Salvia officinalis for hot flushes: Towards determination of mechanism of activity and active principles

Planta Medica

Volumn 79, Issue 9, 2013, Pages 753-760

  Rahte, Sinikka ^a   Evans, Richard ^a,b   Eugster, Philippe J ^c   Marcourt, Laurence ^c   Wolfender, Jean Luc ^c   Kortenkamp, Andreas ^a,b   Tasdemir, Deniz ^a,d  

^a UNIVERSITY OF LONDON   (United Kingdom)

^b BRUNEL UNIVERSITY   (United Kingdom)

^c UNIVERSITY OF GENEVA   (Switzerland)

^d NATIONAL UNIVERSITY OF IRELAND   (Ireland)

Author keywords

estrogenicity; hot flush; Lamiaceae; luteolin 7 O glucoside; menopause; Salvia officinalis

Indexed keywords

ACETYLCHOLINESTERASE; ALCOHOL; HEXANE; SALVIA OFFICINALIS EXTRACT;

ARTICLE; DRUG MECHANISM; EMBRYO; GEL CHROMATOGRAPHY; HOT FLUSH; HUMAN; HUMAN CELL; IN VITRO STUDY; LIQUID CHROMATOGRAPHY; MENOPAUSE; NONHUMAN; SALVIA OFFICINALIS;

CHOLINESTERASE INHIBITORS; DRUG EVALUATION, PRECLINICAL; ESTROGENS; FEMALE; FLAVONES; GLUCOSIDES; HEK293 CELLS; HOT FLASHES; HUMANS; LUTEOLIN; MENOPAUSE; PLANT EXTRACTS; PLANTS, MEDICINAL; SALVIA OFFICINALIS; SEROTONIN UPTAKE INHIBITORS;

LAMIACEAE; SALVIA OFFICINALIS;

EID: 84879232414     PISSN: 00320943     EISSN: 14390221     Source Type: Journal    
DOI: 10.1055/s-0032-1328552     Document Type: Article

References (52)

