Plasma Fatty Acid Ratios Affect Blood Gene Expression Profiles - A Cross-Sectional Study of the Norwegian Women and Cancer Post-Genome Cohort

PLoS ONE

Volumn 8, Issue 6, 2013, Pages

  Olsen, Karina Standahl ^a   Fenton, Christopher ^a   Frøyland, Livar ^b   Waaseth, Marit ^a   Paulssen, Ruth H ^a   Lund, Eiliv ^a  

^a UNIVERSITY OF TROMSØ   (Norway)

^b INSTITUTE OF MARINE RESEARCH   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

ARACHIDONIC ACID; CARDIOVASCULAR AGENT; ICOSAPENTAENOIC ACID; LINOLEIC ACID; LINOLENIC ACID; MICRORNA; NONSTEROID ANTIINFLAMMATORY AGENT; OMEGA 3 FATTY ACID; OMEGA 6 FATTY ACID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA;

ADULT; ARTICLE; AUTOPHAGY; CARDIOVASCULAR DISEASE; COHORT ANALYSIS; CROSS-SECTIONAL STUDY; EXPLORATORY RESEARCH; FATTY ACID BLOOD LEVEL; FEMALE; FOAM CELL; GENE EXPRESSION PROFILING; HORMONE SUBSTITUTION; HUMAN; INFLAMMATION; LIPID METABOLISM; MAJOR CLINICAL STUDY; MIDDLE AGED; NEOPLASM; NORWAY; PROMOTER REGION; SIGNAL TRANSDUCTION;

COHORT STUDIES; CROSS-SECTIONAL STUDIES; FATTY ACIDS; FEMALE; GENOME, HUMAN; HUMANS; MIDDLE AGED; NEOPLASMS; NORWAY; TRANSCRIPTOME;

EID: 84879402032     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0067270     Document Type: Article

References (53)

