Circulating cortisol-associated signature of glucocorticoid-related gene expression in subcutaneous fat of obese subjects

Obesity

Volumn 21, Issue 5, 2013, Pages 960-967

  Pavlatou, Maria G ^a,b   Vickers, Kasey C ^c   Varma, Sudhir ^d   Malek, Rana ^e   Sampson, Maureen ^c   Remaley, Alan T ^c   Gold, Philip W ^b   Skarulis, Monica C ^e   Kino, Tomoshige ^a  

^a EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

^b NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

^c NATIONAL INSTITUTES OF HEALTH   (United States)

^d NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^e NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALRETICULIN; CYTOCHROME P450; CYTOCHROME P450 3A5; CYTOKINE; GAMMA INTERFERON; GLUCOCORTICOID RECEPTOR; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; GUANINE NUCLEOTIDE BINDING PROTEIN GAMMA SUBUNIT; HYDROCORTISONE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 10; INTERLEUKIN 12P70; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 6; INTERLEUKIN 8; MITOGEN ACTIVATED PROTEIN KINASE P38; NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE; PROTEIN ARGININE METHYLTRANSFERASE; SERUM AND GLUCOCORTICOID REGULATED KINASE 1; SMAD3 PROTEIN; SMAD6 PROTEIN; STAT5A PROTEIN; TUMOR NECROSIS FACTOR ALPHA; UNCOUPLING PROTEIN 2; VON HIPPEL LINDAU PROTEIN;

11BHSD1 GENE; 14 3 3N GENE; ABDOMINAL SUBCUTANEOUS FAT; ADULT; ANXA1 GENE; ARTICLE; BIOPSY TECHNIQUE; BODY MASS; CALR GENE; CIRCADIAN RHYTHM; CLINICAL ARTICLE; CLOCK GENE; CONTROLLED STUDY; CYP3A5 GENE; DBT GENE; DSUP1 GENE; DUSP1 GENE; ENERGY BALANCE; ERRB GENE; FEMALE; G6PC GENE; GCPC GENE; GENE; GENE CONTROL; GENE EXPRESSION; GENE FUNCTION; GLUCOSE METABOLISM; GNG2 GENE; HUMAN; HUMAN TISSUE; HYDROCORTISONE BLOOD LEVEL; IL 6 GENE; INFLAMMATION; INSIG2 GENE; MALE; MAPK14 GENE; METABOLIC DISORDER; NFKB GENE; NFKB2 GENE; NUCLEOTIDE SEQUENCE; OBESITY; PEPCK GENE; PHYSIOLOGICAL PROCESS; PRMT1 GENE; PROTEIN BLOOD LEVEL; SERPINE1 GENE; SGK1 GENE; SMAD3 GENE; SMAD6 GENE; STAT5A GENE; SUBCUTANEOUS FAT; TNFALPHA GENE; UCP2 GENE; VHL GENE;

ADULT; BODY MASS INDEX; CIRCADIAN RHYTHM; DEPRESSION; ENERGY METABOLISM; FEMALE; GENE EXPRESSION; GLUCOCORTICOIDS; HUMANS; HYDROCORTISONE; INFLAMMATION; MALE; MIDDLE AGED; OBESITY; RECEPTORS, GLUCOCORTICOID; RNA, MESSENGER; STRESS, PSYCHOLOGICAL; SUBCUTANEOUS FAT; SUBCUTANEOUS FAT, ABDOMINAL; YOUNG ADULT;

EID: 84879339681     PISSN: 19307381     EISSN: 1930739X     Source Type: Journal    
DOI: 10.1002/oby.20073     Document Type: Article

References (40)

