Effect of marine n-3 fatty acids on circulating inflammatory markers in healthy subjects and subjects with cardiovascular risk factors

Inflammation Research

Volumn 60, Issue 4, 2011, Pages 309-319

  Myhrstad, Mari C W ^a   Retterstøl, Kjetil ^b,c   Telle Hansen, Vibeke H ^a,d   Ottestad, Inger ^a,d   Halvorsen, Bente ^b   Holven, Kirsten B ^d   Ulven, Stine M ^a  

^a OSLO METROPOLITAN UNIVERSITY   (Norway)

^b OSLO UNIVERSITY HOSPITAL   (Norway)

^c Norwegian Medicines Agency   (Norway)

^d UNIVERSITY OF OSLO   (Norway)

Author keywords

Atherosclerosis; Circulating inflammatory markers; Inflammation; Omega 3 fatty acids; PBMCs

Indexed keywords

BIOLOGICAL MARKER; C REACTIVE PROTEIN; DOCOSAHEXAENOIC ACID; FISH OIL; GELATINASE A; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; ICOSAPENTAENOIC ACID; INTERCELLULAR ADHESION MOLECULE 1; INTERFERON; INTERLEUKIN 1; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 13; INTERLEUKIN 18; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 6; MONOCYTE CHEMOTACTIC PROTEIN 1; OMEGA 3 FATTY ACID; TUMOR NECROSIS FACTOR; VASCULAR CELL ADHESION MOLECULE 1;

ADULT; AGED; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CONTROLLED STUDY; CYTOKINE RESPONSE; DIET SUPPLEMENTATION; FEMALE; HIGH RISK POPULATION; HUMAN; MALE; REVIEW; RISK REDUCTION; THERAPY EFFECT;

ANIMALS; BIOLOGICAL MARKERS; CARDIOVASCULAR DISEASES; DIETARY FATS; FATTY ACIDS, OMEGA-3; HUMANS; INFLAMMATION; OCEANS AND SEAS; PUBMED; RISK FACTORS;

EID: 79955930583     PISSN: 10233830     EISSN: 1420908X     Source Type: Journal    
DOI: 10.1007/s00011-010-0302-5     Document Type: Review

References (69)

