Alterations of blood-brain barrier and associated factors in acute liver failure

Gastroenterology Research and Practice

Volumn 2013, Issue , 2013, Pages

  Cui, Wei ^a   Sun, Cui Ming ^a   Liu, Pei ^a  

^a CHINA MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

AMMONIA; GELATINASE B; INTERLEUKIN 1; INTERLEUKIN 6; TUMOR NECROSIS FACTOR ALPHA;

ACUTE LIVER FAILURE; BASEMENT MEMBRANE; BLOOD BRAIN BARRIER; BRAIN CAPILLARY; BRAIN EDEMA; CELL VACUOLE; DISEASE ASSOCIATION; HUMAN; MEMBRANE PERMEABILITY; MEMBRANE TRANSPORT; NONHUMAN; PERICYTE; PH; REVIEW; TIGHT JUNCTION; ULTRASTRUCTURE;

EID: 84879386664     PISSN: 16876121     EISSN: 1687630X     Source Type: Journal    
DOI: 10.1155/2013/841707     Document Type: Review

References (57)

1. Lee W. M., Squires R. H. Jr., Nyberg S. L., Doo E., Hoofnagle J. H., Acute liver failure: summary of a workshop. Hepatology 2008 47 4 1401 1415 2-s2.0-42249102412 10.1002/hep.22177
2. Vaquero J., Blei A. T., Etiology and management of fulminant hepatic failure. Current Gastroenterology Reports 2003 5 1 39 47 10.1007/s11894-003- 0008-8
3. Shawcross D. L., Wendon J. A., The neurological manifestations of acute liver failure. Neurochemistry International 2012 60 7 662 671 10.1016/j.neuint.2011.10.006
4. Kimelberg H. K., Water homeostasis in the brain: basic concepts. Neuroscience 2004 129 4 851 860 2-s2.0-9344258586 10.1016/j.neuroscience.2004. 07.033
5. Klatzo I., Neuropathological aspects of brain edema. Journal of Neuropathology and Experimental Neurology 1967 26 1 1 14 2-s2.0-0014046826
6. Kato M., Hughes R. D., Keays R. T., Williams R., Electron microscopic study of brain capillaries in cerebral edema from fulminant hepatic failure. Hepatology 1992 15 6 1060 1066 2-s2.0-0026628303 10.1002/hep.1840150615
7. Traber P. G., Canto M. D., Ganger D. R., Blei A. T., Electron microscopic evaluation of brain edema in rabbits with galactosamine-induced fulminant hepatic failure: ultrastructure and integrity of the blood-brain barrier. Hepatology 1987 7 6 1272 1277 2-s2.0-0023607036
8. Gove C. D., Hughes R. D., Ede R. J., Williams R., Regional cerebral edema and chloride space in galactosamine-induced liver failure in rats. Hepatology 1997 25 2 295 301 2-s2.0-0031014486
9. Nguyen J. H., Blood-brain barrier in acute liver failure. Neurochemistry International 2012 60 7 676 683 10.1016/j.neuint.2011.10.012
10. Wright G., Sharifi Y., Jalan R., Blood-brain barrier in liver failure: are cracks appearing in the wall? Liver International 2010 30 8 1087 1090 2-s2.0-79951657220 10.1111/j.1478-3231.2010.02282.x
11. Chen F., Ohashi N., Li W., Eckman C., Nguyen J. H., Disruptions of occludin and claudin-5 in brain endothelial cells in vitro and in brains of mice with acute liver failure. Hepatology 2009 50 6 1914 1923 2-s2.0-73149087504 10.1002/hep.23203
12. Lv S., Song H. L., Zhou Y., Li L. X., Cui W., Wang W., Liu P., Tumour necrosis factor- α affects blood-brain barrier permeability and tight junction-associated occludin in acute liver failure. Liver International 2010 30 8 1198 1210 2-s2.0-79951624699 10.1111/j.1478-3231.2010.02211.x
13. Skowrońska M., Zielińska M., Wójcik-Stanaszek L., Ruszkiewicz J., Milatovic D., Aschner M., Albrecht J., Ammonia increases paracellular permeability of rat brain endothelial cells by a mechanism encompassing oxidative/nitrosative stress and activation of matrix metalloproteinases. Journal of Neurochemistry 2012 121 1 125 134 10.1111/j.1471-4159.2012.07669.x
