Activation of protease-activated receptor 2-mediated signaling by mast cell tryptase modulates cytokine production in primary cultured astrocytes

Mediators of Inflammation

Volumn 2013, Issue , 2013, Pages

  Zeng, Xiaoning ^a   Zhang, Shu ^a   Xu, Luwei ^a   Yang, Haiwei ^a   He, Shaoheng ^a  

^a THE FIRST AFFILIATED HOSPITAL OF NANJING MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; INTERLEUKIN 6; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEINASE ACTIVATED RECEPTOR 2; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE; TRYPTASE; TUMOR NECROSIS FACTOR ALPHA; 2-(4-MORPHOLINYL)-8-PHENYL-4H-1-BENZOPYRAN-4-ONE; CHROMONE DERIVATIVE; CYTOKINE; MORPHOLINE DERIVATIVE; PHOSPHATIDYLINOSITOL 3 KINASE;

ANIMAL CELL; ARTICLE; ASTROCYTE; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; CYTOKINE RELEASE; ENZYME ACTIVITY; MAST CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; WESTERN BLOTTING; ANIMAL; CELL CULTURE; CELL SURVIVAL; DRUG ANTAGONISM; DRUG EFFECT; GENETICS; METABOLISM; SPRAGUE DAWLEY RAT; ANTAGONISTS AND INHIBITORS; DRUG EFFECTS;

ANIMALS; ASTROCYTES; BLOTTING, WESTERN; CELL PROLIFERATION; CELL SURVIVAL; CELLS, CULTURED; CHROMONES; CYTOKINES; INTERLEUKIN-6; MORPHOLINES; PHOSPHATIDYLINOSITOL 3-KINASES; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; RECEPTOR, PAR-2; TRYPTASES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84879306661     PISSN: 09629351     EISSN: 14661861     Source Type: Journal    
DOI: 10.1155/2013/140812     Document Type: Article

References (50)