1. Hu FB, et al. Fish and omega-3 fatty acid intake and risk of coronary heart disease in women. JAMA. 2002;287(14):1815-21. (Pubitemid 34303626)
2. He K, et al. Accumulated evidence on fish consumption and coronary heart disease mortality: a meta-analysis of cohort studies. Circulation. 2004;109(22):2705-11. (Pubitemid 38737914)
3. Burr ML, et al. Effects of changes in fat, fish, and fibre intakes on death and myocardial reinfarction: diet and reinfarction trial (DART). Lancet. 1989;2(8666):757-61. (Pubitemid 19234807)
4. Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial. Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto miocardico. Lancet. 1999;354(9177):447-55.
5. Tavazzi L, et al. Effect of n-3 polyunsaturated fatty acids in patients with chronic heart failure (the GISSI-HF trial): a randomised, double-blind, placebo-controlled trial. Lancet. 2008;372(9645):1223-30.
6. Yokoyama M, et al. Effects of eicosapentaenoic acid on major coronary events in hypercholesterolaemic patients (JELIS): a randomised open-label, blinded endpoint analysis. Lancet. 2007; 369(9567):1090-8. (Pubitemid 46483662)
7. Hartweg J et al. Omega-3 polyunsaturated fatty acids (PUFA) for type 2 diabetes mellitus. Cochrane Database Syst Rev. 2008;1:CD003205.
8. Harris WS. n-3 fatty acids and serum lipoproteins: human studies. Am J Clin Nutr. 1997;65(5 Suppl):1645S-54S.
9. Geleijnse JM, et al. Blood pressure response to fish oil supplementation: metaregression analysis of randomized trials. J Hypertens. 2002;20(8):1493-9. (Pubitemid 34921171)
10. Knapp HR. Dietary fatty acids in human thrombosis and hemostasis. Am J Clin Nutr. 1997;65(5 Suppl):1687S-98S.
11. Hornstra G. Influence of dietary fat type on arterial thrombosis tendency. J Nutr Health Aging. 2001;5(3):160-6. (Pubitemid 32678487)
12. Christensen JH, et al. n-3 polyunsaturated fatty acids, heart rate variability and ventricular arrhythmias in post-AMI-patients. A clinical controlled trial. Ugeskr Laeger. 1997;159(37):5525-9.
13. Nodari S, et al. The role of n-3 PUFAs in preventing the arrhythmic risk in patients with idiopathic dilated cardiomyopathy. Cardiovasc Drugs Ther. 2009;23(1):5-15.
14. Packard RR, Libby P. Inflammation in atherosclerosis: from vascular biology to biomarker discovery and risk prediction. Clin Chem. 2008;54(1):24-38. (Pubitemid 351182593)
15. Libby P, Ridker PM, Hansson GK. Inflammation in atherosclerosis: from pathophysiology to practice. J Am Coll Cardiol. 2009;54(23):2129-38.
16. Vasan RS. Biomarkers of cardiovascular disease: molecular basis and practical considerations. Circulation. 2006;113(19):2335-62. (Pubitemid 43947980)
17. Postadzhiyan AS, et al. Circulating soluble adhesion molecules ICAM-1 and VCAM-1 and their association with clinical outcome, troponin T and C-reactive protein in patients with acute coronary syndromes. Clin Biochem. 2008;41(3):126-33. (Pubitemid 351173037)
18. Hartford M, et al. C-reactive protein, interleukin-6, secretory phospholipase A2 group IIA and intercellular adhesion molecule- 1 in the prediction of late outcome events after acute coronary syndromes. J Intern Med. 2007;262(5):526-36. (Pubitemid 47620509)
19. Calder PC. n-3 polyunsaturated fatty acids, inflammation, and inflammatory diseases. Am J Clin Nutr. 2006;83(6 Suppl):1505S-19S.
20. Lopez-Garcia E, et al. Consumption of (n-3) fatty acids is related to plasma biomarkers of inflammation and endothelial activation in women. J Nutr. 2004;134(7):1806-11. (Pubitemid 38886573)
21. Madsen T, et al. C-reactive protein, dietary n-3 fatty acids, and the extent of coronary artery disease. Am J Cardiol. 2001;88(10):1139-42. (Pubitemid 33043846)
22. Geelen A, et al. Intake of n-3 fatty acids from fish does not lower serum concentrations of C-reactive protein in healthy subjects. Eur J Clin Nutr. 2004;58(10):1440-2. (Pubitemid 39377930)
23. Vega-Lopez S, et al. Supplementation with omega3 polyunsaturated fatty acids and all-rac alpha-tocopherol alone and in combination failed to exert an anti-inflammatory effect in human volunteers. Metabolism. 2004;53(2):236-40. (Pubitemid 38168897)
24. Madsen T, et al. The effect of dietary n-3 fatty acids on serum concentrations of C-reactive protein: a dose-response study. Br J Nutr. 2003;89(4):517-22. (Pubitemid 36582122)
25. Yusof HM, Miles EA, Calder P. Influence of very long-chain n-3 fatty acids on plasma markers of inflammation in middle-aged men. Prostaglandins Leukot Essent Fatty Acids. 2008;78(3):219-28. (Pubitemid 351514916)
