A quantitative evaluation of the permeability of the blood brain barrier of portacaval shunted rats

Metabolic Brain Disease

Volumn 15, Issue 2, 2000, Pages 93-103

  Alexander, B ^a   Li, X ^a   Benjamin, I S ^a   Segal, M B ^a   Sherwood, R ^b   Preston, J E ^c  

^a ST THOMAS HOSPITAL   (United Kingdom)

^b KING'S COLLEGE LONDON   (United Kingdom)

^c KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Amino acids; Blood brain barrier; Portacaval anastomosis; Portal systemic encephalopathy

Indexed keywords

AMINO ACID; AMMONIA; AROMATIC AMINO ACID; GLUTAMIC ACID; MANNITOL; PHENYLALANINE;

AMINO ACID TRANSPORT; ARTICLE; BLOOD BRAIN BARRIER; BRAIN PERFUSION; CEREBROSPINAL FLUID ANALYSIS; CONTROLLED STUDY; DETOXIFICATION; MALE; NONHUMAN; PERMEABILITY; PORTOCAVAL SHUNT; RAT;

ACETATES; ANIMAL; BLOOD-BRAIN BARRIER; BRAIN; CARBON RADIOISOTOPES; CEREBROVASCULAR CIRCULATION; DISEASE MODELS, ANIMAL; GLUTAMIC ACID; HEPATIC ENCEPHALOPATHY; MALE; MANNITOL; PERMEABILITY; PHENYLALANINE; PORTACAVAL SHUNT, SURGICAL; RATS; RATS, SPRAGUE-DAWLEY; SUPPORT, NON-U.S. GOV'T; TRITIUM;

EID: 0033783671     PISSN: 08857490     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02679976     Document Type: Article

References (38)

1. The entry of amino acids into brain and CSF during development, using in situ perfusion in the rat
2. Changes in the kinetics of the acidic amino acid brain and CSF uptake during development in the rat
3. Brain amine metabolism during portal systemic encephalopathy
4. Prolongation of survival time of an isolated perfused rat brain preparation with an isolated perfused rat liver
5. Differentiation between the effects of unprocessed portal blood and reduced liver function on brain indole amine metabolism in the portacaval shunted rat
6. The dependence of hepatic function upon sufficient oxygen supply during prolonged isolated rat liver perfusion
7. An investigation of the relationship between the liver and brain using an isolated perfused rat brain preparation
8. Portacaval transposition in the rat: Definition of a valuable model for hepatic research
9. Acute effects of L-tryptophan on brain extracellular 5-HT and 5-HIAA levels in chronic experimental portal-systemic encephalopathy
10. Elevated brain 5-hydroxytryptophol levels in experimental portal-systemic encephalopathy
11. The effect of ammonia infusion on brain monoamine metabolism in portacaval shunted rats
12. Effect of portacaval anastomosis on electrically-stimulated release of glutamate from rat hippocampal slices
13. Pathogenesis and treatment of portal systemic encephalopathy: An update
14. Type II Alzheimer changes experimentally produced in astrocytes in the rat
15. Neutral amino acid transport characterization of the isolated luminal and abluminal membranes of the blood-brain barrier
16. Hepatic encephalopathy - A unifying hypothesis
17. Amino acids in hepatic coma
18. Kinetic analysis of carrier mediated blood-brain barrier transport with reference to amino acids
19. Hyperdynamic circulation of liver disease 40 years later: Pathophysiology and clinical consequences
20. Hepatic encephalopathy and ascites
21. Blood-brain neutral amino acid transport activity is increased after portal anastomosis
22. Effect of hyperammonaemia and methionine sulfoximine on the kinetic parameters of blood-brain transport of leucine and phenylalanine
23. Astrocytes
24. Passage of amino acids and glucose across the blood-brain barrier in patients with hepatic encephalopathy
25. Enhanced permeability to horseradish peroxidase across cerebral vessels in the rat after portacaval anastomosis
26. Role of oxyproline in the regulation of neutral amino acid transport across the blood-brain barrier
27. Glutamine transport by the blood-brain barrier: A possible mechanism for nitrogen removal
28. The effects of galactosamine-induced hepatic failure upon blood-brain barrier permeability
29. Plasma-like activity in rats with hepatic encephalopathy is due to GABA and taurine
30. Regional blood-brain barrier permeability to amino acids after portacaval anastomosis
31. Lower limits of cerebrovascular permeability to non-electrolytes in the conscious rat
32. Visual evoked potentials : Hepatic encephalopathy resembles the post-ictal state but differs from hyperammonaemia
33. Flumazenil in cirrhotic patients in hepatic coma: A randomized double-blind placebo-controlled crossover trial
34. Permeability of the blood-brain barrier to 14C-mannitol using the rat in situ brain perfusion technique
35. Glycine transport into the anaesthetized developing rat brain and cerebrospinal fluid
36. The treatment of hepatic encephalopathy
37. Permeability of the blood brain barrier after portacaval anastomosis in the rat
38. 14C in the rat