Metabolism and pathways for denitration of organic nitrates in the human liver

Journal of Pharmacology and Experimental Therapeutics

Volumn 346, Issue 1, 2013, Pages 96-104

  Govoni, Mirco ^a,b   Tocchetti, Paola ^b   Lundberg, Jon O ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b NicOx SA   (France)

Author keywords

[No Author keywords available]

Indexed keywords

3 (AMINOPROPYL) 1 HYDROXY 3 ISOPROPYL 2 OXO 1 TRIAZENE; CELL PROTEIN; CYTOCHROME P450; CYTOCHROME P450 1A2; FERULIC ACID; FLURBIPROFEN; GLYCERYL TRINITRATE; NITRATE; NITRIC OXIDE DONOR; NITRITE; NITROOXYBUTYLALCOHOL; ORGANIC NITRATE; UNCLASSIFIED DRUG;

ARTICLE; CELL FRACTIONATION; CHEMICAL ANALYSIS; CHEMICAL MODIFICATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DENITRATION; DRUG METABOLISM; DRUG TARGETING; ENZYME ACTIVITY; ENZYME INHIBITION; FIRST PASS EFFECT; HUMAN; HUMAN CELL; HUMAN TISSUE; INTRACELLULAR SIGNALING; LIVER; LIVER CELL; LIVER METABOLISM; MAXIMUM PLASMA CONCENTRATION; NITRATE METABOLISM; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; QUANTITATIVE ANALYSIS; STRUCTURE ACTIVITY RELATION; TIME TO MAXIMUM PLASMA CONCENTRATION;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BUTANES; CYCLOOXYGENASE INHIBITORS; CYTOCHROME P-450 CYP1A2; CYTOSOL; ENZYME INHIBITORS; FEMALE; FLURBIPROFEN; FREE RADICAL SCAVENGERS; HUMANS; KINETICS; LIVER; MALE; METABOLIC DETOXICATION, PHASE I; MICROSOMES, LIVER; MITOCHONDRIA, LIVER; NITRIC OXIDE; NITRO COMPOUNDS; NITROGLYCERIN; VASODILATOR AGENTS;

EID: 84879321495     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.113.203356     Document Type: Article

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