14. Nguyen J. H., Yamamoto S., Steers J., Sevlever D., Lin W., Shimojima N., Castanedes-Casey M., Genco P., Golde T., Richelson E., Dickson D., McKinney M., Eckman C. B., Matrix metalloproteinase-9 contributes to brain extravasation and edema in fulminant hepatic failure mice. Journal of Hepatology 2006 44 6 1105 1114 2-s2.0-33746924079 10.1016/j.jhep.2005.09.019
15. Abbott N. J., Patabendige A. A. K., Dolman D. E. M., Yusof S. R., Begley D. J., Structure and function of the blood-brain barrier. Neurobiology of Disease 2010 37 1 13 25 2-s2.0-70449529433 10.1016/j.nbd.2009.07.030
16. Vorbrodt A. W., Dobrogowska D. H., Molecular anatomy of intercellular junctions in brain endothelial and epithelial barriers: electron microscopist's view. Brain Research Reviews 2003 42 3 221 242 2-s2.0-0038730794 10.1016/S0165-0173(03)00177-2
17. Liu W. Y., Wang Z. B., Zhang L. C., Wei X., Li L., Tight junction in blood-brain barrier: an overview of structure, regulation, and regulator substances. CNS Neuroscience & Therapeutics 2012 18 8 609 615 10.1111/j.1755-5949.2012.00340.x
18. Sandoval K. E., Witt K. A., Blood-brain barrier tight junction permeability and ischemic stroke. Neurobiology of Disease 2008 32 2 200 219 2-s2.0-53749096762 10.1016/j.nbd.2008.08.005
19. Livingstone A. S., Potvin M., Goresky C. A., Changes in the blood-brain barrier in hepatic coma after hepatectomy in the rat. Gastroenterology 1977 73 4, part 1 697 704 2-s2.0-0017669099
20. Kristiansen R. G., Lindal S., Myreng K., Neuropathological changes in the brain of pigs with acute liver failure. Scandinavian Journal of Gastroenterology 2010 45 7-8 935 943
21. Thumburu K. K., Taneja S., Vasishta R. K., Dhiman R. K., Neuropathology of acute liver failure. Neurochemistry International 2012 60 7 672 675 10.1016/j.neuint.2011.10.013
22. Laursen H., Schrøder H., Westergaard E., The effect of portocaval anastomosis on the permeability to horseradish peroxidase of cerebral vessels of the rat. Acta Pathologica Microbiologica Scandinavica A 1975 83 2 266 268 2-s2.0-0016693131
23. Ott P., Larsen F. S., Blood-brain barrier permeability to ammonia in liver failure: a critical reappraisal. Neurochemistry International 2004 44 4 185 198 2-s2.0-0242331238 10.1016/S0197-0186(03)00153-0
24. Dixit V., Chang T. M. S., Brain edema and the blood brain barrier in galactosamine-induced fulminant hepatic failure rats. An animal model for evaluation of liver support systems. ASAIO Transactions 1990 36 1 21 27 2-s2.0-0025270484
25. Cauli O., López-Larrubia P., Rodrigo R., Agusti A., Boix J., Nietocharques L., Cerdn S., Felipo V., Brain region-selective mechanisms contribute to the progression of cerebral alterations in acute liver failure in rats. Gastroenterology 2011 140 2 638 645 2-s2.0-79251552307 10.1053/j.gastro.2010.10.043
26. Zaki A. E. O., Wardle E. N., Canalese J., Potential toxins of acute liver failure and their effects on blood-brain barrier permeability. Experientia 1983 39 9 988 991 2-s2.0-0020633854
27. Horowitz M. E., Schafer D. F., Molnar P., Increased blood-brain transfer in a rabbit model of acute liver failure. Gastroenterology 1983 84 5, part 1 1003 1011 2-s2.0-0020570402
28. Chavarria L., Oria M., Romero-Gimenez J., Alonso J., Lope-Piedrafita S., Cordoba J., Diffusion tensor imaging supports the cytotoxic origin of brain edema in a rat model of acute liver failure. Gastroenterology 2010 138 4 1566 1573 2-s2.0-77949854341 10.1053/j.gastro.2009.10.003
29. Sarna G. S., Bradbury M. W. B., Cavanagh J., Permeability of the blood-brain barrier after portocaval anastomosis in the rat. Brain Research 1977 138 3 550 554 2-s2.0-0017704958 10.1016/0006-8993(77)90692-8
