Global metabolite profiling of human colorectal cancer xenografts in mice using HPLC-MS/MS

Journal of Proteome Research

Volumn 12, Issue 6, 2013, Pages 2980-2986

  Loftus, Neil J ^a   Lai, Lindsay ^b,c   Wilkinson, Robert W ^b   Odedra, Rajesh ^b   Wilson, Ian D ^b,d   Barnes, Alan J ^a  

^a Waters Mass Spectrometry Center   (United Kingdom)

^b ASTRAZENECA   (United Kingdom)

^c UNIVERSITY OF MANCHESTER   (United Kingdom)

^d IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

colorectal cancer; LC MS; metabolomics; metabonomics; tumor xenografts

Indexed keywords

ARACHIDONIC ACID; ICOSAPENTAENOIC ACID; LYSOPHOSPHATIDYLCHOLINE; METHIONINE; PALMITIC ACID; PHENYLALANINE; TRYPTOPHAN; TYROSINE; URIDINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COLORECTAL CANCER; CONTROLLED STUDY; GENE EXPRESSION PROFILING; HUMAN; HUMAN CELL; MALE; METABOLITE; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; NUCLEAR REPROGRAMMING; PRIORITY JOURNAL; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; TANDEM MASS SPECTROMETRY; TUMOR XENOGRAFT;

CITRUS MACROPHYLLA; MUS;

EID: 84879392620     PISSN: 15353893     EISSN: 15353907     Source Type: Journal    
DOI: 10.1021/pr400260h     Document Type: Article

References (36)