1. Wall R, Ross RP, Fitzgerald GF, Stanton C, (2010) Fatty acids from fish: the anti-inflammatory potential of long-chain omega-3 fatty acids. Nutr Rev 68: 280-289.
2. Simopoulos AP, (2006) Evolutionary aspects of diet, the omega-6/omega-3 ratio and genetic variation: nutritional implications for chronic diseases. Biomed Pharmacother 60: 502-507.
3. Jakobsen MU, O'Reilly EJ, Heitmann BL, Pereira MA, Balter K, et al. (2009) Major types of dietary fat and risk of coronary heart disease: a pooled analysis of 11 cohort studies. Am J Clin Nutr 89: 1425-1432.
4. Duplus E, Forest C, (2002) Is there a single mechanism for fatty acid regulation of gene transcription? Biochemical Pharmacology 64: 893-901.
5. Bouwens M, van de Rest O, Dellschaft N, Bromhaar MG, de Groot LC, et al. (2009) Fish-oil supplementation induces antiinflammatory gene expression profiles in human blood mononuclear cells. Am J Clin Nutr 90: 415-424.
6. Plourde M, Cunnane SC, (2007) Extremely limited synthesis of long chain polyunsaturates in adults: implications for their dietary essentiality and use as supplements. Appl Physiol Nutr Metab 32: 619-634.
7. Spychalla JP, Kinney AJ, Browse J, (1997) Identification of an animal ω-3 fatty acid desaturase by heterologous expression in Arabidopsis. Proceedings of the National Academy of Sciences 94: 1142-1147.
8. Goodstine SL, Zheng T, Holford TR, Ward BA, Carter D, et al. (2003) Dietary (n-3)/(n-6) fatty acid ratio: possible relationship to premenopausal but not postmenopausal breast cancer risk in U.S. women. The Journal of Nutrition 133: 1409-1414.
9. Berquin IM, Edwards IJ, Chen YQ, (2008) Multi-targeted therapy of cancer by omega-3 fatty acids. Cancer Lett 269: 363-377.
10. Hibbeln JR, Nieminen LR, Blasbalg TL, Riggs JA, Lands WE, (2006) Healthy intakes of n-3 and n-6 fatty acids: estimations considering worldwide diversity. The American Journal of Clinical Nutrition 83: S1483-1493S.
11. Welch AA, Lund E, Amiano P, Dorronsoro M, Brustad M, et al. (2002) Variability of fish consumption within the 10 European countries participating in the European Investigation into Cancer and Nutrition (EPIC) study. Public Health Nutr 5: 1273-1285.
12. Brustad M, Braaten T, Lund E, (2004) Predictors for cod-liver oil supplement use [mdash] the Norwegian Women and Cancer Study. Eur J Clin Nutr 58: 128-136.
13. Ambring A, Johansson M, Axelsen M, Gan L, Strandvik B, et al. (2006) Mediterranean-inspired diet lowers the ratio of serum phospholipid n-6 to n-3 fatty acids, the number of leukocytes and platelets, and vascular endothelial growth factor in healthy subjects. Am J Clin Nutr 83: 575-581.
14. Guebre-Egziabher F, Rabasa-Lhoret R, Bonnet F, Bastard JP, Desage M, et al. (2007) Nutritional intervention to reduce the n-6//n-3 fatty acid ratio increases adiponectin concentration and fatty acid oxidation in healthy subjects. Eur J Clin Nutr.
15. Kalogeropoulos N, Panagiotakos DB, Pitsavos C, Chrysohoou C, Rousinou G, et al. (2010) Unsaturated fatty acids are inversely associated and n-6/n-3 ratios are positively related to inflammation and coagulation markers in plasma of apparently healthy adults. Clinica Chimica Acta 411: 584-591.
16. Simopoulos AP, (2008) The importance of the omega-6/omega-3 fatty acid ratio in cardiovascular disease and other chronic diseases. Experimental Biology and Medicine 233: 674-688.
17. Weaver KL, Ivester P, Seeds M, Case LD, Arm JP, et al. (2009) Effect of dietary fatty acids on inflammatory gene expression in health humans. Journal of Biological Chemistry 284: 15400-15407.
18. Afman LA, Müller M, (2012) Human nutrigenomics of gene regulation by dietary fatty acids. Progress in Lipid Research 51: 63-70.
19. Bouwens M, Grootte Bromhaar M, Jansen J, Muller M, Afman LA (2009) Postprandial dietary lipid-specific effects on human peripheral blood mononuclear cell gene expression profiles. Am J Clin Nutr: ajcn.2009.28586.
20. Griffin BA, (2008) How relevant is the ratio of dietary n-6 to n-3 polyunsaturated fatty acids to cardiovascular disease risk? Evidence from the OPTILIP study. Curr Opin Lipidol 19: 57-62.
21. Dumeaux V, Borresen-Dale AL, Frantzen JO, Kumle M, Kristensen V, et al. (2008) Gene expression analyses in breast cancer epidemiology: the Norwegian Women and Cancer postgenome cohort study. Breast Cancer Research 10: R13.
22. Lund E, Dumeaux V, Braaten T, Hjartaker A, Engeset D, et al. (2008) Cohort profile: The Norwegian Women and Cancer Study- NOWAC- Kvinner og kreft. Int J Epidemiol 37: 36-41.
23. Waaseth M, Bakken K, Dumeaux V, Olsen KS, Rylander C, et al. (2008) Hormone replacement therapy use and plasma levels of sex hormones in the Norwegian Women and Cancer Postgenome Cohort- a cross-sectional analysis. BMC Womens Health 8: 1.
24. Dumeaux V, Olsen KS, Nuel G, Paulssen RH, Borresen-Dale AL, et al. (2010) Deciphering normal blood gene expression variation-The NOWAC postgenome study. PLoS Genet 6: e1000873.
25. Dumeaux V, Lund E, Borresen-Dale AL, (2008) Comparison of globin RNA processing methods for genome-wide transcriptome analysis from whole blood. Biomarkers in Medicine 2: 11-21.
