Zinc supplementation inhibits the increase in osteoclastogenesis and decrease in osteoblastogenesis in streptozotocin-induced diabetic rats

European Journal of Pharmacology

Volumn 714, Issue 1-3, 2013, Pages 41-47

  Iitsuka, Natsumi ^a   Hie, Mamiko ^a   Tsukamoto, Ikuyo ^a  

^a NARA WOMEN'S UNIVERSITY   (Japan)

Author keywords

Diabetes mellitus; IGF 1 catenin signaling; Osteoblastogenesis; Osteoclastogenesis; RANK; Zinc

Indexed keywords

ACID PHOSPHATASE TARTRATE RESISTANT ISOENZYME; ALKALINE PHOSPHATASE; BETA CATENIN; CALCIUM; CATHEPSIN K; COLLAGEN; DICKKOPF 1 PROTEIN; GLYCOGEN SYNTHASE KINASE 3BETA; HYDROXYPROLINE; MESSENGER RNA; OSTEOCALCIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR BINDING PROTEIN; PROTEIN C FOS; PROTEIN C JUN; PROTEIN KINASE B; RECEPTOR ACTIVATOR OF NUCLEAR FACTOR KAPPA B; SCLEROSTIN; SOMATOMEDIN C; SOMATOMEDIN C RECEPTOR; TRANSCRIPTION FACTOR DLX5; TRANSCRIPTION FACTOR OSTERIX; TRANSCRIPTION FACTOR RUNX2; ZINC;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE DEVELOPMENT; BONE METABOLISM; CELL COUNT; CONTROLLED STUDY; DIET SUPPLEMENTATION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; FEMALE; GENE EXPRESSION; HISTOLOGY; INTRACELLULAR SIGNALING; METAPHYSIS; NONHUMAN; OSTEOBLAST; OSTEOCLAST; OSTEOCLASTOGENESIS; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS INHIBITION; RAT; STREPTOZOCIN DIABETES; TREATMENT DURATION; TREATMENT OUTCOME;

DIABETES MELLITUS; IGF-1/Β-CATENIN SIGNALING; OSTEOBLASTOGENESIS; OSTEOCLASTOGENESIS; RANK; ZINC;

ANIMALS; BETA CATENIN; BIOLOGICAL MARKERS; BODY WEIGHT; CELL DIFFERENTIATION; DIABETES MELLITUS, EXPERIMENTAL; DIETARY SUPPLEMENTS; EATING; FEMALE; GENE EXPRESSION REGULATION; INSULIN-LIKE GROWTH FACTOR I; ORGAN SIZE; OSTEOBLASTS; OSTEOCLASTS; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, WISTAR; RECEPTOR ACTIVATOR OF NUCLEAR FACTOR-KAPPA B; SIGNAL TRANSDUCTION; TIBIA; ZINC;

EID: 84879485012     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2013.05.020     Document Type: Article

References (40)

