The control of movement following traumatic brain injury

Comprehensive Physiology

Volumn 3, Issue 1, 2013, Pages 121-139

  Kozlowski, Dorothy A ^a   Leasure, J Leigh ^b   Schallert, Timothy ^c  

^a DEPAUL UNIVERSITY   (United States)

^b University of Houston   (United States)

^c UNIVERSITY OF TEXAS AT AUSTIN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL; ARTICLE; BRAIN INJURY; CONVALESCENCE; DISEASE MODEL; HUMAN; KINESIOTHERAPY; MOVEMENT (PHYSIOLOGY); NERVE CELL PLASTICITY; PATHOPHYSIOLOGY; PHYSIOLOGY;

ANIMALS; BRAIN INJURIES; DISEASE MODELS, ANIMAL; EXERCISE THERAPY; HUMANS; MOVEMENT; NEURONAL PLASTICITY; RECOVERY OF FUNCTION;

ANIMALIA;

EID: 84879430407     PISSN: None     EISSN: 20404603     Source Type: Journal    
DOI: 10.1002/cphy.c110005     Document Type: Article

References (160)

1. Adkins-Muir DL, Jones TA. Cortical electrical stimulation combined with rehabilitative training: Enhanced functional recovery and dendritic plasticity following focal cortical ischemia in rats. Neurol Res 25: 780-788, 2003.
2. Adkins DL, Voorhies AC, Jones TA. Behavioral and neuroplastic effects of focal endothelin-1 induced sensorimotor cortex lesions. Neuroscience 128: 473-486, 2004.
3. Alessio HM, Hagerman AE, Nagy S, Philip B, Byrnes RN, Woodward JL, Callahan P,Wiley RL. Exercise improves biomarkers of health and stress in animals fed ad libitum. Physiol Behav 84: 65-72, 2005.
4. Allred RP, Cappellini CH, Jones TA. The "good" limb makes the "bad" limbworse: Experience-dependent interhemispheric disruption of functional outcome after cortical infarcts in rats. Behav Neurosci 124: 124-132, 2010.
5. Allred RP, Jones TA. Maladaptive effects of learning with the lessaffected forelimb after focal cortical infarcts in rats. Exp Neurol 210: 172-181, 2008.
6. Allred RP, Maldonado MA, Hsu JE, Jones TA. Training the "lessaffected" forelimb after unilateral cortical infarcts interferes with functional recovery of the impaired forelimb in rats. Restor Neurol Neurosci 23: 297-302, 2005.
7. Ansari MA, Roberts KN, Scheff SW. A time course of contusioninduced oxidative stress and synaptic proteins in cortex in a rat model of TBI. J Neurotrauma 25: 513-526, 2008.
8. Archer T, Svensson K, Alricsson M. Physical exercise ameliorates deficits induced by traumatic brain injury. Acta Neurol Scand 125: 293-302, 2012.
9. Bell KR. Complications associated with immobility after TBI. In: Zasler ND, Katz DI, Zafonte RD, editors. Brain Injury Medicine: Principles and Practice, New York: Demos, 2007, pp. 605-615.
10. Black JE, Isaacs KR, Anderson BJ, Alcantara AA, Greenough WT. Learning causes synaptogenesis, whereas motor activity causes angiogenesis, in cerebellar cortex of adult rats. Proc Natl Acad Sci U S A 87: 5568-5572, 1990.
11. Bland S, Gonzales R, Schallert T. Movement related glutamate levels in rat hippocampus, striatum, and sensorimotor cortex. Neurosci Lett 277: 119-122, 1999.
12. Brene S, Bjornebekk A, Aberg E, Mathe AA, Olson L, Werme M. Running is rewarding and antidepressive. Physiol Behav 92: 136-140, 2007.
13. Brooks V. Handbook of Physiology. In: Brookhart JM, Mountcastle VB, editors. The Nervous System: Motor Control, Part 1, Bethesda: American Physiological Society, 1981. pp. 1480.
14. Brooks VB. Handbook of Physiology. In: Brookhart JM, Mountcastle VB, editors. The Nervous System: Motor Control, Part 2, Bethesda: American Physiological Society, 1981.
15. Bury SD, Adkins DL, Ishida JT, Kotzer CM, Eichhorn AC, Jones TA. Denervation facilitates neuronal growth in the motor cortex of rats in the presence of behavioral demand. Neurosci Lett 287: 85-88, 2000.
16. Bury SD, Eichhorn AC, Kotzer CM, Jones TA. Reactive astrocytic responses to denervation in the motor cortex of adult rats are sensitive to manipulations of behavioral experience. Neuropharmacology 39: 743-755, 2000.