26. Troyanskaya O, Cantor M, Sherlock G, Brown P, Hastie T, et al. (2001) Missing value estimation methods for DNA microarrays. Bioinformatics 17: 520-525.
27. Bolstad BM, Irizarry RA, Astrand M, Speed TP, (2003) A comparison of normalization methods for high density oligonucleotide array data based on variance and bias. Bioinformatics 19: 185-193.
28. Araujo P, Nguyen TT, Froyland L, Wang J, Kang JX, (2008) Evaluation of a rapid method for the quantitative analysis of fatty acids in various matrices. J Chromatogr A 1212: 106-113.
29. de Aloysio D, Gambacciani M, Meschia M, Pansini F, Modena AB, et al. (1999) The effect of menopause on blood lipid and lipoprotein levels. Atherosclerosis 147: 147-153.
30. Huang da W, Sherman BT, Lempicki RA, (2009) Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nature protocols 4: 44-57.
31. Subramanian A, Tamayo P, Mootha VK, Mukherjee S, Ebert BL, et al. (2005) Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles. Proceedings of the National Academy of Sciences of the United States of America 102: 15545-15550.
32. Chapkin RS, Kim W, Lupton JR, McMurray DN, (2009) Dietary docosahexaenoic and eicosapentaenoic acid: emerging mediators of inflammation. Prostaglandins Leukot Essent Fatty Acids 81: 187-191.
33. Lee JY, Plakidas A, Lee WH, Heikkinen A, Chanmugam P, et al. (2003) Differential modulation of Toll-like receptors by fatty acids. Journal of Lipid Research 44: 479-486.
34. Brea D, Sobrino T, Rodriguez-Yanez M, Ramos-Cabrer P, Agulla J, et al. (2011) Toll-like receptors 7 and 8 expression is associated with poor outcome and greater inflammatory response in acute ischemic stroke. Clin Immunol 139: 193-198.
35. Wan JB, Huang LL, Rong R, Tan R, Wang J, et al. (2010) Endogenously decreasing tissue n-6/n-3 fatty acid ratio reduces atherosclerotic lesions in apolipoprotein E-deficient mice by inhibiting systemic and vascular inflammation. Arteriosclerosis, thrombosis, and vascular biology 30: 2487-2494.
36. Cazzola M, Calzetta L, Bettoncelli G, Novelli L, Cricelli C, et al. (2011) Asthma and comorbid medical illness. European Respiratory Journal 38: 42-49.
37. Juhn YJ, (2012) Influence of asthma epidemiology on the risk for other diseases. Allergy Asthma Immunol Res 4: 122-131.
38. Myhrstad M, Retterstøl K, Telle-Hansen V, Ottestad I, Halvorsen B, et al. (2011) Effect of marine n-3 fatty acids on circulating inflammatory markers in healthy subjects and subjects with cardiovascular risk factors. Inflammation Research 60: 309-319.
39. Cabré A, Lázaro I, Girona J, Manzanares JM, Marimón F, et al. (2008) Plasma fatty acid binding protein 4 is associated with atherogenic dyslipidemia in diabetes. Journal of Lipid Research 49: 1746-1751.
40. Furuhashi M, Ishimura S, Ota H, Miura T (2011) Lipid Chaperones and Metabolic Inflammation. International Journal of Inflammation 2011.
41. Altucci L, Leibowitz MD, Ogilvie KM, de Lera AR, Gronemeyer H, (2007) RAR and RXR modulation in cancer and metabolic disease. Nat Rev Drug Discov 6: 793-810.
42. Mauldin JP, Nagelin MH, Wojcik AJ, Srinivasan S, Skaflen MD, et al. (2008) Reduced Expression of ATP-Binding Cassette Transporter G1 Increases Cholesterol Accumulation in Macrophages of Patients With Type 2 Diabetes Mellitus. Circulation 117: 2785-2792.
43. Singh R, Cuervo AM, (2011) Autophagy in the cellular energetic balance. Cell Metab 13: 495-504.
44. Knævelsrud H, Simonsen A, (2012) Lipids in autophagy: Constituents, signaling molecules and cargo with relevance to disease. Biochimica et Biophysica Acta (BBA)- Molecular and Cell Biology of Lipids 1821: 1133-1145.
45. Rovito D, Giordano C, Vizza D, Plastina P, Barone I, et al. (2013) Omega-3 PUFA ethanolamides DHEA and EPEA induce autophagy through PPARgamma activation in MCF-7 breast cancer cells. J Cell Physiol 228: 1314-1322.
46. Trajkovski M, Hausser J, Soutschek J, Bhat B, Akin A, et al. (2011) MicroRNAs 103 and 107 regulate insulin sensitivity. Nature 474: 649-653.
47. Jiang L, Liu X, Chen Z, Jin Y, Heidbreder CE, et al. (2010) MicroRNA-7 targets IGF1R (insulin-like growth factor 1 receptor) in tongue squamous cell carcinoma cells. Biochemical Journal 432: 199-205.
48. Sebastiani G, Grieco FA, Spagnuolo I, Galleri L, Cataldo D, et al. (2011) Increased expression of microRNA miR-326 in type 1 diabetic patients with ongoing islet autoimmunity. Diabetes/Metabolism Research and Reviews 27: 862-866.
49. Würdinger T, Tannous BA, Saydam O, Skog J, Grau S, et al. (2008) miR-296 Regulates Growth Factor Receptor Overexpression in Angiogenic Endothelial Cells. Cancer Cell 14: 382-393.
50. Cazanave SC, Mott JL, Elmi NA, Bronk SF, Masuoka HC, et al. (2011) A role for miR-296 in the regulation of lipoapoptosis by targeting PUMA. Journal of Lipid Research 52: 1517-1525.
51. Hyson D, Rutledge JC, Berglund L, (2003) Postprandial lipemia and cardiovascular disease. Current atherosclerosis reports 5: 437-444.
52. Burdge GC, Powell J, Calder PC, (2006) Lack of effect of meal fatty acid composition on postprandial lipid, glucose and insulin responses in men and women aged 50-65 years consuming their habitual diets. Br J Nutr 96: 489-500.
53. Arab L, (2003) Biomarkers of Fat and Fatty Acid Intake. J Nutr 133: 925S-932.