Common variants in and near IRS1 and subclinical cardiovascular disease in the Framingham Heart Study

Atherosclerosis

Volumn 229, Issue 1, 2013, Pages 149-154

  Lim, Soo ^a,b   Hong, Jaeyoung ^d   Liu, Ching Ti ^d   Hivert, Marie France ^a,e   White, Charles C ^f   Murabito, Joanne M ^g,h   O'Donnell, Christopher J ^a,h   Dupuis, Josée ^d,h   Florez, Jose C ^a,c   Meigs, James B ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b Seoul National University Bundang Hospital   (South Korea)

^c BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^d BOSTON UNIVERSITY SCHOOL OF PUBLIC HEALTH   (United States)

^e UNIVERSITÉ DE SHERBROOKE   (Canada)

^f BOSTON UNIVERSITY   (United States)

^g BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^h FRAMINGHAM HEART STUDY   (United States)

Author keywords

2q36.3; Ankle brachial index; Genetic association; IRS1; Subclinical atherosclerosis

Indexed keywords

INSULIN RECEPTOR SUBSTRATE 1;

ADULT; ANKLE BRACHIAL INDEX; ARTERIAL WALL THICKNESS; ARTICLE; ATHEROSCLEROSIS; CHROMOSOME 2Q; COMMON CAROTID ARTERY; CORONARY ARTERY DISEASE; DISEASE ASSOCIATION; FEMALE; GENE LOCUS; HUMAN; INSULIN RESISTANCE; INTERNAL CAROTID ARTERY; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM;

AGED; ANKLE BRACHIAL INDEX; AORTA, ABDOMINAL; ATHEROSCLEROSIS; CARDIOVASCULAR DISEASES; CAROTID INTIMA-MEDIA THICKNESS; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENETIC VARIATION; GENOTYPE; HUMANS; INSULIN RECEPTOR SUBSTRATE PROTEINS; MALE; MASSACHUSETTS; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK FACTORS; SEVERITY OF ILLNESS INDEX; VASCULAR CALCIFICATION;

EID: 84879416563     PISSN: 00219150     EISSN: 18791484     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2013.03.037     Document Type: Article

References (32)