17. Bury SD, Jones TA. Unilateral sensorimotor cortex lesions in adult rats facilitate motor skill learning with the "unaffected" forelimb and training-induced dendritic structural plasticity in the motor cortex. J Neurosci 22: 8597-8606, 2002.
18. Chytrova G, Ying Z, Gomez-Pinilla F. Exercise normalizes levels of MAG and Nogo-A growth inhibitors after brain trauma. Eur J Neurosci 27: 1-11, 2008.
19. Cotman CW, Berchtold NC, Christie LA. Exercise builds brain health: Key roles of growth factor cascades and inflammation. Trends Neurosci 30: 464-472, 2007.
20. Cramer SC, Chopp M. Recovery recapitulates ontogeny. Trends Neurosci 23: 265-271, 2000.
21. Dail WG, Feeney DM,Murray HM, Linn RT, Boyeson MG. Responses to cortical injury: II. Widespread depression of the activity of an enzyme in cortex remote from a focal injury. Brain Res 211: 79-89, 1981.
22. Dancause N, Barbay S, Frost SB, Plautz EJ, Chen D, Zoubina EV, Stowe AM, Nudo RJ. Extensive cortical rewiring after brain injury. J Neurosci 25: 10167-10179, 2005.
23. de Witt BW, Ehrenberg KM, McAloon RL, Panos AH, Shaw KE, Raghavan PV, Skidmore ER, Kline AE. Abbreviated environmental enrichment enhances neurobehavioral recovery comparably to continuous exposure after traumatic brain injury. Neurorehabil Neural Repair 25: 343-350, 2011.
24. DeBow SB, McKenna JE, Kolb B, Colbourne F. Immediate constraintinduced movement therapy causes local hyperthermia that exacerbates cerebral cortical injury in rats. Can J Physiol Pharmacol 82: 231-237, 2004.
25. Devine JM, Zafonte RD. Physical exercise and cognitive recovery in acquired brain injury: A review of the literature. PM R 1: 560-575, 2009.
26. Di Russo F, Incoccia C, Formisano R, Sabatini U, Zoccolotti P. Abnormal motor preparation in severe traumatic brain injury with good recovery. J Neurotrauma 22: 297-312, 2005.
27. Dixon CE, Hayes RL. Fluid percussion and cortical impact models of traumatic brain injury. In: Narayan RK, Wilberger JE, Povlishock JT, editors. Neurotrauma, New York: McGraw-Hill, 1996, pp. 1337-1346.
28. DOD. Policy Guidance for Traumatic Brain Injury (TBI): Definition and Reporting Department of Defense, 2007.
29. Dromerick AW, Lang CE, Birkenmeier RL, Wagner JM, Miller JP, Videen TO,Wolf SL, Edwards DF.Very early constraint-induced movement during stroke rehabilitation (VECTORS): A single-center RCT. Neurologyy 73: 195-201, 2009.
30. DVBIC. TBI Numbers, 2010.
31. Eng JJ, Rowe SJ, McLaren LM. Mobility status during inpatient rehabilitation: A comparison of patients with stroke and traumatic brain injury. Arch Phys Med Rehabil 83: 483-490, 2002.
32. Fang PC, Barbay S, Plautz EJ, Hoover E, Strittmatter SM, Nudo RJ. Combination of NEP 1-40 treatment and motor training enhances behavioral recovery after a focal cortical infarct in rats. Stroke 41: 544-549, 2010.
33. Faul M, Xu L,Wald MM, Coronado VG. editors Traumatic brain injury in theUnited States: Emergency department visits,Hospitalizations and Deaths 2002-2006, Centers for Disease Control and Prevention and Control NCfIPa. Atlanta, GA, 2010. pp. 74
34. Feeney DM. From laboratory to clinic: Noradrenergic enhancement of physical therapy for stroke or trauma patients. Adv Neurol 73: 383-394, 1997.
35. Feeney DM, Boyeson MG, Linn RT, Murray HM, Dail WG. Responses to cortical injury: I. Methodology and local effects of contusions in the rat. Brain Res 211: 67-77, 1981.
36. Ferguson L, Stamschror J, Lance S, Pevtsov A, Collela M, Ramos E, McDonough K, DeLaTorre R, Adkins A, Jones T, Kozlowski D. Motor rehabilitative training, exercise, and forelimb constraint after a controlled cortical impact (CCI) to the forelimb sensorimotor cortex: Differential effects on skilled motor function and recovery. National Neurotrauma Society Meeting Abstract, 2010.
37. Frost SB, Barbay S, Friel KM, Plautz EJ, Nudo RJ. Reorganization of remote cortical regions after ischemic brain injury:Apotential substrate for stroke recovery. J Neurophysiol 89: 3205-3214, 2003.
