Tectorigenin Attenuates Palmitate-Induced Endothelial Insulin Resistance via Targeting ROS-Associated Inflammation and IRS-1 Pathway

PLoS ONE

Volumn 8, Issue 6, 2013, Pages

  Wang, Qi ^a   Cheng, Xiao Lan ^a   Zhang, Dong Yan ^b   Gao, Xue Jiao ^c   Zhou, Ling ^a   Qin, Xiao Ying ^a   Xie, Guo Yong ^a   Liu, Kang ^a   Qin, Yong ^a   Liu, Bao Lin ^a   Qin, Min Jian ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b HENAN PROVINCIAL PEOPLE'S HOSPITAL   (China)

^c University of Macau   (Macao)

Author keywords

[No Author keywords available]

Indexed keywords

ENDOTHELIAL NITRIC OXIDE SYNTHASE; ENDOTHELIN 1; I KAPPA B KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INSULIN; INSULIN RECEPTOR SUBSTRATE 1; INTERLEUKIN 6; NITRIC OXIDE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE; TECTORIGENIN; TUMOR NECROSIS FACTOR ALPHA; VASCULAR CELL ADHESION MOLECULE 1; INSULIN RECEPTOR SUBSTRATE; IRS1 PROTEIN, HUMAN; ISOFLAVONE DERIVATIVE; PALMITIC ACID; TNF PROTEIN, HUMAN; TUMOR NECROSIS FACTOR;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOWN REGULATION; DRUG EFFECT; DRUG MECHANISM; ENDOTHELIAL DYSFUNCTION; ENDOTHELIUM CELL; ENZYME ACTIVATION; HUMAN; HUMAN CELL; INFLAMMATION; INSULIN RESISTANCE; MALE; MITOCHONDRIAL MEMBRANE POTENTIAL; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION; VASODILATATION; ANIMAL; CHEMICALLY INDUCED; DISEASE MODEL; DRUG EFFECTS; GENE EXPRESSION REGULATION; IMMUNOLOGY; METABOLISM; MITOCHONDRION; PHYSIOLOGY; UMBILICAL VEIN ENDOTHELIAL CELL; VASCULAR ENDOTHELIUM;

PUERARIA MONTANA VAR. THOMSONII; RATTUS;

ANIMALS; DISEASE MODELS, ANIMAL; ENDOTHELIUM, VASCULAR; GENE EXPRESSION REGULATION; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; INFLAMMATION; INSULIN RECEPTOR SUBSTRATE PROTEINS; INSULIN RESISTANCE; ISOFLAVONES; MALE; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; PALMITIC ACID; RATS; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84879229420     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0066417     Document Type: Article

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