milt enhances hepatic fatty acid catabolism in female mice transgenic for hTNFalpha. Eur J Nutr 46: 679-89.
40. van Vlies N, Ferdinandusse S, Turkenburg M, Wanders RJ, Vaz FM, (2007) PPAR alpha-activation results in enhanced carnitine biosynthesis and OCTN2-mediated hepatic carnitine accumulation. Biochim Biophys Acta 1767: 1134-1142.
41. Hiltunen JK, Qin Y, (2000) beta-oxidation- strategies for the metabolism of a wide variety of acyl-CoA esters. Biochim Biophys Acta 1484: 117-128.
42. Paik WK, Kim S, (1971) Protein methylation. Science 174: 114-119.
43. Paik WK, Kim S, (1975) Protein methylation: chemical, enzymological, and biological significance. Adv Enzymol Relat Areas Mol Biol 42: 227-286.
44. Hoppel CL, Davis AT, (1986) Inter-tissue relationships in the synthesis and distribution of carnitine. Biochem Soc Trans 14: 673-674.
45. Rebouche CJ, Engel AG, (1980) Tissue distribution of carnitine biosynthetic enzymes in man. Biochim Biophys Acta 630: 22-29.
46. Stein R, Englard S, (1982) Properties of rat 6-N-trimethyl-L-lysine hydroxylases: similarities among the kidney, liver, heart, and skeletal muscle activities. Arch Biochem Biophys 217: 324-331.
47. Englard S, Blanchard JS, Midelfort CF, (1985) Gamma-butyrobetaine hydroxylase: stereochemical course of the hydroxylation reaction. Biochemistry 24: 1110-1116.