1. Ossovskaya V. S., Bunnett N. W., Proteaseactivated receptors: contribution to physiology and disease. Physiological Reviews 2004 84 2 579 621 2-s2.0-1642279517 10.1152/physrev.00028.2003
2. Adams M. N., Ramachandran R., Yau M., Suen J. Y., Fairlie D. P., Hollenberg M. D., Hooper J. D., Structure, function and pathophysiology of protease activated receptors. Pharmacology and Therapeutics 2011 130 3 248 282 2-s2.0-79955584619 10.1016/j.pharmthera.2011.01.003
3. Luo W., Wang Y., Reiser G., Protease-activated receptors in the brain: receptor expression, activation, and functions in neurodegeneration and neuroprotection. Brain Research Reviews 2007 56 2 331 345 2-s2.0-36549089651 10.1016/j.brainresrev.2007.08.002
4. Cottrell G. S., Amadesi S., Schmidlin F., Bunnett N., Protease-activated receptor 2: activation, signalling and function. Biochemical Society Transactions 2003 31 6 1191 1197 2-s2.0-0346788901
5. Vergnolle N., Ferazzini M., D'Andrea M. R., Buddenkotte J., Steinhoff M., Proteinase-activated receptors: novel signals for peripheral nerves. Trends in Neurosciences 2003 26 9 496 500 2-s2.0-0041423733 10.1016/S0166-2236(03)00208-X
6. Wang H., Ubl J. J., Reiser G., Four subtypes of protease-activated receptors, co-expressed in rat astrocytes, evoke different physiological signaling. GLIA 2002 37 1 53 63 2-s2.0-0036006726 10.1002/glia.10012
7. Bushell T. J., Plevin R., Cobb S., Irving A. J., Characterization of proteinase-activated receptor 2 signalling and expression in rat hippocampal neurons and astrocytes. Neuropharmacology 2006 50 6 714 725 2-s2.0-33646011568 10.1016/j.neuropharm.2005.11.024
8. Wang Y., Luo W., Reiser G., Activation of protease-activated receptors in astrocytes evokes a novel neuroprotective pathway through release of chemokines of the growth-regulated oncogene/cytokine-induced neutrophil chemoattractant family. European Journal of Neuroscience 2007 26 11 3159 3168 2-s2.0-36248946610 10.1111/j.1460-9568.2007.05938.x
9. Wang Y., Luo W., Reiser G., Proteinase-activated receptor-1 and -2 induce the release of chemokine GRO/CINC-1 from rat astrocytes via differential activation of JNK isoforms, evoking multiple protective pathways in brain. Biochemical Journal 2007 401 1 65 78 2-s2.0-33846316422 10.1042/BJ20060732
10. Wang Y., Luo W., Reiser G., The role of calcium in protease-activated receptor-induced secretion of chemokine GRO/CINC-1 in rat brain astrocytes. Journal of Neurochemistry 2007 103 2 814 819 2-s2.0-34848918931 10.1111/j.1471-4159.2007.04803.x
11. Park G. H., Jeon S. J., Ryu J. R., Choi M. S., Han S., Yang S., Ryu J. H., Cheong J. H., Shin C. Y., Ko K. H., Essential role of mitogen-activated protein kinase pathways in protease activated receptor 2-mediated nitric-oxide production from rat primary astrocytes. Nitric Oxide 2009 21 2 110 119 2-s2.0-68249151075 10.1016/j.niox.2009.05.007
12. Jin G., Hayashi T., Kawagoe J., Takizawa T., Nagata T., Nagano I., Syoji M., Abe K., Deficiency of PAR-2 gene increases acute focal ischemic brain injury. Journal of Cerebral Blood Flow and Metabolism 2005 25 3 302 313 2-s2.0-14644442960 10.1038/sj.jcbfm.9600021
13. Afkhami-Goli A., Noorbakhsh F., Keller A. J., Vergnolle N., Westaway D., Jhamandas J. H., Andrade-Gordon P., Hollenberg M. D., Arab H., Dyck R. H., Power C., Proteinase-activated receptor-2 exerts protective and pathogenic cell type-specific effects in Alzheimer's disease. Journal of Immunology 2007 179 8 5493 5503 2-s2.0-38449113059
14. Lohman R., O'Brien T. J., Cocks T. M., Protease-activated receptor-2 regulates trypsin expression in the brain and protects against seizures and epileptogenesis. Neurobiology of Disease 2008 30 1 84 93 2-s2.0-40849129912 10.1016/j.nbd.2007.12.010
15. Gan J., Greenwood S. M., Cobb S. R., Bushell T. J., Indirect modulation of neuronal excitability and synaptic transmission in the hippocampus by activation of proteinase-activated receptor-2. British Journal of Pharmacology 2011 163 5 984 994 2-s2.0-79958806098 10.1111/j.1476-5381.2011.01293.x
16. Malamud V., Vaaknin A., Abramsky O., Mor M., Burgess L. E., Ben-Yehudah A., Lorberboum-Galski H., Tryptase activates peripheral blood mononuclear cells causing the synthesis and release of TNF- α IL-6 and IL-1 β: possible relevance to multiple sclerosis. Journal of Neuroimmunology 2003 138 1-2 115 122 2-s2.0-0037960323 10.1016/S0165-5728(03)00090-0