38. Fujimoto ST, Longhi L, Saatman KE, Conte V, Stocchetti N, McIntosh TK. Motor and cognitive function evaluation following experimental traumatic brain injury. Neurosci Biobehav Rev 28: 365-378, 2004.
39. Garcia AN, Shah MA, Dixon CE, Wagner AK, Kline AE. Biologic and plastic effects of experimental traumatic brain injury treatment paradigms and their relevance to clinical rehabilitation. PM R 3: S18-S27, 2011.
40. Goldstein LB. Amphetamines and related drugs in motor recovery after stroke. Phys Med Rehabil Clin N Am 14: S125-S134, 2003.
41. Goldstein LB. Neurotransmitters and motor activity: Effects on functional recovery after brain injury. NeuroRx 3: 451-457, 2006.
42. Gordon WA, Sliwinski M, Echo J, McLoughlin M, Sheerer MS, Meili TE. The benefits of exercise in individuals with traumatic brain injury: A retrospective study. J Head Trauma Rehabil 13: 58-67, 1998.
43. Greenwald BD Rigg JL. Neurorehabilitation in traumatic brain injury: Does it make a difference? Mt Sinai J Med 76: 182-189, 2009.
44. Griesbach GS. Exercise following traumatic brain injury: Is it a doubleedged sword? PMR Journal 6: S64-S72, 2011.
45. Griesbach GS, Gomez-Pinilla F, Hovda DA. The upregulation of plasticity-related proteins following TBI is disrupted with acute voluntary exercise. Brain Res 1016: 154-162, 2004.
46. Griesbach GS, Gomez-Pinilla F, Hovda DA. Time window for voluntary exercise-induced increases in hippocampal neuroplasticity molecules after traumatic brain injury is severity dependent. J Neurotrauma 24: 1161-1171, 2007.
47. Griesbach GS, Hovda DA, Gomez-Pinilla F. Exercise-induced improvement in cognitive performance after traumatic brain injury in rats is dependent on BDNF activation. Brain Res 1288: 105-115, 2009.
48. Griesbach GS, Hovda DA, Gomez-Pinilla F, Sutton RL. Voluntary exercise or amphetamine treatment, but not the combination, increases hippocampal brain-derived neurotrophic factor and synapsin I following cortical contusion injury in rats. Neuroscience 154: 530-540, 2008.
49. Griesbach GS, Hovda DA, Molteni R, Wu A, Gomez-Pinilla F. Voluntary exercise following traumatic brain injury: Brain-derived neurotrophic factor upregulation and recovery of function. Neuroscience 125: 129-139, 2004.
50. Griesbach GS, Tio DL, Vincelli J, McArthur DL, Taylor AN. Differential effects of voluntary and forced exercise after traumatic brain injury on stress responses. J Neurotrauma 29: 1426-1433, 2012
51. Hamm RJ, Temple MD, O'Dell DM, Pike BR, Lyeth BG. Exposure to environmental complexity promotes recovery of cognitive function after traumatic brain injury. J Neurotrauma 13: 41-47, 1996.
52. Hansson AC, SommerWH, Metsis M, Stromberg I, Agnati LF, Fuxe K. Corticosterone actions on the hippocampal brain-derived neurotrophic factor expression are mediated by exon IV promoter. J Neuroendocrinol 18: 104-114, 2006.
53. Harris NG, Mironova YA, Hovda DA, Sutton RL. Pericontusion axon sprouting is spatially and temporally consistent with a growthpermissive environment after traumatic brain injury. J Neuropathol Exp Neurol 69: 139-154, 2010.
54. Hellweg S, Johannes S. Physiotherapy after traumatic brain injury: A systematic review of the literature. Brain Inj 22: 365-373, 2008.
55. Hicks RR, Boggs A, Leider D, Kraemer P, Brown R, Scheff SW, Seroogy KB. Effects of exercise following lateral fluid percussion brain injury in rats. Restor Neurol Neurosci 12: 41-47, 1998.
56. Hillman CH, Erickson KI, Kramer AF. Be smart, exercise your heart: Exercise effects on brain and cognition. Nat Rev Neurosci 9: 58-65, 2008.
57. Hoffman AN, Malena RR, Westergom BP, Luthra P, Cheng JP, Aslam HA, Zafonte RD, Kline AE. Environmental enrichment-mediated functional improvement after experimental traumatic brain injury is contingent on task-specific neurobehavioral experience. Neurosci Lett 431: 226-230, 2008.
58. Hoffman JM, Bell KR, Powell JM, Behr J, Dunn EC, Dikmen S, Bombardier CH. A randomized controlled trial of exercise to improve mood after traumatic brain injury. PM R 2: 911-919.
