Decreased RyR2 refractoriness determines myocardial synchronization of aberrant Ca2+ release in a genetic model of arrhythmia

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 25, 2013, Pages 10312-10317

  Brunello, Lucia ^a   Slabaugh, Jessica L ^b   Radwanski, Przemyslaw B ^a   Ho, Hsiang Ting ^a   Belevych, Andriy E ^a   Lou, Qing ^a   Chen, Haiyan ^c   Napolitano, Carlo ^d   Lodola, Francesco ^d   Priori, Silvia G ^d   Fedorov, Vadim V ^b   Volpe, Pompeo ^e   Fill, Michael ^c   Janssen, Paul M L ^b   Györke, Sándor ^a  

^a OHIO STATE UNIVERSITY   (United States)

^b THE OHIO STATE UNIVERSITY COLLEGE OF MEDICINE   (United States)

^c RUSH MEDICAL COLLEGE   (United States)

^d IRCCS   (Italy)

^e UNIVERSITY OF PADOVA   (Italy)

Author keywords

Calcium induced calcium release; Luminal calcium; Ryr2 deactivation; Sarcoplasmic reticulum

Indexed keywords

CALCIUM ION; CALSEQUESTRIN; RYANODINE RECEPTOR 2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CALCIUM TRANSPORT; CATECHOLAMINERGIC POLYMORPHIC VENTRICULAR TACHYCARDIA; FLUORESCENCE IMAGING; HEART ARRHYTHMIA; HEART MUSCLE; HEART MUSCLE CONTRACTILE FORCE; HEART MUSCLE POTENTIAL; HEART MUSCLE REFRACTORY PERIOD; MEMBRANE POTENTIAL; MOUSE; MYOELECTRICITY; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL;

CALCIUM-INDUCED CALCIUM RELEASE; LUMINAL CALCIUM; RYR2 DEACTIVATION; SARCOPLASMIC RETICULUM;

ANIMALS; CALCIUM; CALCIUM SIGNALING; CALSEQUESTRIN; DIASTOLE; DISEASE MODELS, ANIMAL; HEART; HEART VENTRICLES; MALE; MICE; MICE, MUTANT STRAINS; MUTATION; MYOCYTES, CARDIAC; PAPILLARY MUSCLES; RYANODINE RECEPTOR CALCIUM RELEASE CHANNEL; SARCOPLASMIC RETICULUM; TACHYCARDIA, VENTRICULAR;

MUS;

EID: 84879305480     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1300052110     Document Type: Article

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