17. Molino M., Barnathan E. S., Numerof R., Clark J., Dreyer M., Cumashi A., Hoxie J. A., Schechter N., Woolkalis M., Brass L. F., Interactions of mast cell tryptase with thrombin receptors and PAR-2. Journal of Biological Chemistry 1997 272 7 4043 4049 2-s2.0-15444346942 10.1074/jbc.272.7.4043
18. Söderholm J. D., Mast cells and mastocytosis. Digestive Diseases 2009 27 supplement 1 129 136
19. Silverman A., Sutherland A. K., Wilhelm M., Silver R., Mast cells migrate from blood to brain. Journal of Neuroscience 2000 20 1 401 408 2-s2.0-0033994391
20. Christopherson K. S., Ullian E. M., Stokes C. C. A., Mullowney C. E., Hell J. W., Agah A., Lawler J., Mosher D. F., Bornstein P., Barres B. A., Thrombospondins are astrocyte-secreted proteins that promote CNS synaptogenesis. Cell 2005 120 3 421 433 2-s2.0-13544273916 10.1016/j.cell.2004.12.020
21. Nedergaard M., Ransom B., Goldman S. A., New roles for astrocytes: redefining the functional architecture of the brain. Trends in Neurosciences 2003 26 10 523 530 2-s2.0-0141533205 10.1016/j.tins.2003.08.008
22. Koehler R. C., Gebremedhin D., Harder D. R., Role of astrocytes in cerebrovascular regulation. Journal of Applied Physiology 2006 100 1 307 317 2-s2.0-33644826760 10.1152/japplphysiol.00938.2005
23. Ma D. K., Ming G., Song H., Glial influences on neural stem cell development: cellular niches for adult neurogenesis. Current Opinion in Neurobiology 2005 15 5 514 520 2-s2.0-25844458514 10.1016/j.conb.2005.08.003
24. Eyre H., Baune B. T., Neuroplastic changes in depression: a role for the immune system. Psychoneuroendocrinology 2012 37 9 1397 1416 2-s2.0-84859840856 10.1016/j.psyneuen.2012.03.019
25. Noorbakhsh F., Tsutsui S., Vergnolle N., Boven L. A., Shariat N., Vodjgani M., Warren K. G., Andrade-Gordon P., Hollenberg M. D., Power C., Proteinase-activated receptor 2 modulates neuroinflammation in experimental autoimmune encephalomyelitis and multiple sclerosis. Journal of Experimental Medicine 2006 203 2 425 435 2-s2.0-33344473933 10.1084/jem.20052148
26. Kamata H., Hirata H., Redox regulation of cellular signalling. Cellular Signalling 1999 11 1 1 14 2-s2.0-0032889677 10.1016/S0898-6568(98)00037-0
27. Bailey S. L., Carpentier P. A., McMahon E. J., Begolka W. S., Miller S. D., Innate and adaptive immune responses of the central nervous system. Critical Reviews in Immunology 2006 26 2 149 188
28. Sternberg E. M., Neural regulation of innate immunity: a coordinated nonspecific host response to pathogens. Nature Reviews Immunology 2006 6 4 318 328 2-s2.0-33645284772 10.1038/nri1810
29. Valko M., Leibfritz D., Moncol J., Cronin M. T. D., Mazur M., Telser J., Free radicals and antioxidants in normal physiological functions and human disease. International Journal of Biochemistry and Cell Biology 2007 39 1 44 84 2-s2.0-33749986298 10.1016/j.biocel.2006.07.001
30. Floyd R. A., Neuroinflammatory processes are important in neurodegenerative diseases: an hypothesis to explain the increased formation of reactive oxygen and nitrogen species as major factors involved in neurodegenerative disease development. Free Radical Biology and Medicine 1999 26 9-10 1346 1355 2-s2.0-0033021002 10.1016/S0891-5849(98)00293-7
31. Yang C. M., Hsieh H. L., Lin C. C., Shih R. H., Chi P. L., Cheng S. E., Hsiao L. D., Multiple factors from bradykinin-challenged astrocytes contribute to the neuronal apoptosis: involvement of astroglial ROS, MMP-9, and HO-1/CO system. Molecular Neurobiology 2013 47 3 1020 1033
32. Ma D., Jin S., Li E., Doi Y., Parajuli B., Noda M., Sonobe Y., Mizuno T., Suzumura A., The neurotoxic effect of astrocytes activated with toll-like receptor ligands. Journal of Neuroimmunology 2013 254 1-2 10 18
33. Molina-Holgado E., Molina-Holgado F., Mending the broken brain: neuroimmune interactions in neurogenesis. Journal of Neurochemistry 2010 114 5 1277 1290 2-s2.0-77955131100 10.1111/j.1471-4159.2010.06849.x
34. Gadient R. A., Otten U. H., Interleukin-6 (IL-6)-a molecule with both beneficial and destructive potentials. Progress in Neurobiology 1997 52 5 379 390 2-s2.0-0030964023 10.1016/S0301-0082(97)00021-X