59. Hsu JE, Jones TA. Time-sensitive enhancement of motor learning with the less-affected forelimb after unilateral sensorimotor cortex lesions in rats. Eur J Neurosci 22: 2069-2080, 2005.
60. Hsu JE, Jones TA. Contralesional neural plasticity and functional changes in the less-affected forelimb after large and small cortical infarcts in rats. Exp Neurol 201: 479-494, 2006.
61. Humm JL, Kozlowski DA, Bland ST, James DC, Schallert T. Usedependent exaggeration of brain injury: Is glutamate involved? Exp Neurol 157: 349-358, 1999.
62. Humm JL, Kozlowski DA, James DC, Gotts JE, Schallert T. Usedependent exacerbation of brain damage occurs during an early postlesion vulnerable period. Brain Res 783: 286-292, 1998.
63. Incoccia C, Formisano R, Muscato P, Reali G, Zoccolotti P. Reaction and movement times in individuals with chronic traumatic brain injury with good motor recovery. Cortex 40: 111-115, 2004.
64. Jang SH. Review of motor recovery in patients with traumatic brain injury. NeuroRehabilitation 24: 349-353, 2009.
65. Jang SH. Diffusion tensor imaging studies on corticospinal tract injury following traumatic brain injury: A review. NeuroRehabilitation 29: 339-345, 2011.
66. Jenkins WM, Merzenich MM, Ochs MT, Allard T, Guic-Robles E. Functional reorganization of primary somatosensory cortex in adult owl monkeys after behaviorally controlled tactile stimulation. J Physiol 63: 82-104, 1990.
67. Jones TA. Multiple synapse formation in the motor cortex opposite unilateral sensorimotor cortex lesions in adult rats. J Comp Neurol 414: 57-66, 1999.
68. Jones TA, Bury SD, Adkins-Muir DL, Luke LM, Allred RP, Sakata JT. Importance of behavioral manipulations and measures in rat models of brain damage and brain repair. ILAR J 44: 144-152, 2003.
69. Jones TA, Chu CJ, Grande LA, Gregory AD. Motor skills training enhances lesion-induced structural plasticity in the motor cortex of adult rats. J Neurosci 19: 10153-10163, 1999.
70. Jones TA, Jefferson SC. Reflections of experience-expectant development in repair of the adult damaged brain. Dev Psychobiol 53: 466-475, 2011.
71. Jones TA, Liput DJ, Maresh EL, Donlan N, Parikh TJ, Marlowe D, Kozlowski DA. Use-dependent dendritic regrowth is limited after unilateral controlled cortical impact to the forelimb sensorimotor cortex. J Neurotrauma 29: 1455-1468, 2012.
72. Jones TA, Schallert T.Overgrowth and pruning of dendrites in adult rats recovering from neocortical damage. Brain Res 581: 156-160, 1992.
73. Jones TA, Schallert T. Use-dependent growth of pyramidal neurons after neocortical damage. J Neurosci 14: 2140-2152, 1994.
74. Kaas JH, Merzenich MM, Killackey HP. The reorganization of somatosensory cortex following peripheral nerve damage in adult and developing mammals. Annu Rev Neurosci 6: 325-356, 1983.
75. Kasahara M, Menon DK, Salmond CH, Outtrim JG, Taylor Tavares JV, Carpenter TA, Pickard JD, Sahakian BJ, Stamatakis EA. Altered functional connectivity in the motor network after traumatic brain injury. Neurology 75: 168-176.
76. Katz DI,AlexanderMP, Klein RB. Recovery of arm function in patients with paresis after traumatic brain injury. Arch Phys Med Rehabil 79: 488-493, 1998.
77. Katz DI,White DK, AlexanderMP, Klein RB. Recovery of ambulation after traumatic brain injury. Arch Phys Med Rehabil 85: 865-869, 2004.
78. Ke Z, Yip SP, Li L, Zheng XX, Tong KY. The effects of voluntary, involuntary, and forced exercises on brain-derived neurotrophic factor and motor function recovery: A rat brain ischemia model. PLoS One 6: e16643, 2011.
79. Kleim JA, Barbay S, Cooper NR, Hogg TM, Reidel CN, Remple MS, Nudo RJ. Motor learning-dependent synaptogenesis is localized to functionally reorganized motor cortex. Neurobiol Learn Mem 77: 63-77, 2002.
80. Kleim JA, Jones TA. Principles of experience-dependent neural plasticity: Implications for rehabilitation after brain damage. J Speech Lang Hear Res 51: S225-S239, 2008.
81. KlineAE, McAloon RL,Henderson KA, Bansal UK, GantiBM, Ahmed RH, Gibbs RB, Sozda CN. Evaluation of a combined therapeutic regimen of 8-OH-DPAT and environmental enrichment after experimental traumatic brain injury. J Neurotrauma 27: 2021-2032, 2010.