1. Fernie, A. R.; Trethewey, R. N.; Krotzky, A. J.; Willmitzer, L. Metabolite profiling: from diagnostics to systems biology Nat. Rev. Mol. Cell Biol. 2004, 5 (9) 763-769
2. Nicholson, J. K.; Wilson, I. D. Understanding 'global' systems biology: metabonomics and the continuum of metabolism Nat. Rev. Drug Discovery 2003, 2 (8) 668-676
3. Griffin, J. L. The Cinderella story of metabolic profiling: does metabolomics get to go to the functional genomics ball? Philos. Trans. R. Soc., B 2006, 361 (1465) 147-161
4. Nicholson, J. K.; Lindon, J. C. Systems biology: Metabonomics Nature 2008, 455 (7216) 1054-1056
5. Zaugg, K.; Yao, Y.; Reilly, P. T.; Kannan, K.; Kiarash, R.; Mason, J.; Huang, P.; Sawyer, S. K.; Fuerth, B.; Faubert, B.; Kalliomaki, T.; Elia, A.; Luo, X.; Nadeem, V.; Bungard, D.; Yalavarth, S.; Growney, J. D.; Wakeham, A.; Moolani, Y.; Silester, J.; Annick, T. Y.; Bakker, B.; Tsuchihara, K.; Berger, S. L.; Hill, R. P.; Jones, R. G.; Tsao, M.; Robinson, M. O.; Thompson, C. B.; Pan, G.; Mak, T. W. Carnitine palmitoyltransferase 1C promotes cell survival and tumor growth under conditions of metabolic stress Genes Dev. 2011, 25, 1041-1051
6. Stewart, J. D.; Marchan, R.; Lesjak, M. S.; Lambert, J.; Hergenroeder, R.; Ellis, J. K.; Lau, C. H.; Keun, H. C.; Schmitz, G.; Schiller, J.; Eibisch, M.; Hedberg, C.; Waldmann, H.; Ekkehart, L.; Tanner, B.; Sehouli, J.; Sagemueller, J.; Staude, H.; Steiner, E.; Hengster, J. G. Choline-releasing glycerophosphodiesterase EDI3 drives tumor cell migration and metastasis Proc. Natl. Acad. Sci. U. S. A. 2012, 109, 8155-8160
7. Mullen, A. R.; Wheaton, W. W.; Jin, E. S.; Chen, P. H.; Sullivan, L. B.; Cheng, T.; Yang, Y.; Linehaven, W. M.; Chandel, N. S.; DeBerardinis, R. J. Reductive carboxylation supports growth in tumor cells with defective mitochondria Nature 2012, 481, 385-388
8. Ward, P. S.; Thompson, C. B. Metabolic reprogramming: a cancer hallmark even warburg did not anticipate Cancer Cell 2012, 21, 297-308
9. Cairns, R. A.; Harris, I. S.; Mak, T. W. Regulation of cancer cell metabolism Nat. Rev. Cancer 2011, 11, 85-95
10. Griffin, J. L.; Kauppinen, R. A. Tumor metabolomics in animal models of human cancer J. Proteome Res. 2007, 6, 498-505
11. Voskoglou-Nomikos, T.; Pater, J. L.; Seymour, L. Clinical predictive value of the in vitro cell line, human xenograft, and mouse allograft preclinical cancer models Clin. Cancer Res. 2003, 9 (11) 4227-4239
12. Rocha, C. M.; Carrola, J.; Barros, A. S.; Gil, A. M.; Goodfellow, B. J.; Carreira, I. M.; Bernardo, J.; Gomes, A.; Sousa, V.; Carvalho, L.; Duarte, I. F. Metabolic signatures of lung cancer in biofluids: NMR-based metabonomics of blood plasma J. Proteome Res. 2011, 10 (9) 4314-4324
13. Dettmer, K.; Aronov, P. A.; Hammock, B. D. Mass spectrometry-based metabolomics Mass Spectrom. Rev. 2007, 26, 51-78
14. Smith, C. A.; O'Maille, G.; Want, E. J.; Qin, C.; Trauger, S. A.; Brandon, T. R.; Custodio, D. E.; Abagyan, R.; Siuzdak, G. METLIN: A metabolite mass spectral database Ther. Drug Monit. 2005, 27, 747-751
15. Horai, H.; Arita, M.; Kanaya, S.; Nihei, Y.; Ikeda, T.; Suwa, K.; Ojima, Y.; Tanaka, K.; Tanaka, S.; Aoshima, K.; Oda, Y.; Kakazu, Y.; Kusano, M.; Tohge, T.; Matsuda, F.; Sawada, Y.; Hirai, M. Y.; Nakanishi, H.; Ikeda, K.; Akimoto, N.; Maoka, T.; Takahashi, H.; Ara, T.; Sakurai, N.; Suzuki, H.; Shibata, D.; Neumann, S.; Iida, T.; Tanaka, K.; Funatsu, K.; Matsuura, F.; Soga, T.; Taguchi, R.; Saiot, K.; Nishioka, T. MassBank: a public repository for sharing mass spectral data for life sciences J. Mass Spectrom. 2010, 45 (7) 703-714
16. Wishart, D. S.; Knox, C.; Guo, A. C.; Eisner, R.; Young, N.; Gautam, B.; Hau, D. D.; Psychogios, N.; Dong, E.; Bouatra, S.; Mandal, R.; Sinelnikov, I.; Xia, J.; Jia, L.; Cruz, J. A.; Lim, E.; Sobsey, C. A.; Shrivastava, S.; Huang, P.; Liu, P.; Fang, L.; Peng, J.; Fradette, R.; Cheng, D.; Tzur, D.; Clements, M.; Lewis, A.; De Souza, A.; Zuniga, A.; Dawe, M.; Xiong, Y.; Clive, D.; Greiner, R.; Nazyrova, A.; Shaykhutdinov, R.; Li, L.; Vogel, H. J.; Forsythe, I. HMDB: a knowledgebase for the human metabolome Nucleic Acids Res. 2009, 37, D603-610
17. Wang, Y.; Xiao, J.; Suzek, T. O.; Zhang, J.; Wang, J.; Bryant, S. H. PubChem: a public information system for analyzing bioactivities of small molecules Nucleic Acids Res. 2009, 37 (suppl 2) W623-W633
18. Knox, C.; Shrivastava, S.; Stothard, P.; Eisner, R.; Wishart, D. S. BioSpider: a web server for automating metabolome annotations Pac. Symp. Biocomput. 2007, 145-156
19. Schmelzer, K.; Fahy, E.; Subramaniam, S.; Dennis, E. A. The lipid maps initiative in lipidomics Methods Enzymol. 2007, 432, 171-183
