Zinc deficiency suppresses matrix mineralization and retards osteogenesis transiently with catch-up possibly through Runx 2 modulation

Bone

Volumn 46, Issue 3, 2010, Pages 732-741

  Kwun, In Sook ^a   Cho, Young Eun ^a   Lomeda, Ria Ann R ^a   Shin, Hong In ^b   Choi, Je Yong ^c   Kang, Young Hee ^d   Beattie, John H ^e  

^a Andong National University   (South Korea)

^b Kyungpook National University   (South Korea)

^c Kyungpook National University School of Medicine   (South Korea)

^d Hallym University   (South Korea)

^e ROWETT RESEARCH INSTITUTE   (United Kingdom)

Author keywords

Matrix mineralization; Osteoblast differentiation gene; Osteogenesis; Runx2; Zinc

Indexed keywords

ALKALINE PHOSPHATASE; COLLAGEN TYPE 1; OSTEOCALCIN; PARATHYROID HORMONE RECEPTOR; TRANSCRIPTION FACTOR RUNX2; RUNX2 PROTEIN, MOUSE; ZINC;

ANIMAL CELL; ARTICLE; BONE DEVELOPMENT; BONE GROWTH; BONE MINERALIZATION; CELL DIFFERENTIATION; CELL STRAIN 3T3; CELL VIABILITY; CONTROLLED STUDY; DOWN REGULATION; EXTRACELLULAR MATRIX; GENE EXPRESSION; GENETIC TRANSCRIPTION; MOUSE; NONHUMAN; OSTEOBLAST; PROTEIN EXPRESSION; ZINC DEFICIENCY; ANIMAL; ANTAGONISTS AND INHIBITORS; BONE MATRIX; CELL LINE; COMPARATIVE STUDY; DEFICIENCY; GROWTH DISORDER; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; SIGNAL TRANSDUCTION; SYNDROME; TIME;

ANIMALS; BONE MATRIX; CALCIFICATION, PHYSIOLOGIC; CELL LINE; CORE BINDING FACTOR ALPHA 1 SUBUNIT; EXTRACELLULAR MATRIX; GROWTH DISORDERS; MICE; OSTEOGENESIS; SIGNAL TRANSDUCTION; SYNDROME; TIME FACTORS; ZINC;

EID: 77649181110     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2009.11.003     Document Type: Article

References (46)