82. Kline AE,Wagner AK,Westergom BP,Malena RR, Zafonte RD, Olsen AS, Sozda CN, Luthra P, Panda M, Cheng JP, Aslam HA. Acute treatment with the 5-HT(1A) receptor agonist 8-OH-DPAT and chronic environmental enrichment confer neurobehavioral benefit after experimental brain trauma. Behav Brain Res 177: 186-194, 2007.
83. Kozlowski DA, James DC, Schallert T. Use-dependent exaggeration of neuronal injury after unilateral sensorimotor cortex lesions. J Neurosci 16: 4776-4786, 1996.
84. Kozlowski DA, Jones TA, Schallert T. Pruning of dendrites and restoration of function after brain damage: Role of the NMDA receptor. J Restor Neurol Neurosci 7: 119-126, 1994.
85. Kozlowski DA, Lee SM, Hovda DA. Use-dependent degeneration following fluid percussion injury corresponds to areas of increased glucose metabolism. Abstr Soc Neurosci, 1997.
86. Kozlowski DA, Nahed BV, Hovda DA, Lee SM. Paradoxical effects of cortical impact injury on environmentally enriched rats. J Neurotrauma 21: 513-519, 2004.
87. Kozlowski DA, vonStuck SL, Lee SM, Hovda DA, Becker DP. Behaviorally-induced contusions following traumatic brain injury:Usedependent secondary insults. Abstr Soc Neurosci, 1996.
88. Krauss JK, Jankovic J. Movement disorders after TBI. In: Zasler ND, Katz DI, Zafonte RD, editors. Brain Injury Medicine: Principles and Practice, New York: Demos, 2007, pp. 469-489.
89. Krauss JK, Trankle R, Kopp KH. Post-traumatic movement disorders in survivors of severe head injury. Neurology 47: 1488-1492, 1996.
90. Krauss JK, Trankle R, Kopp KH. Posttraumatic movement disorders after moderate or mild head injury. Mov Disord 12: 428-431, 1997.
91. Krauss JK,Wakhloo AK, Nobbe F, Trankle R,Mundinger F, Seeger W. Lesion of dentatothalamic pathways in severe post-traumatic tremor. Neurol Res 17: 409-416, 1995.
92. Leasure JL, JonesM. Forced and voluntary exercise differentially affect brain and behavior. Neuroscience 156: 456-465, 2008.
93. Leasure JL, Schallert T. Consequences of forced disuse of the impaired forelimb after unilateral cortical injury. Behav Brain Res 150: 83-91, 2004.
94. Leunissen I, Coxon JP,GeurtsM, Caeyenberghs K, Michiels K, Sunaert S, Swinnen SP. Disturbed cortico-subcortical interactions during motor task switching in traumatic brain injury. Hum Brain Mapp, 2012 [Epub ahead of print].
95. Li HH, Lee SM, Cai Y, Sutton RL, Hovda DA. Differential gene expression in hippocampus following experimental brain trauma reveals distinct features of moderate and severe injuries. J Neurotrauma 21: 1141-1153, 2004.
96. Lima FD, Oliveira MS, Furian AF, Souza MA, Rambo LM, Ribeiro LR, Silva LF, Retamoso LT, Hoffmann MS, Magni DV, Pereira L, Fighera MR, Mello CF, Royes LF. Adaptation to oxidative challenge induced by chronic physical exercise prevents Na+,K+-ATPase activity inhibition after traumatic brain injury. Brain Res 1279: 147-155, 2009.
97. Lippert-Gruner M, Maegele M, Pokorny J, Angelov DN, Svestkova O, Wittner M, Trojan S. Early rehabilitation model shows positive effects on neural degeneration and recovery from neuromotor deficits following traumatic brain injury. Physiol Res 56: 359-368, 2007.
98. Long JB, Bentley TL, Wessner KA, Cerone C, Sweeney S, Bauman RA. Blast overpressure in rats: Recreating a battlefield injury in the laboratory. J Neurotrauma 26: 827-840, 2009.
99. Lotze M, Grodd W, Rodden FA, Gut E, Schonle PW, Kardatzki B, Cohen LG. Neuroimaging patterns associated with motor control in traumatic brain injury. Neurorehabil Neural Repair 20: 14-23, 2006.
100. Lu D, Qu C, Goussev A, Jiang H, Lu C, Schallert T,Mahmood A, Chen J, Li Y, Chopp M. Statins increase neurogenesis in the dentate gyrus, reduce delayed neuronal death in the hippocampal CA3 region, and improve spatial learning in rat after traumatic brain injury. J Neurotrauma 24: 1132-1146, 2007.
