Thermodynamic origin of the solubility profile of drugs showing one or two maxima against the polarity of aqueous and nonaqueous mixtures: Niflumic acid and caffeine

Journal of Pharmaceutical Sciences

Volumn 91, Issue 3, 2002, Pages 874-883

  Bustamante, P ^a   Navarro, J ^a   Romero, S ^a   Escalera, B ^a  

^a UNIVERSITY OF ALCALÁ   (Spain)

Author keywords

Caffeine; Enthalpy entropy compensation; Hydrates; Niflumic acid; Solubility parameter; Solubility profile; Solvent mixtures; Thermodynamics

Indexed keywords

ACETIC ACID ETHYL ESTER; CAFFEINE; NIFLUMIC ACID;

AQUEOUS SOLUTION; ARTICLE; CHEMICAL COMPOSITION; CORRELATION ANALYSIS; DIFFERENTIAL SCANNING CALORIMETRY; DRUG MIXTURE; DRUG SOLUBILITY; ENTHALPY; ENTROPY; EXPERIMENTAL MODEL; HYDRATION; HYDROGEN BOND; SOLID; SOLID STATE; TEMPERATURE DEPENDENCE; THERMODYNAMICS;

EID: 0036285086     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1002/jps.10076     Document Type: Article

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