Cobalt-Alloy Implant Debris Induce HIF-1α Hypoxia Associated Responses: A Mechanism for Metal-Specific Orthopedic Implant Failure

PLoS ONE

Volumn 8, Issue 6, 2013, Pages

  Samelko, Lauryn ^a   Caicedo, Marco S ^a   Lim, Seung Jae ^b   Della Valle, Craig ^a   Jacobs, Joshua ^a   Hallab, Nadim J ^a  

^a RUSH UNIVERSITY MEDICAL CENTER   (United States)

^b Samsung Medical Center   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ALLOY; COBALT; HYPOXIA INDUCIBLE FACTOR 1ALPHA; POLYMER; REACTIVE OXYGEN METABOLITE; TITANIUM; TUMOR NECROSIS FACTOR ALPHA; VASCULOTROPIN;

ADULT; ARTICLE; CELL LEVEL; CLINICAL ARTICLE; COBALT ALLOY IMPLANT DEBRIS; CONCENTRATION RESPONSE; CONTROLLED STUDY; COPING BEHAVIOR; DISEASE ACTIVITY; DISEASE ASSOCIATION; HIP ARTHROPLASTY; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPOXIA; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; LYMPHOCYTIC INFILTRATION; MACROPHAGE; METAL IMPLANTATION; METAL ON METAL JOINT PROSTHESIS; METAL ON POLYMER PROSTHESIS; MONOCYTE; NECROSIS; ORTHOPEDIC IMPLANT; PARTICLE SIZE; PROSTHESIS FAILURE; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN METABOLISM; PROTEIN SYNTHESIS; SYNOVIAL FLUID; TISSUE GROWTH; TREATMENT RESPONSE; UPREGULATION;

CELL HYPOXIA; CELL LINE; HIP JOINT; HIP PROSTHESIS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; METAL-ON-METAL JOINT PROSTHESES; PARTICULATE MATTER; PROSTHESIS FAILURE; REACTIVE OXYGEN SPECIES; SYNOVIAL FLUID; TRANSCRIPTIONAL ACTIVATION; TUMOR NECROSIS FACTOR-ALPHA; UP-REGULATION; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VITALLIUM;

EID: 84879266607     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0067127     Document Type: Article

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