1. Chesters J.K. Molecular biological approaches to nutrient-gene interactions. Proc. Nutr. Soc. 1998, 157:249-256.
2. Cousins R.J. A role of zinc in the regulation of gene expression. Proc. Nutr. Soc. 1998, 57:307-311.
3. Bremner I., Beattie J.H. Copper and Zinc metabolism in health and disease: speciation and interactions. Proc. Nutr. Soc. 1995, 54:489-499.
4. MacDonald R.S. The role of zinc in growth and cell proliferation. J. Nutr. 2000, 130(5S):1500S-1508S.
5. Lowe N.M., Fraser W.D., Jackson M.J. Is there a potential therapeutic value of copper and zinc for osteoporosis?. Proc. Nutr. Soc. 2002, 61:181-185.
6. Relea P., Revilla M., Ripoll E., Arribas I., Rico H. Zinc, biochemical markers of nutrition, and type I osteoporosis. Age Ageing 1995, 24:303-307.
7. Seco C, Revilla M, Hernandez ER, Gervas J, Gonzalez-Riola J, Villa LF, Rico H. Effects of zinc supplementation on vertebral and femoral bone mass in rats on strenuous treadmill training exercise. 1998;13:508-12.
8. Ovesen J., Moller-Madsen B., Thomsen J.S., Canscher G., Mosekilde L. The positive effects of zinc on skeletal strength in growing rats. Bone 2001, 29:565-570.
9. Rossi L., Migliaccio S., Corsi A., Marzia M., Bianco P., Teti A., et al. Reduced growth and skeletal changes in zinc-deficient growing rats are due to impaired growth plate activity and inanition. J. Nutr. 2001, 131:1142-1146.
10. Wang X., Fosmire G.J., Gay C.V., Leach R.M. Short-term zinc deficiency inhibits chondrocyte proliferation and induces cell apoptosis in the epiphyseal growth plate of young chickens. J. Nutr. 2002, 132:665-673.
11. Freake H.C., Bovoni K.E., Guda K., Huang C., Zinn S.A. Actions and interactions of thyroid hormone and zinc statu in growing rats. J. Nutr. 2001, 131:1135-1141.
12. McNall A.D., Etherton T.D., Josmire G.J. The impaired growth induced by zinc deficiency in rats is associated with decreased expression of the hepatic insulin-like growth factor I and growth hormone receptor genes. J. Nutr. 1995, 125:874-879.
13. Devine A., Rosen C., Mohan S., Baylink D., Prince R. Effects of zinc other nutritional factors on insulin-like growth factor I and insulin-like growth factor binding proteins in postmenopausal women. Am. J. Clin. Nutr. 1998, 68:200-206.
14. Hyun T.H., Barrett-Commor E., Milne D.B. Zinc intakes and plasma concentrations in men with osteoporosis: the Rancho Bernardo Study. Am. J. Clin. Nutr. 2004, 80:715-721.
15. Yamaguchi M., Fukagawa M. Role of zinc in regulation of protein tyrosine phosphatase activity in osteoblastic MC3T3-E1 cells: zinc modulation of insulin-like growth factor-1's effect. Calcif. Tissue Int. 2005, 76:32-38.
16. Lutz W., Burritt M.F., Nixon D.E., Kao P.C., Kumar R. Zinc increases the activity of vitamin D-dependent promoters in osteoblasts. Biochem. Biophy. Res. Commun. 2000, 29:1-7.
17. Wu X., Itoh N., Taniguchi T., Nakanishi T., Tatsu Y., Yumo N., et al. Zinc-induced sodium-dependent vitamin C transporter 2 expresstion: potent roles in osteoblast differentiation. Arch. Biochem. Biophys. 2003, 420:114-120.
18. Hatakeyama D., Kozawa O., otsuka T., Shibata T., Uematsu T. Zinc suppresses IL-6 synthesis by prostaglanding F2alpha in osteoblasts: inhibition of phospholipase C and phospholipase D. J. Cell. Biochem. 2002, 85:621-628.
19. Tang Z., Sahu S.N., Khadeer M.A., Bai G., Franklin R.B., Gupta A. Overexpression of the ZIP1 zinc transporter induces an osteogenic phenotype in mesenchymal stem cells. Bone 2006, 38:181-198.
20. Suzuki T., Ishihara K., Magaki H., Matsurra W., Kohda A., Okumura K., et al. Zinc transporters, Zinct5 and ZincT7, are required for the activation of alkaline phosphatases, zinc-requiring enzymes that are glycosylphosphatidylinositol-anchored to the cytoplasmic membrane. J. Biol. Chem. 2005, 280:637-643.
21. Inoue K., Matsuda K., Itoh M., Kawaguchi H., Tomoike H., Aoyagi T., et al. Osteopenia and male-specific sudden cardiac death in mice lacking a zinc transporter gene, Zinct5. Hum. Mol. Genet. 2002, 11:1775-1784.
22. Franceschi R.T. The developmental control of osteoblast-specific gene expression: role of specific transcription factors and the extracellular matrix environment. Crit. Rev. Oral Biol. Med. 1999, 10:40-57.
