Extracellular brain ammonia levels in association with arterial ammonia, intracranial pressure and the use of albumin dialysis devices in pigs with acute liver failure

Metabolic Brain Disease

Volumn 25, Issue 4, 2010, Pages 407-412

  Zwirner, Kerstin ^a   Thiel, Christian ^a   Thiel, Karolin ^a   Morgalla, Matthias H ^a   Königsrainer, Alfred ^a   Schenk, Martin ^a  

^a UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

Author keywords

Acute liver failure; Cerebral microdialysis; Extracellular brain ammonia; Intracranial pressure

Indexed keywords

AMMONIA;

ACUTE LIVER FAILURE; ALBUMIN DIALYSIS; AMMONIA BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERIAL BLOOD; ARTICLE; CONTROLLED STUDY; EXTRACELLULAR FLUID; FEMALE; INTRACRANIAL PRESSURE; LIVER RESECTION; MALE; MICRODIALYSIS; MORTALITY; NONHUMAN; SWINE;

ALBUMINS; AMMONIA; ANIMALS; BLOOD-BRAIN BARRIER; BRAIN CHEMISTRY; DISEASE PROGRESSION; ELECTROENCEPHALOGRAPHY; EXTRACELLULAR SPACE; FEMALE; HEPATECTOMY; HEPATIC ENCEPHALOPATHY; INTRACRANIAL PRESSURE; LIVER FAILURE, ACUTE; MALE; MICRODIALYSIS; MULTIPLE ORGAN FAILURE; SWINE;

ANIMALIA; SUIDAE;

EID: 78751585393     PISSN: 08857490     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11011-010-9222-x     Document Type: Article

References (31)