1. Chrousos GP,. Stress and disorders of the stress system. Nat Rev Endocrinol 2009; 5: 374-381.
2. Kino T, Chrousos GP,. Glucocorticoid effect on gene expression. In:, Steckler T, Kalin NH, Reul JMHM, (eds). Handbook on Stress and the Brain Part 1. Amsterdam: Elsevier BV; 2004. pp 295-312.
3. Orth DN, Kovacs WJ,. The adrenal cortex. In:, Wilson JD, Foster DW, (eds). Textbook of Endocrinology. Philadelphia: W.B. Saunders Co.; 1998. pp 517-614.
4. Nader N, Chrousos GP, Kino T,. Interactions of the circadian CLOCK system and the HPA axis. Trends Endocrinol Metab 2010; 21: 277-286.
5. O'Malley B,. The Year in Basic Science: nuclear receptors and coregulators. Mol Endocrinol 2008; 22: 2751-2758.
6. Cooper MS, Stewart PM,. 11β-hydroxysteroid dehydrogenase type 1 and its role in the hypothalamus-pituitary-adrenal axis, metabolic syndrome, and inflammation. J Clin Endocrinol Metab 2009; 94: 4645-4654.
7. Berrington de Gonzalez A, Hartge P, Cerhan JR, et al. Body-mass index and mortality among 1.46 million white adults. N Engl J Med 2010; 363: 2211-2219.
8. Shoelson SE, Lee J, Goldfine AB,. Inflammation and insulin resistance. J Clin Invest 2006; 116: 1793-1801.
9. Nieman LK, Ilias I,. Evaluation and treatment of Cushing's syndrome. Am J Med 2005; 118: 1340-1346.
10. Vegiopoulos A, Herzig S,. Glucocorticoids, metabolism and metabolic diseases. Mol Cell Endocrinol 2007; 275: 43-61.
11. Masuzaki H, Paterson J, Shinyama H, et al. A transgenic model of visceral obesity and the metabolic syndrome. Science 2001; 294: 2166-2170.
12. Gold PW, Chrousos GP,. Organization of the stress system and its dysregulation in melancholic and atypical depression: high vs low CRH/NE states. Mol Psychiatry 2002; 7: 254-275.
13. Meyer SE, Chrousos GP, Gold PW,. Major depression and the stress system: a life span perspective. Dev Psychopathol 2001; 13: 565-580.
14. Tresaco B, Bueno G, Pineda I, Moreno LA, Garagorri JM, Bueno M,. Homeostatic model assessment (HOMA) index cut-off values to identify the metabolic syndrome in children. J Physiol Biochem 2005; 61: 381-388.
15. Saad MF, Steil GM, Riad-Gabriel M, et al. Method of insulin administration has no effect on insulin sensitivity estimates from the insulin-modified minimal model protocol. Diabetes 1997; 46: 2044-2048.
16. Benjamini Y, Hochberg, Y,. Controlling the false discovery rate: a practical and powerful approach to multiple testing. J R Statist Soc B 1995; 57: 289-300.
17. Chrousos GP,. Glucocorticoid therapy. In:, Felig P, Frohman LA, (eds). Endocrinology & Metablism. New York: McGraw-Hill; 2001. pp 609-632.
18. Uth N, Sorensen H, Overgaard K, Pedersen PK,. Estimation of VO2max from the ratio between HRmax and HRrest-the Heart Rate Ratio Method. Eur J Appl Physiol 2004; 91: 111-115.
19. Shuldiner AR, Yang R, Gong DW,. Resistin, obesity and insulin resistance-the emerging role of the adipocyte as an endocrine organ. N Engl J Med 2001; 345: 1345-1346.
20. Ouchi N, Parker JL, Lugus JJ, Walsh K,. Adipokines in inflammation and metabolic disease. Nat Rev Immunol 2011; 11: 85-97.
21. Nader N, Chrousos GP, Kino T,. Circadian rhythm transcription factor CLOCK regulates the transcriptional activity of the glucocorticoid receptor by acetylating its hinge region lysine cluster: potential physiological implications. FASEB J 2009; 23: 1572-1583.