101. Luke LM, Allred RP, Jones TA. Unilateral ischemic sensorimotor cortical damage induces contralesional synaptogenesis and enhances skilled reaching with the ipsilateral forelimb in adult male rats. Synapse 54: 187-199, 2004.
102. Maegele M, Lippert-Gruener M, Ester-Bode T, Sauerland S, Schafer U, Molcanyi M, Lefering R, Bouillon B, Neiss WF, Angelov DN, Klug N, McIntosh TK, Neugebauer EA. Reversal of neuromotor and cognitive dysfunction in an enriched environment combined with multimodal early onset stimulation after traumatic brain injury in rats. J Neurotrauma 22: 772-782, 2005.
103. Maldonado MA, Allred RP, Felthauser EL, Jones TA. Motor skill training, but not voluntary exercise, improves skilled reaching after unilateral ischemic lesions of the sensorimotor cortex in rats. Neurorehabil Neural Repair 22: 250-261, 2008.
104. Malec JF, Brown AW, Leibson CL, Flaada JT, Mandrekar JN, Diehl NN, Perkins PK. The mayo classification system for traumatic brain injury severity. J Neurotrauma 24: 1417-1424, 2007.
105. Mark V, Taub E. Constraint-induced movement therapy for chronic stroke hemiparesis and other disabilities. Restor Neurol Neurosci 22: 317-336, 2004.
106. Marmarou A, Foda MA, van den Brink W, Campbell J, Kita H, Demetriadou K. A new model of diffuse brain injury in rats. Part I: Pathophysiology and biomechanics. J Neurosurg 80: 291-300, 1994.
107. Marshall S, Teasell R, Bayona N, Lippert C, Chundamala J, Villamere J, Mackie D, Cullen N, Bayley M. Motor impairment rehabilitation post acquired brain injury. Brain Inj 21: 133-160, 2007.
108. Mayer NH, Esquenazi A, Keenan MAE. Assessing and treating muscle overactivity in the uppermotoneuron syndrome. In: Zasler ND, Katz DI, Zafonte RD, editors. Brain Injury Medicine: Principles and Practice, New York: Demos, 2007, pp. 615-653.
109. Merzenich MM, Nelson RJ, Stryker MP, Cynader MS, Schoppmann A, Zook JM. Somatosensory cortical map changes following digit amputation in adult monkeys. J Comp Neurol 224: 591-605, 1984.
110. Minnich JE, Mann SL, Stock M, Stolzenbach KA, Mortell BM, Soderstrom KE, Bohn MC, Kozlowski DA. Glial cell line-derived neurotrophic factor (GDNF) gene delivery protects cortical neurons from dying following a traumatic brain injury. Restor Neurol Neurosci 28: 293-309, 2010.
111. Mohammed AH, Zhu SW, Darmopil S, Hjerling-Leffler J, Ernfors P, Winblad B, Diamond MC, Eriksson PS, Bogdanovic N. Environmental enrichment and the brain. Prog Brain Res 138: 109-133, 2002'.
112. Mumford N, Duckworth J, Thomas PR, Shum D, Williams G, Wilson PH. Upper-limb virtual rehabilitation for traumatic brain injury: A preliminary within-group evaluation of the elements system. Brain Inj 26: 166-176, 2012.
113. Nativ A. Brain potentials associated with movement in traumatic brain injury. Phys Ther 71: 48-59, 1991.
114. Neumann M, Wang Y, Kim S, Hong SM, Jeng L, Bilgen M, Liu J. Assessing gait impairment following experimental traumatic brain injury in mice. J Neurosci Methods 176: 34-44, 2009.
115. Nudo RJ, Dancause N. Neuroscientific basis for occupational and physical therapy interventions. In: Zasler ND, Katz DI, Zafonte RD, editors. Brain Injury Medicine: Principles and Practice, New York: Demos, 2010, pp. 913-928.
116. Nudo RJ,Milliken GW.Reorganization ofmovement representations in primary motor cortex following focal ischemic infarcts in adult squirrel monkeys. J Neurophysiol 75: 2144-2149, 1996.
117. Nudo RJ, Wise BM, SiFuentes F, Milliken GW. Neural substrates for the effects of rehabilitative training on motor recovery after ischemic infarct. Science 272: 1791-1794, 1996.
118. Oostra KM, Vereecke A, Jones K, Vanderstraeten G, Vingerhoets G. Motor imagery ability in patients with traumatic brain injury. Arch Phys Med Rehabil 93: 828-833, 2012.
119. Passineau MJ, Green EJ, Dietrich WD. Therapeutic effects of environmental enrichment on cognitive function and tissue integrity following severe traumatic brain injury in rats. Exp Neurol 168: 373-384, 2001.