1. Asagiri, M., Takayanagi, H., 2007. The molecular understanding of osteoclast differentiation. Bone 40, 251-264. (Pubitemid 46054562)
2. Bennett, C.N., Longo, K.A., Wright, W.S., Suva, L.J., Lane, T.F., Hankenson, K.D., MacDougald, O.A., 2005. Regulation of osteoblastogenesis and bone mass by Wnt10b. Proc. Nat. Acad. Sci. USA 102, 3324-3329. (Pubitemid 40328044)
3. Daughaday, W.H., Rotwein, P., 1989. Insulin-like growth factors I and II. Peptide, messenger ribonucleic acid and gene structures, serum, and tissue concentrations. Endocr. Rev. 10, 68-91. (Pubitemid 19156368)
4. Ducy, P., Zhang, R., Geoffroy, V., Ridall, A.L., Karsenty, G., 1997. Osf2/Cbfa1: a transcriptional activator of osteoblast differentiation. Cell 89, 747-754. (Pubitemid 27516177)
5. Ellman, G.L., 1959. Tissue sulfhydryl groups. Arch. Biochem. Biophys. 82, 70-77.
6. Goto, A., Tsukamoto, I., 2003. Increase in tartrate-resistant acid phosphatase of bone at the early stage of ascorbic acid deficiency in the ascorbate-requiring Osteogenic Disorder Shionogi (ODS) rat. Calcif. Tissue Int. 73, 180-185. (Pubitemid 37082365)
7. Hie, M., Iitsuka, N., Otsuka, T., Nakanishi, A., Tsukamoto, I., 2011a. Zinc deficiency decreases osteoblasts and osteoclasts associated with the reduced expression of Runx2 and RANK. Bone.
8. Hie, M., Iitsuka, N., Otsuka, T., Tsukamoto, I., 2011b. Insulin-dependent diabetes mellitus decreases osteoblastogenesis associated with the inhibition of Wnt signaling through increased expression of Sost and Dkk1 and inhibition of Akt activation. Int. J. Mol. Med. 28, 455-462.
9. Hie, M., Shimono, M., Fujii, K., Tsukamoto, I., 2007. Increased cathepsin K and tartrate-resistant acid phosphatase expression in bone of streptozotocin-induced diabetic rats. Bone 41, 1045-1050. (Pubitemid 350116747)
10. Hie, M., Tsukamoto, I., 2010. Increased expression of the receptor for activation of NF-kappaB and decreased runt-related transcription factor 2 expression in bone of rats with streptozotocin-induced diabetes. Int. J. Mol. Med. 26, 611-618.
11. Hie, M., Tsukamoto, I., 2011. Administration of zinc inhibits osteoclastogenesis through the suppression of RANK expression in bone. Eur. J. Pharmacol. 668, 140-146.
12. Hie, M., Yamazaki, M., Tsukamoto, I., 2009. Curcumin suppresses increased bone resorption by inhibiting osteoclastogenesis in rats with streptozotocin-induced diabetes. Eur. J. Pharmacol. 621, 1-9.
13. Hofbauer, L.C., Khosla, S., Dunstan, C.R., Lacey, D.L., Boyle, W.J., Riggs, B.L., 2000. The roles of osteoprotegerin and osteoprotegerin ligand in the paracrine regulation of bone resorption. J. Bone Miner. Res. 15, 2-12. (Pubitemid 30026926)
14. Ishii, J., Kitazawa, R., Mori, K., McHugh, K.P., Morii, E., Kondo, T., Kitazawa, S., 2008. Lipopolysaccharide suppresses RANK gene expression in macrophages by down-regulating PU.1 and MITF. J. Cell. Biochem. 105, 896-904.
15. Kemink, S.A., Hermus, A.R., Swinkels, L.M., Lutterman, J.A., Smals, A.G., 2000. Osteopenia in insulin-dependent diabetes mellitus; prevalence and aspects of pathophysiology. J. Endocrinol. Invest. 23, 295-303. (Pubitemid 30426548)
16. Kishi, S., Yamaguchi, M., 1994. Inhibitory effect of zinc compounds on osteoclast-like cell formation in mouse marrow cultures. Biochem. Pharmacol. 48, 1225-1230. (Pubitemid 24298374)
17. Komori, T., 2006. Regulation of osteoblast differentiation by transcription factors. J. Cell. Biochem. 99, 1233-1239.
18. Krakauer, J.C., McKenna, M.J., Buderer, N.F., Rao, D.S., Whitehouse, F.W., Parfitt, A.M., 1995. Bone loss and bone turnover in diabetes. Diabetes 44, 775-782.
19. Kwun, I.S., Cho, Y.E., Lomeda, R.A., Shin, H.I., Choi, J.Y., Kang, Y.H., Beattie, J.H., 2010. Zinc deficiency suppresses matrix mineralization and retards osteogenesis transiently with catch-up possibly through Runx 2 modulation. Bone 46, 732-741.
20. Lee, M.H., Kim, Y.J., Kim, H.J., Park, H.D., Kang, A.R., Kyung, H.M., Sung, J.H., Wozney, J.M., Kim, H.J., Ryoo, H.M., 2003. BMP-2-induced Runx2 expression is mediated by Dlx5, and TGF-beta 1 opposes the BMP-2-induced osteoblast differentiation by suppression of Dlx5 expression. J. Biol. Chem. 278, 34387-34394. (Pubitemid 37553284)