1. W Bernal C Hall CJ Karvellas G Auzinger E Sizer J Wendon 2007 Arterial ammonia and clinical risk factors for encephalopathy and intracranial hypertension in acute liver failure Hepatology 46 1844 1852 10.1002/hep.21838 17685471 1:CAS:528:DC%2BD2sXhsVGiur%2FL
2. CR Bosoi CF Rose 2009 Identifying the direct effects of ammonia on the brain Metab Brain Dis 24 95 102 10.1007/s11011-008-9112-7 19104924 1:CAS:528:DC%2BD1MXhvVOjsr0%3D
3. RF Butterworth 2002 Pathophysiology of hepatic encephalopathy: a new look at ammonia Metab Brain Dis 17 221 227 10.1023/A:1021989230535 12602499 1:CAS:528:DC%2BD3sXislGksQ%3D%3D (Pubitemid 36204752)
4. JO Clemmesen FS Larsen J Kondrup BA Hansen P Ott 1999 Cerebral herniation in patients with acute liver failure is correlated with arterial ammonia concentration Hepatology 29 648 653 10.1002/hep.510290309 10051463 1:STN:280:DyaK1M7mt1emsA%3D%3D
5. Conn HO, Lieberthal MM (1979) The hepatic coma syndrome and lactulose. The Williams & Wilkins Co., Baltimore
6. V Felipo RF Butterworth 2002 Neurobiology of ammonia Prog Neurobiol 67 259 279 10.1016/S0301-0082(02)00019-9 12207972 1:CAS:528:DC%2BD38Xms1Kisbk%3D (Pubitemid 35229984)
7. TI Hassanein F Tofteng RS Brown Jr B McGuire P Lynch R Mehta FS Larsen J Gornbein J Stange AT Blei 2007 Randomized controlled study of extracorporeal albumin dialysis for hepatic encephalopathy in advanced cirrhosis Hepatology 46 1853 1862 10.1002/hep.21930 17975845 1:CAS:528:DC%2BD2sXhsVGiur%2FE
8. U Heemann U Treichel J Loock T Philipp G Gerken M Malago S Klammt M Loehr S Liebe S Mitzner R Schmidt J Stange 2002 Albumin dialysis in cirrhosis with superimposed acute liver injury: a prospective, controlled study Hepatology 36 949 958 12297843 1:CAS:528:DC%2BD38XotlGhsLg%3D
9. R Jalan J Bernuau 2007 Induction of cerebral hyperemia by ammonia plus endotoxin: does hyperammonemia unlock the blood-brain barrier? J Hepatol 47 168 171 10.1016/j.jhep.2007.05.003 17566590 1:CAS:528:DC%2BD2sXnsFKgt7s%3D (Pubitemid 47033883)
10. R Jalan SW Olde Damink PC Hayes NE Deutz A Lee 2004 Pathogenesis of intracranial hypertension in acute liver failure: inflammation, ammonia and cerebral blood flow J Hepatol 41 613 620 10.1016/j.jhep.2004.06.011 15464242 1:CAS:528:DC%2BD2cXotF2isLg%3D (Pubitemid 39297797)
11. K Knubben C Thiel M Schenk A Etspuler T Schenk MH Morgalla A Konigsrainer 2008 A new surgical model for hepatectomy in pigs Eur Surg Res 40 41 46 10.1159/000108765 17890866 1:STN:280:DC%2BD2snmsFKksA%3D%3D (Pubitemid 350085270)
12. AH Lockwood JM McDonald RE Reiman AS Gelbard JS Laughlin TE Duffy F Plum 1979 The dynamics of ammonia metabolism in man. Effects of liver disease and hyperammonemia J Clin Invest 63 449 460 10.1172/JCI109322 429564 1:CAS:528:DyaE1MXitVWrs7g%3D
13. A Mas 2006 Hepatic encephalopathy: from pathophysiology to treatment Digestion 73 Suppl 1 86 93 10.1159/000089783 16498256 1:CAS:528: DC%2BD28XhvVSks7s%3D
14. MD Norenberg KV Rama Rao AR Jayakumar 2009 Signaling factors in the mechanism of ammonia neurotoxicity Metab Brain Dis 24 103 117 10.1007/s11011-008-9113-6 19104923 1:CAS:528:DC%2BD1MXhvVKqu7c%3D
15. HR Pedersen H Ring-Larsen NV Olsen FS Larsen 2007 Hyperammonemia acts synergistically with lipopolysaccharide in inducing changes in cerebral hemodynamics in rats anaesthetised with pentobarbital J Hepatol 47 245 252 10.1016/j.jhep.2007.03.026 17532089 1:CAS:528:DC%2BD2sXnsFKgtbY%3D (Pubitemid 47021255)
16. C Rose LM Ytrebo NA Davies S Sen GI Nedredal M Belanger A Revhaug R Jalan 2007 Association of reduced extracellular brain ammonia, lactate, and intracranial pressure in pigs with acute liver failure Hepatology 46 1883 1892 10.1002/hep.21877 17705298 1:CAS:528:DC%2BD2sXhsVGiurzM
17. PR Saxena PD Verdouw 1982 Redistribution by 5-hydroxytryptamine of carotid arterial blood at the expense of arteriovenous anastomotic blood flow J Physiol 332 501 520 7153937 1:CAS:528:DyaL38XlsFOju7o%3D
18. LE Schmidt LB Svendsen VR Sorensen BA Hansen FS Larsen 2001 Cerebral blood flow velocity increases during a single treatment with the molecular adsorbents recirculating system in patients with acute on chronic liver failure Liver Transplant 7 709 712 10.1053/jlts.2001.26059 1:STN:280: DC%2BD3MvmsVOksQ%3D%3D (Pubitemid 32771470)
19. S Sen C Rose LM Ytrebo NA Davies GI Nedredal SS Drevland M Kjonno FW Prinzen SJ Hodges NE Deutz R Williams RF Butterworth A Revhaug R Jalan 2006 Effect of albumin dialysis on intracranial pressure increase in pigs with acute liver failure: a randomized study Crit Care Med 34 158 164 10.1097/01.CCM. 0000196203.39832.3C 16374170 (Pubitemid 43032393)
20. M Sorensen OL Munk S Keiding 2009 Backflux of ammonia from brain to blood in human subjects with and without hepatic encephalopathy Metab Brain Dis 24 237 242 10.1007/s11011-008-9126-1 19067140 1:CAS:528:DC%2BD1MXhvVKqu7k%3D
21. P Sorkine R Ben Abraham O Szold P Biderman A Kidron H Merchav S Brill R Oren 2001 Role of the molecular adsorbent recycling system (MARS) in the treatment of patients with acute exacerbation of chronic liver failure Crit Care Med 29 1332 1336 10.1097/00003246-200107000-00006 11445681 1:CAS:528: DC%2BD3MXnt1Smt7w%3D (Pubitemid 32641793)
22. V Stadlbauer GA Wright R Jalan 2009 Role of artificial liver support in hepatic encephalopathy Metab Brain Dis 24 15 26 10.1007/s11011-008-9117-2 19101787 1:CAS:528:DC%2BD1MXhvVOjsr4%3D
23. J Stange S Mitzner 1996 A carrier-mediated transport of toxins in a hybrid membrane. Safety barrier between a patients blood and a bioartificial liver Int J Artif Organs 19 677 691 8970836 1:CAS:528:DyaK2sXjtF2hug%3D%3D
24. J Stange S Mitzner W Ramlow T Gliesche H Hickstein R Schmidt 1993 A new procedure for the removal of protein bound drugs and toxins ASAIO J 39 M621 M625 10.1097/00002480-199339030-00090 8268613 1:CAS:528:DyaK2cXjtlWjtLo%3D
25. J Stange W Ramlow S Mitzner R Schmidt H Klinkmann 1993 Dialysis against a recycled albumin solution enables the removal of albumin-bound toxins Artif Organs 17 809 813 10.1111/j.1525-1594.1993.tb00635.x 8240075 1:STN:280:DyaK2c%2FlvVyjsw%3D%3D
26. GI Strauss GM Knudsen J Kondrup K Moller FS Larsen 2001 Cerebral metabolism of ammonia and amino acids in patients with fulminant hepatic failure Gastroenterology 121 1109 1119 10.1053/gast.2001.29310 11677203 1:CAS:528:DC%2BD3MXpt1SrsLc%3D
27. HK Tan 2004 Molecular adsorbent recirculating system (MARS) Ann Acad Med Singapore 33 329 335 15175774 1:STN:280:DC%2BD2c3ns1WhtQ%3D%3D
28. MM Tisdall M Smith 2006 Cerebral microdialysis: research technique or clinical tool Br J Anaesth 97 18 25 10.1093/bja/ael109 16698861 1:STN:280:DC%2BD28zlsVylug%3D%3D
29. F Tofteng L Jorgensen BA Hansen P Ott J Kondrup FS Larsen 2002 Cerebral microdialysis in patients with fulminant hepatic failure Hepatology 36 1333 1340 12447856
30. J Vaquero RF Butterworth 2007 Mechanisms of brain edema in acute liver failure and impact of novel therapeutic interventions Neurol Res 29 683 690 10.1179/016164107X240099 18173908 1:CAS:528:DC%2BD2sXhsVKnsLfN (Pubitemid 350086067)
31. LM Ytrebo RG Kristiansen H Maehre OM Fuskevag T Kalstad A Revhaug MJ Cobos R Jalan CF Rose 2009 L-ornithine phenylacetate attenuates increased arterial and extracellular brain ammonia and prevents intracranial hypertension in pigs with acute liver failure Hepatology 50 165 174 10.1002/hep.22917 19554542