120. Phillips JP, Devier DJ, Feeney DM. Rehabilitation pharmacology: Bridging laboratory work to clinical application. J Head Trauma Rehabil 18: 342-356, 2003.
121. Phillips LL, Reeves TM. Interactive pathology following traumatic brain injury modifies hippocampal plasticity. Restor Neurol Neurosci 19: 213-235, 2001.
122. Povlishock JT. An overview of brain injury Models. In: Neurotrauma, edited by Narayan RK, Wilberger JE, Povlishock JT. New York: McGraw-Hill, 1996.
123. Purves D, AugustineGJ, Fitzpatrick D, HallWC,LaMantia A-S, McNamara JO,White LE. Neuroscience ( 4th ed.). Sunderland, MA: Sinauer Associates, 2008, p. 857.
124. Qu C, Lu D, Goussev A, Schallert T, Mahmood A, Chopp M. Effect of atorvastatin on spatial memory, neuronal survival, and vascular density in female rats after traumatic brain injury. J Neurosurg 103: 695-701, 2005.
125. Quinn B, Sullivan SJ. The identification by physiotherapists of the physical problems resulting from a mild traumatic brain injury. Brain Inj 14: 1063-1076, 2000.
126. Ragnarsson KT. Traumatic brain injury research since the 1998 NIH Consensus Conference: Accomplishments and unmet goals. J Head Trauma Rehabil 21: 379-387, 2006.
127. Rinne MB, Pasanen ME, Vartiainen MV, Lehto TM, Sarajuuri JM, Alaranta HT. Motor performance in physically well-recovered men with traumatic brain injury. J Rehabil Med 38: 224-229, 2006.
128. Risedal A, Zeng J, Johansson BB. Early training may exacerbate brain damage after focal brain ischemia in the rat. J Cereb Blood Flow Metab 19: 997-1003, 1999.
129. Saatman KE, Duhaime AC, Bullock R, Maas AI, Valadka A, Manley GT. Classification of traumatic brain injury for targeted therapies. J Neurotrauma 25: 719-738, 2008.
130. Sacco K, Cauda F, D'Agata F, Duca S, Zettin M, Virgilio R, Nascimbeni A, Belforte G, Eula G, Gastaldi L, Appendino S, Geminiani G. A combined robotic and cognitive training for locomotor rehabilitation: Evidences of cerebral functional reorganization in two chronic traumatic brain injured patients. Front Hum Neurosci 5: 146, 2011.
131. Schaaf MJ, de Jong J, de Kloet ER, Vreugdenhil E. Downregulation of BDNF mRNA and protein in the rat hippocampus by corticosterone. Brain Res 813: 112-120, 1998.
132. Schallert T. Sensorimotor impairment and recovery of function in braindamaged rats: Reappearance of symptoms during old age. Behav Neurosci 97: 159-164., 1983.
133. Schallert T, Fleming SM, Leasure JL, Tillerson JL, Bland ST. CNS plasticity and assessment of forelimb sensorimotor outcome in unilateral rat models of stroke, cortical ablation, parkinsonism and spinal cord injury. Neuropharmacology 39: 777-787, 2000.
134. Schallert T, Jones TA. "Exuberant" neuronal growth after brain damage in adult rats: The essential role of behavioral experience. J Neural Transplant Plast 4: 193-198, 1993.
135. Scheff SW, Price DA, Hicks RR, Baldwin SA, Robinson S, Brackney C. Synaptogenesis in the hippocampal CA1 field following traumatic brain injury. J Neurotrauma 22: 719-732, 2005.
136. Shaw SE, Morris DM, Uswatte G, McKay S, Meythaler JM, Taub E. Constraint-induced movement therapy for recovery of upper-limb function following traumatic brain injury. J Rehabil Res Dev 42: 769-778, 2005.
137. Slobounov S, Sebastianelli W, Moss R. Alteration of posture-related cortical potentials in mild traumatic brain injury. Neurosci Lett 383: 251-255, 2005.
138. Sozda CN, Hoffman AN, Olsen AS, Cheng JP, Zafonte RD, Kline AE. Empirical comparison of typical and atypical environmental enrichment paradigms on functional and histological outcome after experimental traumatic brain injury. J Neurotrauma 27: 1047-1057, 2010.
139. Stevens MC, Lovejoy D, Kim J, Oakes H, Kureshi I, Witt ST. Multiple resting state network functional connectivity abnormalities in mild traumatic brain injury. Brain Imaging Behav, 2012.
140. SuttonRL, Lescaudron L, Stein DG. Unilateral cortical contusion injury in the rat: Vascular disruption and temporal development of cortical necrosis. J Neurotrauma 10: 135-149, 1993.