26. Fujioka S, et al. The effects of eicosapentaenoic acid-fortified food on inflammatory markers in healthy subjects - A randomized, placebo-controlled, double-blind study. J Nutr Sci Vitaminol (Tokyo). 2006;52(4):261-5. (Pubitemid 44520054)
27. Ciubotaru I, Lee YS, Wander RC. Dietary fish oil decreases C-reactive protein, interleukin-6, and triacylglycerol to HDL-cholesterol ratio in postmenopausal women on HRT. J Nutr Biochem. 2003;14(9):513-21. (Pubitemid 37162650)
28. Tsitouras PD, et al. High omega-3 fat intake improves insulin sensitivity and reduces CRP and IL6, but does not affect other endocrine axes in healthy older adults. Horm Metab Res. 2008;40(3):199-205. (Pubitemid 351690524)
29. Pot GK, et al. No effect of fish oil supplementation on serum inflammatory markers and their interrelationships: a randomized controlled trial in healthy, middle-aged individuals. Eur J Clin Nutr. 2009;63(11):1353-9.
30. Paulo MC, et al. Influence of n-3 polyunsaturated fatty acids on soluble cellular adhesion molecules as biomarkers of cardiovascular risk in young healthy subjects. Nutr Metab Cardiovasc Dis. 2008;18(10):664-70.
31. Thies F, et al. Influence of dietary supplementation with long-chain n-3 or n-6 polyunsaturated fatty acids on blood inflammatory cell populations and functions and on plasma soluble adhesion molecules in healthy adults. Lipids. 2001;36(11):1183-93. (Pubitemid 34007971)
32. Miles EA, et al. Influence of age and dietary fish oil on plasma soluble adhesion molecule concentrations. Clin Sci (Lond). 2001;100(1):91-100. (Pubitemid 32057813)
33. Michaeli B, et al. Effects of fish oil on the neuro-endocrine responses to an endotoxin challenge in healthy volunteers. Clin Nutr. 2007;26(1):70-7. (Pubitemid 46179108)
34. Cazzola R, et al. Age- and dose-dependent effects of an eicosa-pentaenoic acid-rich oil on cardiovascular risk factors in healthy male subjects. Atherosclerosis. 2007;193(1):159-67. (Pubitemid 46776697)
35. Troseid M, et al. Serum levels of interleukin-18 are reduced by diet and n-3 fatty acid intervention in elderly high-risk men. Metabolism. 2009;58(11):1543-9.
36. Kelley DS, et al. DHA supplementation decreases serum C-reactive protein and other markers of inflammation in hyper-triglyceridemic men. J Nutr. 2009;139(3):495-501.
37. Murphy KJ, et al. Impact of foods enriched with n-3 long-chain polyunsaturated fatty acids on erythrocyte n-3 levels and cardiovascular risk factors. Br J Nutr. 2007;97(4):749-57. (Pubitemid 46470684)
38. Plat J, et al. Weight loss, but not fish oil consumption, improves fasting and postprandial serum lipids, markers of endothelial function, and inflammatory signatures in moderately obese men. J Nutr. 2007;137(12):2635-40. (Pubitemid 350255290)
39. Browning LM, et al. The impact of long chain n-3 polyunsaturated fatty acid supplementation on inflammation, insulin sensitivity and CVD risk in a group of overweight women with an inflammatory phenotype. Diabetes Obes Metab. 2007;9(1):70-80. (Pubitemid 44921044)
40. Kabir M, et al. Treatment for 2 mo with n 3 polyunsaturated fatty acids reduces adiposity and some atherogenic factors but does not improve insulin sensitivity in women with type 2 diabetes: a randomized controlled study. Am J Clin Nutr. 2007;86(6):1670-9. (Pubitemid 350232182)
41. Krebs JD, et al. Additive benefits of long-chain n-3 polyunsaturated fatty acids and weight-loss in the management of cardiovascular disease risk in overweight hyperinsulinaemic women. Int J Obes (Lond). 2006;30(10):1535-44. (Pubitemid 44470203)
42. Jellema A, Plat J, Mensink RP. Weight reduction, but not a moderate intake of fish oil, lowers concentrations of inflammatory markers and PAI-1 antigen in obese men during the fasting and postprandial state. Eur J Clin Invest. 2004;34(11):766-73. (Pubitemid 39524302)
43. Mori TA, et al. Effect of eicosapentaenoic acid and docosahexaenoic acid on oxidative stress and inflammatory markers in treated-hypertensive type 2 diabetic subjects. Free Radic Biol Med. 2003;35(7):772-81. (Pubitemid 37329480)
44. Chan DC, et al. Effect of atorvastatin and fish oil on plasma high-sensitivity C-reactive protein concentrations in individuals with visceral obesity. Clin Chem. 2002;48(6 Pt 1):877-83. (Pubitemid 34587587)
45. Accinni R, et al. Effects of combined dietary supplementation on oxidative and inflammatory status in dyslipidemic subjects. Nutr Metab Cardiovasc Dis. 2006;16(2):121-7. (Pubitemid 43384709)
46. Hjerkinn EM, et al. Influence of long-term intervention with dietary counseling, long-chain n-3 fatty acid supplements, or both on circulating markers of endothelial activation in men with long-standing hyperlipidemia. Am J Clin Nutr. 2005;81(3):583-9.