30. Alexander B., Li X., Benjamin I. S., Segal M. B., Sherwood R., Preston J. E., A quantitative evaluation of the permeability of the blood brain barrier of portacaval shunted rats. Metabolic Brain Disease 2000 15 2 93 103 2-s2.0-0033783671
31. Wang W., Lv S., Zhou Y., Fu J., Li C., Liu P., Tumor necrosis factor- α affects blood-brain barrier permeability in acetaminophen-induced acute liver failure. European Journal of Gastroenterology and Hepatology 2011 23 7 552 558 2-s2.0-79960102812 10.1097/MEG.0b013e3283470212
32. Goldbecker A., Buchert R., Berding G., Bokemeyer M., Lichtinghagen R., Wilke F., Ahl B., Weissenborn K., Blood-brain barrier permeability for ammonia in patients with different grades of liver fibrosis is not different from healthy controls. Journal of Cerebral Blood Flow and Metabolism 2010 30 7 1384 1393 2-s2.0-77954242705 10.1038/jcbfm.2010.22
33. Ahl B., Weissenborn K., van den Hoff J., Fischer-Wasels D., Köstler H., Hecker H., Burchert W., Regional differences in cerebral blood flow and cerebral ammonia metabolism in patients with cirrhosis. Hepatology 2004 40 1 73 79 2-s2.0-3042737335 10.1002/hep.20290
34. Lockwood A. H., Yap E. W. H., Wong W. H., Cerebral ammonia metabolism in patients with severe liver disease and minimal hepatic encephalopathy. Journal of Cerebral Blood Flow and Metabolism 1991 11 2 337 341 2-s2.0-0025979046
35. 13N-ammonia PET. Metabolic Brain Disease 2007 22 3-4 277 284 2-s2.0-35448997403 10.1007/s11011-007-9066-1
36. Bhatia V., Singh R., Acharya S. K., Predictive value of arterial ammonia for complications and outcome in acute liver failure. Gut 2006 55 1 98 104 2-s2.0-29244463889 10.1136/gut.2004.061754
37. Zwirner K., Thiel C., Thiel K., Morgalla M. H., Königsrainer A., Schenk M., Extracellular brain ammonia levels in association with arterial ammonia, intracranial pressure and the use of albumin dialysis devices in pigs with acute liver failure. Metabolic Brain Disease 2010 25 4 407 412 2-s2.0-78751585393 10.1007/s11011-010-9222-x
38. Bémeur C., Qu H., Desjardins P., Butterworth R. F., IL-1 or TNF receptor gene deletion delays onset of encephalopathy and attenuates brain edema in experimental acute liver failure. Neurochemistry International 2010 56 2 213 215 2-s2.0-77149125563 10.1016/j.neuint.2009.11.010
39. Jiang W., Desjardins P., Butterworth R. F., Direct evidence for central proinflammatory mechanisms in rats with experimental acute liver failure: protective effect of hypothermia. Journal of Cerebral Blood Flow and Metabolism 2009 29 5 944 952 2-s2.0-65549138899 10.1038/jcbfm.2009.18
40. Skowrońska M., Albrecht J., Alterations of blood brain barrier function in hyperammonemia: an overview. Neurotoxicity Research 2012 21 2 236 244 10.1007/s12640-011-9269-4
41. Yamamoto S., Nguyen J. H., TIMP-1/MMP-9 imbalance in brain edema in rats with fulminant hepatic failure. Journal of Surgical Research 2006 134 2 307 314 2-s2.0-33746189720 10.1016/j.jss.2005.11.588
42. Wright G., Shawcross D., Olde Damink S. W. M., Brain cytokine flux in acute liver failure and its relationship with intracranial hypertension. Metabolic Brain Disease 2007 22 3-4 375 388 2-s2.0-35448939296 10.1007/s11011-007-9071-4
43. Odeh M., Sabo E., Srugo I., Oliven A., Relationship between tumor necrosis factor-alpha and ammonia in patients with hepatic encephalopathy due to chronic liver failure. Annals of Medicine 2005 37 8 603 612 2-s2.0-28844437921 10.1080/07853890500317414
44. Jalan R., Olde Damink S. W., Hayes P. C., Deutz N. E. P., Lee A., Pathogenesis of intracranial hypertension in acute liver failure: inflammation, ammonia and cerebral blood flow. Journal of Hepatology 2004 41 4 613 620 2-s2.0-4644341574 10.1016/j.jhep.2004.06.011
