Towards elucidation of the drug release mechanism from compressed hydrophilic matrices made of cellulose ethers. III. Critical use of thermodynamic parameters of activation for modeling the water penetration and drug release processes

Journal of Controlled Release

Volumn 170, Issue 2, 2013, Pages 175-182

  Ferrero, Carmen ^a   Massuelle, Danielle ^b   Jeannerat, Damien ^b   Doelker, Eric ^b  

^a UNIVERSITY OF SEVILLE   (Spain)

^b UNIVERSITY OF GENEVA   (Switzerland)

Author keywords

Activation energy; Caffeine; Diffusion; Drug release mechanism; Hydroxypropyl methylcellulose; Swelling

Indexed keywords

CAFFEINE; CHEMICAL ACTIVATION; DIFFUSION; DISSOLUTION; ETHERS; PH EFFECTS; SWELLING; TEMPERATURE DISTRIBUTION;

ANOMALOUS TRANSPORT; DIMENSIONAL CHANGES; DRUG RELEASE MECHANISM; EFFECT OF TEMPERATURE; HYDROXYPROPYL METHYLCELLULOSE; POLYMER DISSOLUTION; TEMPERATURE DEPENDENCE; THERMODYNAMIC PARAMETER;

ACTIVATION ENERGY;

CAFFEINE; ETHER DERIVATIVE; HYDROXYPROPYLMETHYLCELLULOSE; POLYMER; WATER; DRUG CARRIER; METHYLCELLULOSE;

ARTICLE; CONTROLLED DRUG RELEASE; CONTROLLED STUDY; DIFFUSION; DRUG DIFFUSION; DRUG SOLUBILITY; DRUG STABILITY; FICKIAN DIFFUSION; GEL; HYDROPHILICITY; KINETICS; PH; PRIORITY JOURNAL; TABLET COMPRESSION; THERMODYNAMICS; WATER PERMEABILITY; ANALOGS AND DERIVATIVES; CHEMICAL MODEL; CHEMICAL PHENOMENA; CHEMISTRY; DRUG FORMULATION;

CAFFEINE; DRUG CARRIERS; DRUG COMPOUNDING; ETHERS; HYDROGEN-ION CONCENTRATION; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; HYPROMELLOSE DERIVATIVES; METHYLCELLULOSE; MODELS, CHEMICAL; THERMODYNAMICS; WATER;

EID: 84879465797     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2013.05.016     Document Type: Article

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