23. Franceschi R.T., Iyer B.S. Relationship between collagen synthesis and expression of the osteoblast phenotype in MC3T3-E1 cells. J. Bone Miner. Res. 1992, 7:235-246.
24. Franceschi R.T., Ge C., Xiao G., Roca H., Jiang D. Transcriptional regulation of osteoblasts. Cells Tissues Organs 2009, 189:144-152.
25. Ducy P, Zhang R, Geoffroy V, Ridall AL, Karsenty G. Osf2/Cbfa1: a transcriptional activator of osteoblast differentiation. Cell 19978;9:747-54.
26. Komori T. Regulation of osteoblast differentiation by transcription factors. J. Cell. Biochem. 2006, 99:1233-1239.
27. Otto F., Thornell A.P., Crompton T., Denzel A., Gilmour K.C., Rosewell I.R., et al. Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development. Cell 1997, 89:765-771.
28. Geoffroy V., Ducy P., Karsenty G. A PEBP2a/AML-1-related factor increases osteocalcin promoter activity through its binding to an osteoblast-specific cis-acting element. J. Biol. Chem. 1995, 270:30973-30979.
29. Karesenty G., Ducy P., Starbuck M., Priemel M., Shen J., Geoffroy V., et al. Cbfa1 as a regulator of osteoblast differentiation and function. Bone 1999, 25:107-108.
30. Otto F., Lübbert M., Stock M. Upstream and downstream targets of RUNX proteins. J. Cell. Biochem. 2003, 89:9-18.
31. Takada T., Suzuki N., Ito-Kato E., Noguchi Y., Ito M., Maeno M., et al. Effect of beta-alanyl-L-histidinato zinc on the differentiation of C2C12 cells. Life Sci. 2004, 76:509-520.
32. Maeno M., Ito-Kato E., Suzuki N., Takada T., Takayama T., Ito K., et al. Effect of beta-alanyl-L-histidinato zinc on the differentiation pathway of human periodontal ligament cell. Life Sci. 2004, 74:2493-2504.
33. Byers B.A., Pavlath G.K., Murphy T.J., Karsenty G., Garcia A. Cell-type-dependent up-regulation of in vitro mineralization after overexpression of the osteoblast-specific transcription factor Runx2/Cbfa 1. J. Bone Miner. Res. 2002, 17:1931-1944.
34. Wang D., Christensen K., Chawla K., Xiao G., Krebsbach P.H., Franceschi R.T. Isolation and characterization of MC3T3-E1 preosteoblast subclones with distinct in vitro and in vivo differentiation /mineralization potential. J. Bone Miner. Res. 1999, 14:893-903.
35. Bessey O.A., Lowry O.H., Brock M.J. A method for the rapid determination of alkaline phosphatase with five cubic millimeters of serum. J. Biol. Chem. 1946, 164:321-329.
36. Lowry O.H., Rosebrough N.J., Farr A.L.M., Randall R.J. Protein measurement with the folin phenol reagent. J. Biol. Chem. 1951, 193:265-275.
37. Stein G.S., Lian J.B., Owen T.A. Relationship of cell growth to the regulation of tissue-specific gene expression during osteoblast differentiation. FASEB J. 1990, 4:3111-3123.
38. Cao J., Bobo J.A., Liuzzi J.P., Cousins R.J. Effects of intracellular zinc depletion on metallothionein and ZIP2 transported expression and apoptosis. J. Leukoc. Biol. 2001, 70:559-566.
39. Lian J.B., Stein G.S. Concepts of osteoblast growth and differentiation: basis for modulation of bone cell development and tissue formation. Crit. Rev. Oral Biol. Med. 1992, 3:269-305.
40. Javed A., Barnes G.L., Jasanya B.O., Stein J.L., Gerstenfeld L., Lian J.B., et al. Runt homology domain transcipriton factors (Runx2, Cbfa, and AML) mediate repression of the one sialoprotein promoter: evidence for promoter context-dependent activity of Cbfa proteins. Mol. Cell. Biol. 2001, 21:2891-2905.
41. Qiao M., Shapiro P., Fosbrink M., Rus H., Kumar R., Passaniti A. Cell cycle-dependent phosphorylation of the RUNX2 transcription factor by cdc2 regulates endothelial cell proliferation. J. Biol. Chem. 2006, 281:7118-7128.
42. Hambidge M. Biomarkers of trace mineral intake and status. J. Nutr. 2003, 133:948S-955S.
43. Kirsch T., Harrison G., Worch K.P., Golub E.E. Regulatory roles of zinc in matrix vesicle-mediated mineralization of growth plate cartilage. J. Bone Min. Res. 2000, 15:261-270.
44. Anderson H.C. Molecular biology of matrix vesicles. Clin. Orthop. Relat. Res. 1995, 314:266-280.
45. Kanno S., Anuradha C.D., Hirano S. Localization of zinc after in vitro mineralization in osteoblastic cells. Biol. Trace Elem. Res. 2001, 83:39-47.
46. Hsu H.H.T., Anderson H.C. Effects of zinc and divalent cation chelators on ATP hydrolysis and Ca deposition by rachitic rat matrix vesicles. Bone 1995, 17:473-477.