20. Kanehisa, M.; Araki, M.; Goto, S.; Hattori, M.; Hirakawa, M.; Itoh, M.; Katayama, T.; Kawashima, S.; Okuda, S.; Tokimatsu, T.; Yamanishi, Y. KEGG for linking genomes to life and the environment Nucleic Acids Res. 2008, 36 Database, D480-D484
21. Lean, C. L.; Mackinnon, W. B.; Delikatny, E. J.; Whitehead, R. H.; Mountford, C. E. Cell-surface fucosylation and magnetic resonance spectroscopy characterization of human malignant colorectal cells Biochemistry 1992, 31 (45) 11095-11105
22. Wilkinson, R. W.; Odedra, R.; Heaton, S. P.; Wedge, S. R.; Keen, N. J.; Crafter, C.; Foster, J. R.; Brady, M. C.; Bigley, A.; Brown, E.; Byth, K. F.; Barrass, N. C.; Mundt, K. E.; Foote, K. M.; Heron, N. M.; Jung, F. H.; Mortlock, A. A.; Boyle, F. T.; Green, S. AZD1152, a selective inhibitor of aurora B kinase, inhibits human tumor xenograft growth by inducing apoptosis Clin. Cancer Res. 2007, 13 (12) 3682-3688
23. Rantalainen, M.; Cloarec, O.; Beckonert, O.; Wilson, I. D.; Jackson, D.; Tonge, R.; Rowlinson, R.; Rayner, S.; Nickson, J.; Wilkinson, R. W.; Mills, J. D.; Trygg, J.; Nicholson, J. K.; Holmes, E. Statistically integrated metabonomic-proteomic studies on a human prostate cancer xenograft model in mice J. Proteome Res. 2006, 5 (10) 2642-2655
24. Sangster, T.; Major, H.; Plumb, R.; Wilson, A. J.; Wilson, I. D. A pragmatic and readily implemented quality control strategy for HPLC-MS and GC-MS-based metabonomic analysis Analyst 2006, 131 (10) 1075-1078
25. Gika, H. G.; Theodoridis, G. A.; Wingate, J. E.; Wilson, I. D. Within-day reproducibility of an HPLC-MS-based method for metabonomic analysis: application to human urine J. Proteome Res. 2007, 6 (8) 3291-3303
26. Dunn, W. B.; Broadhurst, D.; Begley, P.; Zelena, E.; Francis-McIntyre, S.; Anderson, N.; Brown, M.; Knowles, J. D.; Halsall, A.; Haselden, J. N.; Nicholls, A. W.; Wilson, I. D.; Kell, D. B.; Goodacre, R. Procedures for large-scale metabolic profiling of serum and plasma using gas chromatography and liquid chromatography coupled to mass spectrometry Nat. Protoc. 2011, 6 (7) 1060-1083
27. Loftus, N.; Miseki, K.; Iida, J.; Gika, H. G.; Theodoridis, G.; Wilson, I. D. Profiling and biomarker identification in plasma from different Zucker rat strains via high mass accuracy multistage mass spectrometric analysis using liquid chromatography/mass spectrometry with a quadrupole ion trap-time of flight mass spectrometer Rapid Commun. Mass Spectrom. 2008, 22 (16) 2547-2554
28. Smith, C. A.; Want, E. J.; O'Maille, G.; Abagyan, R.; Siuzdak, G. XCMS: Processing mass spectrometry data for metabolite profiling using nonlinear peak alignment, matching, and identification Anal. Chem. 2006, 78, 779-787
29. Baran, R.; Kochi, H.; Saito, N.; Suematsu, M.; Soga, T.; Nishioka, T.; Robert, M.; Tomita, M. MathDAMP: a package for differential analysis of metabolite profiles BMC Bioinf. 2006, 7, 530
30. Lommen, A. MetAlign: Interface-driven, versatile metabolomics tool for hyphenated full-scan mass spectrometry data preprocessing Anal. Chem. 2009, 81 (8) 3079-3086
31. Katajamaa, M.; Miettinen, J.; Oresic, M. MZmine: toolbox for processing and visualization of mass spectrometry based molecular profile data Bioinformatics 2006, 22 (5) 634-636
32. Chan, E. C. Y.; Koh, P. K.; Mal, M.; Cheah, P. Y.; Eu, K. W.; Backshall, A.; Cavill, R.; Nicholson, J. K.; Keun, H. C. Metabolic profiling of human colorectal cancer using high-resolution magic angle spinning nuclear magnetic resonance (HR-MAS NMR) spectroscopy and gas chromatography mass spectrometry (GC/MS) J. Proteome Res. 2008, 8 (1) 352-361
33. Seierstad, T.; Roe, K.; Sitter, B.; Halgunset, J.; Flatmark, K.; Ree, A.; Olsen, D.; Gribbestad, I.; Bathen, T. Principal component analysis for the comparison of metabolic profiles from human rectal cancer biopsies and colorectal xenografts using high-resolution magic angle spinning 1H magnetic resonance spectroscopy Mol. Cancer 2008, 7 (1) 33
34. Denkert, C.; Budczies, J.; Weichert, W.; Wohlgemuth, G.; Scholz, M.; Kind, T.; Niesporek, S.; Noske, A.; Buckendahl, A.; Dietel, M.; Fiehn, O. Metabolite profiling of human colon carcinoma-deregulation of TCA cycle and amino acid turnover Mol. Cancer 2008, 7 (1) 72
35. Hakomori, S.-i. Tumor malignancy defined by aberrant glycosylation and sphingo(glyco)lipid metabolism Cancer Res. 1996, 56 (23) 5309-5318
36. Hirayama, A.; Kami, K.; Sugimoto, M.; Sugawara, M.; Toki, N.; Onozuka, H.; Kinoshita, T.; Saito, N.; Ochiai, A.; Tomita, M.; Esumi, H.; Soga, T. Quantitative metabolome profiling of colon and stomach cancer microenvironment by capillary electrophoresis time-of-flight mass spectrometry Cancer Res. 2009, 69, 4918-4925