Short interfering RNA against bax attenuates TNFα-induced ototoxicity in rat organ of corti explants

Otolaryngology - Head and Neck Surgery (United States)

Volumn 148, Issue 5, 2013, Pages 834-840

  Dinh, Christine ^a   Bas, Esperanza ^a   Dinh, John ^a   Vu, Ly ^a   Gupta, Chhavi ^a   Van De Water, Thomas R ^a  

^a UNIVERSITY OF MIAMI EAR INSTITUTE   (United States)

Author keywords

Apoptosis; Auditory hair cell; Bax; Inner ear; Programmed cell death; Tumor necrosis factor

Indexed keywords

PROTEIN BAX; SMALL INTERFERING RNA; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; APOPTOSIS; BASILAR MEMBRANE; CELL VIABILITY; CONFERENCE PAPER; CONTROLLED STUDY; CORTI ORGAN; EXPLANT; HAIR CELL; IN VITRO STUDY; MOUSE; NONHUMAN; OTOTOXICITY; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RNA INTERFERENCE; UPREGULATION; ANIMAL; ARTICLE; BIOSYNTHESIS; CELL SURVIVAL; DISEASE MODEL; DRUG EFFECT; GENE EXPRESSION; HEARING IMPAIRMENT; METABOLISM; RAT; SPRAGUE DAWLEY RAT;

ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CELL SURVIVAL; DISEASE MODELS, ANIMAL; GENE EXPRESSION; HAIR CELLS, AUDITORY; HEARING LOSS; ORGAN OF CORTI; RATS; RATS, SPRAGUE-DAWLEY; RNA, SMALL INTERFERING; TUMOR NECROSIS FACTOR-ALPHA;

MLCS; MLOWN;

EID: 84879312536     PISSN: 01945998     EISSN: 10976817     Source Type: Journal    
DOI: 10.1177/0194599813477631     Document Type: Conference Paper

References (23)

1. Aminpour S, Tinling SP, Brodie HA. Role of tumor necrosis factor-alpha in sensorineural hearing loss after bacterial meningitis. Otol Neurotol. 2005;26:602-609.
2. Van Wijk F, Staecker H, Keithley E, Lefebvre PP. Local perfusion of tumor necrosis factor alpha blocker infliximab to the inner ear improves autoimmune neurosensory hearing loss. Audiol Neurootol. 2006;11:357-365.
3. Zou J, PyykkoI, Sutinen P, Toppila E. Vibration induced hearing loss in guinea pig cochlea: expression of TNF-alpha and VEGF. Hear Res. 2005;202:13-20.
4. Fujioka M, Kanzaki S, Okano HJ, Masuda M, Ogawa K, Okano H. Proinflammatory cytokines expression in noiseinduced damaged cochlea. J Neurosci Res. 2006;83:575-583.
5. Street I, Jobanputra P, Proops DW. Etanercept, a tumour necrosis factor alpha receptor antagonist, and methotrexate in acute sensorineural hearing loss. J Laryngol Otol. 2006;120:1064-1066.
6. So H, Kim HJ, Lee JH, et al. Cisplatin cytotoxicity of auditory cells requires secretions of proinflammatory cytokines via activation of ERK and NF-kB. J Assoc Res Otolaryngol. 2007;8: 338-355.
7. Sutinen P, Zou J, Hunter LL, Toppila E, PyykkoI. Vibrationinduced hearing loss: mechanical and physiological aspects. Otol Neurotol. 2007;28:171-177.
8. Khan M, Szczepek AJ, Haupt H, Olze H, Mazurek B. Expression of proinflammatory cytokines in cochlear explant cultures: influence of normoxia and hypoxia. Neurosci Lett. 2010;479:249-252.
9. Van De Water TR, Lallemend F, Eshraghi AA, et al. Caspases, the enemy within, and their role in oxidative stress-induced apoptosis of inner ear sensory cells. Otol Neurotol. 2004;25:627-632.
10. Wang J, Ruel J, Ladrech S, Bonny C, van de Water TR, Puel JL. Inhibition of the c-Jun-N-terminal kinase-mediated mitochondrial cell death pathway restores auditory function in sound exposed animals. Mol Pharmacol. 2007;71:654-666.
11. Dinh CT, Haake S, Chen S, et al. Dexamethasone protects organ of Corti explants against tumor necrosis factor-alpha-induced loss of auditory hair cells and alters the expression levels of apoptosis-related genes. Neuroscience. 2008;157:405-413.
12. Dinh C, Hoang K, Haake S, et al. Biopolymer-released dexamethasone prevents tumor necrosis factor alpha-induced loss of auditory hair cells in vitro: implications toward the development of a drug-eluting cochlear implant electrode array. Otol Neurotol. 2008;29:1012-1019.
13. Haake SM, Dinh CT, Chen S, Eshraghi AA, Van De Water TR. Dexamethasone protects auditory hair cells against TNFalpha-initiated apoptosis via activation of PI3K/Akt and NFkappaB signaling. Hear Res. 2009;255:22-32.
14. Dinh CT, Bas E, Chan SS, et al. Dexamethasone treatment of tumor necrosis factor-alpha challenged organ of Corti explants activates nuclear factor kappa B signaling that induces changes in gene expression that favor hair cell survival. Neuroscience. 2011;188:157-167.
15. Maeda Y, Sheffield AM, Smith RJH. The therapeutic regulation of gene expression in the inner ear using RNA interference. Adv Otorhinolaryngol. 2009;66:13-36.
16. Hannon GJ. RNA interference. Nature. 2002;418:244-251.
17. Maeda Y, Fukushima K, Nishizaki K, Smith RJ. In vitro and in vivo suppression of GJB2 expression by RNA interference. Hum Mol Genet. 2005;14:1641-1650.
18. Mukherjea D, Jajoo S, Kaur T, Sheehan KE, Ramkumar V, Rybak LP. Transtympanic administration of short interfering (si)RNA for the NOX3 isoform of NADPH oxidase protects against cisplatin-induced hearing loss in the rat. Antioxid Redox Signal. 2011;13:589-598.
19. Mukherjea D, Jajoo S, Whitworth C, et al. Short interfering RNA against transient receptor potential vanilloid 1 attenuates cisplatin-induced hearing loss in the rat. J Neurosci. 2008;28: 13056-13065.
20. Kaur T, Mukherjea D, Sheehan K, Jajoo S, Rybak LP, Ramkumar V. Short interfering RNA against STAT1 attenuates cisplatin-induced ototoxicity in the rat by suppressing inflammation. Cell Death Dis. 2011;2:e180.
21. Mukherjea D, Jajoo, Sheehan K, et al. NOX3 NAPDH oxidase couples transient receptor potential vanilloid 1 to signal transducer and activator of transcription 1-mediated inflammation and hearing loss. Antioxid Redox Signal. 2011;14:999-1010.
22. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 2001;25:402-408.
23. Wolter KG, Hsu YT, Smith CL, Nechushtan A, Xi XG, Youle RJ. Movement of Bax from the cytosol to mitochondria during apoptosis. J Cell Biol. 1997;139:1281-1292.