22. Kino T, Chrousos GP,. Acetylation-mediated epigenetic regulation of glucocorticoid receptor activity: circadian rhythm-associated alterations of glucocorticoid actions in target tissues. Mol Cell Endocrinol 2011; 336: 23-30.
23. Charmandari E, Chrousos GP, Lambrou GI, et al. Peripheral CLOCK regulates target-tissue glucocorticoid receptor transcriptional activity in a circadian fashion in man. PLoS One 2011; 6: e25612.
24. Kino T, Charmandari E, Chrousos GP,. Glucocorticoid receptor: implications for rheumatic diseases. Clin Exp Rheumatol 2011; 29: S32-S41.
25. van de Werve G, Lange A, Newgard C, Mechin MC, Li Y, Berteloot A,. New lessons in the regulation of glucose metabolism taught by the glucose 6-phosphatase system. Eur J Biochem 2000; 267: 1533-1549.
26. Pettit FH, Yeaman SJ, Reed LJ,. Purification and characterization of branched chain α-keto acid dehydrogenase complex of bovine kidney. Proc Natl Acad Sci U S A 1978; 75: 4881-4885.
27. Lang F, Artunc F, Vallon V,. The physiological impact of the serum and glucocorticoid-inducible kinase SGK1. Curr Opin Nephrol Hypertens 2009; 18: 439-448.
28. Mehta R, Steinkraus KA, Sutphin GL, et al. Proteasomal regulation of the hypoxic response modulates aging in C. elegans. Science 2009; 324: 1196-1198.
29. Chi H, Flavell RA,. Acetylation of MKP-1 and the control of inflammation. Sci Signal 2008; 1: pe44.
30. Wancket LM, Frazier WJ, Liu Y,. Mitogen-activated protein kinase phosphatase (MKP)-1 in immunology, physiology, and disease. Life Sci 2012; 90: 237-248.
31. Dong XY, Tang SQ,. Insulin-induced gene: a new regulator in lipid metabolism. Peptides 2010; 31: 2145-2150.
32. Perretti M, Dalli J,. Exploiting the Annexin A1 pathway for the development of novel anti-inflammatory therapeutics. Br J Pharmacol 2009; 158: 936-946.
33. Rhen T, Cidlowski JA,. Antiinflammatory action of glucocorticoids-new mechanisms for old drugs. N Engl J Med 2005; 353: 1711-1723.
34. Hennighausen L, Robinson GW,. Interpretation of cytokine signaling through the transcription factors STAT5A and STAT5B. Genes Dev 2008; 22: 711-721.
35. Zhao J, Meyerkord CL, Du Y, Khuri FR, Fu H,. 14-3-3 proteins as potential therapeutic targets. Semin Cell Dev Biol 2011; 22: 705-712.
36. Kino T, Souvatzoglou E, De Martino MU, Tsopanomihalu M, Wan Y, Chrousos GP,. Protein 14-3-3σ interacts with and favors cytoplasmic subcellular localization of the glucocorticoid receptor, acting as a negative regulator of the glucocorticoid signaling pathway. J Biol Chem 2003; 278: 25651-25656.
37. Clapham DE, Neer EJ,. G protein βγ subunits. Annu Rev Pharmacol Toxicol 1997; 37: 167-203.
38. Kino T, Tiulpakov A, Ichijo T, Chheng L, Kozasa T, Chrousos GP,. G protein β interacts with the glucocorticoid receptor and suppresses its transcriptional activity in the nucleus. J Cell Biol 2005; 169: 885-896.
39. Morrison DK, Davis RJ,. Regulation of MAP kinase signaling modules by scaffold proteins in mammals. Annu Rev Cell Dev Biol 2003; 19: 91-118.
40. Irusen E, Matthews JG, Takahashi A, Barnes PJ, Chung KF, Adcock IM,. p38 Mitogen-activated protein kinase-induced glucocorticoid receptor phosphorylation reduces its activity: role in steroid-insensitive asthma. J Allergy Clin Immunol 2002; 109: 649-657. Development