Cytosolic calcium accumulation and delayed repolarization associated with ventricular arrhythmias in a guinea pig model of Andersen-Tawil syndrome

Heart Rhythm

Volumn 7, Issue 10, 2010, Pages

  Radwański, Przemysaw B ^a,b   Veeraraghavan, Rengasayee ^a,c   Poelzing, Steven ^a,c  

^a UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF UTAH   (United States)

^c Department of Electrical and Computer Engineering   (United States)

Author keywords

Arrhythmia mechanism; Cellular calcium; Mapping; Repolarization; Ventricular arrhythmia

Indexed keywords

CALCIUM; PINACIDIL;

ANDERSEN SYNDROME; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; DRUG MECHANISM; EX VIVO STUDY; GUINEA PIG; HEART PACING; HEART VENTRICLE ARRHYTHMIA; MALE; NONHUMAN; PRIORITY JOURNAL;

EID: 77957266481     PISSN: 15475271     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.hrthm.2010.03.044     Document Type: Article

References (35)

1. N.M. Plaster, R. Tawil, and M. Tristani-Firouzi Mutations in Kir2.1 cause the developmental and episodic electrical phenotypes of Andersen's syndrome Cell 105 2001 511 519
2. M. Tristani-Firouzi, J.L. Jensen, and M.R. Donaldson Functional and clinical characterization of KCNJ2 mutations associated with LQT7 (Andersen syndrome) J Clin Invest 110 2002 381 388
3. R. Tawil, L.J. Ptacek, and S.G. Pavlakis Andersen's syndrome: potassium-sensitive periodic paralysis, ventricular ectopy, and dysmorphic features Ann Neurol 35 1994 326 330
4. L. Zhang, D.W. Benson, and M. Tristani-Firouzi Electrocardiographic features in Andersen-Tawil syndrome patients with KCNJ2 mutations: characteristic T-U-wave patterns predict the KCNJ2 genotype Circulation 111 2005 2720 2726
5. M. Tsuboi, and C. Antzelevitch Cellular basis for electrocardiographic and arrhythmic manifestations of Andersen-Tawil syndrome (LQT7) Heart Rhythm 3 2006 328 335
6. H. Morita, D.P. Zipes, S.T. Morita, and J. Wu Mechanism of U wave and polymorphic ventricular tachycardia in a canine tissue model of Andersen-Tawil syndrome Cardiovasc Res 75 2007 510 518
7. S. Poelzing, and R. Veeraraghavan Heterogeneous ventricular chamber response to hypokalemia and inward rectifier potassium channel blockade underlies bifurcated T wave in guinea pig Am J Physiol Heart Circ Physiol 292 2007 H3043 H3051
8. E. Marban, S.W. Robinson, and W.G. Wier Mechanisms of arrhythmogenic delayed and early afterdepolarizations in ferret ventricular muscle J Clin Invest 78 1986 1185 1192
9. H.B. Nuss, S. Kaab, D.A. Kass, G.F. Tomaselli, and E. Marban Cellular basis of ventricular arrhythmias and abnormal automaticity in heart failure Am J Physiol 277 1999 H80 H91
10. P.G. Volders, M.A. Vos, and B. Szabo Progress in the understanding of cardiac early afterdepolarizations and torsades de pointes: time to revise current concepts Cardiovasc Res 46 2000 376 392
11. K1: a simulation study Am J Physiol Heart Circ Physiol 291 2006 H2597 H2605
12. J. Silva, and Y. Rudy Mechanism of pacemaking in I(K1)-downregulated myocytes Circ Res 92 2003 261 263
13. R. Brandes, V.M. Figueredo, S.A. Camacho, B.M. Massie, and M.W. Weiner Suppression of motion artifacts in fluorescence spectroscopy of perfused hearts Am J Physiol 263 1992 H972 H980