1. NAMS Estrogen and progestogen use in postmenopausal women: 2010 position statement of The North American Menopause Society. Menopause: 2010; 2 242 255
2. Carroll D. G., Kelley K. W. Use of antidepressants for management of hot flashes. Pharmacotherapy: 2009; 11 1357 1374
3. Daly E., Gray A., Barlow D., McPherson K., Roche M., Vessey M. Measuring the impact of menopausal symptoms on quality of life. BMJ: 1993; 6908 836 840
4. Kronenberg F. Hot flashes: epidemiology and physiology. Ann N Y Acad Sci: 1990; 592 52 86
5. Utian W. H. Psychosocial and socioeconomic burden of vasomotor symptoms in menopause: a comprehensive review. Health Qual Life Outcomes: 2005; 3 47
6. Freedman R. R., Krell W. Reduced thermoregulatory null zone in postmenopausal women with hot flashes. Am J Obstet Gynecol: 1999; 1 66 70
7. Kronenberg F. Menopausal hot flashes: a review of physiology and biosociocultural perspective on methods of assessment. J Nutr: 2010; 7 1380S 1385S
8. Weiss G., Skurnick J. H., Goldsmith L. T., Santoro N. F., Park S. J. Menopause and hypothalamic-pituitary sensitivity to estrogen. JAMA: 2004; 24 2991 2996
9. MacLennan A., Broadbent J. L., Lester S., Moore V. Oral oestrogen and combined oestrogen/progesteron therapy versus placebo for hot flushes. Cochrane Database Syst Rev: 2004; 4 CD002978
10. Diel P., Olff S., Schmidt S., Michna H. Molecular identification of potential selective estrogen receptor modulator (SERM) like properties of phytoestrogens in the human breast cancer cell line MCF-7. Planta Med: 2001; 6 510 514
11. Harris D. M., Besselink E., Henning S. M., Go V. L., Heber D. Phytoestrogens induce differential estrogen receptor alpha- or beta-mediated responses in transfected breast cancer cells. Exp Biol Med: 2005; 8 558 568
12. Berendsen H. H. The role of serotonin in hot flushes. Maturitas: 2000; 3 155 164
13. Shanafelt T. D., Barton D. L., Adjei A. A., Loprinzi C. L. Pathophysiology and treatment of hot flashes. Mayo Clin Proc: 2002; 11 1207 1218
14. Sturdee D. W. The menopausal hot flush-anything new? Maturitas: 2008; 1 42 49
15. Berendsen H. H., Broekkamp C. L. Behavioural evidence for functional interactions between 5-HT-receptor subtypes in rats and mice. Br J Pharmacol: 1990; 3 667 673
16. Blakely R. D., Ramamoorthy S., Qian Y., Schroeter S., Bradely C. C. Regulation of antidepressant-sensitive serotonin transporters. In: Reith M. EA. editor Neurotranmittertransporters: structure, function and regulation. Totowa Humana Press, Inc.: 1997; 29 72
17. Togel B., Greve B., Raulin C. Current therapeutic strategies for hyperhidrosis: a review. Eur J Dermatol: 2002; 3 219 223
18. Bartram T. Bartram encyclopedia of herbal medicine. London Grace Publishers: 1995
19. Bommer S., Klein P., Suter A. First time proof of sages tolerability and efficacy in menopausal women with hot flushes. Adv Ther: 2011; 6 490 500
20. Merchenthaler I., Funkhouser J. M., Carver J. M., Lundeen S. G., Ghosh K., Winneker R. C. The effect of estrogens and antiestrogens in a rat model for hot flush. Maturitas: 1998; 3 307 316
21. Sipe K., Leventhal L., Burroughs K., Cosmi S., Johnston G. H., Deecher D. C. Serotonin 2A receptors modulate tail-skin temperature in two rodent models of estrogen deficiency-related thermoregulatory dysfunction. Brain Res: 2004; 2 191 202
22. Rodriguez G. J., Roman D. L., White K. J., Nichols D. E., Barker E. L. Distinct recognition of substrates by the human and Drosophila serotonin transporters. J Pharmacol Exp Ther: 2003; 1 338 346
23. Wilson V. S., Bobseine K., Gray L. E. jr. Development and characterization of a cell line that stably expresses an estrogen-responsive luciferase reporter for the detection of estrogen receptor agonist and antagonists. Toxicol Sci: 2004; 1 69 77
24. Launer L. J., Andersen K., Dewey M. E., Letenneur L., Ott A., Amaducci L. A., Brayne C., Copeland J. R., Dartigues J. F., Kragh-Sorensen P., Lobo A., Martinez-Lage J. M., Stijnen T., Hofman A. Rates and risk factors for dementia and Alzheimers disease: results from EURODEM pooled analyses. EURODEM Incidence Research Group and Work Groups. European Studies of Dementia. Neurology: 1999; 1 78 84
25. Alberca R., Montes-Latorre E., Gil-Neciga E., Mir-Rivera P., Lozano-San Martín P. Alzheimers disease and women. Rev Neurol: 2002; 6 571 579
26. Nilsson S., Koehler K. F., Gustafsson J. A. Development of subtype-selective oestrogen receptor-based therapeutics. Nat Rev Drug Discov: 2011; 10 778 792
27. Greenblatt H. M., Guillou C., Guenard D., Argaman A., Botti S., Badet B., Thal C., Silman I., Sussman J. L. The complex of a bivalent derivative of galanthamine with torpedo acetylcholinesterase displays drastic deformation of the active-site gorge: implications for structure-based drug design. J Am Chem Soc: 2004; 47 15405 15411