45. Tsao N., Hsu H. P., Wu C. M., Liu C. C., Lei H. Y., Tumour necrosis factor- α causes an increase in blood-brain barrier permeability during sepsis. Journal of Medical Microbiology 2001 50 9 812 821 2-s2.0-0034873862
46. Ábrahám C. S., Deli M. A., Joó F., Megyeri P., Torpier G., Intracarotid tumor necrosis factor- α administration increases the blood-brain barrier permeability in cerebral cortex of the newborn pig: quantitative aspects of double-labelling studies and confocal laser scanning analysis. Neuroscience Letters 1996 208 2 85 88 2-s2.0-0029922884 10.1016/0304-3940(96)12546-5
47. Mayhan W. G., Cellular mechanisms by which tumor necrosis factor- α produces disruption of the blood-brain barrier. Brain Research 2002 927 2 144 152 2-s2.0-0037081555 10.1016/S0006-8993(01)03348-0
48. Chen G., Zhang S., Shi J., Ai J., Qi M., Hang C., Simvastatin reduces secondary brain injury caused by cortical contusion in rats: possible involvement of TLR4/NF- B pathway. Experimental Neurology 2009 216 2 398 406 2-s2.0-62049083748 10.1016/j.expneurol.2008.12.019
49. Aslam M., Ahmad N., Srivastava R., Hemmer B., TNF-alpha induced NF B signaling and p65 (RelA) overexpression repress Cldn5 promoter in mouse brain endothelial cells. Cytokine 2012 57 2 269 275 10.1016/j.cyto.2011.10.016
50. Defazio G., Nico B., Trojano M., Ribatti D., Giorelli M., Ricchiuti F., Martino D., Roncali L., Livrea P., Inhibition of protein kinase C counteracts TNF α -induced intercellular adhesion molecule 1 expression and fluid phase endocytosis on brain microvascular endothelial cells. Brain Research 2000 863 1-2 245 248 2-s2.0-0034724969 10.1016/S0006-8993(00)02127-2
51. Chen F., Hori T., Ohashi N., Baine A. M., Eckman C. B., Nguyen J. H., Occludin is regulated by epidermal growth factor receptor activation in brain endothelial cells and brains of mice with acute liver failure. Hepatology 2011 53 4 1294 1305 2-s2.0-79953750268 10.1002/hep.24161
52. Chen F., Radisky E. S., Das P., Batra J., Hata T., Hori T., Baine A. M., Gardner L., Yue M. Y., Bu G., Del Zoppo G., Patel T. C., Nguyen J. H., TIMP-1 attenuates blood-brain barrier permeability in mice with acute liver failure. Journal of Cerebral Blood Flow & Metabolism 2013 10.1038/jcbfm.2013.45
53. Jessy J., Mans A. M., DeJoseph M. R., Hawkins R. A., Hyperam-monaemia causes many of the changes found after portacaval shunting. Biochemical Journal 1990 272 2 311 317 2-s2.0-0025647946
54. Skowrońska M., Zielińska M., Wójcik-Stanaszek L., Ruszkiewicz J., Milatovic D., Aschner M., Albrecht J., Ammonia increases paracellular permeability of rat brain endothelial cells by a mechanism encompassing oxidative/nitrosative stress and activation of matrix metalloproteinases. Journal of Neurochemistry 2012 121 1 125 134 10.1111/j.1471-4159.2012.07669.x
55. Iversen P., Sørensen M., Bak L. K., Waagepetersen H. S., Vafaee M. S., Borghammer P., Mouridsen K., Jensen S. B., Vilstrup H., Schousboe A., Ott P., Gjedde A., Keiding S., Low cerebral oxygen consumption and blood flow in patients with cirrhosis and an scute episode of hepatic encephalopathy. Gastroenterology 2009 136 3 863 871 2-s2.0-60449114813 10.1053/j.gastro.2008.10. 057
56. Dam G., Keiding S., Munk O. L., Ott P., Vilstrup H., Bak L. K., Waagepetersen H. S., Schousboe A., Sørensen M., Hepatic encephalopathy is associated with decreased cerebral oxygen metabolism and blood flow, not increased ammonia uptake. Hepatology 2013 57 1 258 265 10.1002/hep.25995
57. Sørensen M., Update on cerebral uptake of blood ammonia. Metabolic Brain Disease 2013 28 2 155 159