35. Bauer S., Cytokine control of adult neural stem cells: chronic versus acute exposure. Annals of the New York Academy of Sciences 2009 1153 48 56 2-s2.0-60349125018 10.1111/j.1749-6632.2009.03986.x
36. Oshima T., Lee S., Sato A., Oda S., Hirasawa H., Yamashita T., TNF- α contributes to axonal sprouting and functional recovery following traumatic brain injury. Brain Research 2009 1290 102 110 2-s2.0-68949170681 10.1016/j.brainres.2009.07.022
37. Wheeler D., Knapp E., Bandaru V. V. R., Wang Y., Knorr D., Poirier C., Mattson M. P., Geiger J. D., Haughey N. J., Tumor necrosis factor- α -induced neutral sphingomyelinase-2 modulates synaptic plasticity by controlling the membrane insertion of NMDA receptors. Journal of Neurochemistry 2009 109 5 1237 1249 2-s2.0-65549128703 10.1111/j.1471-4159.2009.06038.x
38. Rainey-Smith S. R., Andersson D. A., Williams R. J., Rattray M., Tumour necrosis factor alpha induces rapid reduction in AMPA receptor-mediated calcium entry in motor neurones by increasing cell surface expression of the GluR2 subunit: relevance to neurodegeneration. Journal of Neurochemistry 2010 113 3 692 703 2-s2.0-77950633637 10.1111/j.1471-4159.2010.06634.x
39. Zhang S., Zeng X., Yang H., Hu G., He S., Mast cell tryptase induces microglia activation via protease-activated receptor 2 signaling. Cellular Physiology and Biochemistry 2012 29 5-6 931 940
40. Mueller F. J., McKercher S. R., Imitola J., Loring J. F., Yip S., Khoury S. J., Snyder E. Y., At the interface of the immune system and the nervous system: how neuroinflammation modulates the fate of neural progenitors in vivo. Ernst Schering Research Foundation Workshop 2005 53 83 114 2-s2.0-33644828334
41. Greenwood S. M., Bushell T. J., Astrocytic activation and an inhibition of MAP kinases are required for proteinase-activated receptor-2-mediated protection from neurotoxicity. Journal of Neurochemistry 2010 113 6 1471 1480 2-s2.0-77953102949 10.1111/j.1471-4159.2010.06737.x
42. Li R., Reiser G., Phosphorylation of Ser45 and Ser59 of α b-crystallin and p38/extracellular regulated kinase activity determine α b-crystallin-mediated protection of rat brain astrocytes from C2-ceramide- and staurosporine-induced cell death. Journal of Neurochemistry 2011 118 3 354 364 2-s2.0-79960287784 10.1111/j.1471-4159.2011.07317.x
43. Hou C. H., Tang C. H., Hsu C. J., Hou S. M., Liu J. F., CCN4 induces IL-6 production through avb5 receptor, PI3K, Akt, and NF-kB singling pathway in human synovial fibroblasts. Arthritis Research & Therapy 2013 15 1 R19
44. Kang S. S., Keasey M. P., Cai J., Hagg T., Loss of neuron-astroglial interaction rapidly induces protective CNTF expression after stroke in mice. Journal of Neuroscience 2012 32 27 9277 9287
45. Zala D., Bensadoun J., De Almeida L. P., Leavitt B. R., Gutekunst C., Aebischer P., Hayden M. R., Déglon N., Long-term lentiviral-mediated expression of ciliary neurotrophic factor in the striatum of Huntington's disease transgenic mice. Experimental Neurology 2004 185 1 26 35 2-s2.0-0346993604 10.1016/j.expneurol.2003.09.002
46. Pun S., Santos A. F., Saxena S., Xu L., Caroni P., Selective vulnerability and pruning of phasic motoneuron axons in motoneuron disease alleviated by CNTF. Nature Neuroscience 2006 9 3 408 419 2-s2.0-33344462702 10.1038/nn1653
47. Simon C. M., Jablonka S., Ruiz R., Tabares L., Sendtner M., Ciliary neurotrophic factor-induced sprouting preserves motor function in a mouse model of mild spinal muscular atrophy. Human Molecular Genetics 2009 19 6 973 986 2-s2.0-77950669919 10.1093/hmg/ddp562 ddp562
48. Gomes F. C., Sousa Vde O., Romão L., Emerging roles for TGF-beta1 in nervous system development. International Journal of Developmental Neuroscience 2005 23 5 413 424
49. Romão L. F., De Sousa V. O., Neto V. M., Gomes F. C. A., Glutamate activates GFAP gene promoter from cultured astrocytes through TGF- β 1 pathways. Journal of Neurochemistry 2008 106 2 746 756 2-s2.0-51649115123 10.1111/j.1471-4159.2008.05428.x
50. Garcia C. M., Darland D. C., Massingham L. J., D'Amore P. A., Endothelial cell-astrocyte interactions and TGF β are required for induction of blood-neural barrier properties. Developmental Brain Research 2004 152 1 25 38 2-s2.0-3342950478 10.1016/j.devbrainres.2004.05.008