Hepatoprotective effects of eburicoic acid and dehydroeburicoic acid from Antrodia camphorata in a mouse model of acute hepatic injury

Food Chemistry

Volumn 141, Issue 3, 2013, Pages 3020-3027

  Huang, Guan Jhong ^a   Deng, Jeng Shyan ^b   Huang, Shyh Shyun ^a   Lee, Chao Ying ^b   Hou, Wen Chi ^c   Wang, Sheng Yang ^d   Sung, Ping Jyun ^e,f   Kuo, Yueh Hsiung ^a  

^a CHINA MEDICAL UNIVERSITY   (Taiwan)

^b ASIA UNIVERSITY   (Taiwan)

^c TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^d NATIONAL CHUNG HSING UNIVERSITY   (Taiwan)

^e NATIONAL MUSEUM OF MARINE BIOLOGY AND AQUARIUM   (Taiwan)

^f NATIONAL DONG HWA UNIVERSITY   (Taiwan)

Author keywords

Anti inflammation; Antrodia camphorata; Dehydroeburicoic acid; Eburicoic acid; NO; TNF

Indexed keywords

AMINO ACIDS; ANTIOXIDANTS; CARBON; ENZYMES; NITRIC OXIDE; NOBELIUM; OXYGEN;

ALANINE AMINOTRANSFERASE; ANTI-INFLAMMATION; ANTI-INFLAMMATORY MECHANISM; ANTRODIA CAMPHORATA; ASPARTATE AMINOTRANSFERASE; HEPATOPROTECTIVE EFFECTS; INDUCIBLE NITRIC OXIDE SYNTHASE (INOS); TUMOUR NECROSIS FACTOR ALPHAS;

MAMMALS;

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CARBON TETRACHLORIDE; CATALASE; CYCLOOXYGENASE 2; CYTOCHROME P450 2E1; DEHYDROEBURICOIC ACID; EBURICOIC ACID; FUNGAL EXTRACT; GLUTATHIONE PEROXIDASE; INDUCIBLE NITRIC OXIDE SYNTHASE; LIPID PEROXIDE; LIVER PROTECTIVE AGENT; NITRIC OXIDE; SILYMARIN; SUPEROXIDE DISMUTASE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ANTRODIA CAMPHORATA; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CONTROLLED STUDY; ENZYME ACTIVITY; HISTOPATHOLOGY; LIPID PEROXIDATION; LIVER INJURY; LIVER PROTECTION; MALE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; TREATMENT DURATION; WESTERN BLOTTING;

MUS; TAIWANOFUNGUS CAMPHORATUS;

EID: 84879477473     PISSN: 03088146     EISSN: 18737072     Source Type: Journal    
DOI: 10.1016/j.foodchem.2013.03.061     Document Type: Article

References (29)