14. W. Kong, G.P. Walcott, W.M. Smith, P.L. Johnson, and S.B. Knisley Emission ratiometry for simultaneous calcium and action potential measurements with coloaded dyes in rabbit hearts: reduction of motion and drift J Cardiovasc Electrophysiol 14 2003 76 82
15. R.P. Katra, E. Pruvot, and K.R. Laurita Intracellular calcium handling heterogeneities in intact guinea pig hearts Am J Physiol Heart Circ Physiol 286 2004 H648 H656
16. S.D. Girouard, J.M. Pastore, K.R. Laurita, K.W. Gregory, and D.S. Rosenbaum Optical mapping in a new guinea pig model of ventricular tachycardia reveals mechanisms for multiple wavelengths in a single reentrant circuit Circulation 93 1996 603 613
17. K1 mutations in human left ventricular myocytes and tissue Am J Physiol Heart Circ Physiol 292 2007 H549 H559
18. F.G. Akar, and D.S. Rosenbaum Transmural electrophysiological heterogeneities underlying arrhythmogenesis in heart failure Circ Res 93 2003 638 645
19. R. Coronel, F.J. Wilms-Schopman, T. Opthof, and M.J. Janse Dispersion of repolarization and arrhythmogenesis Heart Rhythm 6 2009 537 543
20. M. Restivo, E.B. Caref, D.O. Kozhevnikov, and N. El-Sherif Spatial dispersion of repolarization is a key factor in the arrhythmogenicity of long QT syndrome J Cardiovasc Electrophysiol 15 2004 323 331
21. K.R. Laurita, and R.P. Katra Delayed after depolarization-mediated triggered activity associated with slow calcium sequestration near the endocardium J Cardiovasc Electrophysiol 16 2005 418 424
22. R.P. Katra, and K.R. Laurita Cellular mechanism of calcium-mediated triggered activity in the heart Circ Res 96 2005 535 542
23. C.G. Nichols, E.N. Makhina, W.L. Pearson, Q. Sha, and A.N. Lopatin Inward rectification and implications for cardiac excitability Circ Res 78 1996 1 7
24. +-induced ventricular fibrillation Physiol Res 50 2001 247 259
25. 2+ release J Physiol 501 Pt 1 1997 3 16
26. 2+] in whole perfused rat hearts using Indo-1 fluorometry Biophys J 65 1993 1973 1982
27. 2+ measurement with Indo-1 in substrate-attached cells: advantages and special considerations Cell Calcium 11 1990 487 500
28. 2+ concentrations Chem Biol 3 1996 765 774
29. A. Luckhoff Measuring cytosolic free calcium concentration in endothelial cells with indo-1: the pitfall of using the ratio of two fluorescence intensities recorded at different wavelengths Cell Calcium 7 1986 233 248
30. H.C. Lee, R. Mohabir, N. Smith, M.R. Franz, and W.T. Clusin Effect of ischemia on calcium-dependent fluorescence transients in rabbit hearts containing indo 1 Correlation with monophasic action potentials and contraction Circulation 78 1988 1047 1059
31. K.R. Laurita, R. Katra, B. Wible, X. Wan, and M.H. Koo Transmural heterogeneity of calcium handling in canine Circ Res 92 2003 668 675
32. F. Abe, H. Karaki, and M. Endoh Effects of cyclopiazonic acid and ryanodine on cytosolic calcium and contraction in vascular smooth muscle Br J Pharmacol 118 1996 1711 1716
33. Ks contributes to the longer action potential of the M cell Circ Res 76 1995 351 365
34. M. Warren, P.K. Guha, and O. Berenfeld Blockade of the inward rectifying potassium current terminates ventricular fibrillation in the guinea pig heart J Cardiovasc Electrophysiol 14 2003 621 631
35. L.C. Baker, R. Wolk, and B.R. Choi Effects of mechanical uncouplers, diacetyl monoxime, and cytochalasin-D on the electrophysiology of perfused mouse hearts Am J Physiol Heart Circ Physiol 287 2004 H1771 H1779