1. Callow A.D. Cardiovascular disease 2005-the global picture. Vascul Pharmacol 2006, 45:302-307.
2. Behn A., Ur E. The obesity epidemic and its cardiovascular consequences. Curr Opin Cardiol 2006, 21:353-360.
3. DeFronzo R.A. Insulin resistance, lipotoxicity, type 2 diabetes and atherosclerosis: the missing links. The Claude Bernard Lecture 2009. Diabetologia 2010, 53:1270-1287.
4. Ingelsson E., Sullivan L.M., Murabito J.M., et al. Prevalence and prognostic impact of subclinical cardiovascular disease in individuals with the metabolic syndrome and diabetes. Diabetes 2007, 56:1718-1726.
5. Harrap S.B., Zammit K.S., Wong Z.Y., et al. Genome-wide linkage analysis of the acute coronary syndrome suggests a locus on chromosome 2. Arterioscler Thromb Vasc Biol 2002, 22:874-878.
6. Samani N.J., Erdmann J., Hall A.S., et al. Genomewide association analysis of coronary artery disease. NEngl J Med 2007, 357:443-453.
7. O'Donnell C.J., Cupples L.A., D'Agostino R.B., et al. Genome-wide association study for subclinical atherosclerosis in major arterial territories in the NHLBI's Framingham Heart Study. BMC Med Genet 2007, 1(8 Suppl.):S4.
8. Rung J., Cauchi S., Albrechtsen A., et al. Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia. Nat Genet 2009, 41:1110-1115.
9. Manning A.K., Hivert M.F., Scott R.A., et al. Agenome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance. Nat Genet 2012, 44:659-669.
10. Kilpelainen T.O., Zillikens M.C., Stancakova A., et al. Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile. Nat Genet 2011, 43:753-760.
11. Voight B.F., Scott L.J., Steinthorsdottir V., et al. Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Nat Genet 2010, 42:579-589.
12. Teslovich T.M., Musunuru K., Smith A.V., et al. Biological, clinical and population relevance of 95 loci for blood lipids. Nature 2010, 466:707-713.
13. Pletcher M.J., Tice J.A., Pignone M., Browner W.S. Using the coronary artery calcium score to predict coronary heart disease events: a systematic review and meta-analysis. Arch Intern Med 2004, 164:1285-1292.
14. Wong N.D., Lopez V.A., Allison M., et al. Abdominal aortic calcium and multi-site atherosclerosis: the Multiethnic Study of Atherosclerosis. Atherosclerosis 2011, 214:436-441.
15. Murabito J.M., White C.C., Kavousi M., et al. Association between chromosome 9p21 variants and the ankle-brachial index identified by a meta-analysis of 21 genome-wide association studies. Circ Cardiovasc Genet 2011, 5:100-112.
16. Rosito G.A., Massaro J.M., Hoffmann U., et al. Pericardial fat, visceral abdominal fat, cardiovascular disease risk factors, and vascular calcification in a community-based sample: the Framingham Heart Study. Circulation 2008, 117:605-613.
17. Meigs J.B., D'Agostino R.B., Wilson P.W., Cupples L.A., Nathan D.M., Singer D.E. Risk variable clustering in the insulin resistance syndrome. The Framingham Offspring Study. Diabetes 1997, 46:1594-1600.
18. Matthews D.R., Hosker J.P., Rudenski A.S., Naylor B.A., Treacher D.F., Turner R.C. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985, 28:412-419.
19. Fox C.S., Cupples L.A., Chazaro I., et al. Genomewide linkage analysis for internal carotid artery intimal medial thickness: evidence for linkage to chromosome 12. Am J Hum Genet 2004, 74:253-261.
20. Parikh N.I., Hwang S.J., Larson M.G., et al. Parental occurrence of premature cardiovascular disease predicts increased coronary artery and abdominal aortic calcification in the Framingham Offspring and Third Generation cohorts. Circulation 2007, 116:1473-1481.
21. Agatston A.S., Janowitz W.R., Hildner F.J., Zusmer N.R., Viamonte M., Detrano R. Quantification of coronary artery calcium using ultrafast computed tomography. JAm Coll Cardiol 1990, 15:827-832.
22. Greenland P., Alpert J.S., Beller G.A., et al. 2010 ACCF/AHA guideline for assessment of cardiovascular risk in asymptomatic adults: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. Circulation 2010, 122:e584-e636.
23. Li Y., Willer C.J., Ding J., Scheet P., Abecasis G.R. MaCH: using sequence and genotype data to estimate haplotypes and unobserved genotypes. Genet Epidemiol 2010, 34:816-834.
24. Dupuis J., Langenberg C., Prokopenko I., et al. New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet 2010, 42:105-116.
25. Li J., Ji L. Adjusting multiple testing in multilocus analyses using the eigenvalues of a correlation matrix. Hered (Edinb) 2005, 95:221-227.
26. Heid I.M., Jackson A.U., Randall J.C., et al. Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat Genet 2010, 42:949-960.
27. Peters S.A., den Ruijter H.M., Bots M.L., Moons K.G. Improvements in risk stratification for the occurrence of cardiovascular disease by imaging subclinical atherosclerosis: a systematic review. Heart 2012, 98:177-184.
28. Bis J.C., Kavousi M., Franceschini N., et al. Meta-analysis of genome-wide association studies from the CHARGE consortium identifies common variants associated with carotid intima media thickness and plaque. Nat Genet 2011, 43:940-947.
29. O'Donnell C.J., Kavousi M., Smith A.V., et al. Genome-wide association study for coronary artery calcification with follow-up in myocardial infarction. Circulation 2011, 124:2855-2864.
30. Doria A., Wojcik J., Xu R., et al. Interaction between poor glycemic control and 9p21 locus on risk of coronary artery disease in type 2 diabetes. JAMA 2008, 300:2389-2397.
31. Rocha V.Z., Libby P. Obesity, inflammation, and atherosclerosis. Nat Rev Cardiol 2009, 6:399-409.
32. Bertoni A.G., Wong N.D., Shea S., et al. Insulin resistance, metabolic syndrome, and subclinical atherosclerosis: the Multi-Ethnic Study of Atherosclerosis (MESA). Diabetes Care 2007, 30:2951-2956.