28. Perry N. S., Houghton P. J., Jenner P., Keith A., Perry E. K. Salvia lavandulaefolia essential oil inhibits cholinesterase in vivo. Phytomedicine: 2002; 1 48 51
29. Loizzo M. R., Menichini F., Tundis R., Bonesi M., Conforti F., Nadjafi F., Statti G. A., Frega N. G. In vitro biological activity of Salvia leriifolia benth essential oil relevant to the treatment of Alzheimers disease. J Oleo Sci: 2009; 8 443 446
30. Ren Y., Houghton P. J., Hider R. C., Howes M. J. Novel diterpenoid acetylcholinesterase inhibitors from Salvia miltiorrhiza. Planta Med: 2004; 3 201 204
31. Akhondzadeh S., Noroozian M., Mohammadi M., Ohadinia S., Jamshidi A. H., Khani M. Salvia officinalis extract in the treatment of patients with mild to moderate Alzheimers disease: a double blind, randomized and placebo-controlled trial. J Clin Pharm Ther: 2003; 1 53 59
32. Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods: 1983; 65 55 63
33. Rhee I. K., van de Meent M., Ingkaninan K., Verpoorte R. Screening for acetylcholinesterase inhibitors from Amaryllidaceae using silica gel thin-layer chromatography in combination with bioactivity staining. J Chromatogr A: 2001; 915 217 223
34. Rhee I. K., van Rijn R. M., Verpoorte R. Qualitative determination of false-positive effects in the acetylcholinesterase assay using thin layer chromatography. Phytochem Anal: 2003; 3 127 131
35. Kivrak I., Duru M. E., Öztürk M., Mercan N., Harmandar M., Topcu G. Antioxidant, anticholinesterase and antimicrobial constituents from the essential oil and ethanol extract of Salvia potentillifolia. Food Chem: 2009; 2 470 479
36. Özgen U., Sevindik H., Kazaz C., Yigit D., Kandemir A., Secen H., Çaliş I. A new sulfated alpha-ionone glycoside from Sonchus erzincanicus Matthews. Molecules: 2010; 4 2593 2599
37. Lu Y., Foo L. Y. Flavonoid and phenolic glycosides from Salvia officinalis. Phytochemistry: 2000; 3 263 267
38. Duke J. A. Handbook of medicinal herbs. 2nd edition. Boca Ranton CRC Press: 2002
39. Paris R. R., Moyse H. Précis de Matière Médicale Paris: Collection de précis de pharmacie. Paris Masson et Cie: 1971
40. Kroszcynski S., Bychowska M. Laction oestrogéne de la sauge (Salvia officinalis). Soc Biol Varsovie: 1939; 6 570 572
41. Perry N. S., Houghton P. J., Sampson J., Theobald A. E., Hart S., Lis-Balchin M., Hoult J. R., Evans P., Jenner P., Milligan S., Perry E. K. In-vitro activity of S. lavandulaefolia (Spanish sage) relevant to treatment of Alzheimers disease. J Pharm Pharmacol: 2001; 10 1347 1356
42. van der Woude H., Ter Veld M. G., Jacobs N., van der Saag P. T., Murk A. J., Rietjens I. M. The stimulation of cell proliferation by quercetin is mediated by the estrogen receptor. Mol Nutr Food Res: 2005; 8 763 771
43. Seo H. S., DeNardo D. G., Jacquot Y., Laios I., Vidal D. S., Zambrana C. R., Leclercq G., Brown P. H. Stimulatory effect of genistein and apigenin on the growth of breast cancer cells correlates with their ability to activate ER alpha. Breast Cancer Res Treat: 2006; 2 121 134
44. Moutsatsou P. The spectrum of phytoestrogens in nature: our knowledge is expanding. Hormones: 2007; 3 173 193
45. Innocenti G., Vegeto E., DallAcqua S., Ciana P., Giorgetti M., Agradi E., Sozzi A., Fico G., Tome F. In vitro estrogenic activity of Achillea millefolium L. Phytomedicine: 2007; 14 147 152
46. Garritano S., Pinto B., Giachi I., Pistelli L., Reali D. Assessment of estrogenic activity of flavonoids from Mediterranean plants using an in vitro short-term test. Phytomedicine: 2005; 12 143 147
47. Virgili F., Acconcia F., Ambra R., Rinna A., Totta P., Marino M. Nutritional flavonoids modulate estrogen receptor alpha signaling. IUBMB Life: 2004; 3 145 151
48. Shimoi K., Okada H., Furugori M., Goda T., Takase S., Suzuki M., Hara Y., Yamamoto H., Kinae N. Intestinal absorption of luteolin and luteolin 7-O-beta-glucoside in rats and humans. FEBS Lett: 1998; 3 220 224
49. Wittemer S. M., Ploch M., Windeck T., Muller S. C., Drewelow B., Derendorf H., Veit M. Bioavailability and pharmacokinetics of caffeoylquinic acids and flavonoids after oral administration of Artichoke leaf extracts in humans. Phytomedicine: 2005; 12 28 38
50. OLeary K. A., Day A. J., Needs P. W., Mellon F. A., OBrien N. M., Williamson G. Metabolism of quercetin-7- and quercetin-3-glucuronides by an in vitro hepatic model: the role of human beta-glucuronidase, sulfotransferase, catechol-O-methyltransferase and multi-resistant protein 2 (MRP2) in flavonoid metabolism. Biochem Pharmacol: 2003; 3 479 491
51. Sperker B., Murdter T. E., Schick M., Eckhardt K., Bosslet K., Kroemer H. K. Interindividual variability in expression and activity of human beta-glucuronidase in liver and kidney: consequences for drug metabolism. J Pharmacol Exp Ther: 1997; 2 914 920
52. Perry N., Court G., Bidet N., Court J., Perry E. European herbs with cholinergic activities: Potential in dementia therapy. Int J Geriatr Psych: 1996; 12 1063 1069