Administration of zinc inhibits osteoclastogenesis through the suppression of RANK expression in bone

European Journal of Pharmacology

Volumn 668, Issue 1-2, 2011, Pages 140-146

  Hie, Mamiko ^a   Tsukamoto, Ikuyo ^a  

^a NARA WOMEN'S UNIVERSITY   (Japan)

Author keywords

M CSF signaling; Osteoblastogenesis; Osteoclastogenesis; RANK; Reactive oxygen species; Zinc

Indexed keywords

ACID PHOSPHATASE TARTRATE RESISTANT ISOENZYME; ALKALINE PHOSPHATASE; BETA CATENIN; BONE MORPHOGENETIC PROTEIN 2; CATHEPSIN K; COLLAGEN; COLONY STIMULATING FACTOR 1; GLUTATHIONE; LIPID PEROXIDE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; OSTEOCALCIN; OSTEOCLAST DIFFERENTIATION FACTOR; PROTEIN C FMS; PROTEIN C FOS; PROTEIN TYROSINE KINASE; REACTIVE OXYGEN METABOLITE; RECEPTOR ACTIVATOR OF NUCLEAR FACTOR KAPPA B; TRANSCRIPTION FACTOR DLX5; TRANSCRIPTION FACTOR OSTERIX; TRANSCRIPTION FACTOR RUNX2; UNCLASSIFIED DRUG; ZINC;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BONE DEVELOPMENT; CELL COUNT; CELL DIFFERENTIATION; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME ACTIVITY; FEMALE; GENE EXPRESSION; HISTOLOGY; IN VITRO STUDY; NONHUMAN; OSTEOBLAST; OSTEOCLAST; OSTEOCLASTOGENESIS; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; RAT; TIBIA;

ANIMALS; BETA CATENIN; BIOLOGICAL MARKERS; CELL COUNT; CELL DIFFERENTIATION; CORE BINDING FACTOR ALPHA 1 SUBUNIT; DOWN-REGULATION; ENZYME ACTIVATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FEMALE; MACROPHAGE COLONY-STIMULATING FACTOR; MONOCYTE-MACROPHAGE PRECURSOR CELLS; OSTEOBLASTS; OSTEOCLASTS; RATS; RATS, WISTAR; REACTIVE OXYGEN SPECIES; RECEPTOR ACTIVATOR OF NUCLEAR FACTOR-KAPPA B; RECEPTOR, MACROPHAGE COLONY-STIMULATING FACTOR; SIGNAL TRANSDUCTION; TIBIA; ZINC;

EID: 80052071591     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2011.07.003     Document Type: Article

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