1. Aebi, H. (1984). Catalase in vitro. Methods of Enzymology, 105, 121-126.
2. Ahmed, A. F., Mahmoud, M. F., Ouf, M. A., & El-Fathaah, E. A. (2011). Aminoguanidine potentiates the hepatoprotective effect of silymarin in CCl4 treated rats. Annals of Hepatology, 10, 207-215.
3. Castro, J. A., De Ferreyra, E. C., De Castro, C. R., De Fenos, O. M., Sasame, H., & Gillette, J. R. (1974). Prevention of carbon tetrachloride-induced necrosis by inhibitors of drug metabolism -Further studies on their mechanism of action. Biochemical Pharmacology, 23, 295-302.
4. Chang, T. N., Huang, S. S., Chang, Y. S., Chang, C. I., Yang, H. L., Deng, J. S., et al. (2011). Analgesic effects and the mechanisms of anti-inflammation of taraxeren-3-one from Diospyros maritima in mice. Journal of Agricultural and Food Chemistry, 59, 9112-9119.
5. Chen, C. C., Shiao, Y. J., Lin, R. D., Shao, Y. Y., Lai, M. N., Lin, C. C., et al. (2006). Neuroprotective diterpenes from the fruiting body of Antrodia camphorata. Journal of Natural Products, 69, 689-691.
6. Choi, J. H., Kim, D. W., Yun, N., Choi, J. S., Islam, M. N., Kim, Y. S., et al. (2011). Protective effects of hyperoside against carbon tetrachloride-induced liver damage in mice. Journal of Natural Products, 74, 1055-1060.
7. Dai, Y. Y., Chuang, C. H., Tsai, C. C., Sio, H. M., Huang, S. C., Chen, J. C., et al. (2003). The protection of Antrodia camphorata against acute hepatotoxicity of alcohol in rats. Journal of Food and Drug Analysis, 11, 177-185.
8. Deng, J. Y., Chen, S. J., Jow, G. M., Hsueh, C. W., & Jeng, C. J. (2009). Dehydroeburicoic acid induces calcium-and calpain-dependent necrosis in human U87MG glioblastomas. Chemical Research in Toxicology, 22, 1817-1826.
9. Domitrovic , R., & Jakovac, H. (2010). Antifibrotic activity of anthocyanidin delphinidin in carbon tetrachloride-induced hepatotoxicity in mice. Toxicology, 272, 1-10.
10. Du, Y. C., Chang, F. R., Wu, T. Y., Hsu, Y. M., El-Shazly, M., Chen, C. F., et al. (2012). Antileukemia component, dehydroeburicoic acid from Antrodia camphorata induces DNA damage and apoptosis in vitro and in vivo models. Phytomedicine, 19, 788-796.
11. Flohe, L., & Otting, F. (1984). Superoxide dismutase assays. Methods of Enzymology, 105, 93-104. (Pubitemid 14165376)
12. Hou, Z., Qin, P., & Ren, G. (2010). Effect of anthocyanin-rich extract from black rice (Oryza sativa L. Japonica) on chronically alcohol-induced liver damage in rats. Journal of Agricultural and Food Chemistry, 58, 3191-3196.
13. Huang, G. J., Huang, S. S., Lin, S. S., Shao, Y. Y., Chen, C. C., Hou, W. C., et al. (2010). Analgesic effects and the mechanisms of anti-inflammation of ergostatrien-3bol from Antrodia camphorata submerged whole broth in mice. Journal of Agricultural and Food Chemistry, 58, 7445-7452.
14. Huang, G. J., Deng, J. S., Huang, S. S., Shao, Y. Y., Chen, C. C., & Kuo, Y. H. (2011). Protective effect of antrosterol from Antrodia camphorata submerged whole broth against carbon tetrachloride-induced acute liver injury in mice. Food Chemistry, 132, 709-716.
15. Huang, G. J., Deng, J. S., Chiu, C. S., Liao, J. C., Hsieh, W. T., Sheu, M. J., et al. (2012). Hispolon protects against acute liver damage in the rat by inhibiting lipid peroxidation, proinflammatory cytokine, oxidative stress and down-regulating the expressions of iNOS, COX-2, and MMP-9. Evidence-Based Complementary and Alternative Medicine, 2012, 480714.
16. Hseu, Y. C., Chen, S. C., Chen, H. C., Liao, J. W., & Yang, H. L. (2008). Antrodia camphorata inhibits proliferation of human breast cancer cells in vitro and in vivo. Food and Chemical Toxicology, 46, 2680-2688.
17. Ko, J. H., Lee, S. J., & Lim, K. T. (2006). Rhus verniciflua Stokes glycoprotein (36 kDa) has protective activity on carbon tetrachloride-induced liver injury in mice. Environmental Toxicology and Pharmacology, 22, 8-14.
18. Lettéron, P., Labbe, G., Degott, C., Berson, A., Fromenty, B., Delaforge, M., et al. (1990). Mechanism for the protective effects of silymarin against carbon tetrachloride-induced lipid peroxidation and hepatotoxicity in mice. Evidence that silymarin acts both as an inhibitor of metabolic activation and as a chainbreaking antioxidant. Biochemical Pharmacology, 39, 2027-2034. (Pubitemid 20187342)
19. León, F., Quintana, J., Rivera, A., Estévez, F., & Bermejo, J. (2004). Lanostanoid triterpenes from Laetiporus sulphureus and apoptosis induction on HL-60 human myeloid leukemia cells. Journal of Natural Products, 67, 2008-2011. (Pubitemid 40092546)
20. Lee, J. H., Lee, Y. J., Shin, J. K., Nam, J. W., Nah, S. Y., Kim, S. H., et al. (2009). Effects of triterpenoids from Poria cocos Wolf on the serotonin type 3A receptor-mediated ion current in Xenopus oocytes. European Journal of Pharmacology, 615, 27-32.
21. Liong, E. C., Xiao, J., Lau, T. Y., Nanji, A. A., & Tipoe, G. L. (2011). Cyclooxygenase inhibitors protect D-galactosamine/lipopolysaccharide induced acute hepatic injury in experimental mice model. Food and Chemical Toxicology, 50, 861-866.
22. Majid, E., Male, K. B., Tzeng, Y. M., Omamogho, J. O., Glennon, J. D., & Luong, J. H. (2009). Cyclodextrin-modified capillary electrophoresis for achiral and chiral separation of ergostane and lanostane compounds extracted from the fruiting body of Antrodia camphorata. Electrophoresis, 30, 1967-1975.
23. Mohammadi, M., & Yazdanparast, R. (2009). Methoxy VO-salen complex: In vitro antioxidant activity, cytotoxicity evaluation and protective effect on CCl4-induced oxidative stress in rats. Food and Chemical Toxicology, 47, 716-721.
24. Mu, Y., Liu, P., Du, G., Du, J., Wang, G., Long, A., et al. (2009). Action mechanism of Yi Guan Jian Decoction on CCl4 induced cirrhosis in rats. Journal of Ethnopharmacology, 121, 35-42.
25. Paglia, E. D., & Valentine, W. N. (1967). Studies on the quantitative and qualitative characterization of erythrocytes glutathione peroxidase. Journal of Laboratory and Clinical Medicine, 70, 158-169.
26. Risal, P., Hwang, P. H., Yun, B. S., Yi, H. K., Cho, B. H., Jang, K. Y., et al. (2012). Hispidin analogue davallialactone attenuates carbon tetrachloride-induced hepatotoxicity in mice. Journal of Natural Products, 75, 1683-1689.
27. Shao, Y. Y., Chen, C. C., Wang, H. Y., Chiu, H. L., Hseu, T. H., & Kuo, Y. H. (2008). Chemical constituents of Antrodia camphorata submerged whole broth. Natural Product Research, 22, 1151-1157.
28. Song, T. Y., & Yen, G. C. (2003). Protective effects of fermented filtrate from Antrodia camphorata in submerged culture against CCl4-induced hepatic toxicity in rats. Journal of Agricultural and Food Chemistry, 51, 1571-1577.
29. Yu, W. G., Qian, J., & Lu, Y. H. (2011). Hepatoprotective effects of 20,40-dihydroxy-60-methoxy-30,50-dimethylchalcone on CCl4-induced acute liver injury in mice. Journal of Agricultural and Food Chemistry, 59, 12821-12829.