141. Swaine BR Sullivan SJ. Longitudinal profile of early motor recovery following severe traumatic brain injury. Brain Inj 10: 347-366, 1996.
142. Taub E, Crago JE, Burgio LD,Groomes TE, Cook EW, 3rd,DeLuca SC, Miller NE.An operant approach to rehabilitationmedicine: overcoming learned nonuse by shaping. J Exp Anal Behav 61: 281-293, 1994.
143. Taub E, Uswatt G. Constraint-Induced Movement therapy: answers and questions after two decades of research. NeuroRehabilitation 21: 93-95, 2006.
144. Teitelbaum P, Cheng MF, Rozin P. Development of feeding parallels its recovery after hypothalamic damage. J Comp Physiol Psychol 67: 430-441, 1969.
145. Thompson SN, Gibson TR, Thompson BM,DengY,Hall ED.Relationship of calpain-mediated proteolysis to the expression of axonal and synaptic plasticity markers following traumatic brain injury in mice. Exp Neurol 201: 253-265, 2006.
146. van Praag H, Kempermann G, Gage FH. Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus. Nature Neuroscience 2: 266-270, 1999.
147. van Praag H, Kempermann G, Gage FH. Neural consequences of environmental enrichment. Nat Rev Neurosci 1: 191-198, 2000.
148. Vaynman S, Gomez-Pinilla F. License to run: Exercise impacts functional plasticity in the intact and injured central nervous system by using neurotrophins. Neurorehabil Neural Repair 19: 283-295, 2005.
149. Voorhies AC, Jones TA. The behavioral and dendritic growth effects of focal sensorimotor cortical damage depend on the method of lesion induction. Behav Brain Res 133: 237-246, 2002.
150. Wagner AK, Kline AE, Sokoloski J, Zafonte RD, Capulong E, Dixon CE. Intervention with environmental enrichment after experimental brain trauma enhances cognitive recovery in male but not female rats. Neurosci Lett 334: 165-168, 2002.
151. Walker WC, Pickett TC.Motor impairment after severe traumatic brain injury: A longitudinal multicenter study. J Rehabil Res Dev 44: 975-982, 2007.
152. Weightman MM, Bolgla R, McCulloch KL, Peterson MD. Physical therapy recommendations for service members with mild traumatic brain injury. J Head Trauma Rehabil 25: 206-218.
153. Whishaw IQ, Piecharka DM, Zeeb F, Stein DG. Unilateral frontal lobe contusion and forelimb function: chronic quantitative and qualitative impairments in reflexive and skilled forelimb movements in rats. J Neurotrauma 21: 1584-1600, 2004.
154. Wiese H, Stude P, Nebel K, Osenberg D, Volzke V, Ischebeck W, Stolke D, Diener HC, Keidel M. Impaired movement-related potentials in acute frontal traumatic brain injury. Clin Neurophysiol 115: 289-298, 2009
155. Xiong Y, Lu D, Qu C, Goussev A, Schallert T, Mahmood A, Chopp M. Effects of erythropoietin on reducing brain damage and improving functional outcome after traumatic brain injury in mice. J Neurosurg 109: 510-521, 2008.
156. Xiong Y, Mahmood A, Lu D, Qu C, Goussev A, Schallert T, Chopp M. Role of gender in outcome after traumatic brain injury and therapeutic effect of erythropoietin in mice. Brain Res 1185: 301-312, 2007.
157. Xiong Y, Mahmood A, Meng Y, Zhang Y, Qu C, Schallert T, Chopp M. Delayed administration of erythropoietin reducing hippocampal cell loss, enhancing angiogenesis and neurogenesis, and improving functional outcome following traumatic brain injury in rats: Comparison of treatment with single and triple dose. J Neurosurg 113: 598-608, 2009.
158. Xiong Y, Mahmood A, Qu C, Kazmi H, Zhang ZG, Noguchi CT, Schallert T, Chopp M. Erythropoietin improves histological and functional outcomes after traumatic brain injury in mice in the absence of the neural erythropoietin receptor. J Neurotrauma 27: 205-215, 2010.
159. Xiong Y,Qu C, Mahmood A, Liu Z,Ning R, LiY,Kaplan DL, Schallert T, Chopp M. Delayed transplantation of human marrow stromal cellseeded scaffolds increases transcallosal neural fiber length, angiogenesis, and hippocampal neuronal survival and improves functional outcome after traumatic brain injury in rats. Brain Res 1263: 183-191, 2009.
160. Zhang Y, Xiong Y, Mahmood A, Meng Y, Qu C, Schallert T, Chopp M. Therapeutic effects of erythropoietin on histological and functional outcomes following traumatic brain injury in rats are independent of hematocrit. Brain Res 1294: 153-164, 2009