47. Berstad P, et al. Supplementation with fish oil affects the association between very long-chain n-3 polyunsaturated fatty acids in serum non-esterified fatty acids and soluble vascular cell adhesion molecule-1. Clin Sci (Lond). 2003;105(1):13-20. (Pubitemid 36819571)
48. Sampson MJ, et al. n-3 polyunsaturated fatty acid supplementation, monocyte adhesion molecule expression and proinflammatory mediators in Type 2 diabetes mellitus. Diabet Med. 2001;18(1):51-8. (Pubitemid 32158109)
49. Seljeflot I, et al. Effects of omega-3 fatty acids and/or antioxidants on endothelial cell markers. Eur J Clin Invest. 1998; 28(8):629-35. (Pubitemid 28380359)
50. Schiano V, et al. Omega-3 polyunsaturated fatty acid in peripheral arterial disease: effect on lipid pattern, disease severity, inflammation profile, and endothelial function. Clin Nutr. 2008;27(2):241-7.
51. Madsen T, Christensen JH, Schmidt EB. C-reactive protein and n-3 fatty acids in patients with a previous myocardial infarction: a placebo-controlled randomized study. Eur J Nutr. 2007;46(7):428-30. (Pubitemid 350276230)
52. Grundt H, et al. Reduction in homocysteine by n-3 polyunsaturated fatty acids after 1 year in a randomised double-blind study following an acute myocardial infarction: no effect on endothelial adhesion properties. Pathophysiol Haemost Thromb. 2003;33(2):88-95. (Pubitemid 37449283)
53. Lee KW, Blann AD, Lip GY. Effects of omega-3 polyunsaturated fatty acids on plasma indices of thrombogenesis and inflammation in patients post-myocardial infarction. Thromb Res. 2006;118(3):305-12. (Pubitemid 44067196)
54. Seierstad SL, et al. Dietary intake of differently fed salmon; the influence on markers of human atherosclerosis. Eur J Clin Invest. 2005;35(1):52-9. (Pubitemid 40187954)
55. Thies F, et al. Association of n-3 polyunsaturated fatty acids with stability of atherosclerotic plaques: a randomised controlled trial. Lancet. 2003;361(9356):477-85. (Pubitemid 36173713)
56. Johansen O, et al. The effect of supplementation with omega-3 fatty acids on soluble markers of endothelial function in patients with coronary heart disease. Arterioscler Thromb Vasc Biol. 1999;19(7):1681-6. (Pubitemid 29323826)
57. Pasterkamp G, Daemen M. Circulating cells: the biofactory for markers of atherosclerotic disease. Eur Heart J. 2008;29(22):2701-2.
58. Visvikis-Siest S, et al. Peripheral blood mononuclear cells (PBMCs): a possible model for studying cardiovascular biology systems. Clin Chem Lab Med. 2007;45(9):1154-68. (Pubitemid 47396267)
59. Lee CH, Olson P, Evans RM. Minireview: lipid metabolism, metabolic diseases, and peroxisome proliferator-activated receptors. Endocrinology. 2003;144(6):2201-7. (Pubitemid 36629867)
60. Castrillo A, et al. Liver X receptor-dependent repression of matrix metalloproteinase-9 expression in macrophages. J Biol Chem. 2003;278(12):10443- 9. (Pubitemid 36800310)
61. Joseph SB, et al. Reciprocal regulation of inflammation and lipid metabolism by liver X receptors. Nat Med. 2003;9(2):213-9. (Pubitemid 36227724)
62. Lee JY, et al. Differential modulation of Toll-like receptors by fatty acids: preferential inhibition by n-3 polyunsaturated fatty acids. J Lipid Res. 2003;44(3):479-86. (Pubitemid 37279695)
63. Wong SW, et al. Fatty acids modulate Toll-like receptor 4 activation through regulation of receptor dimerization and recruitment into lipid rafts in a reactive oxygen species-dependent manner. J Biol Chem. 2009;284(40):27384-92.
64. Oh da Y, et al. GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects. Cell. 2010;142(5):687-98.
65. Bouwens M, Afman LA, Muller M. Fasting induces changes in peripheral blood mononuclear cell gene expression profiles related to increases in fatty acid beta-oxidation: functional role of peroxisome proliferator activated receptor alpha in human peripheral blood mononuclear cells. Am J Clin Nutr. 2007;86(5):1515-23. (Pubitemid 350126259)
66. Weaver KL, et al. Effect of dietary fatty acids on inflammatory gene expression in healthy humans. J Biol Chem. 2009;284(23):15400-7.
67. Bouwens M, et al. Fish-oil supplementation induces antiinflammatory gene expression profiles in human blood mononuclear cells. Am J Clin Nutr. 2009;90(2):415-24.
68. de Roos B, et al. Identification of potential serum biomarkers of inflammation and lipid modulation that are altered by fish oil supplementation in healthy volunteers. Proteomics. 2008;8(10):1965-74.
69. Lankinen M, et al. Fatty fish intake decreases lipids related to inflammation and insulin signaling - a lipidomics approach. PLoS one. 2009;4(4):e5258.