21. Lutz, W., Burritt, M.F., Nixon, D.E., Kao, P.C., Kumar, R., 2000. Zinc increases the activity of vitamin D-dependent promoters in osteoblasts. Biochem. Biophys. Res. Commun. 271, 1-7. (Pubitemid 30444847)
22. Miyama, K., Yamada, G., Yamamoto, T.S., Takagi, C., Miyado, K., Sakai, M., Ueno, N., Shibuya, H., 1999. A BMP-inducible gene, dlx5, regulates osteoblast differentiation and mesoderm induction. Dev. Biol. 208, 123-133. (Pubitemid 29149452)
23. Nagai, M., Sato, N., 1999. Reciprocal gene expression of osteoclastogenesis inhibitory factor and osteoclast differentiation factor regulates osteoclast formation. Biochem. Biophys. Res. Commun. 257, 719-723. (Pubitemid 29301509)
24. Nishi, Y., 1996. Zinc and growth. J. Am. Coll. Nutr. 15, 340-344. (Pubitemid 26264563)
25. Ohkawa, H., Ohishi, N., Yagi, K., 1979. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal. Biochem. 95, 351-358. (Pubitemid 9194347)
26. Ovesen, J., Moller-Madsen, B., Thomsen, J.S., Danscher, G., Mosekilde, L., 2001. The positive effects of zinc on skeletal strength in growing rats. Bone 29, 565-570. (Pubitemid 33124300)
27. Parfitt, A.M., Drezner, M.K., Glorieux, F.H., Kanis, J.A., Malluche, H., Meunier, P.J., Ott, S.M., Recker, R.R., 1987. Bone histomorphometry: standardization of nomenclature, symbols, and units. Report of the ASBMR Histomorphometry Nomenclature Committee. J. Bone Miner. Res. 2, 595-610.
28. Rossi, L., Migliaccio, S., Corsi, A., Marzia, M., Bianco, P., Teti, A., Gambelli, L., Cianfarani, S., Paoletti, F., Branca, F., 2001. Reduced growth and skeletal changes in zinc-deficient growing rats are due to impaired growth plate activity and inanition. J. Nutr. 131, 1142-1146. (Pubitemid 32279632)
29. Seco, C., Revilla, M., Hernandez, E.R., Gervas, J., Gonzalez-Riola, J., Villa, L.F., Rico, H., 1998. Effects of zinc supplementation on vertebral and femoral bone mass in rats on strenuous treadmill training exercise. J. Bone Miner. Res. 13, 508-512. (Pubitemid 28146234)
30. Seino, S., Seino, M., Nishi, S., Bell, G.I., 1989. Structure of the human insulin receptor gene and characterization of its promoter. Proc. Nat. Acad. Sci. USA 86, 114-118. (Pubitemid 19036344)
31. Szkudelski, T., 2001. The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas. Physiol. Res. 50, 537-546. (Pubitemid 34087272)
32. Takada, I., Kouzmenko, A.P., Kato, S., 2009. Wnt and PPARgamma signaling in osteoblastogenesis and adipogenesis. Nat. Rev. Rheumatol. 5, 442-447.
33. Tsuchida, T., Sato, K., Miyakoshi, N., Abe, T., Kudo, T., Tamura, Y., Kasukawa, Y., Suzuki, K., 2000. Histomorphometric evaluation of the recovering effect of human parathyroid hormone (1-34) on bone structure and turnover in streptozotocin-induced diabetic rats. Calcif. Tissue Int. 66, 229-233. (Pubitemid 30091766)
34. Tuominen, J.T., Impivaara, O., Puukka, P., Ronnemaa, T., 1999. Bone mineral density in patients with type 1 and type 2 diabetes. Diabetes Care 22, 1196-1200. (Pubitemid 29293977)
35. Werner, H., Hernandez-Sanchez, C., Karnieli, E., Leroith, D., 1995. The regulation of IGF-I receptor gene expression. Int. J. Biochem. Cell Biol. 27, 987-994.
36. Wu, X., Bishopric, N.H., Discher, D.J., Murphy, B.J., Webster, K.A., 1996. Physical and functional sensitivity of zinc finger transcription factors to redox change. Mol. Cell. Biol. 16, 1035-1046. (Pubitemid 26061675)
37. Wu, X., Itoh, N., Taniguchi, T., Nakanishi, T., Tatsu, Y., Yumoto, N., Tanaka, K., 2003. Zinc-induced sodium-dependent vitamin C transporter 2 expression: potent roles in osteoblast differentiation. Arch. Biochem. Biophys. 420, 114-120. (Pubitemid 37406663)
38. Yamaguchi, M., Goto, M., Uchiyama, S., Nakagawa, T., 2008. Effect of zinc on gene expression in osteoblastic MC3T3-E1 cells: enhancement of Runx2, OPG, and regucalcin mRNA expressions. Mol. Cell. Biochem. 312, 157-166.
39. Yamaguchi, M., Uchiyama, S., 2004. Receptor activator of NF-kappaB ligand-stimulated osteoclastogenesis in mouse marrow culture is suppressed by zinc in vitro. Int. J. Mol. Med. 14, 81-85.
40. Yavropoulou, M.P., Yovos, J.G., 2007. The role of the Wnt signaling pathway in osteoblast commitment and differentiation. Hormones (Athens) 6, 279-294.