Towards elucidation of the drug release mechanism from compressed hydrophilic matrices made of cellulose ethers. II. Evaluation of a possible swelling-controlled drug release mechanism using dimensionless analysis

Journal of Controlled Release

Volumn 141, Issue 2, 2010, Pages 223-233

  Ferrero, Carmen ^a   Massuelle, Danielle ^a   Doelker, Eric ^a  

^a UNIVERSITY OF GENEVA   (Switzerland)

Author keywords

Cellulose ethers; Coefficient of diffusion; Compressed hydrophilic matrices; Deborah number; Drug release mechanism; Glass transition temperature; Polymer chain relaxation; Sodium salicylate; Swelling interface number; Swelling controlled systems

Indexed keywords

CELLULOSE ETHER; CELLULOSE ETHERS; COEFFICIENT OF DIFFUSION; CONTROLLED SYSTEM; DEBORAH NUMBERS; DRUG RELEASE MECHANISM; GLASS TRANSITION TEMPERATURE; POLYMER CHAINS; SODIUM SALICYLATE;

CELLULOSE; DIFFUSION; ETHERS; GLASS; GLASS TRANSITION; HYDROPHILICITY; MECHANICAL TESTING; ORGANIC COMPOUNDS; POLYMERS; SODIUM; SUPERCONDUCTING TRANSITION TEMPERATURE; SUPRAMOLECULAR CHEMISTRY; SWELLING;

MATRIX ALGEBRA;

ETHER; HYDROXYETHYLCELLULOSE; HYDROXYPROPYLCELLULOSE; HYDROXYPROPYLMETHYLCELLULOSE; SALICYLATE SODIUM;

ARTICLE; CONTROLLED STUDY; DIMENSIONLESS ANALYSIS; DRUG RELEASE; DRUG TRANSPORT; FLOW KINETICS; GLASS TRANSITION TEMPERATURE; HYDROPHILICITY; MATHEMATICAL ANALYSIS; MOLECULAR WEIGHT; PRIORITY JOURNAL; SPECTROPHOTOMETER; SWELLING CONTROLLED DRUG RELEASE; TABLET COMPRESSION; VISCOSITY; WATER TRANSPORT;

CELLULOSE; CHEMISTRY, PHARMACEUTICAL; DELAYED-ACTION PREPARATIONS; DIFFUSION; DRUG CARRIERS; DRUG COMPOUNDING; KINETICS; METHYLCELLULOSE; MODELS, BIOLOGICAL; MOLECULAR CONFORMATION; SODIUM SALICYLATE; SOLUBILITY; TABLETS; TRANSITION TEMPERATURE; VISCOSITY; WATER;

CELLULOSE ETHERS; DIFFUSION; DRUGS; ETHERS; GLASS TRANSITION TEMPERATURE; MECHANICAL TESTS; ORGANIC COMPOUNDS; RELAXATION; SWELLING; WATER; WETTABILITY;

EID: 72249085168     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2009.09.011     Document Type: Article

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